SIMILAR PATTERNS OF AMINO ACIDS FOR 5TUI_B_CTCB405

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		5 THR A 396
GLY A 322
PRO A 184
GLY A 186
PHE A 197
 None
 1.08A 5tuiB-1cbgA:
undetectable		 5tuiB-1cbgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR
DNA POLYMERASE

(Human
alphaherpesvirus
1;
Human
alphaherpesvirus
1) 		PF02282
(Herpes_UL42)
PF11590
(DNAPolymera_Pol) 		5 LEU B1234
THR B1233
GLY A 172
PHE A 165
VAL A 167
 None
 1.03A 5tuiB-1dmlB:
undetectable		 5tuiB-1dmlB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		5 GLY A 154
THR A  55
GLY A  56
VAL A 138
ILE A  50
 None
 1.18A 5tuiB-1f3gA:
undetectable		 5tuiB-1f3gA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		5 PHE A  57
GLU A  48
VAL A 219
THR A 225
GLY A 221
 None
 0.99A 5tuiB-1l2uA:
undetectable		 5tuiB-1l2uA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 GLY X 226
LEU X 261
THR X 265
VAL X 276
ILE X 223
 None
 1.36A 5tuiB-1ogoX:
undetectable		 5tuiB-1ogoX:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A  29
LEU A  11
PRO A  52
GLY A  33
ILE A  27
 None
 1.29A 5tuiB-1rxmA:
undetectable		 5tuiB-1rxmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		5 PHE A  18
GLU A 268
GLY A  12
PHE A   4
ILE A   6
 None
 1.25A 5tuiB-1vliA:
undetectable		 5tuiB-1vliA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x27 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		5 GLU A 125
LEU A 220
THR A 210
GLY A 201
ILE A 183
 None
 1.09A 5tuiB-1x27A:
undetectable		 5tuiB-1x27A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2m INTERFERON,
ALPHA-INDUCIBLE
PROTEIN (CLONE
IFI-15K)

(Homo sapiens) 		PF00240
(ubiquitin) 		5 LEU A  54
GLY A  64
PHE A  15
VAL A  17
ILE A  32
 None
 1.35A 5tuiB-1z2mA:
undetectable		 5tuiB-1z2mA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 PHE A 298
LEU A 306
PRO A 275
VAL A 203
ILE A 234
 None
 1.06A 5tuiB-1zapA:
undetectable		 5tuiB-1zapA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 VAL A  83
GLY A 124
PHE A  32
VAL A  30
ILE A  19
 None
 1.07A 5tuiB-2g1sA:
undetectable		 5tuiB-2g1sA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 VAL A 267
LEU A 187
GLY A 277
GLY A 282
ILE A 109
 None
 1.29A 5tuiB-2hfsA:
undetectable		 5tuiB-2hfsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		5 VAL A1215
LEU A 987
THR A1174
GLY A1208
GLY A 969
 None
 1.25A 5tuiB-2iusA:
undetectable		 5tuiB-2iusA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxr TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00791
(ZU5) 		5 PHE A  10
GLY A  23
PHE A  77
VAL A  81
ILE A  28
 None
 1.17A 5tuiB-2kxrA:
undetectable		 5tuiB-2kxrA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		5 GLY A 438
PRO A  40
GLY A  52
PHE A  70
ILE A 104
 None
 1.14A 5tuiB-2vc2A:
undetectable		 5tuiB-2vc2A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		5 GLY A 120
GLY A 114
PHE A 183
VAL A 155
ILE A 150
 None
 1.21A 5tuiB-2vmxA:
undetectable		 5tuiB-2vmxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbv FIBER PROTEIN

(Canine
mastadenovirus
A) 		no annotation 5 LEU A 482
THR A 526
GLY A 525
GLY A 406
ILE A 383
 None
 1.19A 5tuiB-2wbvA:
undetectable		 5tuiB-2wbvA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 359
VAL A  83
THR A 525
GLY A 522
ILE A 452
 None
 0.99A 5tuiB-2x40A:
undetectable		 5tuiB-2x40A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 PHE O  34
THR O 261
GLY O 262
VAL O 162
ILE O  51
 None
 1.34A 5tuiB-2zf5O:
undetectable		 5tuiB-2zf5O:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfb HEMOGLOBIN SUBUNIT
ALPHA

(Psittacula
krameri) 		PF00042
(Globin) 		5 GLY A 133
PHE A  98
LEU A  83
GLY A  64
GLY A 102
 None
HEM  A 150 (-4.2A)
HEM  A 150 (-4.6A)
None
None
 1.10A 5tuiB-2zfbA:
undetectable		 5tuiB-2zfbA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 GLY A 124
GLU A   9
LEU A 162
GLY A  14
GLY A 128
 None
 1.28A 5tuiB-2zuyA:
undetectable		 5tuiB-2zuyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b85 PHOSPHATE
STARVATION-INDUCIBLE
PROTEIN

(Corynebacterium
glutamicum) 		PF02562
(PhoH) 		5 LEU A 301
GLY A 144
PHE A 237
VAL A 265
ILE A 131
 None
SO4  A 401 (-3.2A)
None
None
None
 1.11A 5tuiB-3b85A:
undetectable		 5tuiB-3b85A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		5 LEU A 142
THR A 174
GLY A 175
PRO A 280
ILE A 438
 None
 1.18A 5tuiB-3b98A:
undetectable		 5tuiB-3b98A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		5 GLY A 287
VAL A 298
THR A 188
GLY A 233
ILE A 284
 None
 0.90A 5tuiB-3cerA:
undetectable		 5tuiB-3cerA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 GLY A  12
GLY A 205
PHE A 196
VAL A 193
ILE A  24
 None
None
None
FAD  A 609 ( 3.8A)
FAD  A 609 (-4.6A)
 0.88A 5tuiB-3da1A:
13.7		 5tuiB-3da1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 GLY A 221
PHE A 260
VAL A 291
LEU A 312
VAL A 254
 None
 1.22A 5tuiB-3eh2A:
undetectable		 5tuiB-3eh2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbu ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13302
(Acetyltransf_3) 		5 GLY A  71
PHE A  90
LEU A   8
GLY A  87
VAL A 134
 None
COA  A 169 (-4.6A)
None
None
COA  A 169 ( 4.8A)
 1.12A 5tuiB-3fbuA:
undetectable		 5tuiB-3fbuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01436
(NHL) 		5 GLY A 673
PHE A 686
VAL A 605
PRO A 636
GLY A 653
 None
 1.13A 5tuiB-3fw0A:
undetectable		 5tuiB-3fw0A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		5 GLY A 326
PHE A 343
VAL A 257
PRO A 291
ILE A 359
 None
 1.15A 5tuiB-3hrpA:
undetectable		 5tuiB-3hrpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihw CENTG3

(Homo sapiens) 		PF00071
(Ras) 		5 GLU A 120
THR A 230
GLY A 197
VAL A  94
ILE A 142
 None
 1.26A 5tuiB-3ihwA:
undetectable		 5tuiB-3ihwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00437
(T2SSE) 		5 LEU A 127
THR A 129
GLY A 130
VAL A 243
ILE A 211
 None
 1.25A 5tuiB-3jvvA:
undetectable		 5tuiB-3jvvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		5 GLY A 276
PHE A 248
GLY A 187
PHE A 206
ILE A 178
 None
 1.44A 5tuiB-3kjxA:
2.7		 5tuiB-3kjxA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meb ASPARTATE
AMINOTRANSFERASE

(Giardia
intestinalis) 		PF00155
(Aminotran_1_2) 		5 GLY A 107
VAL A 329
PHE A  78
VAL A 312
ILE A 265
 SO4  A 500 ( 3.2A)
None
None
None
None
 1.13A 5tuiB-3mebA:
undetectable		 5tuiB-3mebA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 LEU A  43
THR A  37
GLY A  36
GLY A  71
PHE A 269
 None
 1.35A 5tuiB-3mjfA:
3.6		 5tuiB-3mjfA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 GLY A1013
LEU A 503
GLY A 912
GLY A 531
ILE A 598
 None
 0.86A 5tuiB-3nafA:
2.9		 5tuiB-3nafA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyf D-ARGININE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 GLY A1153
THR A1042
GLY A1043
VAL A1030
ILE A1158
 None
FAD  A1500 (-3.5A)
None
None
None
 1.40A 5tuiB-3nyfA:
4.0		 5tuiB-3nyfA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 333
VAL A 271
LEU A 336
GLY A 392
GLY A 229
 None
 1.21A 5tuiB-3oytA:
undetectable		 5tuiB-3oytA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 THR A  56
GLY A  54
GLY A 232
VAL A 222
ILE A 220
 None
None
HEM  A 701 ( 3.9A)
None
None
 1.30A 5tuiB-3pc3A:
2.2		 5tuiB-3pc3A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 213
VAL A 248
LEU A 204
THR A 230
GLY A 301
 PEG  A 508 (-3.5A)
None
None
None
None
 1.01A 5tuiB-3peiA:
undetectable		 5tuiB-3peiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		5 THR A  76
GLY A  75
PHE A 116
VAL A 216
ILE A 123
 None
ZN  A 314 ( 4.4A)
None
None
None
 1.04A 5tuiB-3psqA:
undetectable		 5tuiB-3psqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		5 GLY A 123
GLY A  84
PHE A  85
VAL A  89
ILE A  69
 None
 1.41A 5tuiB-3qbdA:
undetectable		 5tuiB-3qbdA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		5 GLY A 143
VAL A 230
GLY A 235
PHE A 205
ILE A 145
 None
 1.30A 5tuiB-3scyA:
undetectable		 5tuiB-3scyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00215
(OMPdecase) 		5 PHE A  46
GLU A  37
VAL A 208
THR A 214
GLY A 210
 None
None
U5P  A 232 (-4.9A)
PEG  A 234 ( 4.5A)
U5P  A 232 (-3.4A)
 1.01A 5tuiB-3uwqA:
undetectable		 5tuiB-3uwqA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v70 GTPASE IMAP FAMILY
MEMBER 1

(Homo sapiens) 		PF04548
(AIG1) 		5 GLY A 206
VAL A 178
LEU A 211
GLY A 182
PHE A 188
 None
 1.05A 5tuiB-3v70A:
undetectable		 5tuiB-3v70A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Streptomyces
avermitilis) 		PF00215
(OMPdecase) 		5 VAL A  93
LEU A  20
PRO A  63
PHE A  46
VAL A  50
 None
 1.29A 5tuiB-3v75A:
undetectable		 5tuiB-3v75A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Streptomyces
chartreusis) 		PF01370
(Epimerase) 		5 PHE A  18
VAL A 115
GLY A  20
VAL A 217
ILE A 213
 None
 1.36A 5tuiB-3vpsA:
3.9		 5tuiB-3vpsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN

(Thermus
thermophilus) 		PF00497
(SBP_bac_3) 		5 GLU A  38
VAL A  89
THR A  92
GLY A  17
ILE A  14
 None
 1.17A 5tuiB-3vvdA:
undetectable		 5tuiB-3vvdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN

(Thermus
thermophilus) 		PF00497
(SBP_bac_3) 		5 GLY A  42
VAL A  89
THR A  92
GLY A  17
ILE A  14
 None
 0.84A 5tuiB-3vvdA:
undetectable		 5tuiB-3vvdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfj 2-DEHYDROPANTOATE
2-REDUCTASE

(Enterococcus
faecium) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A  83
THR A  78
GLY A   7
VAL A 117
ILE A 122
 None
None
NAD  A 401 ( 4.6A)
None
None
 1.44A 5tuiB-3wfjA:
4.0		 5tuiB-3wfjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 GLY A 162
LEU A 198
GLY A 189
GLY A  41
ILE A  48
 None
None
None
None
SO4  A 603 (-4.9A)
 1.12A 5tuiB-3wfoA:
undetectable		 5tuiB-3wfoA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 GLY A 162
LEU A 198
GLY A 189
GLY A  41
ILE A  48
 None
 1.15A 5tuiB-3wfpA:
undetectable		 5tuiB-3wfpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		5 GLU A 159
LEU A 187
GLY A 215
PRO A 172
GLY A 169
 MN  A1002 (-2.4A)
None
None
None
None
 1.13A 5tuiB-3wqoA:
undetectable		 5tuiB-3wqoA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 GLY A 278
GLU A 381
GLY A 367
PHE A 312
VAL A 315
 None
 0.99A 5tuiB-4aioA:
undetectable		 5tuiB-4aioA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 GLY B 321
GLY B 113
GLY B 286
PHE B 299
ILE B 315
 None
 1.01A 5tuiB-4akxB:
undetectable		 5tuiB-4akxB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 GLY A 317
THR A 120
GLY A 117
GLY A 321
ILE A  29
 None
 0.93A 5tuiB-4atyA:
2.9		 5tuiB-4atyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		5 GLY A 242
THR A 250
GLY A 179
GLY A 207
VAL A  63
 None
None
GOL  A 402 (-3.3A)
None
None
 0.86A 5tuiB-4eb5A:
undetectable		 5tuiB-4eb5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 GLY A 842
VAL A 875
LEU A 839
VAL A 849
ILE A 846
 None
 1.22A 5tuiB-4ecnA:
undetectable		 5tuiB-4ecnA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		5 GLY A 572
GLY A 162
GLY A 200
VAL A 189
ILE A 584
 None
 0.94A 5tuiB-4el8A:
undetectable		 5tuiB-4el8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 GLU A 357
LEU A 207
THR A  50
GLY A  49
ILE A  25
 None
None
ATP  A 803 (-4.1A)
ATP  A 803 (-3.2A)
None
 1.31A 5tuiB-4ijmA:
undetectable		 5tuiB-4ijmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN

(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		PF00963
(Cohesin)
no annotation 		5 LEU A 159
THR A  68
GLY A 116
GLY B 123
ILE B 130
 None
 1.21A 5tuiB-4iu2A:
undetectable		 5tuiB-4iu2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joi CST COMPLEX SUBUNIT
STN1
CST COMPLEX SUBUNIT
TEN1

(Homo sapiens;
Homo sapiens) 		PF01336
(tRNA_anti-codon)
PF09170
(STN1_2)
no annotation 		5 VAL D  93
THR D  25
GLY D  77
GLY A  76
ILE A  31
 None
 0.90A 5tuiB-4joiD:
undetectable		 5tuiB-4joiD:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 298
THR A 318
GLY A 317
VAL A 287
ILE A 303
 None
 1.16A 5tuiB-4kt1A:
undetectable		 5tuiB-4kt1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 GLY A 351
PHE A 342
VAL A 359
VAL A 320
ILE A 388
 None
 1.38A 5tuiB-4lbwA:
undetectable		 5tuiB-4lbwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		5 PHE A 119
THR A 319
GLY A 339
PRO A 330
GLY A 328
 None
 1.33A 5tuiB-4m29A:
undetectable		 5tuiB-4m29A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 LEU A 333
THR A 330
GLY A 319
GLY A 348
PHE A 374
 None
MG  A 401 (-3.3A)
MG  A 401 (-3.2A)
ADP  A 402 ( 3.7A)
None
 1.04A 5tuiB-4ng4A:
undetectable		 5tuiB-4ng4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 GLY A 479
THR A 517
GLY A 672
PHE A 686
ILE A 645
 None
 0.84A 5tuiB-4nh0A:
undetectable		 5tuiB-4nh0A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkj HEMAGGLUTININ HA2

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  85
GLY A  76
GLY A 106
PHE A 108
ILE A  66
 None
 1.20A 5tuiB-4nkjA:
undetectable		 5tuiB-4nkjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		5 THR A  91
GLY A  88
GLY A 510
VAL A 124
ILE A 444
 ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
None
None
None
 1.15A 5tuiB-4pj1A:
undetectable		 5tuiB-4pj1A:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 298
THR A 318
GLY A 317
VAL A 287
ILE A 303
 None
 1.11A 5tuiB-4qxeA:
undetectable		 5tuiB-4qxeA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3j PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 5 GLU C 487
LEU C 495
GLY C 491
PHE C 417
ILE C 462
 None
 1.34A 5tuiB-4u3jC:
undetectable		 5tuiB-4u3jC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 GLY A 298
PHE A 297
VAL A 367
LEU A 353
GLY A 312
 None
 1.15A 5tuiB-4v2xA:
undetectable		 5tuiB-4v2xA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 249
THR A 251
PHE A 338
VAL A 276
ILE A 144
 None
 1.28A 5tuiB-4wojA:
undetectable		 5tuiB-4wojA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
ALPHA
STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida;
Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY)
PF00622
(SPRY)
PF13765
(PRY) 		5 GLY A 208
LEU A 211
GLY B 148
PRO A  13
GLY A  11
 None
 1.22A 5tuiB-4wvmA:
undetectable		 5tuiB-4wvmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		5 GLY A 172
LEU A  52
GLY A  44
PHE A 180
ILE A 258
 None
 1.18A 5tuiB-4yisA:
undetectable		 5tuiB-4yisA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 GLY B 200
VAL B  10
GLY B 141
GLY B 312
VAL B 184
 FAD  B 401 ( 4.2A)
FAD  B 401 (-4.5A)
None
FAD  B 401 (-4.6A)
None
 1.06A 5tuiB-4yjfB:
13.9		 5tuiB-4yjfB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 222
THR A 226
PHE A 252
VAL A 260
ILE A 289
 None
 1.30A 5tuiB-4zpqA:
undetectable		 5tuiB-4zpqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Mus musculus) 		PF03061
(4HBT) 		5 GLY A 251
VAL A 146
GLY A  78
PHE A 334
VAL A 279
 COA  A 401 ( 3.8A)
None
None
None
None
 0.93A 5tuiB-4zv3A:
undetectable		 5tuiB-4zv3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5akr COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 GLY A 152
LEU A  19
PHE A 124
VAL A  81
ILE A 154
 None
 1.27A 5tuiB-5akrA:
undetectable		 5tuiB-5akrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		5 THR A 122
GLY A 118
PRO A 141
GLY A 241
PHE A  20
 None
 1.09A 5tuiB-5epeA:
undetectable		 5tuiB-5epeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5x SITE-2 PROTEASE

(Archaeoglobus
fulgidus) 		PF00571
(CBS) 		5 VAL A 269
PRO A 267
GLY A 265
VAL A 254
ILE A 283
 None
AMP  A1354 (-4.8A)
None
None
None
 1.29A 5tuiB-5g5xA:
undetectable		 5tuiB-5g5xA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis) 		PF01370
(Epimerase) 		5 GLY A  12
THR A 123
PHE A  50
VAL A  29
ILE A  19
 None
 1.29A 5tuiB-5gmoA:
3.0		 5tuiB-5gmoA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov PL-2 SCFV CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 GLY C  91
VAL C  34
GLY C  49
GLY C 110
VAL C1044
 None
 1.05A 5tuiB-5kovC:
undetectable		 5tuiB-5kovC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE

(Leishmania
major) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 211
LEU A 321
GLY A 218
GLY A 147
ILE A 327
 None
 1.15A 5tuiB-5l16A:
undetectable		 5tuiB-5l16A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE

(Acaryochloris
marina) 		no annotation 5 PHE A 255
LEU A 210
GLY A 471
VAL A 249
ILE A 254
 None
 1.23A 5tuiB-5lpcA:
undetectable		 5tuiB-5lpcA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4C

(Nora virus) 		no annotation 5 LEU A 143
THR A 149
GLY A 148
PRO A 126
ILE A 137
 None
 1.16A 5tuiB-5mm2A:
undetectable		 5tuiB-5mm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2b PUTATIVE FIMBRIAL
SUBUNIT TYPE 1

(Burkholderia
pseudomallei) 		no annotation 5 GLY A  37
THR A  56
GLY A  73
PHE A  65
ILE A  39
 EDO  A 208 (-3.4A)
None
None
None
None
 1.03A 5tuiB-5n2bA:
undetectable		 5tuiB-5n2bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 VAL A  84
GLY A 126
PHE A  35
VAL A  33
ILE A  22
 None
 0.98A 5tuiB-5n7qA:
undetectable		 5tuiB-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2n I-ONUI_E-AG007820

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		5 GLY A 201
PHE A 200
LEU A 215
VAL A 252
ILE A 249
 None
 1.40A 5tuiB-5t2nA:
undetectable		 5tuiB-5t2nA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 GLY A 433
PHE A 474
VAL A 166
LEU A 413
GLY A 164
 None
 1.05A 5tuiB-5tr1A:
undetectable		 5tuiB-5tr1A:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		12 GLY A  94
PHE A  95
GLU A 102
VAL A 181
LEU A 198
THR A 207
GLY A 220
PRO A 296
GLY A 299
PHE A 344
VAL A 348
ILE A 371
 None
SO4  A 403 ( 4.8A)
None
FAD  A 405 ( 4.9A)
None
None
None
FAD  A 405 ( 4.2A)
SO4  A 403 ( 3.5A)
None
None
None
 0.40A 5tuiB-5tufA:
60.9		 5tuiB-5tufA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		6 GLU A 102
GLY A 220
PRO A 296
GLY A 299
PHE A 343
VAL A 347
 None
 0.40A 5tuiB-5tulA:
53.0		 5tuiB-5tulA:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		5 GLU A 102
PRO A 296
GLY A 299
PHE A 344
VAL A 348
 None
FAD  A 401 (-3.4A)
None
None
None
 0.66A 5tuiB-5tumA:
50.2		 5tuiB-5tumA:
79.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 GLY A  25
VAL A 168
GLY A 188
GLY A  98
VAL A  70
 None
None
None
NAP  A 301 (-3.8A)
NAP  A 301 (-3.8A)
 0.84A 5tuiB-5u9pA:
4.5		 5tuiB-5u9pA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLY A 148
PHE A 103
LEU A 194
GLY A 168
GLY A 142
 None
None
None
None
GTP  A 501 (-2.8A)
 1.31A 5tuiB-5ucyA:
undetectable		 5tuiB-5ucyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 VAL A 107
LEU A 264
PRO A  45
VAL A  85
ILE A  77
 None
 1.44A 5tuiB-6czmA:
undetectable		 5tuiB-6czmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 5 VAL A 446
LEU A 413
PRO A 427
GLY A 409
ILE A 404
 None
 1.25A 5tuiB-6enzA:
undetectable		 5tuiB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 GLY A 184
GLY A 109
GLY A 231
VAL A 203
ILE A 200
 None
FAD  A 601 (-3.1A)
None
None
None
 0.85A 5tuiB-6eo5A:
undetectable		 5tuiB-6eo5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 5 VAL A 218
LEU A 399
THR A 221
GLY A 220
VAL A 302
 None
None
FAD  A 601 (-3.0A)
FAD  A 601 ( 4.0A)
None
 1.22A 5tuiB-6f72A:
undetectable		 5tuiB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 GLY C 175
VAL C 335
THR C 322
PRO C 318
ILE C 358
 ATP  C 602 ( 3.4A)
None
None
None
None
 1.14A 5tuiB-6fkhC:
undetectable		 5tuiB-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 5 GLY A 355
PHE A 353
VAL A 462
GLY A 457
PRO A 450
 ADP  A 602 ( 4.1A)
None
None
None
None
 1.04A 5tuiB-6gngA:
undetectable		 5tuiB-6gngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g71 DNA PRIMASE

(Pyrococcus
furiosus) 		PF01896
(DNA_primase_S) 		4 ASP A 120
ARG A 105
LEU A   2
MET A   3
 None
 1.42A 5tuiB-1g71A:
undetectable		 5tuiB-1g71A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ASP A 173
ARG A 177
LEU A 249
MET A 252
 None
 1.48A 5tuiB-1jkwA:
undetectable		 5tuiB-1jkwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ASP A 696
ARG A 407
ARG A 411
LEU A 222
 None
 1.26A 5tuiB-1ut9A:
0.0		 5tuiB-1ut9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASP A 350
ARG A 333
LEU A 582
MET A 503
 None
 1.13A 5tuiB-1v7vA:
0.4		 5tuiB-1v7vA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ASP A  29
ARG A 237
LEU A 197
MET A 362
 None
 1.33A 5tuiB-2b42A:
0.0		 5tuiB-2b42A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ASP A 611
ARG A  33
ARG A  34
LEU A 555
 None
 1.34A 5tuiB-2ddhA:
0.0		 5tuiB-2ddhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 ASP A 257
ARG A 290
LEU A 274
MET A 276
 None
 1.44A 5tuiB-2e4uA:
2.8		 5tuiB-2e4uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ASP A 623
ARG A 746
ARG A 575
LEU A 763
 None
 1.41A 5tuiB-2eyqA:
0.0		 5tuiB-2eyqA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 ASP A 271
ARG A 264
ARG A 260
LEU A  30
 None
 1.21A 5tuiB-2l7bA:
undetectable		 5tuiB-2l7bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 ASP A 271
ARG A 264
ARG A 260
LEU A  71
 None
 1.48A 5tuiB-2l7bA:
undetectable		 5tuiB-2l7bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 ASP A 133
ARG A  93
LEU A 249
MET A 252
 None
 1.36A 5tuiB-2osyA:
0.0		 5tuiB-2osyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF04998
(RNA_pol_Rpb1_5)
PF01192
(RNA_pol_Rpb6) 		4 ASP C 318
ARG C 322
ARG C 290
LEU K  13
 None
 1.03A 5tuiB-2pmzC:
2.5		 5tuiB-2pmzC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		4 ASP A  95
ARG A  98
ARG A  85
LEU A  61
 None
 1.43A 5tuiB-3bh1A:
undetectable		 5tuiB-3bh1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ASP A  31
ARG A 239
LEU A 199
MET A 364
 None
 1.12A 5tuiB-3hd8A:
undetectable		 5tuiB-3hd8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 ASP A 581
ARG A 584
LEU A 652
MET A 647
 None
 1.23A 5tuiB-3hzjA:
undetectable		 5tuiB-3hzjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 ARG A  66
ARG A  93
LEU A 199
MET A 175
 None
 1.30A 5tuiB-3k5wA:
3.0		 5tuiB-3k5wA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ASP A 442
ARG A 427
LEU A 161
MET A 157
 None
 1.42A 5tuiB-3mx3A:
undetectable		 5tuiB-3mx3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ASP A 442
ARG A 427
LEU A 161
MET A 157
 None
 1.47A 5tuiB-3mx3A:
undetectable		 5tuiB-3mx3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		4 ASP A 213
ARG A 217
ARG A 216
LEU A 114
 None
None
AMP  A 242 ( 3.3A)
None
 0.98A 5tuiB-3nuaA:
undetectable		 5tuiB-3nuaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 116
ARG A 120
LEU A  13
MET A  35
 None
 1.49A 5tuiB-3ozyA:
undetectable		 5tuiB-3ozyA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh0 UNCHARACTERIZED
PROTEIN YNCE

(Escherichia
coli) 		no annotation 4 ASP A 239
ARG A 244
ARG A 242
LEU A 353
 None
 1.30A 5tuiB-3vh0A:
undetectable		 5tuiB-3vh0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		4 ASP A 106
ARG A 108
LEU A  52
MET A  55
 None
None
None
DLZ  A1511 ( 3.7A)
 1.15A 5tuiB-3zxsA:
undetectable		 5tuiB-3zxsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		4 ASP A 162
ARG A 152
ARG A 154
LEU A 457
 None
 1.27A 5tuiB-4b61A:
0.5		 5tuiB-4b61A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASP A 377
ARG A1310
ARG A 380
LEU A  57
 None
 1.42A 5tuiB-4iglA:
undetectable		 5tuiB-4iglA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 ASP A 148
ARG A  39
LEU A 547
MET A 550
 None
 1.25A 5tuiB-4jeuA:
undetectable		 5tuiB-4jeuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ASP A 473
ARG A 476
LEU A 253
MET A 208
 None
 1.37A 5tuiB-4y9lA:
1.4		 5tuiB-4y9lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 4 ASP A  62
ARG A  65
LEU A 170
MET A 168
 None
 1.32A 5tuiB-4yubA:
undetectable		 5tuiB-4yubA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA

(Danio rerio) 		PF01504
(PIP5K) 		4 ASP A 260
ARG A 244
LEU A 199
MET A 285
 None
 1.35A 5tuiB-5e3tA:
undetectable		 5tuiB-5e3tA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 ASP A 326
ARG A 328
LEU A 512
MET A 508
 None
 1.34A 5tuiB-5jrlA:
undetectable		 5tuiB-5jrlA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ASP A  47
ARG A  49
ARG A  96
LEU A 205
MET A 222
 FAD  A 405 (-3.0A)
FAD  A 405 ( 4.6A)
None
None
None
 0.71A 5tuiB-5tufA:
60.9		 5tuiB-5tufA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMS
ICMW

(Legionella
pneumophila;
Legionella
pneumophila) 		PF12608
(T4bSS_IcmS)
no annotation 		4 ASP A  91
ARG B 139
ARG B 133
LEU A 108
 None
 1.48A 5tuiB-5x1eA:
undetectable		 5tuiB-5x1eA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 4 ASP A 373
ARG A 377
LEU A 474
MET A 473
 None
 1.29A 5tuiB-6f72A:
undetectable		 5tuiB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 4 ASP A 269
ARG A 387
LEU A 321
MET A 323
 None
 1.44A 5tuiB-6fx0A:
undetectable		 5tuiB-6fx0A:
undetectable