SIMILAR PATTERNS OF AMINO ACIDS FOR 5TRQ_B_ACTB307_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0p | SITE-SPECIFICRECOMBINASE XERD (Escherichiacoli) |
PF00589(Phage_integrase)PF02899(Phage_int_SAM_1) | 3 | GLU A 285HIS A 281VAL A 264 | None | 0.41A | 5trqB-1a0pA:undetectable | 5trqB-1a0pA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1di6 | MOLYBDENUM COFACTORBIOSYNTHETIC ENZYME (Escherichiacoli) |
PF00994(MoCF_biosynth) | 3 | GLU A 144HIS A 156VAL A 181 | None | 0.84A | 5trqB-1di6A:0.0 | 5trqB-1di6A:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxy | D-2-HYDROXYISOCAPROATE DEHYDROGENASE (Lactobacilluscasei) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | GLU A 12HIS A 305VAL A 304 | None | 0.89A | 5trqB-1dxyA:0.0 | 5trqB-1dxyA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5r | PROLINE OXIDASE (Streptomycessp. TH1) |
PF05118(Asp_Arg_Hydrox)PF05373(Pro_3_hydrox_C) | 3 | GLU A 247HIS A 238VAL A 243 | None | 0.86A | 5trqB-1e5rA:9.3 | 5trqB-1e5rA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h5b | MURINE T CELLRECEPTOR (TCR)VALPHA DOMAIN (Mus musculus) |
PF07686(V-set) | 3 | GLU A 15HIS A 14VAL A 112 | None | 0.78A | 5trqB-1h5bA:0.0 | 5trqB-1h5bA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbe | KINASE SUPPRESSOR OFRAS (Mus musculus) |
no annotation | 3 | GLU A 373HIS A 367VAL A 348 | None ZN A 2 (-3.0A) ZN A 2 ( 4.3A) | 0.73A | 5trqB-1kbeA:undetectable | 5trqB-1kbeA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ku2 | SIGMA FACTOR SIGA (Thermusaquaticus) |
PF00140(Sigma70_r1_2)PF04539(Sigma70_r3)PF04542(Sigma70_r2) | 3 | GLU A 281HIS A 278VAL A 277 | None | 0.93A | 5trqB-1ku2A:undetectable | 5trqB-1ku2A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lht | MYOGLOBIN (Caretta caretta) |
PF00042(Globin) | 3 | GLU A 27HIS A 24VAL A 114 | None | 0.88A | 5trqB-1lhtA:undetectable | 5trqB-1lhtA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1l | SUPPRESSOR OF FUSED (Homo sapiens) |
PF05076(SUFU) | 3 | GLU A 207HIS A 176VAL A 203 | None | 0.83A | 5trqB-1m1lA:0.0 | 5trqB-1m1lA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mo0 | TRIOSEPHOSPHATEISOMERASE (Caenorhabditiselegans) |
PF00121(TIM) | 3 | GLU A 128HIS A 137VAL A 141 | None | 0.93A | 5trqB-1mo0A:undetectable | 5trqB-1mo0A:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1orp | ENDONUCLEASE III (Geobacillusstearothermophilus) |
PF00633(HHH)PF00730(HhH-GPD) | 3 | GLU A 162HIS A 178VAL A 138 | None | 0.83A | 5trqB-1orpA:undetectable | 5trqB-1orpA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1otr | PROTEIN CUE2 (Saccharomycescerevisiae) |
PF02845(CUE) | 3 | GLU A 34HIS A 31VAL A 30 | None | 0.91A | 5trqB-1otrA:undetectable | 5trqB-1otrA:10.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s58 | B19 PARVOVIRUSCAPSID (Primateerythroparvovirus1) |
PF00740(Parvo_coat) | 3 | GLU A 215HIS A 216VAL A 213 | None | 0.81A | 5trqB-1s58A:2.3 | 5trqB-1s58A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkp | IRON-RICHDPSA-HOMOLOG PROTEIN (Halobacteriumsalinarum) |
PF00210(Ferritin) | 3 | GLU A 56HIS A 64VAL A 55 | None | 0.89A | 5trqB-1tkpA:undetectable | 5trqB-1tkpA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcn | CTP SYNTHETASE (Thermusthermophilus) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | GLU A 131HIS A 127VAL A 108 | None | 0.63A | 5trqB-1vcnA:0.0 | 5trqB-1vcnA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w36 | EXODEOXYRIBONUCLEASEV GAMMA CHAIN (Escherichiacoli) |
PF04257(Exonuc_V_gamma) | 3 | GLU C 387HIS C 390VAL C 425 | None | 0.66A | 5trqB-1w36C:undetectable | 5trqB-1w36C:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5v | CARBONIC ANHYDRASE(CARBONATEDEHYDRATASE)(CARBONICDEHYDRATASE) (Mycobacteriumtuberculosis) |
PF00484(Pro_CA) | 3 | GLU A 153HIS A 156VAL A 110 | None | 0.87A | 5trqB-2a5vA:undetectable | 5trqB-2a5vA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abk | ENDONUCLEASE III (Escherichiacoli) |
PF00633(HHH)PF00730(HhH-GPD)PF10576(EndIII_4Fe-2S) | 3 | GLU A 160HIS A 176VAL A 137 | None | 0.85A | 5trqB-2abkA:undetectable | 5trqB-2abkA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 3 | GLU A 180HIS A 103VAL A 165 | None | 0.77A | 5trqB-2aniA:undetectable | 5trqB-2aniA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 3 | GLU A 933HIS A1348VAL A 970 | None | 0.93A | 5trqB-2b39A:undetectable | 5trqB-2b39A:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 3 | GLU A1137HIS A1178VAL A1140 | None | 0.92A | 5trqB-2b39A:undetectable | 5trqB-2b39A:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7s | RNA-DEPENDENT RNAPOLYMERASE (Foot-and-mouthdisease virus) |
PF00680(RdRP_1) | 3 | GLU A 286HIS A 14VAL A 15 | None | 0.92A | 5trqB-2d7sA:undetectable | 5trqB-2d7sA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq3 | SERYL-TRNASYNTHETASE (Aquifexaeolicus) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 3 | GLU A 298HIS A 291VAL A 290 | None | 0.90A | 5trqB-2dq3A:undetectable | 5trqB-2dq3A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dy3 | ALANINE RACEMASE (Corynebacteriumglutamicum) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | GLU A 211HIS A 195VAL A 193 | None | 0.88A | 5trqB-2dy3A:undetectable | 5trqB-2dy3A:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3q | PROTEIN YBL047C (Saccharomycescerevisiae) |
PF00627(UBA) | 3 | GLU A1356HIS A1360VAL A1346 | None | 0.90A | 5trqB-2g3qA:undetectable | 5trqB-2g3qA:9.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi4 | CYTOCHROME P450 1A2 (Homo sapiens) |
PF00067(p450) | 3 | GLU A 168HIS A 164VAL A 199 | None | 0.68A | 5trqB-2hi4A:undetectable | 5trqB-2hi4A:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | GLU A 497HIS A 508VAL A 512 | SO4 A 603 ( 4.6A)NoneNone | 0.75A | 5trqB-2ihtA:undetectable | 5trqB-2ihtA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3m | PROLYL-TRNASYNTHETASE (Enterococcusfaecalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF04073(tRNA_edit) | 3 | GLU A 454HIS A 23VAL A 20 | None | 0.90A | 5trqB-2j3mA:undetectable | 5trqB-2j3mA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4t | ANGIOGENIN-4 (Mus musculus) |
PF00074(RnaseA) | 3 | GLU A 106HIS A 112VAL A 111 | None | 0.91A | 5trqB-2j4tA:undetectable | 5trqB-2j4tA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l9p | UNCHARACTERIZEDPROTEIN (Staphylococcusepidermidis) |
PF08327(AHSA1) | 3 | GLU A 34HIS A 38VAL A 44 | None | 0.76A | 5trqB-2l9pA:undetectable | 5trqB-2l9pA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8q | HYPOTHETICAL PROTEIN (Paraburkholderiaxenovorans) |
PF07883(Cupin_2) | 3 | GLU A 79HIS A 100VAL A 98 | None NI A 300 (-3.3A)None | 0.82A | 5trqB-2o8qA:4.9 | 5trqB-2o8qA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okl | PEPTIDE DEFORMYLASE2 (Bacillus cereus) |
PF01327(Pep_deformylase) | 3 | GLU A 137HIS A 87VAL A 139 | None | 0.88A | 5trqB-2oklA:undetectable | 5trqB-2oklA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qga | ADENYLOSUCCINATELYASE (Plasmodiumvivax) |
PF00206(Lyase_1)PF08328(ASL_C) | 3 | GLU B 145HIS B 189VAL B 192 | None | 0.89A | 5trqB-2qgaB:undetectable | 5trqB-2qgaB:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x6k | PHOSPHOTIDYLINOSITOL3 KINASE 59F (Drosophilamelanogaster) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka) | 3 | GLU A 570HIS A 573VAL A 565 | None | 0.89A | 5trqB-2x6kA:undetectable | 5trqB-2x6kA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yql | PHD FINGER PROTEIN21A (Homo sapiens) |
PF00628(PHD) | 3 | GLU A 9HIS A 8VAL A 30 | None | 0.89A | 5trqB-2yqlA:undetectable | 5trqB-2yqlA:9.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yr0 | HYPOTHETICAL PROTEINTTHA0223 (Thermusthermophilus) |
PF08241(Methyltransf_11) | 3 | GLU A 163HIS A 227VAL A 226 | None | 0.87A | 5trqB-2yr0A:undetectable | 5trqB-2yr0A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yz1 | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPESUBSTRATE 1 (Mus musculus) |
PF07686(V-set) | 3 | GLU A 59HIS A 60VAL A 64 | None | 0.84A | 5trqB-2yz1A:undetectable | 5trqB-2yz1A:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asm | RIBONUCLEASE HIII (Geobacillusstearothermophilus) |
PF01351(RNase_HII)PF11858(DUF3378) | 3 | GLU A 232HIS A 235VAL A 238 | None | 0.78A | 5trqB-3asmA:undetectable | 5trqB-3asmA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b02 | TRANSCRIPTIONALREGULATOR, CRPFAMILY (Thermusthermophilus) |
PF00027(cNMP_binding)PF13545(HTH_Crp_2) | 3 | GLU A 144HIS A 142VAL A 140 | None | 0.87A | 5trqB-3b02A:undetectable | 5trqB-3b02A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bga | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 3 | GLU A 381HIS A 382VAL A 389 | None | 0.81A | 5trqB-3bgaA:undetectable | 5trqB-3bgaA:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bgw | DNAB-LIKEREPLICATIVE HELICASE (Bacillus phageSPP1) |
PF00772(DnaB)PF03796(DnaB_C) | 3 | GLU A 16HIS A 39VAL A 104 | None | 0.75A | 5trqB-3bgwA:undetectable | 5trqB-3bgwA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3chl | ALPHA-14 GIARDIN (Giardiaintestinalis) |
PF00191(Annexin) | 3 | GLU A 230HIS A 237VAL A 221 | None | 0.89A | 5trqB-3chlA:undetectable | 5trqB-3chlA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cou | NUCLEOSIDEDIPHOSPHATE-LINKEDMOIETY X MOTIF 16 (Homo sapiens) |
PF00293(NUDIX) | 3 | GLU A 80HIS A 133VAL A 137 | None | 0.88A | 5trqB-3couA:undetectable | 5trqB-3couA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cyj | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Rubrobacterxylanophilus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | GLU A 129HIS A 127VAL A 130 | None | 0.92A | 5trqB-3cyjA:undetectable | 5trqB-3cyjA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dec | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 3 | GLU A 357HIS A 358VAL A 365 | None | 0.91A | 5trqB-3decA:undetectable | 5trqB-3decA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N) | 3 | GLU A1220HIS A1184VAL A1187 | NoneMD1 A1245 ( 4.6A)None | 0.86A | 5trqB-3egwA:undetectable | 5trqB-3egwA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fo5 | THIOESTERASE,ADIPOSE ASSOCIATED,ISOFORM BFIT2 (Homo sapiens) |
PF01852(START) | 3 | GLU A 577HIS A 433VAL A 432 | None | 0.78A | 5trqB-3fo5A:undetectable | 5trqB-3fo5A:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g0k | PUTATIVE MEMBRANEPROTEIN (Novosphingobiumaromaticivorans) |
PF12680(SnoaL_2) | 3 | GLU A 7HIS A 11VAL A 75 | CA A 130 (-2.4A)NoneNone | 0.81A | 5trqB-3g0kA:undetectable | 5trqB-3g0kA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gd7 | FUSION COMPLEX OFCYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR, RESIDUES1193-1427 ANDMALTOSE/MALTODEXTRINIMPORT ATP-BINDINGPROTEIN MALK,RESIDUES 219-371 (Escherichiacoli;Homo sapiens) |
PF00005(ABC_tran)PF08402(TOBE_2) | 3 | GLU A1548HIS A1526VAL A1516 | None | 0.90A | 5trqB-3gd7A:undetectable | 5trqB-3gd7A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il2 | REDOX-SENSINGTRANSCRIPTIONALREPRESSOR REX (Thermusthermophilus) |
PF02629(CoA_binding)PF06971(Put_DNA-bind_N) | 3 | GLU A 22HIS A 27VAL A 64 | None | 0.83A | 5trqB-3il2A:undetectable | 5trqB-3il2A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jtm | FORMATEDEHYDROGENASE,MITOCHONDRIAL (Arabidopsisthaliana) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | GLU A 243HIS A 220VAL A 238 | None | 0.82A | 5trqB-3jtmA:undetectable | 5trqB-3jtmA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3me5 | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Shigellaflexneri) |
PF00145(DNA_methylase) | 3 | GLU A 67HIS A 70VAL A 40 | None | 0.81A | 5trqB-3me5A:undetectable | 5trqB-3me5A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3meb | ASPARTATEAMINOTRANSFERASE (Giardiaintestinalis) |
PF00155(Aminotran_1_2) | 3 | GLU A 116HIS A 119VAL A 144 | None | 0.91A | 5trqB-3mebA:undetectable | 5trqB-3mebA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2o | BIOSYNTHETICARGININEDECARBOXYLASE (Vibriovulnificus) |
PF02784(Orn_Arg_deC_N) | 3 | GLU A 170HIS A 174VAL A 176 | None | 0.84A | 5trqB-3n2oA:undetectable | 5trqB-3n2oA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nap | CAPSID PROTEIN (Triatoma virus) |
PF00073(Rhv) | 3 | GLU B 101HIS B 219VAL B 172 | None | 0.77A | 5trqB-3napB:undetectable | 5trqB-3napB:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzq | BIOSYNTHETICARGININEDECARBOXYLASE (Escherichiacoli) |
PF02784(Orn_Arg_deC_N) | 3 | GLU A 187HIS A 191VAL A 193 | None | 0.90A | 5trqB-3nzqA:undetectable | 5trqB-3nzqA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0v | ALPHA/BETA HYDROLASEFOLD PROTEIN (Sphaerobacterthermophilus) |
PF12697(Abhydrolase_6) | 3 | GLU A 224HIS A 220VAL A 120 | None | 0.81A | 5trqB-3r0vA:undetectable | 5trqB-3r0vA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rfn | BB_1WNU_001 (Pyrococcushorikoshii) |
no annotation | 3 | GLU A 5HIS A 9VAL A 35 | None ZN A 1 (-3.3A)None | 0.52A | 5trqB-3rfnA:undetectable | 5trqB-3rfnA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rlf | MALTOSE/MALTODEXTRINIMPORT ATP-BINDINGPROTEIN MALK (Escherichiacoli) |
PF00005(ABC_tran)PF08402(TOBE_2) | 3 | GLU A 339HIS A 317VAL A 307 | None | 0.91A | 5trqB-3rlfA:undetectable | 5trqB-3rlfA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpd | METHIONINE SYNTHASE(B12-INDEPENDENT) (Shewanella sp.W3-18-1) |
PF01717(Meth_synt_2) | 3 | GLU A 165HIS A 155VAL A 115 | None | 0.92A | 5trqB-3rpdA:undetectable | 5trqB-3rpdA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3svt | SHORT-CHAIN TYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumulcerans) |
PF13561(adh_short_C2) | 3 | GLU A 133HIS A 129VAL A 78 | None | 0.89A | 5trqB-3svtA:undetectable | 5trqB-3svtA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqh | QUINONEOXIDOREDUCTASE (Coxiellaburnetii) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 3 | GLU A 107HIS A 38VAL A 317 | None | 0.92A | 5trqB-3tqhA:undetectable | 5trqB-3tqhA:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulk | KETOL-ACIDREDUCTOISOMERASE (Escherichiacoli) |
PF01450(IlvC)PF07991(IlvN) | 3 | GLU A 141HIS A 111VAL A 115 | GLU A 141 ( 0.6A)HIS A 111 (-1.0A)VAL A 115 ( 0.6A) | 0.81A | 5trqB-3ulkA:undetectable | 5trqB-3ulkA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnv | GLYOXYLATE REDUCTASE (Paecilomycessp.'thermophila') |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | GLU A 203HIS A 183VAL A 199 | None | 0.90A | 5trqB-3wnvA:undetectable | 5trqB-3wnvA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zh9 | DELTA (Bacillussubtilis) |
PF06144(DNA_pol3_delta) | 3 | GLU B 188HIS B 181VAL B 178 | NoneSO4 B1340 ( 3.9A)None | 0.86A | 5trqB-3zh9B:undetectable | 5trqB-3zh9B:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bla | MALTOSE-BINDINGPERIPLASMIC PROTEIN,SUPPRESSOR OF FUSEDHOMOLOG (Escherichiacoli;Homo sapiens) |
PF05076(SUFU)PF12470(SUFU_C)PF13416(SBP_bac_8) | 3 | GLU A 547HIS A 516VAL A 543 | None | 0.81A | 5trqB-4blaA:undetectable | 5trqB-4blaA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpt | PHENYLALANINE-4-HYDROXYLASE (PAH)(PHE-4-MONOOXYGENASE) (Legionellapneumophila) |
PF00351(Biopterin_H) | 3 | GLU A 117HIS A 122VAL A 115 | None | 0.79A | 5trqB-4bptA:undetectable | 5trqB-4bptA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzj | PROTEIN TRANSPORTPROTEIN SEC13 (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | GLU B 41HIS B 43VAL B 2 | None | 0.91A | 5trqB-4bzjB:undetectable | 5trqB-4bzjB:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d4z | DEOXYHYPUSINEHYDROXYLASE (Homo sapiens) |
PF13646(HEAT_2) | 3 | GLU A 266HIS A 240VAL A 269 | None FE A 302 (-3.5A)None | 0.87A | 5trqB-4d4zA:undetectable | 5trqB-4d4zA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e5k | PHOSPHITEDEHYDROGENASE(THERMOSTABLEVARIANT) (Pseudomonasstutzeri) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | GLU A 196HIS A 174VAL A 192 | NoneNAD A 401 (-4.6A)None | 0.92A | 5trqB-4e5kA:undetectable | 5trqB-4e5kA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e6y | CITRATE SYNTHASE (Vibriovulnificus) |
PF00285(Citrate_synt) | 3 | GLU A 196HIS A 200VAL A 212 | None | 0.61A | 5trqB-4e6yA:undetectable | 5trqB-4e6yA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hbk | ALDO-KETO REDUCTASEFAMILY 1, MEMBER B4(ALDOSE REDUCTASE) (Schistosomajaponicum) |
PF00248(Aldo_ket_red) | 3 | GLU A 143HIS A 87VAL A 88 | None | 0.89A | 5trqB-4hbkA:undetectable | 5trqB-4hbkA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kmh | SUPPRESSOR OF FUSEDHOMOLOG (Homo sapiens) |
PF05076(SUFU)PF12470(SUFU_C) | 3 | GLU A 207HIS A 176VAL A 203 | None | 0.84A | 5trqB-4kmhA:undetectable | 5trqB-4kmhA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n02 | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Streptococcuspneumoniae) |
PF01070(FMN_dh) | 3 | GLU A 180HIS A 142VAL A 143 | NoneSO4 A 403 ( 3.8A)None | 0.86A | 5trqB-4n02A:undetectable | 5trqB-4n02A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nec | PUTATIVESAM-DEPENDENTMETHYLTRANSFERASE (Streptomyceslasaliensis) |
PF13649(Methyltransf_25) | 3 | GLU A 151HIS A 215VAL A 214 | None | 0.89A | 5trqB-4necA:undetectable | 5trqB-4necA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5f | TYPE IIIPANTOTHENATE KINASE (Burkholderiathailandensis) |
PF03309(Pan_kinase) | 3 | GLU A 214HIS A 118VAL A 221 | None CL A 304 (-4.7A)None | 0.79A | 5trqB-4o5fA:undetectable | 5trqB-4o5fA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oby | ARGININE--TRNALIGASE (Escherichiacoli) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 3 | GLU A 147HIS A 151VAL A 153 | None | 0.89A | 5trqB-4obyA:undetectable | 5trqB-4obyA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | GLU A 128HIS A 124VAL A 105 | None | 0.60A | 5trqB-4zdkA:undetectable | 5trqB-4zdkA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwe | CYTOCHROME P450HYDROXYLASE (Streptomycesavermitilis) |
PF00067(p450) | 3 | GLU A 90HIS A 91VAL A 86 | NoneHEM A 403 (-3.9A)None | 0.63A | 5trqB-5cweA:undetectable | 5trqB-5cweA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dcf | TYROSINE RECOMBINASEXERD,DNA TRANSLOCASEFTSK (Escherichiacoli) |
PF00589(Phage_integrase)PF09397(Ftsk_gamma) | 3 | GLU A 176HIS A 172VAL A 155 | None | 0.46A | 5trqB-5dcfA:undetectable | 5trqB-5dcfA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT RRP42 (Saccharomycescerevisiae) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 3 | GLU E 72HIS E 70VAL E 71 | None | 0.90A | 5trqB-5g06E:undetectable | 5trqB-5g06E:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9f | CRISPR SYSTEMCASCADE SUBUNIT CASA (Escherichiacoli) |
PF09481(CRISPR_Cse1) | 3 | GLU A 240HIS A 238VAL A 106 | None | 0.59A | 5trqB-5h9fA:undetectable | 5trqB-5h9fA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ho9 | EXTRACELLULARARABINANASE (Geobacillusstearothermophilus) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 3 | GLU A 73HIS A 54VAL A 53 | AHR A 718 ( 3.0A)AHR A 719 ( 3.7A)None | 0.93A | 5trqB-5ho9A:undetectable | 5trqB-5ho9A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihe | DNA POLYMERASE IISMALL SUBUNIT (Pyrococcusabyssi) |
PF00149(Metallophos) | 3 | GLU A 502HIS A 513VAL A 561 | D5M A 701 (-3.6A)NoneD5M A 701 (-3.7A) | 0.81A | 5trqB-5iheA:undetectable | 5trqB-5iheA:21.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j4r | WELO5 (Hapalosiphonwelwitschii) |
no annotation | 3 | GLU A 125HIS A 129VAL A 136 | None | 0.08A | 5trqB-5j4rA:44.1 | 5trqB-5j4rA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 3 | GLU A 158HIS A 192VAL A 189 | None | 0.87A | 5trqB-5jjrA:undetectable | 5trqB-5jjrA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks8 | PYRUVATE CARBOXYLASESUBUNIT ALPHA (Methylobacillusflagellatus) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | GLU A 12HIS A 41VAL A 15 | None | 0.92A | 5trqB-5ks8A:undetectable | 5trqB-5ks8A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7v | GLYCOSIDE HYDROLASE (Bacteroidesvulgatus) |
PF13320(DUF4091) | 3 | GLU A 219HIS A 225VAL A 218 | None | 0.86A | 5trqB-5l7vA:undetectable | 5trqB-5l7vA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot4 | INTERAPTIN (Legionellapneumophila) |
no annotation | 3 | GLU A 622HIS A 618VAL A 652 | None | 0.76A | 5trqB-5ot4A:undetectable | 5trqB-5ot4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ttk | AMINE OXIDASE (Pseudomonasputida) |
PF01593(Amino_oxidase) | 3 | GLU A 119HIS A 115VAL A 467 | None | 0.84A | 5trqB-5ttkA:undetectable | 5trqB-5ttkA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7m | GLANDICOLINE BO-METHYLTRANSFERASEROQN (Penicilliumrubens) |
no annotation | 3 | GLU A 196HIS A 200VAL A 213 | None | 0.57A | 5trqB-5w7mA:undetectable | 5trqB-5w7mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9s | GLYCOSYL HYDROLASEFAMILY 3 PROTEIN (Bifidobacteriumlongum) |
no annotation | 3 | GLU A 693HIS A 691VAL A 674 | None | 0.88A | 5trqB-5z9sA:undetectable | 5trqB-5z9sA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zdm | - (-) |
no annotation | 3 | GLU A 167HIS A 126VAL A 110 | None | 0.92A | 5trqB-5zdmA:undetectable | 5trqB-5zdmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brd | RIFAMPINMONOOXYGENASE (Streptomycesvenezuelae) |
no annotation | 3 | GLU A 426HIS A 431VAL A 422 | None | 0.69A | 5trqB-6brdA:undetectable | 5trqB-6brdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8s | LOGANIC ACIDO-METHYLTRANSFERASE (Catharanthusroseus) |
no annotation | 3 | GLU A 190HIS A 192VAL A 193 | None | 0.86A | 5trqB-6c8sA:undetectable | 5trqB-6c8sA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c90 | EXOSOME RNA HELICASEMTR4,EXOSOME RNAHELICASE MTR4 (Homo sapiens) |
no annotation | 3 | GLU A 294HIS A 298VAL A 99 | None | 0.36A | 5trqB-6c90A:undetectable | 5trqB-6c90A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdd | NPL4 ZINC FINGER (Chaetomiumthermophilum) |
no annotation | 3 | GLU A 576HIS A 572VAL A 568 | None | 0.75A | 5trqB-6cddA:undetectable | 5trqB-6cddA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6q | EXOSOME RNA HELICASEMTR4 (Homo sapiens) |
no annotation | 3 | GLU M 294HIS M 298VAL M 99 | None | 0.69A | 5trqB-6d6qM:undetectable | 5trqB-6d6qM:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 3 | GLU A 335HIS A 336VAL A 344 | None | 0.82A | 5trqB-6etzA:undetectable | 5trqB-6etzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fkh | ATP SYNTHASE SUBUNITALPHA, CHLOROPLASTICATP SYNTHASE DELTACHAIN, CHLOROPLASTIC (Spinaciaoleracea;Spinaciaoleracea) |
no annotationno annotation | 3 | GLU C 18HIS d 141VAL d 85 | None | 0.84A | 5trqB-6fkhC:undetectable | 5trqB-6fkhC:undetectable |