SIMILAR PATTERNS OF AMINO ACIDS FOR 5TUD_D_ERMD1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		6 MET A 388
ALA A 422
PHE A 452
GLN A 382
LEU A 396
VAL A 399
 None
 1.46A 5tudD-1e32A:
undetectable		 5tudD-1e32A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faw HEMOGLOBIN (ALPHA
SUBUNIT)

(Anser anser) 		PF00042
(Globin) 		5 VAL A  62
PHE A 128
VAL A 109
LEU A 129
VAL A 132
 HEM  A 150 (-4.2A)
None
None
None
HEM  A 150 (-4.9A)
 1.21A 5tudD-1fawA:
2.6		 5tudD-1fawA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		5 VAL A 220
MET A 160
PHE A 155
VAL A 143
LEU A 181
 None
 1.19A 5tudD-1h1yA:
undetectable		 5tudD-1h1yA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jke D-TYR-TRNATYR
DEACYLASE

(Escherichia
coli) 		PF02580
(Tyr_Deacylase) 		5 ALA A  11
VAL A 110
GLN A 116
LEU A  50
VAL A  66
 None
 1.20A 5tudD-1jkeA:
undetectable		 5tudD-1jkeA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 390
PHE A 463
VAL A 426
LEU A 451
VAL A 465
 None
CU  A 500 (-4.8A)
None
None
None
 1.09A 5tudD-1kyaA:
undetectable		 5tudD-1kyaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 SER A 541
PHE A 578
GLN A 422
LEU A 427
VAL A 586
 None
 1.24A 5tudD-1mpxA:
undetectable		 5tudD-1mpxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 ASP A   8
VAL A 389
ALA A 424
GLN A 373
LEU A 370
 None
 1.28A 5tudD-1nbwA:
undetectable		 5tudD-1nbwA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASP A  60
VAL A 403
ALA A 423
VAL A 399
LEU A 221
 None
 1.27A 5tudD-1ovmA:
undetectable		 5tudD-1ovmA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 VAL B 339
MET B 359
ALA B 397
VAL B 321
LEU B 314
 None
 1.28A 5tudD-1pjmB:
1.0		 5tudD-1pjmB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		5 SER E 129
VAL E  29
VAL E 153
GLN E   4
VAL E 136
 None
 1.20A 5tudD-1qrpE:
undetectable		 5tudD-1qrpE:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE

(Thuja plicata) 		PF05368
(NmrA) 		5 VAL A  79
ALA A  85
PHE A 117
VAL A  21
VAL A 155
 None
 1.13A 5tudD-1qydA:
undetectable		 5tudD-1qydA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		5 VAL B  67
PHE B 134
VAL B 114
LEU B 135
VAL B 138
 HEM  B 148 (-3.9A)
None
None
None
None
 1.21A 5tudD-1spgB:
undetectable		 5tudD-1spgB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN ALPHA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		5 VAL A  64
PHE A 130
VAL A 111
LEU A 131
VAL A 134
 HEM  A 144 (-3.8A)
None
None
None
None
 1.06A 5tudD-1v4uA:
2.3		 5tudD-1v4uA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 VAL A 286
ALA A 273
VAL A 326
LEU A 293
VAL A 178
 None
 1.20A 5tudD-2akjA:
undetectable		 5tudD-2akjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		5 ALA A 382
PHE A 219
VAL A 259
LEU A 412
VAL A 415
 None
 1.06A 5tudD-2bghA:
undetectable		 5tudD-2bghA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		5 VAL X 212
MET X 281
ALA X   4
PHE X   7
LEU X 216
 None
 1.25A 5tudD-2bq8X:
undetectable		 5tudD-2bq8X:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		5 VAL A 375
ALA A 353
PHE A 330
LEU A 382
VAL A 316
 None
None
None
None
NA  A1004 (-4.4A)
 1.10A 5tudD-2e54A:
undetectable		 5tudD-2e54A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		5 VAL A  88
ALA A 120
VAL A 212
LEU A  33
VAL A  65
 None
 1.23A 5tudD-2eekA:
undetectable		 5tudD-2eekA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 PHE A 305
PHE A 304
VAL A 290
LEU A 359
VAL A 363
 None
 1.28A 5tudD-2gjxA:
undetectable		 5tudD-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 372
PHE A 305
PHE A 304
LEU A 359
VAL A 363
 None
 0.98A 5tudD-2gjxA:
undetectable		 5tudD-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 VAL I 372
PHE I 305
PHE I 304
LEU I 359
VAL I 363
 None
 0.96A 5tudD-2gk1I:
undetectable		 5tudD-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 390
PHE A 463
VAL A 426
LEU A 451
VAL A 465
 None
CU  A 601 (-4.9A)
None
None
None
 1.14A 5tudD-2hzhA:
undetectable		 5tudD-2hzhA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASP A 340
ALA A 390
PHE A 463
VAL A 426
VAL A 465
 None
None
CU  A 601 (-4.9A)
None
None
 1.23A 5tudD-2hzhA:
undetectable		 5tudD-2hzhA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		5 MET A 125
ALA A 133
PHE A 106
LEU A  34
VAL A  32
 None
 0.94A 5tudD-2npnA:
undetectable		 5tudD-2npnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o79 LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		5 MET A 102
ALA A  74
VAL A 149
LEU A 121
VAL A  87
 None
 1.28A 5tudD-2o79A:
undetectable		 5tudD-2o79A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ALA A 221
PHE A 262
VAL A 258
GLN A 278
VAL A 266
 None
GOL  A3003 (-4.9A)
None
None
GOL  A3003 (-3.7A)
 0.99A 5tudD-2okxA:
undetectable		 5tudD-2okxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		6 SER A 314
ALA A 250
PHE A 318
VAL A 308
LEU A 264
VAL A 266
 None
 1.42A 5tudD-2phlA:
undetectable		 5tudD-2phlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 389
PHE A 462
VAL A 425
LEU A 450
VAL A 464
 None
CU  A 499 (-4.9A)
None
None
None
 1.11A 5tudD-2qt6A:
undetectable		 5tudD-2qt6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
BETA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 VAL B  67
PHE B 134
VAL B 114
LEU B 135
VAL B 138
 HEM  B 148 ( 4.0A)
None
None
EDO  B2775 ( 4.8A)
None
 1.09A 5tudD-2r1hB:
undetectable		 5tudD-2r1hB:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 ASP A 117
ALA A 207
PHE A 124
LEU A  97
VAL A  90
 None
 1.06A 5tudD-2vg8A:
undetectable		 5tudD-2vg8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		5 VAL A 127
ALA A  86
PHE A 174
LEU A 144
VAL A 164
 None
 1.22A 5tudD-2wokA:
undetectable		 5tudD-2wokA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 390
PHE A 461
VAL A 426
LEU A 449
VAL A 463
 None
CU  A 501 ( 4.9A)
None
None
None
 1.10A 5tudD-2xybA:
undetectable		 5tudD-2xybA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		5 ASP A 351
VAL A 370
PHE A 343
PHE A 341
LEU A 365
 None
 1.18A 5tudD-2xycA:
undetectable		 5tudD-2xycA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfb HEMOGLOBIN SUBUNIT
ALPHA

(Psittacula
krameri) 		PF00042
(Globin) 		5 VAL A  62
PHE A 128
VAL A 109
LEU A 129
VAL A 132
 HEM  A 150 ( 3.9A)
None
None
None
None
 1.23A 5tudD-2zfbA:
undetectable		 5tudD-2zfbA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		5 MET A 246
ALA A 252
PHE A 253
VAL A 266
VAL A 366
 None
 1.28A 5tudD-3b2zA:
undetectable		 5tudD-3b2zA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq BETA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		5 VAL B  67
PHE B 134
VAL B 114
LEU B 135
VAL B 138
 HEM  B 147 (-4.2A)
None
None
None
None
 1.17A 5tudD-3bcqB:
undetectable		 5tudD-3bcqB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 SER A 212
ALA A 206
PHE A 203
LEU A 224
VAL A 220
 None
 1.24A 5tudD-3c8tA:
undetectable		 5tudD-3c8tA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 ALA A 330
PHE A 274
GLN A 316
LEU A 279
VAL A 277
 None
None
GOL  A 435 ( 4.6A)
None
None
 1.22A 5tudD-3ei8A:
undetectable		 5tudD-3ei8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		5 PHE A  30
PHE A  29
VAL A 301
GLN A  94
VAL A  35
 None
 1.28A 5tudD-3g1zA:
undetectable		 5tudD-3g1zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
ALPHA

(Camelus
dromedarius) 		PF00042
(Globin) 		5 VAL A  62
PHE A 128
VAL A 109
LEU A 129
VAL A 132
 HEM  A 142 ( 4.0A)
None
None
None
None
 1.11A 5tudD-3gdjA:
2.5		 5tudD-3gdjA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		5 VAL A  89
MET A 119
ALA A 106
LEU A  32
VAL A   6
 None
 1.29A 5tudD-3lkeA:
undetectable		 5tudD-3lkeA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml3 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin) 		5 VAL A 608
ALA A 670
GLN A 633
LEU A 624
VAL A 622
 None
 1.16A 5tudD-3ml3A:
undetectable		 5tudD-3ml3A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 390
PHE A 463
VAL A 426
LEU A 451
VAL A 465
 None
CU  A1503 ( 4.9A)
None
None
None
 1.11A 5tudD-3pxlA:
undetectable		 5tudD-3pxlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfi TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF03816
(LytR_cpsA_psr) 		5 SER A 226
VAL A 216
VAL A 147
LEU A 157
VAL A 161
 None
 1.05A 5tudD-3qfiA:
undetectable		 5tudD-3qfiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00160
(Pro_isomerase) 		5 VAL A 422
PHE A 274
VAL A 400
LEU A 262
VAL A 275
 None
 1.12A 5tudD-3rfyA:
2.3		 5tudD-3rfyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0o RIBONUCLEASE T2

(Homo sapiens) 		PF00445
(Ribonuclease_T2) 		5 SER A 103
VAL A  40
GLN A 183
LEU A 238
VAL A  47
 None
 1.22A 5tudD-3t0oA:
undetectable		 5tudD-3t0oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		5 ASP A  13
SER A  17
VAL A  78
ASN A 164
VAL A 167
 None
None
None
NA  A 401 ( 4.7A)
None
 1.20A 5tudD-3t8jA:
undetectable		 5tudD-3t8jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 SER A  49
VAL A  67
PHE A 101
PHE A  84
LEU A 105
 None
 1.15A 5tudD-3u0bA:
undetectable		 5tudD-3u0bA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		5 VAL A 351
MET A 261
ALA A 117
ASN A 292
VAL A 342
 None
 1.18A 5tudD-3u1hA:
undetectable		 5tudD-3u1hA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		5 ASP A 266
ALA A 251
PHE A 312
LEU A 318
VAL A 316
 None
 1.06A 5tudD-3u7gA:
undetectable		 5tudD-3u7gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 SER A 294
ALA A 261
PHE A 289
GLN A 281
LEU A 284
 None
 0.97A 5tudD-3vpzA:
undetectable		 5tudD-3vpzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		5 MET A 190
PHE A 208
VAL A 128
LEU A 212
VAL A  92
 CHW  A 504 ( 4.8A)
None
None
CHW  A 504 (-4.1A)
None
 1.15A 5tudD-3vvaA:
3.3		 5tudD-3vvaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		5 PHE A 116
PHE A 150
VAL A 194
GLN A 136
VAL A 115
 None
 1.22A 5tudD-3w9vA:
undetectable		 5tudD-3w9vA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtg HEMOGLOBIN SUBUNIT
ALPHA-A

(Dromaius
novaehollandiae) 		PF00042
(Globin) 		5 VAL A  62
PHE A 128
VAL A 109
LEU A 129
VAL A 132
 HEM  A 201 (-3.9A)
None
None
None
None
 1.08A 5tudD-3wtgA:
undetectable		 5tudD-3wtgA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 ASP K  32
SER K  16
ALA K  46
GLN K  64
LEU K  37
 None
 1.20A 5tudD-3wxrK:
undetectable		 5tudD-3wxrK:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 412
PHE A 485
VAL A 448
LEU A 473
VAL A 487
 None
CU  A 617 ( 4.9A)
None
None
None
 1.15A 5tudD-3x1bA:
undetectable		 5tudD-3x1bA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		5 VAL A 259
ALA A 114
PHE A  97
PHE A 202
VAL A 224
 None
 1.28A 5tudD-3zgjA:
undetectable		 5tudD-3zgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 5 VAL A 474
ALA A 642
PHE A 729
LEU A 613
VAL A 603
 None
 1.27A 5tudD-4a7kA:
undetectable		 5tudD-4a7kA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		5 VAL X  53
MET X 126
ALA X 159
PHE X  94
LEU X  99
 None
None
ACT  X1288 ( 4.2A)
None
None
 1.20A 5tudD-4ac1X:
undetectable		 5tudD-4ac1X:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 MET A 235
ALA A 346
VAL A 249
LEU A 228
VAL A 223
 None
 1.17A 5tudD-4az7A:
3.3		 5tudD-4az7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF00179
(UQ_con)
PF10275
(Peptidase_C65) 		5 SER A1121
ALA A1226
PHE A1114
VAL A1257
LEU A1104
 None
 1.03A 5tudD-4ddiA:
undetectable		 5tudD-4ddiA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 PHE A 171
PHE A 170
ASN A 167
LEU A  82
VAL A 145
 None
 1.12A 5tudD-4df3A:
undetectable		 5tudD-4df3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Mus musculus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 MET A1102
ALA A1074
VAL A1149
LEU A1121
VAL A1087
 None
 1.23A 5tudD-4dklA:
25.1		 5tudD-4dklA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		5 VAL B  67
PHE B 133
VAL B 114
LEU B 134
VAL B 137
 HEM  B 202 (-3.9A)
None
None
None
None
 1.15A 5tudD-4esaB:
undetectable		 5tudD-4esaB:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		12 ASP A 135
SER A 139
VAL A 208
MET A 218
ALA A 225
PHE A 340
PHE A 341
ASN A 344
VAL A 348
GLN A 359
LEU A 362
VAL A 366
 ERM  A2001 (-3.2A)
ERM  A2001 (-3.6A)
ERM  A2001 (-4.0A)
ERM  A2001 (-3.7A)
ERM  A2001 (-3.4A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.9A)
None
ERM  A2001 ( 4.1A)
ERM  A2001 ( 4.2A)
 0.47A 5tudD-4ib4A:
39.2		 5tudD-4ib4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 VAL A  74
ALA A 192
PHE A 151
VAL A 168
VAL A 150
 None
 1.24A 5tudD-4ijmA:
undetectable		 5tudD-4ijmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 389
PHE A 460
VAL A 425
LEU A 448
VAL A 462
 None
 1.15A 5tudD-4jhvA:
undetectable		 5tudD-4jhvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1c VACUOLAR CALCIUM ION
TRANSPORTER

(Saccharomyces
cerevisiae) 		PF01699
(Na_Ca_ex) 		5 SER A 200
VAL A 329
PHE A 352
VAL A 364
LEU A 127
 None
None
IOD  A 516 (-4.4A)
None
None
 1.21A 5tudD-4k1cA:
undetectable		 5tudD-4k1cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A1113
PHE A1289
PHE A1290
ASN A1293
VAL A1297
 P0G  A1401 (-2.9A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
None
 0.38A 5tudD-4ldeA:
30.8		 5tudD-4ldeA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ASP A 332
ALA A 200
PHE A 144
PHE A 163
LEU A 388
 GOL  A 602 (-2.8A)
TRS  A 601 ( 4.0A)
TRS  A 601 (-4.8A)
TRS  A 601 ( 3.9A)
None
 1.24A 5tudD-4m8uA:
undetectable		 5tudD-4m8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		5 SER A 210
VAL A 148
PHE A 177
PHE A 223
LEU A 155
 None
 1.29A 5tudD-4mupA:
undetectable		 5tudD-4mupA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 SER A 140
VAL A 358
ALA A 106
LEU A  16
VAL A 116
 None
 1.07A 5tudD-4nesA:
undetectable		 5tudD-4nesA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Bacillus
anthracis) 		PF13407
(Peripla_BP_4) 		5 SER A  97
VAL A 330
VAL A 335
GLN A 141
LEU A 142
 PAV  A 401 ( 4.5A)
EDO  A 407 ( 4.8A)
None
EDO  A 407 ( 3.6A)
None
 1.24A 5tudD-4pz0A:
undetectable		 5tudD-4pz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 ALA A1207
PHE A1126
VAL A1231
LEU A1279
VAL A1122
 None
 1.26A 5tudD-4r04A:
2.7		 5tudD-4r04A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 MET A1102
ALA A1074
VAL A1149
LEU A1121
VAL A1087
 None
 1.26A 5tudD-4u14A:
27.1		 5tudD-4u14A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		5 MET A 246
ALA A 252
PHE A 253
VAL A 266
VAL A 366
 None
 1.19A 5tudD-4wk7A:
undetectable		 5tudD-4wk7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 MET A1101
ALA A1073
VAL A1148
LEU A1120
VAL A1086
 None
 1.28A 5tudD-4wtvA:
undetectable		 5tudD-4wtvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		5 VAL A 348
ALA A 403
GLN A 336
LEU A 337
VAL A 367
 None
 1.14A 5tudD-4xpdA:
undetectable		 5tudD-4xpdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		5 MET A  68
ALA A 192
VAL A 102
LEU A 112
VAL A 116
 None
 1.19A 5tudD-5a60A:
undetectable		 5tudD-5a60A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		5 SER A 245
VAL A 395
ALA A 254
LEU A 417
VAL A 410
 None
 1.07A 5tudD-5b2dA:
undetectable		 5tudD-5b2dA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE

(Streptomyces
sp. CNQ-418) 		PF04820
(Trp_halogenase) 		5 SER A  17
VAL A  48
ALA A 177
VAL A 366
VAL A  54
 None
 1.20A 5tudD-5bukA:
undetectable		 5tudD-5bukA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme) 		5 MET A 102
ALA A  74
VAL A 149
LEU A 121
VAL A  87
 None
 1.27A 5tudD-5bz6A:
undetectable		 5tudD-5bz6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 5 SER B 246
VAL B 199
MET B 276
VAL B 281
LEU B 369
 None
 1.27A 5tudD-5cwwB:
1.5		 5tudD-5cwwB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 MET A1104
ALA A1076
VAL A1151
LEU A1123
VAL A1089
 None
 1.28A 5tudD-5eutA:
2.7		 5tudD-5eutA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 ASP B 121
PHE B 306
PHE B 307
ASN B 310
VAL B 314
 P32  B 400 (-2.2A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
None
 0.75A 5tudD-5f8uB:
28.6		 5tudD-5f8uB:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN

(Zika virus) 		PF00948
(Flavi_NS1) 		5 ASP A 180
VAL A 171
MET A  67
ALA A  27
VAL A  71
 None
 1.18A 5tudD-5gs6A:
undetectable		 5tudD-5gs6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 SER A 207
VAL A 325
ALA A 240
LEU A 262
VAL A 266
 None
 1.07A 5tudD-5hyhA:
4.1		 5tudD-5hyhA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		5 VAL A 165
ALA A  73
PHE A  37
PHE A 144
LEU A  25
 None
 1.26A 5tudD-5jheA:
4.4		 5tudD-5jheA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC

(Mycobacterium
tuberculosis) 		PF01547
(SBP_bac_1) 		5 ALA A 430
PHE A 232
PHE A 240
GLN A 218
LEU A 222
 None
 1.17A 5tudD-5k2yA:
undetectable		 5tudD-5k2yA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltg AUTOPHAGY-RELATED
PROTEIN 18

(Ogataea angusta) 		no annotation 5 ALA A 274
PHE A  39
PHE A  43
GLN A 521
VAL A  46
 None
 1.25A 5tudD-5ltgA:
undetectable		 5tudD-5ltgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 VAL A 127
ALA A 249
PHE A 283
VAL A 106
LEU A 138
 None
 1.19A 5tudD-5o0sA:
undetectable		 5tudD-5o0sA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		5 ASP E 178
PHE E 171
VAL E 167
LEU E 211
VAL E 207
 None
 1.16A 5tudD-5of4E:
undetectable		 5tudD-5of4E:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1) 		5 SER A 226
MET A 248
PHE A 229
LEU A 126
VAL A 124
 None
 1.07A 5tudD-5tr9A:
undetectable		 5tudD-5tr9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus) 		no annotation 5 SER D  47
VAL D 177
ALA D  89
VAL D 167
LEU D 390
 None
 1.24A 5tudD-5ybbD:
undetectable		 5tudD-5ybbD:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		no annotation 5 MET A 102
ALA A  74
VAL A 149
LEU A 121
VAL A  87
 None
 1.27A 5tudD-5yqrA:
undetectable		 5tudD-5yqrA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
MONOBODY YSX1

(Escherichia
coli;
Homo sapiens;
synthetic
construct) 		no annotation 5 MET A1274
VAL A1312
GLN A1307
LEU A1306
VAL B   9
 None
 1.30A 5tudD-6apxA:
undetectable		 5tudD-6apxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA

(Thermus
thermophilus) 		no annotation 5 VAL A 188
PHE A 309
PHE A 161
VAL A 144
VAL A 313
 None
 1.28A 5tudD-6barA:
undetectable		 5tudD-6barA:
10.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 9 ASP A 134
SER A 138
VAL A 208
ALA A 222
PHE A 327
PHE A 328
VAL A 335
LEU A 350
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 1.06A 5tudD-6bqhA:
31.9		 5tudD-6bqhA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 9 ASP A 134
SER A 138
VAL A 208
PHE A 327
PHE A 328
ASN A 331
VAL A 335
LEU A 350
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.93A 5tudD-6bqhA:
31.9		 5tudD-6bqhA:
69.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 SER A 311
PHE A 309
VAL A 261
LEU A 266
VAL A 281
 None
 1.29A 5tudD-6etzA:
undetectable		 5tudD-6etzA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 LEU A 502
VAL A 506
THR A 510
GLU A 442
 None
 0.90A 5tudD-1a6dA:
0.0		 5tudD-1a6dA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 LEU A  65
THR A 101
LEU A 228
GLU A 145
 None
 0.91A 5tudD-1al8A:
0.0		 5tudD-1al8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au1 INTERFERON-BETA

(Homo sapiens) 		PF00143
(Interferon) 		4 LEU A 106
VAL A 101
LEU A 160
GLU A  61
 None
 0.92A 5tudD-1au1A:
2.7		 5tudD-1au1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw9 GLUTATHIONE
S-TRANSFERASE III

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  11
VAL A  16
THR A  20
LEU A 213
 None
 0.98A 5tudD-1aw9A:
undetectable		 5tudD-1aw9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Lactobacillus
casei) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 312
VAL A 316
THR A 320
GLU A  28
 None
 0.97A 5tudD-1dxyA:
0.0		 5tudD-1dxyA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey1 ANTITERMINATION
FACTOR NUSB

(Escherichia
coli) 		PF01029
(NusB) 		4 LEU A  51
VAL A  55
THR A  59
LEU A 110
 None
 0.90A 5tudD-1ey1A:
0.7		 5tudD-1ey1A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 LEU A 170
VAL A 177
THR A 282
LEU A 204
 None
 0.99A 5tudD-1f1xA:
0.0		 5tudD-1f1xA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbt FRUCTOSE-2,6-BISPHOS
PHATASE

(Rattus
norvegicus) 		PF00300
(His_Phos_1) 		5 LEU A  48
VAL A  67
LEU A 138
LEU A  75
GLU A 130
 None
 1.34A 5tudD-1fbtA:
undetectable		 5tudD-1fbtA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fng PROTEIN (MHC CLASS
II I-EK, BETA CHAIN)

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 LEU B 161
VAL B 159
THR B 157
GLU B 187
 None
 0.80A 5tudD-1fngB:
undetectable		 5tudD-1fngB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 LEU A 438
VAL A 489
LEU A 427
GLU A 212
 None
 0.96A 5tudD-1gk2A:
0.0		 5tudD-1gk2A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL B 628
THR B 630
LEU B 532
GLU B 539
 None
 0.92A 5tudD-1gl9B:
0.1		 5tudD-1gl9B:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 LEU A 103
VAL A 114
LEU A 134
GLU A  48
 None
 0.90A 5tudD-1gqjA:
2.2		 5tudD-1gqjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7g D-TYROSYL-TRNA(TYR)
DEACYLASE

(Haemophilus
influenzae) 		PF02580
(Tyr_Deacylase) 		5 LEU A 117
VAL A 119
THR A 121
LEU A  50
LEU A 142
 None
 1.12A 5tudD-1j7gA:
undetectable		 5tudD-1j7gA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf0 OBELIN

(Obelia
longissima) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 VAL A   7
LEU A 100
LEU A 110
GLU A 107
 None
 0.98A 5tudD-1jf0A:
undetectable		 5tudD-1jf0A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 4 LEU O 267
VAL O 288
THR O 286
LEU O 242
 None
 0.96A 5tudD-1jn0O:
undetectable		 5tudD-1jn0O:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION

(Escherichia
coli) 		PF08943
(CsiD) 		4 LEU A 283
VAL A 173
LEU A 190
GLU A  92
 None
 0.99A 5tudD-1jr7A:
undetectable		 5tudD-1jr7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		5 LEU B 310
VAL B 320
THR B 324
LEU B 424
GLU B 432
 None
 1.43A 5tudD-1k5sB:
undetectable		 5tudD-1k5sB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 LEU A 298
VAL A 317
LEU A 388
LEU A 325
GLU A 380
 None
 1.31A 5tudD-1k6mA:
undetectable		 5tudD-1k6mA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 149
VAL A 153
THR A 157
LEU A  95
 None
 0.90A 5tudD-1k9aA:
3.9		 5tudD-1k9aA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4i SFAE PROTEIN

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 LEU A  20
VAL A  18
LEU A  82
GLU A  38
 None
 0.85A 5tudD-1l4iA:
undetectable		 5tudD-1l4iA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 VAL A 280
LEU A 163
LEU A 272
GLU A 264
 None
 0.97A 5tudD-1lnzA:
undetectable		 5tudD-1lnzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m39 CALTRACTIN, ISOFORM
1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU A 163
LEU A 107
LEU A 112
GLU A 117
 None
 0.98A 5tudD-1m39A:
undetectable		 5tudD-1m39A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 4 LEU A  54
VAL A  57
THR A  59
LEU A 296
 None
 0.92A 5tudD-1nluA:
undetectable		 5tudD-1nluA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		4 LEU A 674
VAL A 678
THR A 682
LEU A 717
 None
 0.85A 5tudD-1oxjA:
undetectable		 5tudD-1oxjA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p27 MAGO NASHI PROTEIN
HOMOLOG

(Homo sapiens) 		PF02792
(Mago_nashi) 		4 LEU A 129
VAL A 133
LEU A   7
GLU A  58
 None
 0.73A 5tudD-1p27A:
undetectable		 5tudD-1p27A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qun PAPD-LIKE CHAPERONE
FIMC

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 LEU A  20
VAL A  18
LEU A  82
GLU A  38
 None
 0.60A 5tudD-1qunA:
undetectable		 5tudD-1qunA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		4 LEU A  33
LEU A  98
LEU A  46
GLU A  80
 None
 0.85A 5tudD-1qzzA:
undetectable		 5tudD-1qzzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  50
LEU A  71
LEU A  38
GLU A  16
 None
 0.93A 5tudD-1rtrA:
2.2		 5tudD-1rtrA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw0 CONSERVED
HYPOTHETICAL PROTEIN

(Salmonella
enterica) 		PF02578
(Cu-oxidase_4) 		4 LEU A  34
THR A 104
LEU A  54
GLU A  48
 None
 0.96A 5tudD-1rw0A:
undetectable		 5tudD-1rw0A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 5 LEU G 113
VAL G 117
THR G  62
LEU G 144
GLU G 105
 None
 1.50A 5tudD-1rzrG:
undetectable		 5tudD-1rzrG:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 LEU A  49
LEU A  95
LEU A  75
GLU A  67
 None
 0.87A 5tudD-1susA:
undetectable		 5tudD-1susA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		4 LEU A 353
VAL A 355
THR A 357
LEU A 259
 None
 0.80A 5tudD-1sznA:
undetectable		 5tudD-1sznA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF09209
(DUF1956) 		4 LEU A 148
VAL A 152
THR A 156
LEU A 173
 None
 0.85A 5tudD-1t33A:
3.2		 5tudD-1t33A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq8 HYPOTHETICAL PROTEIN
RV1636

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		4 LEU A 123
VAL A 125
LEU A 111
GLU A  99
 None
 0.81A 5tudD-1tq8A:
undetectable		 5tudD-1tq8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A 316
VAL A  48
THR A 420
GLU A 432
 None
 0.77A 5tudD-1tufA:
undetectable		 5tudD-1tufA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		5 VAL A  10
THR A 113
LEU A 101
LEU A   5
GLU A 106
 None
 1.33A 5tudD-1u2vA:
undetectable		 5tudD-1u2vA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 LEU C1004
LEU C1040
LEU C1045
GLU C1016
 None
 0.98A 5tudD-1u6gC:
undetectable		 5tudD-1u6gC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp8 HYPOTHETICAL PROTEIN
AF0103

(Archaeoglobus
fulgidus) 		PF02887
(PK_C) 		4 VAL A  59
THR A  61
LEU A  49
GLU A  17
 None
 0.95A 5tudD-1vp8A:
undetectable		 5tudD-1vp8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 LEU A 123
VAL A 125
THR A 127
LEU A 108
 None
 0.90A 5tudD-1x2gA:
undetectable		 5tudD-1x2gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x51 A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF14815
(NUDIX_4) 		4 LEU A  73
LEU A  26
LEU A 125
GLU A  52
 None
 0.88A 5tudD-1x51A:
undetectable		 5tudD-1x51A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x99 LECTIN

(Xerocomellus
chrysenteron) 		PF07367
(FB_lectin) 		4 LEU A   9
VAL A  11
LEU A  57
LEU A  86
 None
 0.94A 5tudD-1x99A:
undetectable		 5tudD-1x99A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 LEU A 152
THR A 706
LEU A 159
GLU A 164
 None
 0.77A 5tudD-1xc6A:
undetectable		 5tudD-1xc6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq9 PHOSPHOGLYCERATE
MUTASE

(Plasmodium
falciparum) 		PF00300
(His_Phos_1) 		4 VAL A  63
THR A  65
LEU A 238
GLU A 225
 None
 0.90A 5tudD-1xq9A:
undetectable		 5tudD-1xq9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 4 THR A   4
LEU A  12
LEU A  17
GLU A 306
 None
 0.95A 5tudD-1y8aA:
undetectable		 5tudD-1y8aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		4 LEU A 279
LEU A  48
LEU A 258
GLU A 250
 None
 0.90A 5tudD-1ybeA:
undetectable		 5tudD-1ybeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 275
VAL A 279
LEU A 258
GLU A 242
 None
 0.96A 5tudD-1yt3A:
undetectable		 5tudD-1yt3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE

(Streptomyces
sp. CL190) 		PF11468
(PTase_Orf2) 		4 LEU A  95
VAL A  91
LEU A  83
GLU A  80
 None
 0.98A 5tudD-1zcwA:
undetectable		 5tudD-1zcwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		4 VAL A 172
THR A  95
LEU A 192
GLU A 295
 None
 0.98A 5tudD-1zq1A:
undetectable		 5tudD-1zq1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		4 VAL A 172
THR A  95
LEU A 195
GLU A 229
 None
 0.90A 5tudD-1zq1A:
undetectable		 5tudD-1zq1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		5 LEU A  42
VAL A   5
THR A 150
LEU A 240
GLU A  36
 None
 1.43A 5tudD-2akoA:
undetectable		 5tudD-2akoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azo MUTH

(Escherichia
coli) 		PF02976
(MutH) 		4 LEU A 221
LEU A 142
LEU A  17
GLU A  77
 None
 0.91A 5tudD-2azoA:
undetectable		 5tudD-2azoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268

(Pseudomonas
aeruginosa) 		PF05544
(Pro_racemase) 		5 LEU A  64
VAL A  76
THR A 114
LEU A  18
LEU A  59
 None
 1.28A 5tudD-2azpA:
undetectable		 5tudD-2azpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjs ISOPENICILLIN N
SYNTHETASE

(Aspergillus
nidulans) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LEU A 231
VAL A 233
THR A 235
LEU A 250
 None
 0.83A 5tudD-2bjsA:
undetectable		 5tudD-2bjsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 LEU A 241
VAL A 239
THR A 237
LEU A 253
 None
 0.89A 5tudD-2cb0A:
undetectable		 5tudD-2cb0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		4 LEU A 155
THR A 110
LEU A 185
LEU A 216
 None
 0.80A 5tudD-2d3yA:
undetectable		 5tudD-2d3yA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5v HEPATOCYTE NUCLEAR
FACTOR 6

(Rattus
norvegicus) 		PF00046
(Homeobox)
PF02376
(CUT) 		4 VAL A 107
THR A 105
LEU A 126
GLU A 118
 None
 0.84A 5tudD-2d5vA:
undetectable		 5tudD-2d5vA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzm FAS-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 4 LEU A  76
VAL A  78
THR A  80
GLU A  60
 None
 0.89A 5tudD-2dzmA:
undetectable		 5tudD-2dzmA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		4 LEU A 241
VAL A 239
THR A 237
LEU A 253
 None
 0.91A 5tudD-2e5fA:
undetectable		 5tudD-2e5fA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LEU A 202
VAL A 204
LEU A 134
LEU A 279
 None
 0.93A 5tudD-2ejwA:
undetectable		 5tudD-2ejwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis) 		PF00230
(MIP) 		4 VAL A 183
THR A 182
LEU A  18
LEU A  73
 None
None
GOL  A 501 (-4.7A)
None
 0.88A 5tudD-2f2bA:
undetectable		 5tudD-2f2bA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6r BIFUNCTIONAL
COENZYME A SYNTHASE

(Mus musculus) 		PF01121
(CoaE) 		4 THR A  69
LEU A  46
LEU A 256
GLU A 251
 None
 0.84A 5tudD-2f6rA:
undetectable		 5tudD-2f6rA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsn HYPOTHETICAL PROTEIN
TA0583

(Thermoplasma
acidophilum) 		no annotation 4 VAL A 277
THR A 301
LEU A 198
GLU A 193
 None
 0.95A 5tudD-2fsnA:
undetectable		 5tudD-2fsnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 LEU A 198
VAL A 200
LEU A 349
GLU A 357
 None
 0.85A 5tudD-2gj4A:
undetectable		 5tudD-2gj4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpj SIDEROPHORE-INTERACT
ING PROTEIN

(Shewanella
putrefaciens) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 LEU A 130
THR A  61
LEU A 116
LEU A 205
 None
FAD  A 500 (-4.0A)
None
None
 0.97A 5tudD-2gpjA:
undetectable		 5tudD-2gpjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		4 LEU A 114
VAL A 116
THR A 118
LEU A 104
 None
 0.94A 5tudD-2hszA:
undetectable		 5tudD-2hszA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 LEU B  73
VAL B  77
THR B  81
LEU B 182
 None
 0.89A 5tudD-2iaeB:
undetectable		 5tudD-2iaeB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK

(Escherichia
coli) 		PF02586
(SRAP) 		4 LEU A  53
VAL A  51
LEU A  80
GLU A 150
 None
 0.94A 5tudD-2icuA:
undetectable		 5tudD-2icuA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		4 VAL A  54
THR A  23
LEU A 111
GLU A 130
 None
None
None
UNX  A   1 (-2.2A)
 0.96A 5tudD-2if6A:
undetectable		 5tudD-2if6A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixq PROTEIN AFAD

(Escherichia
coli) 		PF05775
(AfaD) 		4 LEU A  16
THR A 142
LEU A   6
GLU A  42
 LEU  A  16 ( 0.4A)
THR  A 142 ( 0.2A)
LEU  A   6 ( 0.5A)
GLU  A  42 ( 0.5A)
 0.96A 5tudD-2ixqA:
undetectable		 5tudD-2ixqA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 LEU A 415
VAL A 411
THR A 407
LEU A 371
LEU A 298
 None
 1.24A 5tudD-2j6hA:
1.8		 5tudD-2j6hA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 LEU A  73
VAL A  77
THR A  81
GLU A 178
 None
 0.98A 5tudD-2jakA:
undetectable		 5tudD-2jakA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 LEU A  73
VAL A  77
THR A  81
LEU A 182
 None
 0.63A 5tudD-2jakA:
undetectable		 5tudD-2jakA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 VAL X 220
LEU X 118
LEU X 197
GLU X 165
 None
 0.76A 5tudD-2jfeX:
undetectable		 5tudD-2jfeX:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		4 LEU A  80
LEU A 124
LEU A  65
GLU A  60
 None
 0.95A 5tudD-2l6fA:
8.3		 5tudD-2l6fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgx FERMITIN FAMILY
HOMOLOG 2

(Homo sapiens) 		no annotation 5 VAL A  24
THR A  25
LEU A  48
LEU A  79
GLU A  19
 None
 1.24A 5tudD-2lgxA:
undetectable		 5tudD-2lgxA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		4 LEU A 201
THR A 331
LEU A 129
GLU A 123
 None
 0.96A 5tudD-2o78A:
2.6		 5tudD-2o78A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ool SENSOR PROTEIN

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 LEU A 107
VAL A 109
THR A 111
LEU A 131
 None
 0.99A 5tudD-2oolA:
2.1		 5tudD-2oolA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE

(Lactobacillus
plantarum) 		PF01643
(Acyl-ACP_TE) 		4 LEU A 225
VAL A 233
THR A 255
LEU A 187
 None
 0.98A 5tudD-2ownA:
undetectable		 5tudD-2ownA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 LEU A  81
LEU A  92
LEU A 123
GLU A 113
 None
 0.96A 5tudD-2pcqA:
undetectable		 5tudD-2pcqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		4 VAL A 239
THR A 235
LEU A 145
LEU A 250
 None
 0.92A 5tudD-2pl3A:
undetectable		 5tudD-2pl3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE

(uncultured
Thermotogales
bacterium) 		PF01966
(HD) 		4 LEU A 133
VAL A  40
THR A  37
LEU A 122
 None
 0.98A 5tudD-2pq7A:
undetectable		 5tudD-2pq7A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 LEU A  40
VAL A 133
THR A 135
LEU A 202
 None
OMP  A 450 (-4.4A)
OMP  A 450 (-2.8A)
None
 0.94A 5tudD-2przA:
undetectable		 5tudD-2przA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		4 LEU A1032
VAL A1030
THR A1028
GLU A 988
 None
 0.90A 5tudD-2psoA:
undetectable		 5tudD-2psoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		4 LEU A 123
VAL A 120
LEU A 148
LEU A  17
 None
FAD  A 500 (-4.1A)
None
None
 0.98A 5tudD-2qa1A:
undetectable		 5tudD-2qa1A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LEU D 226
THR D 314
LEU D 242
LEU D 128
 None
 0.94A 5tudD-2qe7D:
undetectable		 5tudD-2qe7D:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A  32
VAL A  30
LEU A 251
GLU A 246
 None
 0.98A 5tudD-2qtyA:
undetectable		 5tudD-2qtyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvg TWO COMPONENT
RESPONSE REGULATOR

(Legionella
pneumophila) 		PF00072
(Response_reg) 		4 LEU A 132
LEU A  62
LEU A  13
GLU A  37
 None
 0.89A 5tudD-2qvgA:
undetectable		 5tudD-2qvgA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU 1 186
VAL 1 190
THR 1 194
LEU 1 219
 None
 0.96A 5tudD-2r6r1:
undetectable		 5tudD-2r6r1:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 LEU A 579
LEU A 557
LEU A 610
GLU A 606
 None
 0.90A 5tudD-2rfoA:
undetectable		 5tudD-2rfoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwj TYPE III EXPORT
PROTEIN PSCE
TYPE III EXPORT
PROTEIN PSCF
TYPE III EXPORT
PROTEIN PSCG

(Pseudomonas
aeruginosa) 		PF08988
(T3SS_needle_E)
PF09392
(T3SS_needle_F)
PF09477
(Type_III_YscG) 		4 LEU E  27
LEU G   9
LEU F  82
GLU E   9
 None
 0.95A 5tudD-2uwjE:
4.3		 5tudD-2uwjE:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU B 120
VAL B 122
THR B 124
GLU B  83
 None
 0.92A 5tudD-2uzxB:
undetectable		 5tudD-2uzxB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		4 LEU A 121
THR A 157
LEU A 403
GLU A 395
 None
 0.93A 5tudD-2ve3A:
1.4		 5tudD-2ve3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkc NEDD4-BINDING
PROTEIN 2

(Homo sapiens) 		PF01713
(Smr) 		4 LEU A1725
VAL A1727
THR A1729
LEU A1709
 None
 0.93A 5tudD-2vkcA:
undetectable		 5tudD-2vkcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A 283
VAL A 337
THR A 338
LEU A 259
GLU A 370
 None
 1.46A 5tudD-2wgyA:
2.0		 5tudD-2wgyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		4 LEU A  50
VAL A  60
LEU A 221
GLU A 176
 None
 0.94A 5tudD-2wymA:
undetectable		 5tudD-2wymA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 LEU A 478
VAL A 425
THR A 424
LEU A 379
GLU A 372
 None
 1.43A 5tudD-2x49A:
undetectable		 5tudD-2x49A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 LEU A  38
VAL A  71
THR A  83
LEU A  32
 None
 0.94A 5tudD-2y05A:
undetectable		 5tudD-2y05A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		4 LEU A 337
VAL A 341
THR A 345
GLU A 459
 None
 0.73A 5tudD-2yu1A:
undetectable		 5tudD-2yu1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 133
THR A 163
LEU A 116
GLU A  89
 None
 0.97A 5tudD-2z0mA:
undetectable		 5tudD-2z0mA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 LEU A 492
LEU A 411
LEU A 470
GLU A 421
 None
 0.91A 5tudD-2z1aA:
undetectable		 5tudD-2z1aA:
22.13