SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_A_7V7A201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1axk | GLUXYN-1 (Bacillussubtilis) |
PF00457(Glyco_hydro_11)PF00722(Glyco_hydro_16) | 4 | THR A 247THR A 266ARG A 268GLN A 283 | None | 0.95A | 5tzoA-1axkA:34.6 | 5tzoA-1axkA:58.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1axk | GLUXYN-1 (Bacillussubtilis) |
PF00457(Glyco_hydro_11)PF00722(Glyco_hydro_16) | 5 | TYR A 264THR A 266ARG A 268GLN A 283TRP A 285 | None | 0.53A | 5tzoA-1axkA:34.6 | 5tzoA-1axkA:58.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1f5j | BETA-1,4-XYLANASE (Dictyoglomusthermophilum) |
PF00457(Glyco_hydro_11) | 5 | TYR A 121THR A 123ARG A 125GLN A 139TRP A 141 | None | 0.94A | 5tzoA-1f5jA:25.4 | 5tzoA-1f5jA:42.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h1a | ENDO-1,4-BETA-XYLANASE (Chaetomiumthermophilum) |
PF00457(Glyco_hydro_11) | 5 | THR A 101TYR A 119THR A 121GLN A 137TRP A 139 | None | 0.90A | 5tzoA-1h1aA:28.8 | 5tzoA-1h1aA:52.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h1a | ENDO-1,4-BETA-XYLANASE (Chaetomiumthermophilum) |
PF00457(Glyco_hydro_11) | 5 | TYR A 119THR A 121ARG A 123GLN A 137TRP A 139 | NoneNoneGOL A1196 (-2.8A)NoneNone | 1.28A | 5tzoA-1h1aA:28.8 | 5tzoA-1h1aA:52.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hix | ENDO-1,4-BETA-XYLANASE (Streptomycessp. S38) |
PF00457(Glyco_hydro_11) | 5 | TYR A 117THR A 119ARG A 121GLN A 135TRP A 137 | None | 0.48A | 5tzoA-1hixA:27.6 | 5tzoA-1hixA:54.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1igo | FAMILY 11 XYLANASE (Bacillussubtilis) |
PF00457(Glyco_hydro_11) | 4 | THR A 107THR A 126ARG A 128GLN A 142 | None | 1.06A | 5tzoA-1igoA:25.2 | 5tzoA-1igoA:48.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1igo | FAMILY 11 XYLANASE (Bacillussubtilis) |
PF00457(Glyco_hydro_11) | 5 | TYR A 124THR A 126ARG A 128GLN A 142TRP A 144 | None | 0.73A | 5tzoA-1igoA:25.2 | 5tzoA-1igoA:48.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 4 | THR A 67TYR A 142THR A 144ARG A 121 | None | 1.29A | 5tzoA-1imvA:undetectable | 5tzoA-1imvA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyn | CHLOROPLASTICASCORBATE PEROXIDASE (Nicotianatabacum) |
PF00141(peroxidase) | 4 | THR A 164TYR A 206ARG A 167TRP A 195 | NA A 297 (-3.2A)NoneNoneNone | 1.39A | 5tzoA-1iynA:undetectable | 5tzoA-1iynA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k32 | TRICORN PROTEASE (Thermoplasmaacidophilum) |
PF03572(Peptidase_S41)PF07676(PD40)PF14684(Tricorn_C1)PF14685(Tricorn_PDZ) | 4 | THR A 209THR A 985ARG A 913GLN A1047 | None | 1.08A | 5tzoA-1k32A:undetectable | 5tzoA-1k32A:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k32 | TRICORN PROTEASE (Thermoplasmaacidophilum) |
PF03572(Peptidase_S41)PF07676(PD40)PF14684(Tricorn_C1)PF14685(Tricorn_PDZ) | 4 | TRP A 214THR A 985ARG A 913GLN A1047 | None | 1.32A | 5tzoA-1k32A:undetectable | 5tzoA-1k32A:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kqj | A/G-SPECIFIC ADENINEGLYCOSYLASE (Escherichiacoli) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | TRP A 77THR A 78TYR A 51ARG A 58 | NoneNoneNoneGOL A 302 (-2.9A) | 1.36A | 5tzoA-1kqjA:undetectable | 5tzoA-1kqjA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ks5 | ENDOGLUCANASE A (Aspergillusniger) |
PF01670(Glyco_hydro_12) | 4 | TRP A 45THR A 203TYR A 61GLN A 19 | None | 1.02A | 5tzoA-1ks5A:16.6 | 5tzoA-1ks5A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tr7 | FIMH PROTEIN (Escherichiacoli) |
no annotation | 4 | TRP B 103THR B 57TYR B 77ARG B 60 | None | 1.01A | 5tzoA-1tr7B:undetectable | 5tzoA-1tr7B:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u69 | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF06983(3-dmu-9_3-mt) | 4 | THR A 119THR A 88ARG A 147GLN A 85 | None | 1.25A | 5tzoA-1u69A:undetectable | 5tzoA-1u69A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u9c | APC35852 (Geobacillusstearothermophilus) |
PF01965(DJ-1_PfpI) | 4 | THR A 148THR A 150ARG A 183GLN A 201 | None | 1.37A | 5tzoA-1u9cA:undetectable | 5tzoA-1u9cA:20.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1yna | ENDO-1,4-BETA-XYLANASE (Thermomyceslanuginosus) |
PF00457(Glyco_hydro_11) | 4 | THR A 120ARG A 122GLN A 136TRP A 138 | None | 0.44A | 5tzoA-1ynaA:27.7 | 5tzoA-1ynaA:44.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 4 | THR X 618THR X 669ARG X 672GLN X 627 | None | 1.41A | 5tzoA-1z3iX:undetectable | 5tzoA-1z3iX:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlp | PETAL DEATH PROTEIN (Dianthuscaryophyllus) |
PF13714(PEP_mutase) | 4 | THR A 180TYR A 198THR A 206ARG A 228 | None | 1.28A | 5tzoA-1zlpA:undetectable | 5tzoA-1zlpA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0j | GALACTOSYLGALACTOSYLXYLOSYLPROTEIN3-BETA-GLUCURONOSYLTRANSFERASE 2 (Homo sapiens) |
PF03360(Glyco_transf_43) | 4 | THR A 189TYR A 190THR A 104GLN A 107 | None | 1.16A | 5tzoA-2d0jA:undetectable | 5tzoA-2d0jA:19.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2f6b | FAMILY 11 XYLANASE (Bacillus) |
PF00457(Glyco_hydro_11) | 5 | TYR A 125THR A 127ARG A 129GLN A 143TRP A 145 | None | 0.59A | 5tzoA-2f6bA:25.1 | 5tzoA-2f6bA:47.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gvk | HEME PEROXIDASE (Bacteroidesthetaiotaomicron) |
PF04261(Dyp_perox) | 4 | THR A 268TYR A 186THR A 272ARG A 245 | NoneNoneNoneEDO A 323 (-4.0A) | 1.39A | 5tzoA-2gvkA:undetectable | 5tzoA-2gvkA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEALPHA-SUBUNIT (Aromatoleumaromaticum) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | TRP A 471THR A 231THR A 807ARG A 811 | None | 1.32A | 5tzoA-2ivfA:undetectable | 5tzoA-2ivfA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j89 | METHIONINE SULFOXIDEREDUCTASE A (Populustrichocarpa) |
PF01625(PMSR) | 4 | THR A 137TYR A 135ARG A 92GLN A 41 | None | 1.24A | 5tzoA-2j89A:undetectable | 5tzoA-2j89A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lpu | KMATG10 (Kluyveromycesmarxianus) |
PF03987(Autophagy_act_C) | 4 | TRP A 21THR A 19ARG A 26GLN A 35 | None | 1.32A | 5tzoA-2lpuA:undetectable | 5tzoA-2lpuA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT BETA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | TRP B 41TYR B 63THR B 64ARG B 94 | NoneNoneNoneSH0 A 503 (-2.7A) | 1.33A | 5tzoA-2v4jB:undetectable | 5tzoA-2v4jB:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcl | CYANOBACTERIALPHYCOERYTHROBILIN (Prochlorococcusphage P-SSM2) |
PF05996(Fe_bilin_red) | 4 | TRP A 47THR A 62ARG A 75TRP A 44 | None | 1.19A | 5tzoA-2vclA:undetectable | 5tzoA-2vclA:20.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vul | GH11 XYLANASE (Escherichiacoli) |
PF00457(Glyco_hydro_11) | 4 | TYR A 122ARG A 126GLN A 140TRP A 142 | None | 0.67A | 5tzoA-2vulA:28.5 | 5tzoA-2vulA:51.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vzx | GREEN FLUORESCENTPROTEIN (Dendronephthyasp. SSAL-2002) |
PF01353(GFP) | 4 | THR A 176TYR A 177ARG A 104TRP A 89 | NoneNoneNoneCR8 A 64 ( 3.8A) | 1.08A | 5tzoA-2vzxA:undetectable | 5tzoA-2vzxA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh1 | KYNURENINE/ALPHA-AMINOADIPATEAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | THR A 99THR A 275ARG A 257GLN A 91 | None | 1.30A | 5tzoA-2xh1A:undetectable | 5tzoA-2xh1A:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsj | SULFITE REDUCTASEBETA SUBUNIT (Desulfomicrobiumnorvegicum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr)PF12838(Fer4_7) | 4 | TRP B 41TYR B 63THR B 64ARG B 94 | NoneNoneNoneSRM A 503 (-2.7A) | 1.38A | 5tzoA-2xsjB:undetectable | 5tzoA-2xsjB:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ybr | SINGLE CHAINANTIBODY FRAGMENT9004G (Homo sapiens) |
PF07686(V-set) | 4 | TRP A 107TYR B 219ARG B 228GLN B 221 | None | 1.17A | 5tzoA-2ybrA:undetectable | 5tzoA-2ybrA:26.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2u | UPF0026 PROTEINMJ0257 (Methanocaldococcusjannaschii) |
PF04055(Radical_SAM)PF08608(Wyosine_form) | 4 | TRP A 61TRP A 89TYR A 142THR A 56 | None | 1.28A | 5tzoA-2z2uA:undetectable | 5tzoA-2z2uA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahy | BETA-GLUCOSIDASE (Trichodermareesei) |
PF00232(Glyco_hydro_1) | 4 | THR A 370TYR A 298THR A 299ARG A 341 | NoneTRS A 500 (-4.1A)NoneNone | 1.27A | 5tzoA-3ahyA:undetectable | 5tzoA-3ahyA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cvd | PLASTOCYANIN (Phormidiumlaminosum) |
PF00127(Copper-bind) | 4 | THR A 102TYR A 85THR A 86GLN A 47 | None | 1.19A | 5tzoA-3cvdA:undetectable | 5tzoA-3cvdA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djl | PROTEIN AIDB (Escherichiacoli) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 4 | THR A 298THR A 378ARG A 375TRP A 362 | None | 1.38A | 5tzoA-3djlA:undetectable | 5tzoA-3djlA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dnf | 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATEREDUCTASE (Aquifexaeolicus) |
PF02401(LYTB) | 4 | THR A 166THR A 196ARG A 226GLN A 200 | None | 1.40A | 5tzoA-3dnfA:undetectable | 5tzoA-3dnfA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ham | AMINOGLYCOSIDEPHOSPHOTRANSFERASE (Enterococcusfaecium) |
PF01636(APH) | 4 | TYR A 95THR A 94ARG A 92GLN A 97 | None | 1.41A | 5tzoA-3hamA:undetectable | 5tzoA-3hamA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE LARGEMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | TYR A 176THR A 178ARG A 278GLN A 357 | NoneNoneNO3 A5658 (-4.0A)NO3 A5658 (-3.1A) | 1.15A | 5tzoA-3hrdA:undetectable | 5tzoA-3hrdA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3if2 | AMINOTRANSFERASE (Psychrobacterarcticus) |
PF00155(Aminotran_1_2) | 4 | THR A 151THR A 218ARG A 415TRP A 368 | None | 1.32A | 5tzoA-3if2A:undetectable | 5tzoA-3if2A:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv1 | P22 PROTEIN (Trypanosomabrucei) |
PF02330(MAM33) | 4 | TRP A 79THR A 80THR A 91GLN A 104 | None | 1.36A | 5tzoA-3jv1A:undetectable | 5tzoA-3jv1A:19.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lb9 | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 4 | THR A 156THR A 175ARG A 177GLN A 6 | None | 0.87A | 5tzoA-3lb9A:12.4 | 5tzoA-3lb9A:60.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lb9 | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 5 | TYR A 173THR A 175ARG A 177GLN A 6TRP A 8 | None | 0.59A | 5tzoA-3lb9A:12.4 | 5tzoA-3lb9A:60.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mf9 | ENDO-1,4-BETA-XYLANASE (Thermopolysporaflexuosa) |
PF00457(Glyco_hydro_11) | 4 | THR A 101THR A 120ARG A 122GLN A 136 | None | 1.03A | 5tzoA-3mf9A:28.0 | 5tzoA-3mf9A:56.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mf9 | ENDO-1,4-BETA-XYLANASE (Thermopolysporaflexuosa) |
PF00457(Glyco_hydro_11) | 5 | TYR A 118THR A 120ARG A 122GLN A 136TRP A 138 | None | 0.72A | 5tzoA-3mf9A:28.0 | 5tzoA-3mf9A:56.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mw3 | NEUREXIN-2-BETA (Rattusnorvegicus) |
PF02210(Laminin_G_2) | 4 | TRP A 102THR A 101TYR A 100ARG A 130 | None | 1.05A | 5tzoA-3mw3A:undetectable | 5tzoA-3mw3A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mw4 | NEUREXIN-2-BETA (Mus musculus) |
PF02210(Laminin_G_2) | 4 | TRP A 98THR A 97TYR A 96ARG A 126 | None | 1.08A | 5tzoA-3mw4A:undetectable | 5tzoA-3mw4A:25.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qv9 | PYRUVATE KINASE 2 (Trypanosomacruzi) |
PF00224(PK)PF02887(PK_C) | 4 | THR A 424THR A 428ARG A 427GLN A 431 | None | 1.37A | 5tzoA-3qv9A:undetectable | 5tzoA-3qv9A:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxb | PUTATIVE XYLOSEISOMERASE (Rhodospirillumrubrum) |
PF01261(AP_endonuc_2) | 4 | THR A 36TYR A 37THR A 40ARG A 52 | NoneNoneNoneEDO A 360 ( 3.2A) | 1.39A | 5tzoA-3qxbA:undetectable | 5tzoA-3qxbA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9r | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (Mycobacteroidesabscessus) |
PF01259(SAICAR_synt) | 4 | THR A 181TYR A 180THR A 176ARG A 173 | THR A 181 ( 0.8A)TYR A 180 ( 1.3A)THR A 176 ( 0.8A)ARG A 173 ( 0.6A) | 1.40A | 5tzoA-3r9rA:undetectable | 5tzoA-3r9rA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | TRP B 561THR B 727THR B 899ARG B 563 | None | 1.38A | 5tzoA-3v0aB:undetectable | 5tzoA-3v0aB:9.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4v | INTEGRIN BETA-7 (Homo sapiens) |
PF00362(Integrin_beta) | 4 | THR B 419ARG B 124GLN B 122TRP B 421 | None | 1.37A | 5tzoA-3v4vB:undetectable | 5tzoA-3v4vB:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vta | CUCUMISIN (Cucumis melo) |
PF00082(Peptidase_S8) | 4 | TRP A 246THR A 141THR A 201ARG A 199 | None | 1.39A | 5tzoA-3vtaA:undetectable | 5tzoA-3vtaA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vz0 | PUTATIVENAD-DEPENDENTALDEHYDEDEHYDROGENASE (Gluconobacteroxydans) |
PF00171(Aldedh) | 4 | THR A 13THR A 6ARG A 16GLN A 163 | None | 1.23A | 5tzoA-3vz0A:undetectable | 5tzoA-3vz0A:17.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vzm | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 4 | THR A 91THR A 110ARG A 112GLN A 127 | NoneNoneDFX A 201 (-3.9A)DFX A 201 (-4.3A) | 0.82A | 5tzoA-3vzmA:35.1 | 5tzoA-3vzmA:91.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vzm | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 5 | TYR A 108THR A 110ARG A 112GLN A 127TRP A 129 | NoneNoneDFX A 201 (-3.9A)DFX A 201 (-4.3A)None | 0.46A | 5tzoA-3vzmA:35.1 | 5tzoA-3vzmA:91.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zse | ENDO-1,4-BETA-XYLANASE (Thermobifidafusca) |
PF00457(Glyco_hydro_11) | 4 | THR A 140THR A 159ARG A 161GLN A 175 | NoneNoneFXP A1207 (-4.1A)FXP A1207 (-4.3A) | 0.78A | 5tzoA-3zseA:28.4 | 5tzoA-3zseA:55.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zse | ENDO-1,4-BETA-XYLANASE (Thermobifidafusca) |
PF00457(Glyco_hydro_11) | 5 | TYR A 157THR A 159ARG A 161GLN A 175TRP A 177 | NoneNoneFXP A1207 (-4.1A)FXP A1207 (-4.3A)None | 0.48A | 5tzoA-3zseA:28.4 | 5tzoA-3zseA:55.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvu | BETA-MANNOSIDASE (Trichodermaharzianum) |
PF00703(Glyco_hydro_2) | 4 | TRP A 87THR A 88TYR A 89THR A 39 | None | 1.41A | 5tzoA-4cvuA:2.8 | 5tzoA-4cvuA:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e5t | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME, C-TERMINALDOMAIN PROTEIN (Labrenziaalexandrii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | THR A 83TYR A 78ARG A 60GLN A 61 | None | 1.32A | 5tzoA-4e5tA:undetectable | 5tzoA-4e5tA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4frx | ANAEROBICALLY-INDUCED OUTER MEMBRANEPORIN OPRE (Pseudomonasaeruginosa) |
PF03573(OprD) | 4 | THR A 145THR A 143ARG A 114GLN A 141 | None | 1.24A | 5tzoA-4frxA:undetectable | 5tzoA-4frxA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4frx | ANAEROBICALLY-INDUCED OUTER MEMBRANEPORIN OPRE (Pseudomonasaeruginosa) |
PF03573(OprD) | 4 | THR A 151THR A 143ARG A 114GLN A 141 | None | 1.37A | 5tzoA-4frxA:undetectable | 5tzoA-4frxA:19.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hk9 | ENDO-1,4-BETA-XYLANASE 2 (Trichodermareesei) |
PF00457(Glyco_hydro_11) | 6 | THR A 100TYR A 118THR A 120ARG A 122GLN A 136TRP A 138 | NoneNoneNoneXYP A 203 (-3.7A)XYP A 203 (-4.0A)None | 0.94A | 5tzoA-4hk9A:29.2 | 5tzoA-4hk9A:50.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ixl | XYLANASE (Bacillus sp.(in: Bacteria)) |
PF00457(Glyco_hydro_11) | 4 | TYR A 124ARG A 128GLN A 142TRP A 144 | None | 0.90A | 5tzoA-4ixlA:24.6 | 5tzoA-4ixlA:41.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ixl | XYLANASE (Bacillus sp.(in: Bacteria)) |
PF00457(Glyco_hydro_11) | 4 | TYR A 124THR A 126GLN A 142TRP A 144 | None | 0.64A | 5tzoA-4ixlA:24.6 | 5tzoA-4ixlA:41.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5r | OXYGENASE (Streptomycesargillaceus) |
PF01494(FAD_binding_3) | 4 | THR A 105THR A 60ARG A 59GLN A 310 | None | 1.27A | 5tzoA-4k5rA:undetectable | 5tzoA-4k5rA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7w | HD DOMAIN-CONTAININGPROTEIN 2 (Homo sapiens) |
PF13023(HD_3) | 4 | TRP A 35TYR A 168THR A 171GLN A 144 | None | 1.41A | 5tzoA-4l7wA:undetectable | 5tzoA-4l7wA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdp | BETA-GLUCOSIDASE (Humicola grisea) |
PF00232(Glyco_hydro_1) | 4 | THR A 380TYR A 308THR A 309ARG A 351 | NoneGOL A 507 (-4.1A)NoneNone | 1.15A | 5tzoA-4mdpA:undetectable | 5tzoA-4mdpA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pgj | HUMAN HEAVY CHAINDOMAIN ANTIBODY (Homo sapiens) |
PF07686(V-set) | 4 | TRP A 111TYR A 110THR A 100GLN A 104 | None | 1.33A | 5tzoA-4pgjA:undetectable | 5tzoA-4pgjA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pju | COHESIN SUBUNIT SA-2DOUBLE-STRAND-BREAKREPAIR PROTEIN RAD21HOMOLOG (Homo sapiens) |
PF08514(STAG)no annotation | 4 | TRP B 381THR A 626THR A 586GLN A 590 | None | 1.42A | 5tzoA-4pjuB:undetectable | 5tzoA-4pjuB:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rep | GAMMA-CAROTENEDESATURASE (Nonlabensdokdonensis) |
PF01593(Amino_oxidase) | 4 | TRP A 309THR A 410ARG A 313TRP A 368 | NoneGOL A 502 ( 4.1A)NoneNone | 1.42A | 5tzoA-4repA:undetectable | 5tzoA-4repA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk6 | GLUCOSE-RESISTANCEAMYLASE REGULATOR (Weissellaparamesenteroides) |
PF13377(Peripla_BP_3) | 4 | THR A 224TYR A 216THR A 185ARG A 195 | NoneNoneNoneGLC A 401 (-2.6A) | 1.33A | 5tzoA-4rk6A:undetectable | 5tzoA-4rk6A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w65 | GLYCOSYL HYDROLASEFAMILY PROTEIN (Mycolicibacteriumfortuitum) |
PF00722(Glyco_hydro_16) | 4 | THR A 220TYR A 219THR A 203ARG A 140 | THR A 220 ( 0.8A)TYR A 219 ( 1.3A)THR A 203 ( 0.8A)ARG A 140 ( 0.6A) | 1.05A | 5tzoA-4w65A:5.6 | 5tzoA-4w65A:24.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6y | NANOBODY NBFEDF9 (Lama glama) |
PF07686(V-set) | 4 | THR B 28TYR B 29THR B 53ARG B 54 | None | 1.33A | 5tzoA-4w6yB:undetectable | 5tzoA-4w6yB:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0v | 2',5'-PHOSPHODIESTERASE 12 (Homo sapiens) |
PF03372(Exo_endo_phos) | 4 | THR A 236TYR A 235ARG A 233TRP A 197 | None | 1.07A | 5tzoA-4z0vA:undetectable | 5tzoA-4z0vA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfm | PUTATIVE6-PHOSPHO-BETA-GALACTOBIOSIDASE (Geobacillusstearothermophilus) |
PF00232(Glyco_hydro_1) | 4 | TRP A 15THR A 473ARG A 403GLN A 407 | None | 1.26A | 5tzoA-4zfmA:undetectable | 5tzoA-4zfmA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7m | BETA-XYLOSIDASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | TRP A 280THR A 274GLN A 230TRP A 763 | None ZN A1909 ( 4.4A)NoneNone | 1.29A | 5tzoA-5a7mA:undetectable | 5tzoA-5a7mA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2v | HYDRAZINE SYNTHASEALPHA SUBUNIT (CandidatusKueneniastuttgartiensis) |
no annotation | 4 | TRP A 458TYR A 554ARG A 490GLN A 557 | None | 1.38A | 5tzoA-5c2vA:undetectable | 5tzoA-5c2vA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cd6 | TPR-DOMAINCONTAINING PROTEIN (Parabacteroidesdistasonis) |
PF17128(DUF5107) | 4 | TRP A 299THR A 560TYR A 561THR A 564 | None | 1.16A | 5tzoA-5cd6A:undetectable | 5tzoA-5cd6A:14.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ej3 | ENDO-1,4-BETA-XYLANASE B (Streptomyceslividans) |
PF00457(Glyco_hydro_11) | 4 | THR A 100THR A 119ARG A 121GLN A 135 | None | 1.26A | 5tzoA-5ej3A:27.5 | 5tzoA-5ej3A:49.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ej3 | ENDO-1,4-BETA-XYLANASE B (Streptomyceslividans) |
PF00457(Glyco_hydro_11) | 5 | TYR A 117THR A 119ARG A 121GLN A 135TRP A 137 | None | 0.74A | 5tzoA-5ej3A:27.5 | 5tzoA-5ej3A:49.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyy | CENTROLOBIUMTOMENTOSUM LECTIN (Centrolobiumtomentosum) |
PF00139(Lectin_legB) | 4 | THR A 183TYR A 177THR A 176GLN A 71 | None | 1.03A | 5tzoA-5eyyA:undetectable | 5tzoA-5eyyA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 4 | TRP A 323TRP A 744THR A 666TRP A 685 | BGC A1003 (-3.9A)NoneNoneNone | 1.42A | 5tzoA-5gw7A:undetectable | 5tzoA-5gw7A:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxf | ACRYLYL-COAREDUCTASE ACUI (Ruegeriapomeroyi) |
PF00107(ADH_zinc_N) | 4 | THR A 156ARG A 231GLN A 235TRP A 217 | None | 1.22A | 5tzoA-5gxfA:undetectable | 5tzoA-5gxfA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hi8 | ANTENNA PROTEIN (Prochlorococcusphage P-HM1) |
PF06206(CpeT) | 4 | TYR A 41THR A 43ARG A 55GLN A 57 | NoneNoneNoneACT A 202 (-3.8A) | 1.24A | 5tzoA-5hi8A:undetectable | 5tzoA-5hi8A:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbk | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 4 | THR A 370TYR A 298THR A 299ARG A 341 | NoneGOL A 501 (-4.1A)NoneNone | 1.22A | 5tzoA-5jbkA:undetectable | 5tzoA-5jbkA:18.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jrm | ENDO-1,4-BETA-XYLANASE (Fusariumoxysporum) |
PF00457(Glyco_hydro_11) | 4 | TYR A 117ARG A 121GLN A 135TRP A 137 | None | 0.71A | 5tzoA-5jrmA:27.6 | 5tzoA-5jrmA:47.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kis | RHS2 (Yersiniaentomophaga) |
no annotation | 4 | TRP B 480THR B 470ARG B 657GLN B 652 | None | 1.26A | 5tzoA-5kisB:undetectable | 5tzoA-5kisB:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5njf | METALLOPROTEASE PMBA (Escherichiacoli) |
PF01523(PmbA_TldD) | 4 | THR B 290THR B 325ARG B 316GLN B 326 | None | 1.06A | 5tzoA-5njfB:undetectable | 5tzoA-5njfB:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 4 | THR B 25TYR B 28THR B 10ARG B 11 | None | 1.42A | 5tzoA-5swiB:undetectable | 5tzoA-5swiB:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u38 | LECTIN (Platypodiumelegans) |
PF00139(Lectin_legB) | 4 | THR A 183TYR A 177THR A 176GLN A 71 | None | 1.35A | 5tzoA-5u38A:undetectable | 5tzoA-5u38A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wh8 | PUTATIVECARBOHYDRATE-ACTIVEENZYME (unculturedorganism) |
no annotation | 4 | THR A 116TYR A 122THR A 124GLN A 126 | None | 1.38A | 5tzoA-5wh8A:undetectable | 5tzoA-5wh8A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wut | ULAM111 (Flavobacteriumsp.) |
no annotation | 4 | THR A 70TYR A 44THR A 68GLN A 66 | None | 1.42A | 5tzoA-5wutA:5.0 | 5tzoA-5wutA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3r | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 4 | TRP A1730THR A1732THR A1737GLN A1789 | None | 0.91A | 5tzoA-6b3rA:undetectable | 5tzoA-6b3rA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bfu | SPIKE PROTEIN (CoronavirusHKU15) |
no annotation | 4 | THR A 444TYR A 436ARG A 292GLN A 293 | None | 1.28A | 5tzoA-6bfuA:undetectable | 5tzoA-6bfuA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bpz | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,MOUSEPIEZO1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 4 | TRP A1730THR A1732THR A1737GLN A1789 | None | 1.11A | 5tzoA-6bpzA:undetectable | 5tzoA-6bpzA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eks | SIALIDASE (Vibrio cholerae) |
no annotation | 4 | TRP A 553THR A 554TYR A 394GLN A 423 | None | 1.40A | 5tzoA-6eksA:4.7 | 5tzoA-6eksA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 4 | THR A 635THR A 589GLN A 573TRP A 575 | None | 1.42A | 5tzoA-6eojA:undetectable | 5tzoA-6eojA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f9n | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTORSUBUNIT 1 (Homo sapiens) |
no annotation | 4 | TYR A 701THR A 782GLN A 798TRP A 784 | None | 1.23A | 5tzoA-6f9nA:undetectable | 5tzoA-6f9nA:15.96 |