SIMILAR PATTERNS OF AMINO ACIDS FOR 5TQR_B_SAMB8009_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		5 LEU A 146
GLY A  66
VAL A  72
TYR A  48
HIS A 143
 None
None
None
None
FE  A 400 (-3.4A)
 1.45A 5tqrB-1ltzA:
undetectable		 5tqrB-1ltzA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 160
TYR A 204
ASN A 241
HIS A 242
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.56A 5tqrB-1pegA:
2.3		 5tqrB-1pegA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 LEU A 227
GLY A 200
VAL A 205
ASN A 226
HIS A 225
 None
 1.24A 5tqrB-1qmhA:
0.0		 5tqrB-1qmhA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 113
CYH A 117
GLY A 118
VAL A 130
TYR A 300
 None
 1.13A 5tqrB-1ykwA:
0.0		 5tqrB-1ykwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TYR A 371
VAL A  42
TYR A  12
TYR A 372
HIS A 332
 None
 1.41A 5tqrB-2d3lA:
undetectable		 5tqrB-2d3lA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TYR A 371
VAL A  42
TYR A  12
TYR A 372
HIS A 332
 None
 1.40A 5tqrB-2dieA:
undetectable		 5tqrB-2dieA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 GLY A  74
TYR A 287
TYR A 288
ASN A 291
TYR A  54
 None
EDO  A  19 (-3.6A)
None
None
None
 1.25A 5tqrB-2etvA:
0.0		 5tqrB-2etvA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella virus
1) 		PF00856
(SET) 		5 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.08A 5tqrB-2g46A:
6.4		 5tqrB-2g46A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella virus
1) 		PF00856
(SET) 		5 TYR A  16
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 SAH  A 301 (-4.7A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 0.90A 5tqrB-2g46A:
6.4		 5tqrB-2g46A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 151
TYR A 193
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.66A 5tqrB-2r3aA:
13.2		 5tqrB-2r3aA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.54A 5tqrB-2w5zA:
9.5		 5tqrB-2w5zA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 136
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.41A 5tqrB-3bo5A:
13.7		 5tqrB-3bo5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyx CARBONIC ANHYDRASE

(Saccharomyces
cerevisiae) 		PF00484
(Pro_CA) 		5 LEU A 201
GLY A 199
TYR A 198
HIS A 112
TYR A  62
 None
None
None
ZN  A   1 (-3.2A)
None
 1.41A 5tqrB-3eyxA:
undetectable		 5tqrB-3eyxA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 LEU A 220
CYH A 267
GLY A 268
VAL A 245
TYR A 272
 None
 1.45A 5tqrB-3hq2A:
undetectable		 5tqrB-3hq2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 LEU A 231
CYH A 234
GLY A 235
TYR A 238
VAL A 376
 None
 1.48A 5tqrB-3ibjA:
3.0		 5tqrB-3ibjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 GLY A 460
VAL A 429
TYR A 427
ASN A 462
TYR A 657
 None
 1.47A 5tqrB-3mc2A:
undetectable		 5tqrB-3mc2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.26A 5tqrB-3ooiA:
4.2		 5tqrB-3ooiA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		5 GLY A2151
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.35A 5tqrB-3opeA:
17.3		 5tqrB-3opeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Clostridium
perfringens) 		PF00698
(Acyl_transf_1) 		6 LEU A  90
GLY A  93
TYR A  95
VAL A 226
TYR A 235
ASN A 229
 None
 1.41A 5tqrB-3ptwA:
undetectable		 5tqrB-3ptwA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		6 GLY A  74
TYR A  75
TYR A 223
ASN A 251
HIS A 252
TYR A 285
 SAM  A 484 (-3.4A)
None
SAM  A 484 (-3.6A)
SAM  A 484 (-3.1A)
None
SAM  A 484 (-4.8A)
 0.85A 5tqrB-3rc0A:
undetectable		 5tqrB-3rc0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus musculus) 		PF00856
(SET) 		5 GLY A 257
TYR A 291
TYR A 318
ASN A 320
TYR A 357
 SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
None
SAH  A 394 (-3.4A)
None
 0.42A 5tqrB-4c1qA:
8.9		 5tqrB-4c1qA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		5 LEU A 205
GLY A 256
VAL A 185
TYR A 150
TYR A 234
 None
 1.40A 5tqrB-4mlgA:
undetectable		 5tqrB-4mlgA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 LEU A 109
TYR A  43
VAL A  50
TYR A 195
TYR A 198
 None
 1.39A 5tqrB-4q69A:
undetectable		 5tqrB-4q69A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		5 GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.37A 5tqrB-4qeoA:
11.7		 5tqrB-4qeoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		6 GLY A5408
TYR A5451
TYR A5472
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
SAH  A5602 (-3.1A)
None
None
 0.54A 5tqrB-4z4pA:
12.2		 5tqrB-4z4pA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		6 GLY A4782
TYR A4825
TYR A4846
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.9A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.63A 5tqrB-5f59A:
12.5		 5tqrB-5f59A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.65A 5tqrB-5f6lA:
11.9		 5tqrB-5f6lA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812) 		no annotation 5 LEU A  88
CYH A  37
TYR A 334
VAL A 352
TYR A 333
 None
 1.18A 5tqrB-5li4A:
undetectable		 5tqrB-5li4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1074
TYR A1118
ASN A1141
HIS A1142
TYR A1179
 SAM  A1304 ( 3.2A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.42A 5tqrB-5lsuA:
4.0		 5tqrB-5lsuA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3j INOSITOL
MONOPHOSPHATASE

(Medicago
truncatula) 		PF00459
(Inositol_P) 		5 LEU A 160
CYH A 245
GLY A 244
TYR A 243
VAL A 261
 None
 1.50A 5tqrB-5t3jA:
undetectable		 5tqrB-5t3jA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
 SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
 0.38A 5tqrB-5tegA:
10.3		 5tqrB-5tegA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 LEU A 154
GLY A 283
TYR A 282
VAL A 146
TYR A 275
 None
 1.32A 5tqrB-5tu0A:
undetectable		 5tqrB-5tu0A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1049
TYR A1085
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.35A 5tqrB-5tuyA:
3.2		 5tqrB-5tuyA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		5 LEU A  58
CYH A 283
GLY A 285
VAL A 258
HIS A 300
 None
 1.14A 5tqrB-5vn5A:
undetectable		 5tqrB-5vn5A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1137
TYR A1173
ASN A1200
HIS A1201
TYR A1242
 SAM  A3001 (-3.6A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
 0.41A 5tqrB-5vsdA:
3.8		 5tqrB-5vsdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 8 LEU B 804
CYH B 807
GLY B 808
TYR B 809
TYR B 878
ASN B 880
HIS B 881
TYR B 918
 None
None
A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-3.9A)
None
None
 0.26A 5tqrB-5wfcB:
52.9		 5tqrB-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 5 LEU A  88
CYH A  92
GLY A  93
VAL A 467
TYR A 101
 None
 1.46A 5tqrB-5y50A:
undetectable		 5tqrB-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 5 GLY A1156
TYR A1200
ASN A1223
HIS A1224
TYR A1261
 SAM  A1301 (-3.6A)
SAM  A1301 (-3.9A)
SAM  A1301 (-3.2A)
None
SAM  A1301 (-4.9A)
 0.40A 5tqrB-6cenA:
4.2		 5tqrB-6cenA:
undetectable