SIMILAR PATTERNS OF AMINO ACIDS FOR 5TUI_B_CTCB405_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g71 DNA PRIMASE

(Pyrococcus
furiosus) 		PF01896
(DNA_primase_S) 		4 ASP A 120
ARG A 105
LEU A   2
MET A   3
 None
 1.42A 5tuiB-1g71A:
undetectable		 5tuiB-1g71A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ASP A 173
ARG A 177
LEU A 249
MET A 252
 None
 1.48A 5tuiB-1jkwA:
undetectable		 5tuiB-1jkwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ASP A 696
ARG A 407
ARG A 411
LEU A 222
 None
 1.26A 5tuiB-1ut9A:
0.0		 5tuiB-1ut9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASP A 350
ARG A 333
LEU A 582
MET A 503
 None
 1.13A 5tuiB-1v7vA:
0.4		 5tuiB-1v7vA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ASP A  29
ARG A 237
LEU A 197
MET A 362
 None
 1.33A 5tuiB-2b42A:
0.0		 5tuiB-2b42A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ASP A 611
ARG A  33
ARG A  34
LEU A 555
 None
 1.34A 5tuiB-2ddhA:
0.0		 5tuiB-2ddhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 ASP A 257
ARG A 290
LEU A 274
MET A 276
 None
 1.44A 5tuiB-2e4uA:
2.8		 5tuiB-2e4uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ASP A 623
ARG A 746
ARG A 575
LEU A 763
 None
 1.41A 5tuiB-2eyqA:
0.0		 5tuiB-2eyqA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 ASP A 271
ARG A 264
ARG A 260
LEU A  30
 None
 1.21A 5tuiB-2l7bA:
undetectable		 5tuiB-2l7bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 ASP A 271
ARG A 264
ARG A 260
LEU A  71
 None
 1.48A 5tuiB-2l7bA:
undetectable		 5tuiB-2l7bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 ASP A 133
ARG A  93
LEU A 249
MET A 252
 None
 1.36A 5tuiB-2osyA:
0.0		 5tuiB-2osyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF04998
(RNA_pol_Rpb1_5)
PF01192
(RNA_pol_Rpb6) 		4 ASP C 318
ARG C 322
ARG C 290
LEU K  13
 None
 1.03A 5tuiB-2pmzC:
2.5		 5tuiB-2pmzC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		4 ASP A  95
ARG A  98
ARG A  85
LEU A  61
 None
 1.43A 5tuiB-3bh1A:
undetectable		 5tuiB-3bh1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ASP A  31
ARG A 239
LEU A 199
MET A 364
 None
 1.12A 5tuiB-3hd8A:
undetectable		 5tuiB-3hd8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 ASP A 581
ARG A 584
LEU A 652
MET A 647
 None
 1.23A 5tuiB-3hzjA:
undetectable		 5tuiB-3hzjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 ARG A  66
ARG A  93
LEU A 199
MET A 175
 None
 1.30A 5tuiB-3k5wA:
3.0		 5tuiB-3k5wA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ASP A 442
ARG A 427
LEU A 161
MET A 157
 None
 1.42A 5tuiB-3mx3A:
undetectable		 5tuiB-3mx3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ASP A 442
ARG A 427
LEU A 161
MET A 157
 None
 1.47A 5tuiB-3mx3A:
undetectable		 5tuiB-3mx3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		4 ASP A 213
ARG A 217
ARG A 216
LEU A 114
 None
None
AMP  A 242 ( 3.3A)
None
 0.98A 5tuiB-3nuaA:
undetectable		 5tuiB-3nuaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 116
ARG A 120
LEU A  13
MET A  35
 None
 1.49A 5tuiB-3ozyA:
undetectable		 5tuiB-3ozyA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh0 UNCHARACTERIZED
PROTEIN YNCE

(Escherichia
coli) 		no annotation 4 ASP A 239
ARG A 244
ARG A 242
LEU A 353
 None
 1.30A 5tuiB-3vh0A:
undetectable		 5tuiB-3vh0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		4 ASP A 106
ARG A 108
LEU A  52
MET A  55
 None
None
None
DLZ  A1511 ( 3.7A)
 1.15A 5tuiB-3zxsA:
undetectable		 5tuiB-3zxsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		4 ASP A 162
ARG A 152
ARG A 154
LEU A 457
 None
 1.27A 5tuiB-4b61A:
0.5		 5tuiB-4b61A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASP A 377
ARG A1310
ARG A 380
LEU A  57
 None
 1.42A 5tuiB-4iglA:
undetectable		 5tuiB-4iglA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 ASP A 148
ARG A  39
LEU A 547
MET A 550
 None
 1.25A 5tuiB-4jeuA:
undetectable		 5tuiB-4jeuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ASP A 473
ARG A 476
LEU A 253
MET A 208
 None
 1.37A 5tuiB-4y9lA:
1.4		 5tuiB-4y9lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 4 ASP A  62
ARG A  65
LEU A 170
MET A 168
 None
 1.32A 5tuiB-4yubA:
undetectable		 5tuiB-4yubA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA

(Danio rerio) 		PF01504
(PIP5K) 		4 ASP A 260
ARG A 244
LEU A 199
MET A 285
 None
 1.35A 5tuiB-5e3tA:
undetectable		 5tuiB-5e3tA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 ASP A 326
ARG A 328
LEU A 512
MET A 508
 None
 1.34A 5tuiB-5jrlA:
undetectable		 5tuiB-5jrlA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ASP A  47
ARG A  49
ARG A  96
LEU A 205
MET A 222
 FAD  A 405 (-3.0A)
FAD  A 405 ( 4.6A)
None
None
None
 0.71A 5tuiB-5tufA:
60.9		 5tuiB-5tufA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMS
ICMW

(Legionella
pneumophila;
Legionella
pneumophila) 		PF12608
(T4bSS_IcmS)
no annotation 		4 ASP A  91
ARG B 139
ARG B 133
LEU A 108
 None
 1.48A 5tuiB-5x1eA:
undetectable		 5tuiB-5x1eA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 4 ASP A 373
ARG A 377
LEU A 474
MET A 473
 None
 1.29A 5tuiB-6f72A:
undetectable		 5tuiB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 4 ASP A 269
ARG A 387
LEU A 321
MET A 323
 None
 1.44A 5tuiB-6fx0A:
undetectable		 5tuiB-6fx0A:
undetectable