SIMILAR PATTERNS OF AMINO ACIDS FOR 5TUD_A_ERMA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c72 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Gallus gallus) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ASP A 156
VAL A 155
PHE A 140
LEU A 134
LEU A 180
 None
 1.12A 5tudA-1c72A:
undetectable		 5tudA-1c72A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnt CILIARY NEUROTROPHIC
FACTOR

(Homo sapiens) 		PF01110
(CNTF) 		5 SER 1 172
VAL 1 161
LEU 1  34
LEU 1 112
VAL 1 116
 None
 0.84A 5tudA-1cnt1:
1.4		 5tudA-1cnt1:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 LEU A 330
ASP A 357
LEU A 462
LEU A 277
VAL A 305
 None
 0.99A 5tudA-1fc9A:
undetectable		 5tudA-1fc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2

(Homo sapiens) 		PF00790
(VHS) 		5 VAL A 131
VAL A  85
PHE A 106
LEU A  66
VAL A 101
 None
 1.18A 5tudA-1mhqA:
undetectable		 5tudA-1mhqA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 ASP A  15
VAL A 238
LEU A  31
LEU A   8
VAL A 124
 GOL  A3001 (-3.6A)
None
None
None
CA  A2001 ( 4.7A)
 1.12A 5tudA-1q8fA:
undetectable		 5tudA-1q8fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 VAL A 288
VAL A  48
LEU A  57
LEU A  39
VAL A  22
 None
 1.04A 5tudA-1vmaA:
undetectable		 5tudA-1vmaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		5 LEU A 371
VAL A 410
ALA A 402
PHE A   5
LEU A 392
 None
 1.13A 5tudA-1wcgA:
undetectable		 5tudA-1wcgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 SER A 465
ALA A 289
LEU A 427
LEU A 456
VAL A 461
 None
 1.05A 5tudA-2d4eA:
undetectable		 5tudA-2d4eA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		5 LEU X 457
ASP X 453
VAL X 362
ALA X 349
LEU X 414
 None
 0.84A 5tudA-2de0X:
1.9		 5tudA-2de0X:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 LEU A  55
MET A 125
PHE A 132
LEU A 151
LEU A 160
 None
 1.17A 5tudA-2dulA:
undetectable		 5tudA-2dulA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		5 VAL A 375
ALA A 353
PHE A 330
LEU A 382
VAL A 316
 None
None
None
None
NA  A1004 (-4.4A)
 1.10A 5tudA-2e54A:
undetectable		 5tudA-2e54A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 LEU A 254
PHE A 305
PHE A 304
LEU A 359
VAL A 363
 None
 1.17A 5tudA-2gjxA:
undetectable		 5tudA-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 372
PHE A 305
PHE A 304
LEU A 359
VAL A 363
 None
 0.97A 5tudA-2gjxA:
undetectable		 5tudA-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 LEU I 254
PHE I 305
PHE I 304
LEU I 359
VAL I 363
 None
 1.16A 5tudA-2gk1I:
undetectable		 5tudA-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 VAL I 372
PHE I 305
PHE I 304
LEU I 359
VAL I 363
 None
 0.95A 5tudA-2gk1I:
undetectable		 5tudA-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5l FEOA

(Ruminiclostridium
thermocellum) 		PF04023
(FeoA) 		5 LEU A  18
VAL A  72
ALA A   7
LEU A  60
VAL A  55
 None
 1.18A 5tudA-2k5lA:
undetectable		 5tudA-2k5lA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		5 MET A 125
ALA A 133
PHE A 106
LEU A  34
VAL A  32
 None
 0.94A 5tudA-2npnA:
undetectable		 5tudA-2npnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		6 LEU A  63
VAL A  45
ALA A 129
PHE A  95
LEU A  77
VAL A  94
 None
 1.47A 5tudA-2o6rA:
undetectable		 5tudA-2o6rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A  63
VAL A  45
PHE A  95
LEU A  77
VAL A  94
 None
 1.07A 5tudA-2o6sA:
undetectable		 5tudA-2o6sA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		5 SER A 314
ALA A 250
PHE A 318
LEU A 264
VAL A 266
 None
 1.14A 5tudA-2phlA:
undetectable		 5tudA-2phlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25

(Homo sapiens) 		PF00621
(RhoGEF) 		5 ALA B 191
PHE B 207
LEU B 287
LEU B 288
VAL B 206
 None
 1.06A 5tudA-2rgnB:
3.2		 5tudA-2rgnB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 VAL A 524
VAL A 528
ALA A 500
LEU A 505
LEU A 544
 None
 1.11A 5tudA-2vf8A:
2.2		 5tudA-2vf8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		6 LEU A  23
ASP A 117
ALA A 207
PHE A 124
LEU A  97
VAL A  90
 None
 1.25A 5tudA-2vg8A:
undetectable		 5tudA-2vg8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		6 VAL A 127
ALA A  86
PHE A 174
LEU A 143
LEU A 144
VAL A 164
 None
 1.49A 5tudA-2wokA:
undetectable		 5tudA-2wokA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A 152
VAL A 151
PHE A 136
LEU A 130
LEU A 176
 None
 1.09A 5tudA-2wrtA:
undetectable		 5tudA-2wrtA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		5 ASP A 351
VAL A 370
PHE A 343
PHE A 341
LEU A 365
 None
 1.14A 5tudA-2xycA:
undetectable		 5tudA-2xycA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		5 VAL A 341
PHE A 294
LEU A 287
LEU A 271
VAL A 267
 None
 1.17A 5tudA-3cskA:
3.6		 5tudA-3cskA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5o SERUM AMYLOID
P-COMPONENT

(Homo sapiens) 		PF00354
(Pentaxin) 		5 LEU A   4
ALA A  39
PHE A  11
PHE A 150
VAL A 196
 None
 1.07A 5tudA-3d5oA:
undetectable		 5tudA-3d5oA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL P 134
ALA P 163
LEU P  45
LEU P 126
VAL P 234
 None
None
FAD  P 449 ( 4.3A)
None
None
 1.18A 5tudA-3fg2P:
undetectable		 5tudA-3fg2P:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A  31
VAL A 212
ALA A 187
LEU A 233
LEU A 230
 None
 1.11A 5tudA-3hf9A:
undetectable		 5tudA-3hf9A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 LEU A 100
ALA A  81
PHE A 155
LEU A 208
VAL A 212
 None
 1.14A 5tudA-3ik2A:
undetectable		 5tudA-3ik2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		5 LEU A 234
ALA A 133
PHE A 126
LEU A 168
VAL A 172
 None
 1.17A 5tudA-3k31A:
undetectable		 5tudA-3k31A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Cytophaga
hutchinsonii) 		PF02769
(AIRS_C) 		5 LEU A 254
ASP A 255
PHE A 217
LEU A 209
LEU A  64
 None
 1.11A 5tudA-3kizA:
undetectable		 5tudA-3kizA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 MET A 228
ALA A 216
PHE A 255
LEU A 269
LEU A 289
 None
 1.17A 5tudA-3ktcA:
undetectable		 5tudA-3ktcA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 VAL A 124
ALA A 191
PHE A 152
LEU A 155
VAL A 151
 None
 1.12A 5tudA-3m62A:
3.3		 5tudA-3m62A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 212
MET A 150
ALA A 171
LEU A 110
LEU A 163
 None
 1.18A 5tudA-3mi9A:
2.3		 5tudA-3mi9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		5 ASP A 100
SER A 288
PHE A 300
LEU A 307
LEU A 187
 None
 1.05A 5tudA-3qh4A:
undetectable		 5tudA-3qh4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv0 MITOCHONDRIAL ACIDIC
PROTEIN MAM33

(Saccharomyces
cerevisiae) 		PF02330
(MAM33) 		5 PHE A 265
PHE A 264
LEU A 258
LEU A  57
VAL A  53
 None
 1.17A 5tudA-3qv0A:
undetectable		 5tudA-3qv0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A 241
VAL A 249
LEU A  36
LEU A  69
VAL A 223
 None
 1.13A 5tudA-3tsdA:
undetectable		 5tudA-3tsdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzt GLYCOSYL TRANSFERASE
FAMILY 8

(Anaerococcus
prevotii) 		PF01501
(Glyco_transf_8) 		5 LEU A 118
ALA A 130
LEU A   7
LEU A  20
VAL A 110
 EDO  A 302 (-4.3A)
None
None
None
None
 0.95A 5tudA-3tztA:
undetectable		 5tudA-3tztA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 SER A  49
VAL A  67
PHE A 101
PHE A  84
LEU A 105
 None
 1.13A 5tudA-3u0bA:
undetectable		 5tudA-3u0bA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		5 ASP A 266
ALA A 251
PHE A 312
LEU A 318
VAL A 316
 None
 1.06A 5tudA-3u7gA:
undetectable		 5tudA-3u7gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 340
ALA A 156
LEU A 269
LEU A 368
VAL A 362
 None
 0.91A 5tudA-3u9sA:
undetectable		 5tudA-3u9sA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 5 VAL A   5
PHE A  95
LEU A  88
LEU A 119
VAL A 100
 None
 1.15A 5tudA-3wvrA:
undetectable		 5tudA-3wvrA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		6 SER A 310
VAL A 145
PHE A  88
LEU A 276
LEU A 250
VAL A 248
 None
 1.43A 5tudA-4a14A:
undetectable		 5tudA-4a14A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 LEU A 265
VAL A 160
ALA A 275
LEU A 247
LEU A 243
 None
 0.97A 5tudA-4af1A:
2.5		 5tudA-4af1A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 VAL A 497
ALA A 525
LEU A  67
LEU A  71
VAL A  74
 None
 1.17A 5tudA-4ainA:
2.0		 5tudA-4ainA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A  23
ALA A  40
PHE A  72
PHE A  77
LEU A  68
 None
 1.10A 5tudA-4bkmA:
undetectable		 5tudA-4bkmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9v RNF43

(Xenopus
tropicalis) 		no annotation 5 LEU A 122
ALA A  67
PHE A 133
LEU A 103
VAL A 101
 None
 0.95A 5tudA-4c9vA:
undetectable		 5tudA-4c9vA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 ASP A 504
ALA A 325
PHE A 455
LEU A 521
LEU A 500
 None
 1.16A 5tudA-4eipA:
undetectable		 5tudA-4eipA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		5 SER A 687
PHE A 471
LEU A 653
LEU A 627
VAL A 625
 GOL  A 805 (-2.8A)
None
None
None
None
 1.06A 5tudA-4etpA:
undetectable		 5tudA-4etpA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3

([Candida]
glabrata) 		PF00225
(Kinesin) 		5 SER A 650
PHE A 432
LEU A 616
LEU A 590
VAL A 588
 None
 1.06A 5tudA-4gkrA:
undetectable		 5tudA-4gkrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 LEU A 279
SER A 488
PHE A 328
LEU A 317
VAL A 287
 None
 1.18A 5tudA-4ia5A:
undetectable		 5tudA-4ia5A:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		12 LEU A 132
ASP A 135
VAL A 136
SER A 139
VAL A 208
MET A 218
ALA A 225
PHE A 340
PHE A 341
LEU A 347
LEU A 362
VAL A 366
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-4.0A)
ERM  A2001 (-3.7A)
ERM  A2001 (-3.4A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.2A)
ERM  A2001 ( 4.1A)
ERM  A2001 ( 4.2A)
 0.40A 5tudA-4ib4A:
38.9		 5tudA-4ib4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 ALA A 278
PHE A 448
PHE A 447
LEU A 441
LEU A 219
 None
 0.82A 5tudA-4issA:
undetectable		 5tudA-4issA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 486
ALA A 392
PHE A 337
PHE A 333
LEU A 506
 None
 1.07A 5tudA-4kxbA:
undetectable		 5tudA-4kxbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 5 VAL B 533
ALA B 545
LEU B 503
LEU B 499
VAL B 414
 None
 1.15A 5tudA-4l27B:
undetectable		 5tudA-4l27B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		5 VAL A 262
SER A 264
VAL A 297
PHE A 201
LEU A 209
 None
 1.04A 5tudA-4l9mA:
undetectable		 5tudA-4l9mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 ASP A 172
ALA A 132
PHE A 213
LEU A 122
LEU A 214
 None
 1.14A 5tudA-4n78A:
2.5		 5tudA-4n78A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 SER A 140
VAL A 358
ALA A 106
LEU A  16
VAL A 116
 None
 1.09A 5tudA-4nesA:
undetectable		 5tudA-4nesA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 SER A 700
PHE A 479
LEU A 665
LEU A 639
VAL A 637
 None
 1.02A 5tudA-4ozqA:
undetectable		 5tudA-4ozqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 SER A 468
ALA A 419
LEU A 479
LEU A 555
VAL A 537
 None
 1.04A 5tudA-4q6kA:
undetectable		 5tudA-4q6kA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trt DNA POLYMERASE III
SUBUNIT BETA

(Deinococcus
radiodurans) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ALA A 342
PHE A 278
LEU A 300
LEU A 287
VAL A 276
 None
 0.98A 5tudA-4trtA:
undetectable		 5tudA-4trtA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		PF01661
(Macro) 		5 VAL A 168
ALA A 181
LEU A 193
LEU A 153
VAL A 152
 None
 1.17A 5tudA-4umlA:
undetectable		 5tudA-4umlA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 506
SER A 507
VAL A 464
LEU A 428
VAL A 432
 None
 1.16A 5tudA-4w7sA:
undetectable		 5tudA-4w7sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbh PROTEIN NOTUM
HOMOLOG

(Homo sapiens) 		PF03283
(PAE) 		5 LEU A 124
ALA A 175
LEU A 216
LEU A 249
VAL A 259
 None
 1.10A 5tudA-4wbhA:
undetectable		 5tudA-4wbhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwj PHOSPHOCARRIER
PROTEIN HPR

(Escherichia
coli) 		PF00381
(PTS-HPr) 		5 VAL B  78
ALA B  82
PHE B  22
LEU B  53
LEU B  50
 None
 1.16A 5tudA-4xwjB:
undetectable		 5tudA-4xwjB:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		5 VAL A 348
PHE A 320
LEU A 269
LEU A 308
VAL A 310
 None
 1.14A 5tudA-4zz7A:
undetectable		 5tudA-4zz7A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		5 LEU A  42
VAL A  24
PHE A  74
LEU A  56
VAL A  73
 None
 1.16A 5tudA-5a5cA:
undetectable		 5tudA-5a5cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		5 SER A 245
VAL A 395
ALA A 254
LEU A 417
VAL A 410
 None
 1.13A 5tudA-5b2dA:
undetectable		 5tudA-5b2dA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		5 SER A 168
ALA A 157
PHE A  74
LEU A 147
VAL A  79
 None
 1.17A 5tudA-5b4sA:
undetectable		 5tudA-5b4sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 138
ALA A 190
LEU A 103
LEU A  53
VAL A  45
 None
5VT  A 302 (-3.8A)
None
None
None
 1.16A 5tudA-5fahA:
undetectable		 5tudA-5fahA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 138
SER A 139
ALA A 190
LEU A  53
VAL A  45
 None
None
5VT  A 302 (-3.8A)
None
None
 1.09A 5tudA-5fahA:
undetectable		 5tudA-5fahA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		5 VAL A 335
VAL A 328
MET A 318
ALA A 308
VAL A 390
 None
 1.17A 5tudA-5gggA:
undetectable		 5tudA-5gggA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		6 LEU B 169
ALA B 249
PHE B 201
LEU B 183
LEU B 204
VAL B 200
 None
 1.44A 5tudA-5gs2B:
undetectable		 5tudA-5gs2B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		5 SER K 305
PHE K  98
LEU K 274
LEU K 248
VAL K 246
 None
 1.04A 5tudA-5hnzK:
undetectable		 5tudA-5hnzK:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 SER A 207
VAL A 325
ALA A 240
LEU A 262
VAL A 266
 None
 1.11A 5tudA-5hyhA:
1.7		 5tudA-5hyhA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A 278
PHE A 448
PHE A 447
LEU A 441
LEU A 219
 None
 0.81A 5tudA-5i8iA:
2.1		 5tudA-5i8iA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwd DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
betaherpesvirus
5) 		PF03325
(Herpes_PAP) 		5 SER A 127
PHE A  42
LEU A  68
LEU A  48
VAL A  40
 None
 1.16A 5tudA-5iwdA:
undetectable		 5tudA-5iwdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 LEU A 233
ALA A 132
PHE A 125
LEU A 167
VAL A 171
 None
 1.14A 5tudA-5koiA:
undetectable		 5tudA-5koiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 5 SER A 335
ALA A 426
PHE A 388
LEU A 415
LEU A 392
 None
 1.15A 5tudA-5oglA:
3.7		 5tudA-5oglA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB

(Shigella
flexneri) 		PF00006
(ATP-synt_ab) 		5 LEU A 263
ASP A 260
VAL A 261
SER A 220
LEU A 315
 None
 1.18A 5tudA-5swjA:
2.6		 5tudA-5swjA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 LEU A1326
VAL A1330
SER A1332
LEU A1306
VAL A1298
 None
 1.12A 5tudA-5t8vA:
2.5		 5tudA-5t8vA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1) 		5 SER A 226
MET A 248
PHE A 229
LEU A 126
VAL A 124
 None
 1.02A 5tudA-5tr9A:
undetectable		 5tudA-5tr9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 5 LEU A 126
ASP A 129
ALA A 216
PHE A 330
PHE A 331
 89F  A1201 (-4.9A)
89F  A1201 (-3.3A)
89F  A1201 ( 3.9A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
 0.91A 5tudA-5v54A:
34.3		 5tudA-5v54A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii) 		no annotation 5 VAL A 194
VAL A 198
MET A  93
LEU A 137
VAL A 119
 None
 1.13A 5tudA-5wa2A:
undetectable		 5tudA-5wa2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3

(Homo sapiens) 		PF00225
(Kinesin) 		5 SER A 732
PHE A 525
LEU A 701
LEU A 675
VAL A 673
 UNX  A 932 ( 2.7A)
None
UNX  A 931 ( 4.6A)
UNX  A 931 ( 4.2A)
None
 1.08A 5tudA-5wdeA:
undetectable		 5tudA-5wdeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3q ENVELOPE
GLYCOPROTEIN

(Talaromyces
marneffei) 		no annotation 5 ASP A  15
PHE A  19
LEU A 131
LEU A  66
VAL A  18
 None
 1.17A 5tudA-5x3qA:
4.1		 5tudA-5x3qA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xey PHLORETIN HYDROLASE

(Mycobacteroides
abscessus) 		no annotation 5 ASP A 270
SER A 230
ALA A 199
PHE A 103
PHE A 111
 None
 1.14A 5tudA-5xeyA:
undetectable		 5tudA-5xeyA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 VAL A 281
ALA A 330
LEU A 379
LEU A 400
VAL A 259
 None
 1.09A 5tudA-5yh5A:
3.8		 5tudA-5yh5A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 LEU A 867
VAL A 865
SER A 864
MET A 840
LEU A 768
 None
 1.17A 5tudA-5yimA:
4.9		 5tudA-5yimA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 5 LEU A 264
VAL A 405
ALA A 334
LEU A 277
LEU A 377
 None
 1.11A 5tudA-5yqwA:
2.1		 5tudA-5yqwA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E
PHASE 2
FLAGELLIN,FLAGELLIN

(Mus musculus;
Salmonella
enterica) 		no annotation 5 SER A 798
ALA C 423
PHE A 871
LEU A 864
LEU A 812
 None
 1.00A 5tudA-5yudA:
undetectable		 5tudA-5yudA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 5 VAL I  94
PHE I  44
LEU I  30
LEU I  27
VAL I  46
 None
 0.89A 5tudA-6az1I:
undetectable		 5tudA-6az1I:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 5 VAL A 409
PHE A 363
LEU A 404
LEU A 365
VAL A 368
 None
 0.98A 5tudA-6bfuA:
2.8		 5tudA-6bfuA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 8 ASP A 134
SER A 138
VAL A 208
ALA A 222
PHE A 327
PHE A 328
LEU A 350
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.96A 5tudA-6bqhA:
31.5		 5tudA-6bqhA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 8 ASP A 134
VAL A 135
SER A 138
VAL A 208
ALA A 222
PHE A 327
PHE A 328
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
 0.96A 5tudA-6bqhA:
31.5		 5tudA-6bqhA:
69.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2q FERM, RHOGEF
(ARHGEF) AND
PLECKSTRIN DOMAIN
PROTEIN 1
(CHONDROCYTE-DERIVED
)

(Danio rerio) 		no annotation 5 LEU A  76
MET A  47
PHE A  55
LEU A 114
LEU A  66
 None
 1.14A 5tudA-6d2qA:
undetectable		 5tudA-6d2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6din DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A  83
ALA A  38
PHE A  14
LEU A 102
VAL A  73
 None
 1.04A 5tudA-6dinA:
undetectable		 5tudA-6dinA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 LEU S 126
ASP S 129
ALA S 216
PHE S 330
PHE S 331
 None
EP5  S 401 (-3.3A)
EP5  S 401 ( 4.0A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
 0.45A 5tudA-6g79S:
30.4		 5tudA-6g79S:
21.47