SIMILAR PATTERNS OF AMINO ACIDS FOR 5TOA_A_ESTA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis)
PF00704
(Glyco_hydro_18)
5 LEU A 226
LEU A 264
ALA A 263
ILE A 204
LEU A 249
None
0.96A 5toaA-1cnvA:
undetectable
5toaA-1cnvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE


(Escherichia
coli)
PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb)
5 LEU A  56
LEU A  55
ILE A  99
LEU A 104
LEU A  19
None
0.94A 5toaA-1f0xA:
undetectable
5toaA-1f0xA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE


(Escherichia
coli)
PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb)
5 LEU A  62
LEU A  56
ILE A  99
LEU A 104
LEU A  19
None
1.05A 5toaA-1f0xA:
undetectable
5toaA-1f0xA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN


(Human
mastadenovirus
B)
PF00541
(Adeno_knob)
5 LEU A 173
MET A 286
LEU A 210
ILE A 159
LEU A 214
None
1.02A 5toaA-1h7zA:
undetectable
5toaA-1h7zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE


(Curvularia
inaequalis)
PF01569
(PAP2)
5 LEU A  57
LEU A  54
ALA A  53
LEU A  33
LEU A 141
None
1.00A 5toaA-1iduA:
undetectable
5toaA-1iduA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khy CLPB PROTEIN

(Escherichia
coli)
PF02861
(Clp_N)
5 LEU A 110
LEU A 113
ALA A 114
GLU A 117
LEU A  93
None
0.92A 5toaA-1khyA:
undetectable
5toaA-1khyA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E


(Escherichia
coli)
PF00328
(His_Phos_2)
5 ALA A 272
LEU A 386
ILE A 320
LEU A 300
LEU A 286
None
0.92A 5toaA-1nt4A:
undetectable
5toaA-1nt4A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 LEU A 346
LEU A 349
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
LEU A 428
LEU A 525
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
None
EST  A   1 (-3.6A)
0.39A 5toaA-1pcgA:
31.2
5toaA-1pcgA:
59.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 349
ALA A 350
GLU A 353
ARG A 394
ILE A 424
LEU A 525
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
1.22A 5toaA-1pcgA:
31.2
5toaA-1pcgA:
59.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE


(Escherichia
coli)
PF02901
(PFL-like)
5 ALA A1554
GLU A1452
LEU A1443
ILE A1559
LEU A1470
None
1.01A 5toaA-1qhmA:
undetectable
5toaA-1qhmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
5 ALA A1054
MET A1158
ILE A1100
LEU A1150
LEU A1164
None
0.96A 5toaA-1tllA:
undetectable
5toaA-1tllA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT


(Salmonella
enterica)
PF01791
(DeoC)
5 ALA A 244
LEU A 208
LEU A 207
ILE A 177
LEU A 198
None
1.01A 5toaA-1to3A:
undetectable
5toaA-1to3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens)
PF08623
(TIP120)
5 LEU C 716
LEU C 719
ALA C 720
LEU C 727
ILE C 701
None
0.86A 5toaA-1u6gC:
undetectable
5toaA-1u6gC:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 LEU A 233
LEU A 230
ALA A 229
LEU A 280
ILE A 258
None
1.04A 5toaA-1wp9A:
undetectable
5toaA-1wp9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE


(Komagataeibacter
xylinus)
PF01270
(Glyco_hydro_8)
5 LEU A 300
ALA A 301
GLU A 304
LEU A 314
LEU A 317
None
0.95A 5toaA-1wzzA:
undetectable
5toaA-1wzzA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 324
LEU A 327
GLU A 331
MET A 362
LEU A 365
ARG A 372
LEU A 405
None
0.55A 5toaA-1xb7A:
26.1
5toaA-1xb7A:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztd HYPOTHETICAL PROTEIN
PFU-631545-001


(Pyrococcus
furiosus)
PF11469
(Ribonucleas_3_2)
5 LEU A  18
LEU A  21
ALA A  22
GLU A  25
ILE A  69
None
1.05A 5toaA-1ztdA:
undetectable
5toaA-1ztdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztd HYPOTHETICAL PROTEIN
PFU-631545-001


(Pyrococcus
furiosus)
PF11469
(Ribonucleas_3_2)
5 LEU A  18
LEU A  21
ALA A  22
GLU A  25
ILE A  78
None
0.99A 5toaA-1ztdA:
undetectable
5toaA-1ztdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE


(Thermoplasma
acidophilum)
PF03099
(BPL_LplA_LipB)
5 LEU A 238
ALA A 239
ILE A  35
LEU A 159
LEU A   8
None
0.68A 5toaA-2c7iA:
undetectable
5toaA-2c7iA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN


(Streptomyces
coelicolor)
PF00440
(TetR_N)
5 LEU A  57
ALA A  60
LEU A  19
LEU A  21
LEU A 110
None
1.03A 5toaA-2dg8A:
undetectable
5toaA-2dg8A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE


(Candida
albicans)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
5 LEU A  49
ALA A  47
LEU A  96
ILE A   3
LEU A 114
None
0.96A 5toaA-2dkdA:
undetectable
5toaA-2dkdA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151


(Pyrobaculum
aerophilum)
PF01850
(PIN)
5 LEU A  38
ALA A  39
GLU A  42
ILE A 110
LEU A 114
None
0.95A 5toaA-2fe1A:
undetectable
5toaA-2fe1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2


(Homo sapiens)
PF00378
(ECH_1)
5 LEU A 114
ALA A 116
LEU A 119
LEU A 121
ILE A  34
None
1.04A 5toaA-2fw2A:
undetectable
5toaA-2fw2A:
23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 272
MET A 306
LEU A 309
ILE A 438
LEU A 345
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-4.3A)
0.99A 5toaA-2gpvA:
27.4
5toaA-2gpvA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 268
LEU A 271
ALA A 272
GLU A 275
MET A 306
LEU A 309
ARG A 316
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
0.37A 5toaA-2gpvA:
27.4
5toaA-2gpvA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus)
PF09455
(Cas_DxTHG)
5 ALA A 220
LEU A 275
LEU A 271
LEU A 143
LEU A 190
None
0.92A 5toaA-2i71A:
undetectable
5toaA-2i71A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9w VPS28-PROV PROTEIN

(Xenopus laevis)
PF03997
(VPS28)
5 ALA A 211
MET A 204
LEU A 205
LEU A 143
LEU A 160
None
0.89A 5toaA-2j9wA:
undetectable
5toaA-2j9wA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jl4 MALEYLPYRUVATE
ISOMERASE


(Ralstonia sp.
U2)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
5 LEU A 144
ALA A 146
LEU A 186
ILE A  98
LEU A 167
None
0.90A 5toaA-2jl4A:
undetectable
5toaA-2jl4A:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 LEU A 346
LEU A 349
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
LEU A 428
LEU A 525
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
None
EST  A 596 (-3.6A)
0.46A 5toaA-2ocfA:
31.7
5toaA-2ocfA:
53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 349
ALA A 350
GLU A 353
ARG A 394
ILE A 424
LEU A 525
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-3.6A)
1.32A 5toaA-2ocfA:
31.7
5toaA-2ocfA:
53.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
6 LEU A  32
LEU A  35
ALA A  36
MET A  70
LEU A  77
ARG A  80
1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
0.27A 5toaA-2q3yA:
26.5
5toaA-2q3yA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14


(Homo sapiens)
PF00566
(RabGAP-TBC)
5 LEU A 605
ALA A 604
LEU A 568
LEU A 562
LEU A 630
None
1.02A 5toaA-2qq8A:
undetectable
5toaA-2qq8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F


(Enterococcus
faecium)
PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N)
5 LEU A 537
MET A 334
LEU A 549
ILE A 420
LEU A 556
None
1.04A 5toaA-2qr4A:
undetectable
5toaA-2qr4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster)
PF00795
(CN_hydrolase)
5 LEU A 229
ALA A 251
LEU A 345
ARG A  71
LEU A 343
None
1.01A 5toaA-2vhhA:
undetectable
5toaA-2vhhA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
6 LEU A 338
ALA A 334
LEU A 327
ILE A 380
LEU A 142
LEU A 320
None
1.29A 5toaA-3aflA:
undetectable
5toaA-3aflA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhq TRANSCRIPTIONAL
REGULATOR


(Mesorhizobium
japonicum)
PF00440
(TetR_N)
PF14246
(TetR_C_7)
5 LEU A  91
LEU A  94
ALA A  95
LEU A 169
MET A 168
None
0.97A 5toaA-3bhqA:
undetectable
5toaA-3bhqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnr TYPE IV FIMBRIAE
ASSEMBLY PROTEIN


(Xanthomonas
citri)
PF07238
(PilZ)
5 LEU A  52
LEU A  13
ALA A  14
LEU A  21
LEU A 103
None
0.95A 5toaA-3cnrA:
undetectable
5toaA-3cnrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsg TYPE IV FIMBRIAE
ASSEMBLY PROTEIN


(Xanthomonas
campestris)
PF07238
(PilZ)
5 LEU A  52
LEU A  13
ALA A  14
LEU A  21
LEU A 103
None
0.86A 5toaA-3dsgA:
undetectable
5toaA-3dsgA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erv PUTATIVE C39-LIKE
PEPTIDASE


(Bacillus
anthracis)
PF13529
(Peptidase_C39_2)
6 LEU A 134
LEU A 137
ALA A 138
MET A  80
LEU A  81
ILE A 170
None
1.10A 5toaA-3ervA:
undetectable
5toaA-3ervA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 LEU A 117
ALA A 116
LEU A  14
ILE A   3
LEU A 104
None
1.05A 5toaA-3heeA:
undetectable
5toaA-3heeA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS


(Escherichia
coli)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
5 LEU A 352
ALA A 356
LEU A 536
LEU A 535
LEU A 403
None
1.03A 5toaA-3k0sA:
undetectable
5toaA-3k0sA:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 718
LEU A 721
MET A 756
LEU A 763
ARG A 766
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
0.32A 5toaA-3kbaA:
25.4
5toaA-3kbaA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meb ASPARTATE
AMINOTRANSFERASE


(Giardia
intestinalis)
PF00155
(Aminotran_1_2)
5 LEU A 249
LEU A 268
ALA A 251
LEU A 111
ILE A 216
None
1.05A 5toaA-3mebA:
undetectable
5toaA-3mebA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obw PROTEIN PELOTA
HOMOLOG


(Sulfolobus
solfataricus)
PF03463
(eRF1_1)
PF03465
(eRF1_3)
5 LEU A 190
LEU A 191
LEU A 132
ILE A 236
LEU A 227
None
1.06A 5toaA-3obwA:
undetectable
5toaA-3obwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 LEU A 117
ALA A 116
LEU A  14
ILE A   3
LEU A 104
None
1.02A 5toaA-3ph3A:
undetectable
5toaA-3ph3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE


(Corynebacterium
glutamicum)
PF12897
(Aminotran_MocR)
5 LEU A 418
ALA A 419
GLU A 422
ILE A 373
LEU A 393
None
1.05A 5toaA-3pplA:
undetectable
5toaA-3pplA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qay ENDOLYSIN

(Clostridium
virus phiCD27)
PF01520
(Amidase_3)
5 LEU A  85
LEU A  33
ILE A 111
LEU A  37
LEU A 142
None
0.97A 5toaA-3qayA:
undetectable
5toaA-3qayA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1


(synthetic
construct)
PF00104
(Hormone_recep)
5 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
0.27A 5toaA-3ry9A:
25.9
5toaA-3ry9A:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uar GLUTATHIONE
S-TRANSFERASE


(Methylococcus
capsulatus)
PF00043
(GST_C)
PF02798
(GST_N)
6 LEU A  70
LEU A  73
ALA A  74
LEU A  82
ILE A 101
LEU A  94
None
1.33A 5toaA-3uarA:
undetectable
5toaA-3uarA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes)
PF00232
(Glyco_hydro_1)
5 LEU A 252
LEU A 255
ALA A 256
ILE A 335
LEU A 348
None
None
None
NHE  A 502 (-4.4A)
None
0.91A 5toaA-3wh7A:
undetectable
5toaA-3wh7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin)
5 ALA B 347
LEU B 343
LEU B 341
ILE B 151
LEU B 134
None
1.05A 5toaA-4cakB:
undetectable
5toaA-4cakB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 6


(Saccharomyces
cerevisiae)
no annotation 5 ALA C 131
LEU C 126
ILE C 148
LEU C 154
LEU C 106
None
0.97A 5toaA-4ejsC:
undetectable
5toaA-4ejsC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE


(Thermococcus
kodakarensis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 LEU A 338
ALA A 340
LEU A 177
ILE A 394
LEU A 231
None
0.99A 5toaA-4ga6A:
undetectable
5toaA-4ga6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major)
PF00141
(peroxidase)
5 LEU A  62
LEU A  65
ALA A  66
LEU A 123
ILE A  52
None
0.94A 5toaA-4gedA:
undetectable
5toaA-4gedA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
5 ALA A 266
LEU A 338
ILE A 306
LEU A 303
LEU A 328
None
1.00A 5toaA-4gvlA:
undetectable
5toaA-4gvlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
5 LEU L 116
LEU L  67
LEU L  69
LEU L  47
LEU L   8
None
0.96A 5toaA-4heaL:
undetectable
5toaA-4heaL:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE


(Thermotoga
maritima)
PF04055
(Radical_SAM)
PF06968
(BATS)
5 LEU A  35
LEU A  38
ALA A  39
LEU A 214
LEU A 250
None
0.86A 5toaA-4jxcA:
undetectable
5toaA-4jxcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liy FIBER PROTEIN

(Human
mastadenovirus
B)
PF00541
(Adeno_knob)
5 LEU A 173
MET A 286
LEU A 210
ILE A 159
LEU A 214
None
1.04A 5toaA-4liyA:
undetectable
5toaA-4liyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me7 MRNA INTERFERASE
ENDOA


(Bacillus
subtilis)
PF02452
(PemK_toxin)
5 LEU A 106
ALA A 105
MET A  98
ILE A  46
LEU A  94
None
1.04A 5toaA-4me7A:
undetectable
5toaA-4me7A:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
7 LEU A 283
LEU A 286
ALA A 287
GLU A 290
MET A 321
LEU A 324
ARG A 331
None
0.42A 5toaA-4n1yA:
28.6
5toaA-4n1yA:
38.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens)
PF08389
(Xpo1)
5 LEU B 612
LEU B 615
ALA B 616
LEU B 666
ILE B 658
None
0.99A 5toaA-4ol0B:
undetectable
5toaA-4ol0B:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 563
LEU A 566
MET A 601
LEU A 608
ARG A 611
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
0.71A 5toaA-4p6wA:
25.6
5toaA-4p6wA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A


(Saccharomyces
cerevisiae)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 ALA A 524
LEU A 531
ARG A 252
LEU A 188
LEU A 175
None
1.04A 5toaA-4ptfA:
undetectable
5toaA-4ptfA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12)
PF00756
(Esterase)
6 LEU A 148
LEU A 124
LEU A  48
LEU A  47
LEU A  45
LEU A 132
None
1.46A 5toaA-4rgyA:
undetectable
5toaA-4rgyA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 769
LEU A 772
ALA A 773
MET A 807
LEU A 810
LEU A 814
ARG A 817
CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
0.42A 5toaA-4udbA:
25.9
5toaA-4udbA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii)
PF08514
(STAG)
5 LEU A 773
LEU A 776
ALA A 777
LEU A 825
LEU A 826
None
1.05A 5toaA-4uvkA:
undetectable
5toaA-4uvkA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxm TRANSCRIPTIONAL
REGULATOR FLEQ


(Pseudomonas
aeruginosa)
PF06490
(FleQ)
6 LEU A 118
ALA A 121
LEU A 102
ILE A  10
LEU A  84
LEU A  80
None
1.43A 5toaA-4wxmA:
undetectable
5toaA-4wxmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135


(Acanthamoeba
polyphaga
mimivirus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 LEU A  21
LEU A  20
ILE A   9
LEU A 633
LEU A 255
None
0.92A 5toaA-4z26A:
undetectable
5toaA-4z26A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3k SEPIAPTERIN
REDUCTASE


(Homo sapiens)
PF00106
(adh_short)
5 LEU A 238
LEU A  23
LEU A  24
ILE A 152
LEU A   9
None
None
None
NAP  A 801 (-4.5A)
None
0.86A 5toaA-4z3kA:
undetectable
5toaA-4z3kA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF13654
(AAA_32)
5 LEU A 292
LEU A 242
MET A  80
ILE A 312
LEU A  65
None
1.03A 5toaA-4zpxA:
undetectable
5toaA-4zpxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3)
5 ALA A 289
LEU A  18
ILE A  68
LEU A  27
LEU A   5
None
1.01A 5toaA-5avoA:
undetectable
5toaA-5avoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0u ALKYLMERCURY LYASE

(Escherichia
coli)
PF03243
(MerB)
PF12324
(HTH_15)
5 LEU A  28
LEU A  31
ALA A  32
LEU A  92
ILE A 102
None
1.05A 5toaA-5c0uA:
undetectable
5toaA-5c0uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE


(Streptomyces
avermitilis)
PF00067
(p450)
5 ALA A 311
LEU A 335
ILE A 294
LEU A  57
LEU A  46
None
1.02A 5toaA-5cweA:
undetectable
5toaA-5cweA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1


(Rickettsia
prowazekii)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
5 LEU A  56
LEU A  59
ALA A  60
LEU A 277
ILE A 144
None
1.04A 5toaA-5dpdA:
undetectable
5toaA-5dpdA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana)
PF00459
(Inositol_P)
5 LEU A 152
ALA A 151
LEU A 165
LEU A 191
LEU A 205
None
1.05A 5toaA-5esyA:
undetectable
5toaA-5esyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN


(Vibrio cholerae)
PF01497
(Peripla_BP_2)
5 LEU A 226
LEU A 184
LEU A 313
LEU A 258
LEU A 196
None
0.97A 5toaA-5ggyA:
undetectable
5toaA-5ggyA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 LEU B  42
LEU B  39
LEU B 107
ILE B  97
LEU B 128
None
0.91A 5toaA-5gqrB:
undetectable
5toaA-5gqrB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis)
PF13354
(Beta-lactamase2)
6 LEU A  76
ALA A  77
MET A 210
LEU A 128
ILE A 185
LEU A 192
None
1.50A 5toaA-5hw3A:
undetectable
5toaA-5hw3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE


(Mycolicibacterium
thermoresistibile)
PF00982
(Glyco_transf_20)
6 LEU A 303
LEU A 304
ALA A 301
LEU A 281
LEU A 379
LEU A 428
None
None
EDO  A 505 ( 3.7A)
None
None
EDO  A 504 (-4.5A)
1.39A 5toaA-5jijA:
undetectable
5toaA-5jijA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Streptomyces
sp. ML694-90F3)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 LEU A 120
LEU A  73
LEU A  93
ILE A 146
LEU A  65
None
0.92A 5toaA-5jjqA:
undetectable
5toaA-5jjqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8)
5 LEU A 275
LEU A 297
ALA A 296
LEU A 292
LEU A 270
None
0.97A 5toaA-5lfnA:
undetectable
5toaA-5lfnA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-)
no annotation 5 LEU G 219
ALA G 223
LEU G 177
MET G 176
ILE G 428
None
0.95A 5toaA-5mlvG:
undetectable
5toaA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
no annotation 6 LEU A 769
LEU A 772
ALA A 773
MET A 807
LEU A 814
ARG A 817
ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
0.32A 5toaA-5mwpA:
25.6
5toaA-5mwpA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 ALA A4641
LEU A4643
LEU A4563
LEU A4511
LEU A4618
None
1.04A 5toaA-5nugA:
undetectable
5toaA-5nugA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 LEU A 818
LEU A 817
ALA A 816
ILE A 784
LEU A 843
None
1.03A 5toaA-5t9gA:
undetectable
5toaA-5t9gA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus)
PF00535
(Glycos_transf_2)
5 LEU A  20
LEU A  23
ALA A  24
LEU A  59
ILE A  49
None
0.97A 5toaA-5tz8A:
undetectable
5toaA-5tz8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Treponema
pallidum)
PF01547
(SBP_bac_1)
5 LEU A 317
LEU A 139
ALA A 138
LEU A 101
ILE A  46
None
1.00A 5toaA-5u2pA:
undetectable
5toaA-5u2pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR


(Heterocephalus
glaber)
no annotation 5 LEU A 559
LEU A 562
MET A 597
LEU A 604
ARG A 607
486  A 801 (-4.7A)
486  A 801 ( 4.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
0.80A 5toaA-5uc1A:
22.9
5toaA-5uc1A:
16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2


(unidentified)
PF00104
(Hormone_recep)
5 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
0.47A 5toaA-5ufsA:
26.4
5toaA-5ufsA:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens)
no annotation 5 LEU A 716
LEU A 715
ALA A 718
LEU A 740
LEU A 813
None
1.05A 5toaA-5vanA:
undetectable
5toaA-5vanA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus)
no annotation 5 LEU B 264
LEU B 134
LEU B 133
ILE B 248
LEU B 163
FAD  B 601 ( 4.9A)
None
None
None
None
0.95A 5toaA-5x1yB:
undetectable
5toaA-5x1yB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus)
no annotation 5 ALA A 495
LEU A 468
LEU A 469
ILE A 444
LEU A 420
None
1.05A 5toaA-5yv5A:
undetectable
5toaA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn7 AEROBACTIN SYNTHASE
IUCC


(Klebsiella
pneumoniae)
no annotation 5 ALA A 140
LEU A  13
ILE A  39
LEU A  65
LEU A  81
None
1.02A 5toaA-6cn7A:
undetectable
5toaA-6cn7A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa)
no annotation 5 ALA B 278
LEU B   2
MET B   1
LEU B 275
LEU B 107
None
0.97A 5toaA-6et0B:
undetectable
5toaA-6et0B:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2


(Homo sapiens)
no annotation 5 LEU A 225
LEU A 226
ALA A 223
ILE A 242
LEU A 216
None
0.98A 5toaA-6etiA:
undetectable
5toaA-6etiA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens)
no annotation 6 LEU A1776
LEU A1747
LEU A1748
ILE A1835
LEU A1814
LEU A1740
None
1.47A 5toaA-6ez8A:
undetectable
5toaA-6ez8A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190


(Arabidopsis
thaliana)
no annotation 5 LEU B  34
LEU B  31
LEU B  98
ILE B  88
LEU B 120
None
1.03A 5toaA-6fg8B:
undetectable
5toaA-6fg8B:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3w PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190


(Arabidopsis
thaliana)
no annotation 5 LEU B  34
LEU B  31
LEU B  98
ILE B  88
LEU B 120
None
1.03A 5toaA-6g3wB:
undetectable
5toaA-6g3wB:
16.46