SIMILAR PATTERNS OF AMINO ACIDS FOR 5TWJ_B_SAMB201_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0a | PROTEIN (FOLDBIFUNCTIONALPROTEIN) (Escherichiacoli) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ILE A 146ILE A 11GLY A 8GLY A 262LEU A 150 | None | 1.03A | 5twjB-1b0aA:undetectable | 5twjB-1b0aA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3n | AGGLUTININ (Helianthustuberosus) |
PF01419(Jacalin) | 5 | ILE A 141GLY A 142GLY A 11SER A 116VAL A 95 | None | 1.08A | 5twjB-1c3nA:undetectable | 5twjB-1c3nA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ctt | CYTIDINE DEAMINASE (Escherichiacoli) |
PF00383(dCMP_cyt_deam_1)PF08211(dCMP_cyt_deam_2) | 5 | ILE A 76GLY A 82GLY A 79LEU A 52VAL A 38 | None | 1.15A | 5twjB-1cttA:undetectable | 5twjB-1cttA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgs | DNA LIGASE (Thermusfiliformis) |
PF01653(DNA_ligase_aden)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 5 | LEU A 147LEU A 203SER A 202LEU A 216VAL A 170 | None | 1.13A | 5twjB-1dgsA:undetectable | 5twjB-1dgsA:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iov | D-ALA:D-ALA LIGASE (Escherichiacoli) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 5 | LEU A 27GLY A 29LEU A 9SER A 19VAL A 7 | None | 1.15A | 5twjB-1iovA:undetectable | 5twjB-1iovA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1knr | L-ASPARTATE OXIDASE (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | LEU A 202ILE A 14GLY A 15GLY A 20LEU A 370 | NoneFAD A 800 (-4.6A)FAD A 800 (-3.1A)NoneNone | 0.85A | 5twjB-1knrA:undetectable | 5twjB-1knrA:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ILE A 640GLY A 642GLY A 781SER A 809VAL A 654 | None | 0.81A | 5twjB-1n5xA:undetectable | 5twjB-1n5xA:8.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns5 | HYPOTHETICAL PROTEINYBEA (Escherichiacoli) |
PF02590(SPOUT_MTase) | 6 | ILE A 74GLY A 104GLY A 107SER A 123LEU A 127VAL A 132 | None | 1.18A | 5twjB-1ns5A:28.4 | 5twjB-1ns5A:95.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns5 | HYPOTHETICAL PROTEINYBEA (Escherichiacoli) |
PF02590(SPOUT_MTase) | 5 | ILE A 74GLY A 107SER A 123LEU A 127HIS A 129 | None | 0.93A | 5twjB-1ns5A:28.4 | 5twjB-1ns5A:95.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns5 | HYPOTHETICAL PROTEINYBEA (Escherichiacoli) |
PF02590(SPOUT_MTase) | 5 | LEU A 72GLY A 104LEU A 122SER A 123LEU A 127 | None | 0.85A | 5twjB-1ns5A:28.4 | 5twjB-1ns5A:95.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns5 | HYPOTHETICAL PROTEINYBEA (Escherichiacoli) |
PF02590(SPOUT_MTase) | 9 | LEU A 72ILE A 74ILE A 102GLY A 103GLY A 107LEU A 122SER A 123LEU A 127VAL A 132 | None | 0.37A | 5twjB-1ns5A:28.4 | 5twjB-1ns5A:95.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1o6d | HYPOTHETICAL UPF0247PROTEIN TM0844 (Thermotogamaritima) |
PF02590(SPOUT_MTase) | 5 | ILE A 99GLY A 100GLY A 104LEU A 119SER A 120 | None | 0.40A | 5twjB-1o6dA:21.9 | 5twjB-1o6dA:32.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1o6d | HYPOTHETICAL UPF0247PROTEIN TM0844 (Thermotogamaritima) |
PF02590(SPOUT_MTase) | 5 | ILE A 99GLY A 100LEU A 119SER A 120HIS A 126 | None | 0.46A | 5twjB-1o6dA:21.9 | 5twjB-1o6dA:32.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 5 | LEU A 212ILE A 217GLY A 216LEU A 194LEU A 173 | NoneNoneALF A 315 (-3.7A)NoneNone | 1.11A | 5twjB-1rk2A:undetectable | 5twjB-1rk2A:18.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1to0 | HYPOTHETICAL UPF0247PROTEIN YYDA (Bacillussubtilis) |
PF02590(SPOUT_MTase) | 7 | LEU A 76ILE A 78ILE A 107GLY A 108GLY A 112SER A 128HIS A 134 | None | 0.42A | 5twjB-1to0A:23.4 | 5twjB-1to0A:30.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufo | HYPOTHETICAL PROTEINTT1662 (Thermusthermophilus) |
no annotation | 5 | GLY A 35GLY A 32LEU A 16LEU A 41HIS A 39 | None | 1.01A | 5twjB-1ufoA:undetectable | 5twjB-1ufoA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uj2 | URIDINE-CYTIDINEKINASE 2 (Homo sapiens) |
PF00485(PRK) | 5 | LEU A 178ILE A 181GLY A 175LEU A 168VAL A 167 | None | 0.96A | 5twjB-1uj2A:undetectable | 5twjB-1uj2A:21.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1vh0 | HYPOTHETICAL UPF0247PROTEINSAV0024/SA0023 (Staphylococcusaureus) |
PF02590(SPOUT_MTase) | 7 | LEU A 76ILE A 78ILE A 107GLY A 108GLY A 112SER A 128HIS A 134 | None | 0.50A | 5twjB-1vh0A:23.2 | 5twjB-1vh0A:32.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a14 | INDOLETHYLAMINEN-METHYLTRANSFERASE (Homo sapiens) |
PF01234(NNMT_PNMT_TEMT) | 5 | LEU A 193GLY A 190LEU A 183LEU A 186VAL A 160 | None | 1.02A | 5twjB-2a14A:undetectable | 5twjB-2a14A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aeq | FAB HEAVY CHAIN (Mus musculus) |
PF07686(V-set) | 5 | LEU H 18LEU H 116SER H 93LEU H 88VAL H 12 | None | 1.12A | 5twjB-2aeqH:undetectable | 5twjB-2aeqH:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2axq | SACCHAROPINEDEHYDROGENASE (Saccharomycescerevisiae) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | LEU A 8ILE A 75GLY A 11LEU A 53SER A 52 | None | 0.90A | 5twjB-2axqA:undetectable | 5twjB-2axqA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dbr | GLYOXYLATE REDUCTASE (Pyrococcushorikoshii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 210ILE A 156GLY A 157GLY A 162LEU A 236 | NoneNoneNAP A 401 ( 3.7A)NoneNone | 1.01A | 5twjB-2dbrA:2.3 | 5twjB-2dbrA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7t | BASIC AGGLUTININ (Psophocarpustetragonolobus) |
PF00139(Lectin_legB) | 5 | ILE A 109GLY A 108GLY A 103LEU A 89VAL A 90 | None | 1.14A | 5twjB-2e7tA:undetectable | 5twjB-2e7tA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | LEU A 212ILE A 28GLY A 29GLY A 34LEU A 434 | NoneNoneFAD A1000 (-3.3A)NoneNone | 0.95A | 5twjB-2fjaA:undetectable | 5twjB-2fjaA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr1 | ERYTHROMYCINSYNTHASE, ERYAI (Saccharopolysporaerythraea) |
PF08659(KR) | 5 | ILE A1769ILE A1599GLY A1596GLY A1594VAL A1761 | None | 0.98A | 5twjB-2fr1A:undetectable | 5twjB-2fr1A:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g28 | PYRUVATEDEHYDROGENASE E1COMPONENT (Escherichiacoli) |
PF00456(Transketolase_N) | 5 | LEU A 531ILE A 564GLY A 536LEU A 502LEU A 515 | None | 1.04A | 5twjB-2g28A:undetectable | 5twjB-2g28A:10.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Staphylococcusaureus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A 342ILE A 349GLY A 348GLY A 190LEU A 15 | None | 0.96A | 5twjB-2gqdA:undetectable | 5twjB-2gqdA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsj | PROTEIN PPL-2 (Parkiaplatycephala) |
PF00704(Glyco_hydro_18) | 5 | ILE A 78LEU A 140SER A 141LEU A 152VAL A 122 | None | 1.12A | 5twjB-2gsjA:undetectable | 5twjB-2gsjA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hcb | CHROMOSOMALREPLICATIONINITIATOR PROTEINDNAA (Aquifexaeolicus) |
PF00308(Bac_DnaA)PF08299(Bac_DnaA_C) | 5 | LEU A 177ILE A 144GLY A 133LEU A 202VAL A 174 | None | 0.95A | 5twjB-2hcbA:undetectable | 5twjB-2hcbA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpi | DNA POLYMERASE IIIALPHA SUBUNIT (Thermusaquaticus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | ILE A1008GLY A1007LEU A 844SER A 845VAL A 854 | None | 1.03A | 5twjB-2hpiA:undetectable | 5twjB-2hpiA:8.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ius | DNA TRANSLOCASE FTSK (Escherichiacoli) |
PF01580(FtsK_SpoIIIE) | 5 | LEU A 968GLY A1219GLY A1202SER A1207HIS A1218 | None | 1.11A | 5twjB-2iusA:undetectable | 5twjB-2iusA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3t | TRAFFICKING PROTEINPARTICLE COMPLEXSUBUNIT 6A (Homo sapiens) |
PF04051(TRAPP) | 5 | LEU B 131ILE B 136GLY B 135LEU B 69VAL B 65 | None | 0.98A | 5twjB-2j3tB:undetectable | 5twjB-2j3tB:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ola | O-SUCCINYLBENZOICACID SYNTHETASE (Staphylococcusaureus) |
PF13378(MR_MLE_C) | 5 | LEU A 242ILE A 269GLY A 270GLY A 271VAL A 253 | None | 1.07A | 5twjB-2olaA:undetectable | 5twjB-2olaA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ovl | PUTATIVE RACEMASE (Streptomycescoelicolor) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 114ILE A 109ILE A 117GLY A 116LEU A 47 | None | 1.03A | 5twjB-2ovlA:undetectable | 5twjB-2ovlA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmm | UPF0217 PROTEINAF_1056 (Archaeoglobusfulgidus) |
PF04013(Methyltrn_RNA_2) | 6 | LEU A 221ILE A 241GLY A 242GLY A 246LEU A 265SER A 266 | SAM A 301 (-4.3A)SAM A 301 ( 4.8A)SAM A 301 (-3.6A)SAM A 301 (-3.3A)SAM A 301 (-4.4A)SAM A 301 (-4.2A) | 0.66A | 5twjB-2qmmA:6.4 | 5twjB-2qmmA:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmm | UPF0217 PROTEINAF_1056 (Archaeoglobusfulgidus) |
PF04013(Methyltrn_RNA_2) | 6 | LEU A 221ILE A 241GLY A 242GLY A 246SER A 266LEU A 270 | SAM A 301 (-4.3A)SAM A 301 ( 4.8A)SAM A 301 (-3.6A)SAM A 301 (-3.3A)SAM A 301 (-4.2A)SAM A 301 (-4.5A) | 0.50A | 5twjB-2qmmA:6.4 | 5twjB-2qmmA:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 5 | LEU A 144ILE A 142ILE A 149GLY A 148LEU A 140 | None | 1.07A | 5twjB-2qzxA:undetectable | 5twjB-2qzxA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai9 | UPF0217 PROTEINMJ1640 (Methanocaldococcusjannaschii) |
PF04013(Methyltrn_RNA_2) | 5 | LEU X 136ILE X 155GLY X 156GLY X 160LEU X 184 | SAM X 501 (-4.3A)SAM X 501 ( 4.8A)SAM X 501 (-3.2A)SAM X 501 ( 4.2A)SAM X 501 (-4.3A) | 0.63A | 5twjB-3ai9X:7.3 | 5twjB-3ai9X:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai9 | UPF0217 PROTEINMJ1640 (Methanocaldococcusjannaschii) |
PF04013(Methyltrn_RNA_2) | 5 | LEU X 136ILE X 155GLY X 156LEU X 179SER X 180 | SAM X 501 (-4.3A)SAM X 501 ( 4.8A)SAM X 501 (-3.2A)SAM X 501 (-4.4A)SAM X 501 (-4.2A) | 0.54A | 5twjB-3ai9X:7.3 | 5twjB-3ai9X:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai9 | UPF0217 PROTEINMJ1640 (Methanocaldococcusjannaschii) |
PF04013(Methyltrn_RNA_2) | 5 | LEU X 136ILE X 155GLY X 156SER X 180LEU X 184 | SAM X 501 (-4.3A)SAM X 501 ( 4.8A)SAM X 501 (-3.2A)SAM X 501 (-4.2A)SAM X 501 (-4.3A) | 0.41A | 5twjB-3ai9X:7.3 | 5twjB-3ai9X:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aq1 | THERMOSOME SUBUNIT (Methanococcoidesburtonii) |
PF00118(Cpn60_TCP1) | 5 | LEU B 229ILE B 321GLY B 334GLY B 318LEU B 231 | None | 1.01A | 5twjB-3aq1B:undetectable | 5twjB-3aq1B:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aw8 | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Thermusthermophilus) |
PF02222(ATP-grasp) | 5 | LEU A 14ILE A 4GLY A 40LEU A 283LEU A 23 | None | 1.02A | 5twjB-3aw8A:undetectable | 5twjB-3aw8A:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b0p | TRNA-DIHYDROURIDINESYNTHASE (Thermusthermophilus) |
PF01207(Dus) | 5 | LEU A 224ILE A 206GLY A 204LEU A 6VAL A 222 | NoneNoneFMN A 351 (-3.7A)NoneNone | 1.15A | 5twjB-3b0pA:undetectable | 5twjB-3b0pA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp2 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME GIDA (Escherichiacoli) |
PF01134(GIDA)PF13932(GIDA_assoc) | 5 | LEU A 153ILE A 12GLY A 13GLY A 18LEU A 365 | None | 1.10A | 5twjB-3cp2A:undetectable | 5twjB-3cp2A:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fgb | UNCHARACTERIZEDPROTEIN Q89ZH8_BACTN (Bacteroidesthetaiotaomicron) |
PF10282(Lactonase) | 5 | LEU A 191ILE A 205ILE A 184GLY A 188LEU A 219 | None | 0.85A | 5twjB-3fgbA:undetectable | 5twjB-3fgbA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ics | COENZYME A-DISULFIDEREDUCTASE (Bacillusanthracis) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | LEU A 242ILE A 159GLY A 160GLY A 165LEU A 132 | None | 1.07A | 5twjB-3icsA:undetectable | 5twjB-3icsA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ig0 | DNA GYRASE SUBUNIT B (Mycobacteriumtuberculosis) |
PF00986(DNA_gyraseB_C)PF01751(Toprim) | 5 | ILE A 505ILE A 513GLY A 512GLY A 510LEU A 547 | ILE A 505 ( 0.6A)ILE A 513 ( 0.3A)GLY A 512 ( 0.0A)GLY A 510 ( 0.0A)LEU A 547 ( 0.6A) | 1.08A | 5twjB-3ig0A:undetectable | 5twjB-3ig0A:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iv7 | ALCOHOLDEHYDROGENASE IV (Corynebacteriumglutamicum) |
PF00465(Fe-ADH) | 5 | ILE A 198GLY A 197GLY A 224LEU A 263LEU A 171 | None | 1.16A | 5twjB-3iv7A:undetectable | 5twjB-3iv7A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jr3 | NAD-DEPENDENTDEACETYLASE (Thermotogamaritima) |
PF02146(SIR2) | 5 | LEU A 187ILE A 212ILE A 24GLY A 21VAL A 232 | None | 1.04A | 5twjB-3jr3A:undetectable | 5twjB-3jr3A:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzz | SNAP-TAG (Homo sapiens) |
PF01035(DNA_binding_1)PF02870(Methyltransf_1N) | 5 | ILE A 32GLY A 17GLY A 35LEU A 21SER A 22 | None | 1.12A | 5twjB-3kzzA:undetectable | 5twjB-3kzzA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pmo | UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINEN-ACYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00132(Hexapep)PF04613(LpxD) | 5 | ILE A 198GLY A 187GLY A 185LEU A 223SER A 224 | None | 1.02A | 5twjB-3pmoA:undetectable | 5twjB-3pmoA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmr | AVIRULENCE PROTEIN (Hyaloperonosporaparasitica) |
no annotation | 5 | LEU A 107ILE A 111GLY A 112HIS A 114VAL A 70 | None | 1.04A | 5twjB-3rmrA:undetectable | 5twjB-3rmrA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sop | NEURONAL-SPECIFICSEPTIN-3 (Homo sapiens) |
PF00735(Septin) | 5 | LEU A 228ILE A 233GLY A 232LEU A 185SER A 184 | None | 1.08A | 5twjB-3sopA:undetectable | 5twjB-3sopA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sr6 | XANTHINEDEHYDROGENASE/OXIDASE (Bos taurus) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ILE C 640GLY C 642GLY C 781SER C 809VAL C 654 | None | 0.93A | 5twjB-3sr6C:undetectable | 5twjB-3sr6C:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tvi | ASPARTOKINASE (Clostridiumacetobutylicum) |
PF00696(AA_kinase)PF01842(ACT) | 5 | LEU A 274GLY A 272GLY A 211LEU A 276SER A 230 | None | 0.93A | 5twjB-3tviA:undetectable | 5twjB-3tviA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0k | DNA DAMAGE-BINDINGPROTEIN 2 (Danio rerio) |
PF00400(WD40) | 5 | ILE D 195GLY D 170GLY D 188LEU D 208VAL D 210 | None | 0.92A | 5twjB-4a0kD:undetectable | 5twjB-4a0kD:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | GLY B2617LEU B2699LEU B2696HIS B2615VAL B2606 | None | 1.00A | 5twjB-4bedB:undetectable | 5twjB-4bedB:6.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIBINTEGRIN BETA-3 (Homo sapiens;Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2)PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 5 | LEU A 352GLY A 354GLY A 381LEU B 299SER B 300 | None | 0.86A | 5twjB-4cakA:undetectable | 5twjB-4cakA:9.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cso | ORFY PROTEIN,TRANSCRIPTION FACTOR (Thermoproteustenax) |
no annotation | 5 | LEU A 81ILE A 83LEU A 85SER A 86VAL A 72 | None | 0.88A | 5twjB-4csoA:undetectable | 5twjB-4csoA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc7 | PEROXISOMAL2,4-DIENOYL-COAREDUCTASE (Homo sapiens) |
PF13561(adh_short_C2) | 5 | ILE A 40GLY A 41GLY A 35LEU A 206SER A 205 | NAP A 401 (-4.0A)NoneNAP A 401 (-3.5A)NoneNone | 1.03A | 5twjB-4fc7A:undetectable | 5twjB-4fc7A:26.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmw | RNA(GUANINE-9-)-METHYLTRANSFERASEDOMAIN-CONTAININGPROTEIN 2 (Homo sapiens) |
PF01746(tRNA_m1G_MT) | 6 | LEU A 186ILE A 205GLY A 206LEU A 232LEU A 246VAL A 251 | SAH A 301 (-4.1A)SAH A 301 (-4.5A)SAH A 301 (-3.3A)SAH A 301 (-3.8A)SAH A 301 (-4.1A)SAH A 301 (-4.9A) | 0.44A | 5twjB-4fmwA:5.2 | 5twjB-4fmwA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 5 | ILE A 558GLY A 599GLY A 572LEU A 556SER A 554 | None | 1.15A | 5twjB-4fnqA:undetectable | 5twjB-4fnqA:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2c | DYP2 (Amycolatopsissp. ATCC 39116) |
no annotation | 5 | LEU A 141GLY A 144LEU A 60LEU A 63VAL A 158 | None | 1.03A | 5twjB-4g2cA:undetectable | 5twjB-4g2cA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hb5 | ENGINEERED PROTEIN (syntheticconstruct) |
PF12796(Ank_2) | 5 | LEU A 74LEU A 90SER A 91HIS A 82VAL A 86 | None | 1.16A | 5twjB-4hb5A:undetectable | 5twjB-4hb5A:25.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3c | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E (Sinorhizobiummeliloti) |
PF04452(Methyltrans_RNA) | 5 | ILE A 194GLY A 195GLY A 199LEU A 219LEU A 224 | None | 0.56A | 5twjB-4j3cA:8.0 | 5twjB-4j3cA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwg | TRNA(GUANINE(9)-N1)-METHYLTRANSFERASE (Schizosaccharomycespombe) |
PF01746(tRNA_m1G_MT) | 5 | LEU A 183ILE A 202GLY A 203LEU A 229VAL A 248 | NoneACY A 302 ( 4.8A)ACY A 302 (-3.9A)NoneNone | 0.52A | 5twjB-4jwgA:5.4 | 5twjB-4jwgA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwg | TRNA(GUANINE(9)-N1)-METHYLTRANSFERASE (Schizosaccharomycespombe) |
PF01746(tRNA_m1G_MT) | 5 | LEU A 183ILE A 202GLY A 203LEU A 243VAL A 248 | NoneACY A 302 ( 4.8A)ACY A 302 (-3.9A)NoneNone | 0.57A | 5twjB-4jwgA:5.4 | 5twjB-4jwgA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwh | TRNA(GUANINE(9)-N1)-METHYLTRANSFERASE (Schizosaccharomycespombe) |
PF01746(tRNA_m1G_MT) | 6 | LEU A 183ILE A 202GLY A 203LEU A 229LEU A 243VAL A 248 | SAH A 401 (-4.2A)SAH A 401 (-4.3A)SAH A 401 (-3.1A)SAH A 401 (-3.9A)SAH A 401 (-4.6A)SAH A 401 (-4.8A) | 0.54A | 5twjB-4jwhA:6.0 | 5twjB-4jwhA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwj | TRNA(GUANINE(9)-N1)-METHYLTRANSFERASE (Saccharomycescerevisiae) |
PF01746(tRNA_m1G_MT) | 5 | LEU A 186GLY A 206LEU A 232LEU A 246VAL A 251 | SAH A 302 (-4.2A)SAH A 302 (-3.1A)SAH A 302 (-3.8A)SAH A 302 (-4.2A)SAH A 302 (-4.8A) | 0.45A | 5twjB-4jwjA:5.2 | 5twjB-4jwjA:24.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n9f | CORE-BINDING FACTORSUBUNIT BETA (Homo sapiens) |
no annotation | 5 | LEU a 103GLY a 105LEU a 125SER a 22VAL a 108 | None | 0.93A | 5twjB-4n9fa:undetectable | 5twjB-4n9fa:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdk | MAGNESIUM-PROTOPORPHYRINO-METHYLTRANSFERASE (Synechocystissp. PCC 6803) |
PF07109(Mg-por_mtran_C) | 5 | LEU A 80ILE A 78LEU A 76SER A 75VAL A 52 | NoneNoneNoneSAH A 301 (-3.8A)None | 1.06A | 5twjB-4qdkA:undetectable | 5twjB-4qdkA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r04 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80)PF12918(TcdB_N)PF12919(TcdA_TcdB)PF12920(TcdA_TcdB_pore) | 5 | LEU A 365ILE A 387GLY A 281GLY A 280VAL A 367 | None | 1.05A | 5twjB-4r04A:undetectable | 5twjB-4r04A:5.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvc | ABC TRANSPORTERATP-BINDING PROTEIN (Geobacilluskaustophilus) |
PF00005(ABC_tran) | 5 | GLY A 29GLY A 184LEU A 188LEU A 4VAL A 26 | None | 1.00A | 5twjB-4rvcA:undetectable | 5twjB-4rvcA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tpn | PUTATIVE P450-LIKEPROTEIN (Streptomycesscabiei) |
PF00067(p450) | 5 | LEU A 374LEU A 142LEU A 125HIS A 123VAL A 126 | None | 0.78A | 5twjB-4tpnA:undetectable | 5twjB-4tpnA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4us4 | TRANSPORTER (Bacillushalodurans) |
PF00209(SNF) | 5 | ILE A 400GLY A 94LEU A 234SER A 233LEU A 239 | NoneNoneNoneTRP A 601 (-2.9A)None | 0.99A | 5twjB-4us4A:undetectable | 5twjB-4us4A:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzs | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | LEU A 448ILE A 453GLY A 452GLY A 629SER A 612 | None | 1.14A | 5twjB-4uzsA:undetectable | 5twjB-4uzsA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6z | ALCOHOLDEHYDROGENASE 1 (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 118GLY A 123SER A 96LEU A 93HIS A 66 | NoneNoneNoneNone ZN A 401 ( 3.1A) | 0.71A | 5twjB-4w6zA:undetectable | 5twjB-4w6zA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wct | FRUCTOSYLAMINE:OXYGENOXIDOREDUCTASE (Aspergillusfumigatus) |
PF01266(DAO) | 5 | LEU A 220ILE A 15GLY A 16GLY A 21LEU A 363 | NoneFAD A 500 (-4.7A)FAD A 500 (-3.5A)NoneNone | 1.00A | 5twjB-4wctA:undetectable | 5twjB-4wctA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0l | HAPTOGLOBIN (Homo sapiens) |
PF00089(Trypsin) | 5 | LEU C 198ILE C 250ILE C 374GLY C 356GLY C 188 | None | 1.16A | 5twjB-4x0lC:undetectable | 5twjB-4x0lC:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkj | D-LACTATEDEHYDROGENASE (Sporolactobacillusinulinus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 203ILE A 151GLY A 152GLY A 157LEU A 229 | NoneNoneNAD A 401 (-3.4A)NoneNone | 0.99A | 5twjB-4xkjA:2.2 | 5twjB-4xkjA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1k | OUTER MEMBRANEPROTEIN OPRM (Pseudomonasaeruginosa) |
PF02321(OEP) | 5 | LEU A 52GLY A 54LEU A 234LEU A 237VAL A 161 | None | 0.94A | 5twjB-4y1kA:undetectable | 5twjB-4y1kA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zo3 | ACYLHOMOSERINELACTONASE (Chryseobacteriumsp. StRB126) |
PF00753(Lactamase_B) | 5 | LEU A 55ILE A 97GLY A 58LEU A 128LEU A 125 | None | 0.98A | 5twjB-4zo3A:undetectable | 5twjB-4zo3A:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cju | ISOBUTYRYL-COAMUTASE FUSED (Cupriavidusmetallidurans) |
PF01642(MM_CoA_mutase)PF02310(B12-binding)PF03308(ArgK) | 5 | ILE A 43ILE A 81GLY A 113LEU A 60VAL A 69 | NoneNoneB12 A1101 ( 4.8A)NoneNone | 1.08A | 5twjB-5cjuA:undetectable | 5twjB-5cjuA:9.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlc | PYRIDOXINE5'-PHOSPHATESYNTHASE (Pseudomonasaeruginosa) |
PF03740(PdxJ) | 5 | ILE A 97ILE A 64LEU A 72HIS A 56VAL A 55 | None | 1.07A | 5twjB-5dlcA:undetectable | 5twjB-5dlcA:25.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dm3 | L-GLUTAMINESYNTHETASE (Chromohalobactersalexigens) |
PF00120(Gln-synt_C) | 5 | ILE A 375GLY A 374GLY A 294SER A 266HIS A 290 | NoneNoneNoneADP A 501 (-2.9A)None | 1.04A | 5twjB-5dm3A:undetectable | 5twjB-5dm3A:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dm3 | L-GLUTAMINESYNTHETASE (Chromohalobactersalexigens) |
PF00120(Gln-synt_C) | 5 | ILE A 375GLY A 374LEU A 267SER A 266HIS A 290 | NoneNoneNoneADP A 501 (-2.9A)None | 1.15A | 5twjB-5dm3A:undetectable | 5twjB-5dm3A:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5erb | POLYKETIDE SYNTHASE (Bacillusamyloliquefaciens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 97ILE A 162GLY A 251GLY A 208LEU A 99 | None | 1.12A | 5twjB-5erbA:undetectable | 5twjB-5erbA:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsw | RNA DEPENDENT RNAPOLYMERASE QDE-1 (Thielaviaterrestris) |
PF05183(RdRP) | 5 | ILE A 355ILE A 331GLY A 332SER A 406VAL A 542 | None | 1.13A | 5twjB-5fswA:undetectable | 5twjB-5fswA:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fya | PATATIN-LIKEPROTEIN, PLPD (Pseudomonasaeruginosa) |
PF01734(Patatin) | 5 | ILE A 232ILE A 40GLY A 41GLY A 297VAL A 65 | None | 1.02A | 5twjB-5fyaA:undetectable | 5twjB-5fyaA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gha | SULFUR TRANSFERASETTUA (Thermusthermophilus) |
PF01171(ATP_bind_3) | 5 | LEU A 63GLY A 56LEU A 67SER A 68VAL A 52 | None | 0.91A | 5twjB-5ghaA:undetectable | 5twjB-5ghaA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs7 | CHOLOYLGLYCINEHYDROLASE (Enterococcusfaecalis) |
PF02275(CBAH) | 5 | LEU A 142ILE A 149GLY A 166LEU A 73VAL A 112 | None | 0.73A | 5twjB-5gs7A:undetectable | 5twjB-5gs7A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8k | UDP-2,3-DIACYLGLUCOSAMINE HYDROLASE (Haemophilusinfluenzae) |
PF00149(Metallophos) | 5 | LEU A 10GLY A 41GLY A 79LEU A 12SER A 13 | NoneNoneNoneNoneACT A 304 ( 3.8A) | 1.16A | 5twjB-5k8kA:undetectable | 5twjB-5k8kA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kd5 | METALLOPEPTIDASE (Bacteroidesthetaiotaomicron) |
PF13402(Peptidase_M60)PF17291(M60-like_N) | 5 | ILE A 435ILE A 439LEU A 404HIS A 438VAL A 370 | None | 1.09A | 5twjB-5kd5A:undetectable | 5twjB-5kd5A:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kxj | L-ASPARTATE OXIDASE (Salmonellaenterica) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | LEU A 202ILE A 14GLY A 15GLY A 20LEU A 370 | None | 0.93A | 5twjB-5kxjA:undetectable | 5twjB-5kxjA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfj | MITOCHONDRIALRIBONUCLEASE PPROTEIN 1 (Homo sapiens) |
no annotation | 5 | LEU A 290ILE A 309GLY A 310LEU A 336LEU A 351 | SAM A 501 (-4.2A)SAM A 501 (-4.4A)SAM A 501 (-3.3A)SAM A 501 (-3.9A)SAM A 501 (-4.0A) | 0.64A | 5twjB-5nfjA:5.6 | 5twjB-5nfjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o96 | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E (Legionellapneumophila) |
no annotation | 5 | ILE A 195GLY A 196GLY A 200LEU A 219LEU A 224 | NoneSAM A 501 (-4.1A)SAM A 501 (-2.9A)SAM A 501 (-4.9A)SAM A 501 (-4.5A) | 0.46A | 5twjB-5o96A:9.2 | 5twjB-5o96A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj1 | DNA TOPOISOMERASE 1 (Mycobacteriumtuberculosis) |
no annotation | 5 | LEU A 526ILE A 531GLY A 530LEU A 522SER A 521 | None | 0.98A | 5twjB-5uj1A:undetectable | 5twjB-5uj1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vwn | TRIOSEPHOSPHATEISOMERASE (Trichomonasvaginalis) |
no annotation | 5 | ILE A 81GLY A 80LEU A 50LEU A 54VAL A 60 | None | 1.12A | 5twjB-5vwnA:undetectable | 5twjB-5vwnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yat | MITOCHONDRIALALCOHOLDEHYDROGENASEISOZYME III (Komagataellaphaffii) |
no annotation | 5 | GLY A 121GLY A 126SER A 99LEU A 96HIS A 69 | NoneNone ZN A 405 ( 4.9A)None ZN A 404 (-3.2A) | 0.69A | 5twjB-5yatA:undetectable | 5twjB-5yatA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bxn | DIPHTHAMIDEBIOSYNTHESIS ENZYMEDPH2 (CandidatusMethanoperedensnitroreducens) |
no annotation | 5 | LEU A 246ILE A 229GLY A 257LEU A 299VAL A 279 | None | 1.16A | 5twjB-6bxnA:undetectable | 5twjB-6bxnA:undetectable |