SIMILAR PATTERNS OF AMINO ACIDS FOR 5TRQ_B_ACTB306

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 GLU A 291
ARG A 278
TYR A 279
 None
 0.52A 5trqB-1c0aA:
0.0		 5trqB-1c0aA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		3 GLU A 146
ARG A 297
TYR A 299
 FE2  A 325 (-2.4A)
PCV  A 327 ( 2.9A)
None
 0.63A 5trqB-1drtA:
9.7		 5trqB-1drtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		3 GLU A 370
ARG A 386
TYR A 387
 None
 0.63A 5trqB-1kehA:
0.0		 5trqB-1kehA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 GLU A 108
ARG A 111
TYR A 107
 None
 0.67A 5trqB-1khoA:
0.3		 5trqB-1khoA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 GLU A 312
ARG A 317
TYR A 310
 None
 0.63A 5trqB-1r5nA:
0.0		 5trqB-1r5nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		3 GLU A 463
ARG A 274
TYR A 461
 None
 0.62A 5trqB-1slqA:
0.0		 5trqB-1slqA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		3 GLU A 141
ARG A 144
TYR A 140
 None
 0.50A 5trqB-1tf0A:
undetectable		 5trqB-1tf0A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		3 GLU A 333
ARG A 336
TYR A 332
 None
 0.54A 5trqB-1tf0A:
undetectable		 5trqB-1tf0A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN BETA

(Crotalus
durissus) 		PF00059
(Lectin_C) 		3 GLU C 324
ARG C 213
TYR C 214
 None
 0.64A 5trqB-1umrC:
undetectable		 5trqB-1umrC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		3 GLU A  79
ARG A  67
TYR A  69
 None
 0.66A 5trqB-1vkyA:
0.0		 5trqB-1vkyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 3 GLU A 198
ARG A 185
TYR A 196
 None
 0.54A 5trqB-1xksA:
0.0		 5trqB-1xksA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		3 GLU A  37
ARG A 261
TYR A  75
 None
 0.64A 5trqB-1z7aA:
undetectable		 5trqB-1z7aA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		3 GLU C 201
ARG C 217
TYR C 218
 None
 0.56A 5trqB-2advC:
undetectable		 5trqB-2advC:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arc ARABINOSE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF02311
(AraC_binding) 		3 GLU A  90
ARG A  52
TYR A  92
 None
 0.65A 5trqB-2arcA:
3.0		 5trqB-2arcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5k MORF-RELATED GENE 15
ISOFORM 1

(Homo sapiens) 		PF11717
(Tudor-knot) 		3 GLU A  27
ARG A  16
TYR A  65
 None
 0.63A 5trqB-2f5kA:
undetectable		 5trqB-2f5kA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 3 GLU L 368
ARG L 410
TYR L 527
 None
 0.64A 5trqB-2frvL:
undetectable		 5trqB-2frvL:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1u FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		3 GLU A 146
ARG A  43
TYR A  79
 None
 0.47A 5trqB-2j1uA:
undetectable		 5trqB-2j1uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens) 		PF04099
(Sybindin) 		3 GLU D  81
ARG D  74
TYR D  75
 None
 0.65A 5trqB-2j3tD:
undetectable		 5trqB-2j3tD:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 GLU A  45
ARG A  79
TYR A  80
 None
 0.50A 5trqB-2jisA:
undetectable		 5trqB-2jisA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsn TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens) 		no annotation 3 GLU A  71
ARG A  64
TYR A  65
 None
 0.40A 5trqB-2jsnA:
undetectable		 5trqB-2jsnA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwj TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY

(Myxococcus
xanthus) 		PF02559
(CarD_CdnL_TRCF) 		3 GLU A  97
ARG A  94
TYR A  98
 None
 0.63A 5trqB-2lwjA:
undetectable		 5trqB-2lwjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 GLU A 364
ARG A 362
TYR A 365
 None
 0.64A 5trqB-2nadA:
undetectable		 5trqB-2nadA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oku ACYL-COA
DEHYDROGENASE FAMILY
PROTEIN

(Porphyromonas
gingivalis) 		PF12186
(AcylCoA_dehyd_C) 		3 GLU A 463
ARG A 459
TYR A 464
 None
 0.55A 5trqB-2okuA:
undetectable		 5trqB-2okuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		3 GLU A 153
ARG A 128
TYR A 154
 None
 0.58A 5trqB-2opjA:
undetectable		 5trqB-2opjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 220
ARG A 195
TYR A 221
 None
 0.46A 5trqB-2oqhA:
undetectable		 5trqB-2oqhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		3 GLU A 193
ARG A 190
TYR A 185
 None
 0.63A 5trqB-2pl2A:
undetectable		 5trqB-2pl2A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		3 GLU A 293
ARG A 286
TYR A 287
 None
 0.40A 5trqB-2q8nA:
undetectable		 5trqB-2q8nA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rem DISULFIDE
OXIDOREDUCTASE

(Xylella
fastidiosa) 		PF13462
(Thioredoxin_4) 		3 GLU A  14
ARG A 165
TYR A 166
 None
 0.48A 5trqB-2remA:
undetectable		 5trqB-2remA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 GLU A 108
ARG A 111
TYR A 107
 None
 0.66A 5trqB-2wxuA:
undetectable		 5trqB-2wxuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1w VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF00047
(ig) 		3 GLU L 167
ARG L 164
TYR L 165
 None
 0.51A 5trqB-2x1wL:
undetectable		 5trqB-2x1wL:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		3 GLU A 638
ARG A 622
TYR A 623
 None
 0.28A 5trqB-2xsgA:
undetectable		 5trqB-2xsgA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		3 GLU A  68
ARG A  89
TYR A  90
 None
 0.58A 5trqB-2ylzA:
undetectable		 5trqB-2ylzA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 GLU A 372
ARG A 370
TYR A  93
 None
 0.47A 5trqB-2yr5A:
undetectable		 5trqB-2yr5A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		3 GLU A  82
ARG A 311
TYR A  87
 None
 0.67A 5trqB-3aovA:
undetectable		 5trqB-3aovA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb5 STRESS RESPONSIVE
ALPHA-BETA PROTEIN

(Jannaschia sp.
CCS1) 		PF07876
(Dabb) 		3 GLU A   9
ARG A  53
TYR A  54
 None
 0.45A 5trqB-3bb5A:
undetectable		 5trqB-3bb5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE

(Bdellovibrio
bacteriovorus) 		no annotation 3 GLU A 181
ARG A 153
TYR A 182
 None
 0.52A 5trqB-3cawA:
undetectable		 5trqB-3cawA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		3 GLU A  37
ARG A 261
TYR A  75
 None
 0.61A 5trqB-3cl6A:
undetectable		 5trqB-3cl6A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dup MUTT/NUDIX FAMILY
PROTEIN

(Rhodospirillum
rubrum) 		PF15916
(DUF4743) 		3 GLU A  88
ARG A 106
TYR A  90
 None
PO4  A 299 ( 3.3A)
None
 0.56A 5trqB-3dupA:
undetectable		 5trqB-3dupA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 GLU A 364
ARG A 362
TYR A 365
 None
 0.66A 5trqB-3fn4A:
undetectable		 5trqB-3fn4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5b NETRIN RECEPTOR
UNC5B

(Rattus
norvegicus) 		PF00531
(Death)
PF00791
(ZU5)
PF17217
(UPA) 		3 GLU A 776
ARG A 755
TYR A 774
 None
 0.61A 5trqB-3g5bA:
undetectable		 5trqB-3g5bA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7v O-SUCCINYLBENZOATE
SYNTHASE

(Thermosynechococcus
elongatus) 		PF13378
(MR_MLE_C) 		3 GLU A 191
ARG A 163
TYR A 192
 None
 0.54A 5trqB-3h7vA:
undetectable		 5trqB-3h7vA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ira CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03190
(Thioredox_DsbH) 		3 GLU A  29
ARG A   4
TYR A  24
 None
 0.64A 5trqB-3iraA:
undetectable		 5trqB-3iraA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		3 GLU A 195
ARG A 202
TYR A 193
 None
 0.66A 5trqB-3kb1A:
undetectable		 5trqB-3kb1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		3 GLU A  50
ARG A 139
TYR A  49
 None
 0.59A 5trqB-3lm4A:
undetectable		 5trqB-3lm4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		3 GLU A 342
ARG A 329
TYR A 331
 None
 0.47A 5trqB-3lrkA:
undetectable		 5trqB-3lrkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		3 GLU A  12
ARG A   8
TYR A 368
 None
 0.65A 5trqB-3mzsA:
undetectable		 5trqB-3mzsA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 GLU A 172
ARG A 166
TYR A 167
 None
 0.59A 5trqB-3oc7A:
undetectable		 5trqB-3oc7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H

(Bacillus
subtilis) 		PF13176
(TPR_7) 		3 GLU A 109
ARG A 105
TYR A 121
 None
 0.49A 5trqB-3q15A:
undetectable		 5trqB-3q15A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Alicyclobacillus
acidocaldarius) 		PF13472
(Lipase_GDSL_2) 		3 GLU A 139
ARG A 191
TYR A 137
 None
EDO  A 303 (-3.3A)
EDO  A 303 (-4.5A)
 0.66A 5trqB-3rjtA:
undetectable		 5trqB-3rjtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		3 GLU A  39
ARG A 265
TYR A  76
 None
 0.62A 5trqB-3s6oA:
undetectable		 5trqB-3s6oA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyw HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 GLU A 121
ARG A 258
TYR A 259
 None
 0.66A 5trqB-3uywA:
undetectable		 5trqB-3uywA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		3 GLU A 242
ARG A 218
TYR A 243
 None
 0.56A 5trqB-3va8A:
undetectable		 5trqB-3va8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		3 GLU A 244
ARG A 220
TYR A 245
 None
 0.60A 5trqB-3vdgA:
undetectable		 5trqB-3vdgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE

(Archaeoglobus
fulgidus) 		no annotation 3 GLU A 587
ARG A 514
TYR A 515
 None
 0.50A 5trqB-3vgpA:
undetectable		 5trqB-3vgpA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 GLU A 126
ARG A 145
TYR A 124
 None
 0.65A 5trqB-3wfaA:
undetectable		 5trqB-3wfaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 GLU A 240
ARG A 254
TYR A 255
 None
 0.60A 5trqB-4aalA:
undetectable		 5trqB-4aalA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		3 GLU A 240
ARG A 206
TYR A 207
 None
 0.53A 5trqB-4csiA:
2.4		 5trqB-4csiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 239
ARG A 215
TYR A 240
 None
 0.56A 5trqB-4dhgA:
undetectable		 5trqB-4dhgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fiu HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 GLU A 120
ARG A 253
TYR A 254
 None
 0.38A 5trqB-4fiuA:
undetectable		 5trqB-4fiuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkx HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 GLU E 119
ARG E 255
TYR E 256
 None
 0.53A 5trqB-4hkxE:
undetectable		 5trqB-4hkxE:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		3 GLU A 122
ARG A 133
TYR A 134
 None
 0.37A 5trqB-4houA:
undetectable		 5trqB-4houA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		3 GLU A 113
ARG A 116
TYR A 112
 None
 0.51A 5trqB-4i1aA:
undetectable		 5trqB-4i1aA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 GLU A  70
ARG A 110
TYR A 117
 None
 0.66A 5trqB-4i7iA:
undetectable		 5trqB-4i7iA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		3 GLU A  57
ARG A  52
TYR A  58
 None
 0.41A 5trqB-4jgiA:
undetectable		 5trqB-4jgiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		3 GLU A 140
ARG A 192
TYR A 138
 None
 0.64A 5trqB-4jj6A:
undetectable		 5trqB-4jj6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpk ENOYL-COA
HYDRATASE/ISOMERASE

(Shewanella
pealeana) 		PF00378
(ECH_1) 		3 GLU A 180
ARG A 174
TYR A 175
 None
 0.49A 5trqB-4kpkA:
undetectable		 5trqB-4kpkA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kps HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 GLU A 120
ARG A 255
TYR A 256
 None
 0.63A 5trqB-4kpsA:
undetectable		 5trqB-4kpsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 3 GLU A 229
ARG A 226
TYR A 230
 None
 0.62A 5trqB-4l9aA:
undetectable		 5trqB-4l9aA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ

(Ruegeria
lacuscaerulensis) 		PF16867
(DMSP_lyase) 		3 GLU A  94
ARG A 108
TYR A 110
 None
None
MES  A 202 ( 4.3A)
 0.51A 5trqB-4la2A:
6.8		 5trqB-4la2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN

(Methanopyrus
kandleri) 		PF03787
(RAMPs) 		3 GLU A 105
ARG A 150
TYR A 151
 None
 0.66A 5trqB-4n0lA:
undetectable		 5trqB-4n0lA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 GLU A 140
ARG A 168
TYR A 126
 None
 0.66A 5trqB-4pdxA:
undetectable		 5trqB-4pdxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		3 GLU A 141
ARG A 144
TYR A 140
 None
 0.49A 5trqB-4po0A:
undetectable		 5trqB-4po0A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 GLU A 129
ARG A  47
TYR A  48
 None
 0.52A 5trqB-4ptsA:
undetectable		 5trqB-4ptsA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjv DNA-DIRECTED RNA
POLYMERASE SUBUNIT L

(Thermococcus
kodakarensis) 		PF13656
(RNA_pol_L_2) 		3 GLU B  46
ARG B  56
TYR B  16
 None
 0.61A 5trqB-4qjvB:
undetectable		 5trqB-4qjvB:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 GLU A 365
ARG A 363
TYR A 366
 None
 0.63A 5trqB-4xybA:
undetectable		 5trqB-4xybA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 GLU A 522
ARG A 576
TYR A 526
 None
 0.54A 5trqB-4z3yA:
undetectable		 5trqB-4z3yA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpc SECRETED EFFECTOR
PROTEIN SOPD

(Salmonella
enterica) 		PF11047
(SopD) 		3 GLU A 194
ARG A 191
TYR A 187
 None
 0.58A 5trqB-5cpcA:
undetectable		 5trqB-5cpcA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cq9 SECRETED EFFECTOR
PROTEIN SOPD2

(Salmonella
enterica) 		PF11047
(SopD) 		3 GLU A 194
ARG A 191
TYR A 187
 None
 0.58A 5trqB-5cq9A:
undetectable		 5trqB-5cq9A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		3 GLU A 140
ARG A 143
TYR A 139
 None
 0.58A 5trqB-5dqfA:
undetectable		 5trqB-5dqfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		3 GLU A 332
ARG A 335
TYR A 331
 None
 0.36A 5trqB-5dqfA:
undetectable		 5trqB-5dqfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		3 GLU A 506
ARG A  58
TYR A  82
 None
 0.65A 5trqB-5f15A:
undetectable		 5trqB-5f15A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		3 GLU A 333
ARG A 336
TYR A 332
 None
 0.58A 5trqB-5ghkA:
undetectable		 5trqB-5ghkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6j PIERISIN-1

(Pieris rapae) 		no annotation 3 GLU A 141
ARG A 178
TYR A 143
 None
 0.62A 5trqB-5h6jA:
undetectable		 5trqB-5h6jA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6n PIERISIN-1

(Pieris rapae) 		no annotation 3 GLU A 141
ARG A 178
TYR A 143
 None
 0.61A 5trqB-5h6nA:
undetectable		 5trqB-5h6nA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 3 GLU A 209
ARG A 256
TYR A 257
 None
 0.25A 5trqB-5j4rA:
44.1		 5trqB-5j4rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		3 GLU A  61
ARG A  82
TYR A  83
 None
 0.64A 5trqB-5m10A:
undetectable		 5trqB-5m10A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 GLU A 673
ARG A 860
TYR A 680
 None
 0.40A 5trqB-5n4lA:
undetectable		 5trqB-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 3 GLU A 144
ARG A 147
TYR A 143
 None
 0.62A 5trqB-5oklA:
undetectable		 5trqB-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 GLU A 140
ARG A 143
TYR A 139
 None
 0.49A 5trqB-5oriA:
undetectable		 5trqB-5oriA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 GLU A 332
ARG A 335
TYR A 331
 None
 0.52A 5trqB-5oriA:
undetectable		 5trqB-5oriA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owg PCYX_EBK42635

(marine
metagenome) 		no annotation 3 GLU A 176
ARG A  47
TYR A  48
 None
 0.60A 5trqB-5owgA:
undetectable		 5trqB-5owgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0z LIPOPROTEIN,
PUTATIVE

(Geobacter
metallireducens) 		no annotation 3 GLU A 137
ARG A 107
TYR A 108
 None
 0.62A 5trqB-5t0zA:
undetectable		 5trqB-5t0zA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLU D 250
ARG D 929
TYR D 245
 None
 0.36A 5trqB-5t4yD:
undetectable		 5trqB-5t4yD:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		3 GLU A  50
ARG A  53
TYR A  49
 None
 0.60A 5trqB-5uhuA:
undetectable		 5trqB-5uhuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		3 GLU A2901
ARG A2931
TYR A2765
 None
 0.66A 5trqB-5xauA:
undetectable		 5trqB-5xauA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhb NISIN IMMUNITY
PROTEIN

(Lactococcus
lactis) 		no annotation 3 GLU A  51
ARG A 108
TYR A 110
 None
 0.65A 5trqB-5xhbA:
undetectable		 5trqB-5xhbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 3 GLU A 141
ARG A 144
TYR A 140
 None
 0.65A 5trqB-5yxeA:
undetectable		 5trqB-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 3 GLU A 333
ARG A 336
TYR A 332
 None
 0.30A 5trqB-5yxeA:
undetectable		 5trqB-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 3 GLU A 272
ARG A 313
TYR A 270
 None
 0.46A 5trqB-6bwcA:
undetectable		 5trqB-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 3 GLU A 124
ARG A 135
TYR A 136
 None
 0.49A 5trqB-6c6kA:
undetectable		 5trqB-6c6kA:
undetectable