SIMILAR PATTERNS OF AMINO ACIDS FOR 5TOA_A_ESTA601_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnv | CONCANAVALIN B (Canavaliaensiformis) |
PF00704(Glyco_hydro_18) | 5 | LEU A 226LEU A 264ALA A 263ILE A 204LEU A 249 | None | 0.96A | 5toaA-1cnvA:undetectable | 5toaA-1cnvA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0x | D-LACTATEDEHYDROGENASE (Escherichiacoli) |
PF01565(FAD_binding_4)PF09330(Lact-deh-memb) | 5 | LEU A 56LEU A 55ILE A 99LEU A 104LEU A 19 | None | 0.94A | 5toaA-1f0xA:undetectable | 5toaA-1f0xA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0x | D-LACTATEDEHYDROGENASE (Escherichiacoli) |
PF01565(FAD_binding_4)PF09330(Lact-deh-memb) | 5 | LEU A 62LEU A 56ILE A 99LEU A 104LEU A 19 | None | 1.05A | 5toaA-1f0xA:undetectable | 5toaA-1f0xA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7z | ADENOVIRUS FIBREPROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 5 | LEU A 173MET A 286LEU A 210ILE A 159LEU A 214 | None | 1.02A | 5toaA-1h7zA:undetectable | 5toaA-1h7zA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 5 | LEU A 57LEU A 54ALA A 53LEU A 33LEU A 141 | None | 1.00A | 5toaA-1iduA:undetectable | 5toaA-1iduA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khy | CLPB PROTEIN (Escherichiacoli) |
PF02861(Clp_N) | 5 | LEU A 110LEU A 113ALA A 114GLU A 117LEU A 93 | None | 0.92A | 5toaA-1khyA:undetectable | 5toaA-1khyA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nt4 | GLUCOSE-1-PHOSPHATASE (Escherichiacoli) |
PF00328(His_Phos_2) | 5 | ALA A 272LEU A 386ILE A 320LEU A 300LEU A 286 | None | 0.92A | 5toaA-1nt4A:undetectable | 5toaA-1nt4A:22.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | LEU A 346LEU A 349ALA A 350GLU A 353LEU A 387MET A 388LEU A 391ARG A 394LEU A 428LEU A 525 | EST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 ( 3.7A)EST A 1 (-2.8A)EST A 1 (-4.0A)NoneEST A 1 ( 3.9A)EST A 1 (-3.7A)NoneEST A 1 (-3.6A) | 0.39A | 5toaA-1pcgA:31.2 | 5toaA-1pcgA:59.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 349ALA A 350GLU A 353ARG A 394ILE A 424LEU A 525 | EST A 1 ( 4.8A)EST A 1 ( 3.7A)EST A 1 (-2.8A)EST A 1 (-3.7A)EST A 1 ( 4.5A)EST A 1 (-3.6A) | 1.22A | 5toaA-1pcgA:31.2 | 5toaA-1pcgA:59.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhm | PYRUVATEFORMATE-LYASE (Escherichiacoli) |
PF02901(PFL-like) | 5 | ALA A1554GLU A1452LEU A1443ILE A1559LEU A1470 | None | 1.01A | 5toaA-1qhmA:undetectable | 5toaA-1qhmA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tll | NITRIC-OXIDESYNTHASE, BRAIN (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 5 | ALA A1054MET A1158ILE A1100LEU A1150LEU A1164 | None | 0.96A | 5toaA-1tllA:undetectable | 5toaA-1tllA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to3 | PUTATIVE ALDOLASEYIHT (Salmonellaenterica) |
PF01791(DeoC) | 5 | ALA A 244LEU A 208LEU A 207ILE A 177LEU A 198 | None | 1.01A | 5toaA-1to3A:undetectable | 5toaA-1to3A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u6g | TIP120 PROTEIN (Homo sapiens) |
PF08623(TIP120) | 5 | LEU C 716LEU C 719ALA C 720LEU C 727ILE C 701 | None | 0.86A | 5toaA-1u6gC:undetectable | 5toaA-1u6gC:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wp9 | ATP-DEPENDENT RNAHELICASE, PUTATIVE (Pyrococcusfuriosus) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | LEU A 233LEU A 230ALA A 229LEU A 280ILE A 258 | None | 1.04A | 5toaA-1wp9A:undetectable | 5toaA-1wp9A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzz | PROBABLEENDOGLUCANASE (Komagataeibacterxylinus) |
PF01270(Glyco_hydro_8) | 5 | LEU A 300ALA A 301GLU A 304LEU A 314LEU A 317 | None | 0.95A | 5toaA-1wzzA:undetectable | 5toaA-1wzzA:22.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 324LEU A 327GLU A 331MET A 362LEU A 365ARG A 372LEU A 405 | None | 0.55A | 5toaA-1xb7A:26.1 | 5toaA-1xb7A:34.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ztd | HYPOTHETICAL PROTEINPFU-631545-001 (Pyrococcusfuriosus) |
PF11469(Ribonucleas_3_2) | 5 | LEU A 18LEU A 21ALA A 22GLU A 25ILE A 69 | None | 1.05A | 5toaA-1ztdA:undetectable | 5toaA-1ztdA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ztd | HYPOTHETICAL PROTEINPFU-631545-001 (Pyrococcusfuriosus) |
PF11469(Ribonucleas_3_2) | 5 | LEU A 18LEU A 21ALA A 22GLU A 25ILE A 78 | None | 0.99A | 5toaA-1ztdA:undetectable | 5toaA-1ztdA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7i | PUTATIVE LIPOATEPROTEIN LIGASE (Thermoplasmaacidophilum) |
PF03099(BPL_LplA_LipB) | 5 | LEU A 238ALA A 239ILE A 35LEU A 159LEU A 8 | None | 0.68A | 5toaA-2c7iA:undetectable | 5toaA-2c7iA:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dg8 | PUTATIVE TETR-FAMILYTRANSCRIPTIONALREGULATORY PROTEIN (Streptomycescoelicolor) |
PF00440(TetR_N) | 5 | LEU A 57ALA A 60LEU A 19LEU A 21LEU A 110 | None | 1.03A | 5toaA-2dg8A:undetectable | 5toaA-2dg8A:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkd | PHOSPHOACETYLGLUCOSAMINE MUTASE (Candidaalbicans) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I) | 5 | LEU A 49ALA A 47LEU A 96ILE A 3LEU A 114 | None | 0.96A | 5toaA-2dkdA:undetectable | 5toaA-2dkdA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fe1 | CONSERVEDHYPOTHETICAL PROTEINPAE0151 (Pyrobaculumaerophilum) |
PF01850(PIN) | 5 | LEU A 38ALA A 39GLU A 42ILE A 110LEU A 114 | None | 0.95A | 5toaA-2fe1A:undetectable | 5toaA-2fe1A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fw2 | TESTIS-SPECIFICCHROMODOMAIN PROTEINY 2 (Homo sapiens) |
PF00378(ECH_1) | 5 | LEU A 114ALA A 116LEU A 119LEU A 121ILE A 34 | None | 1.04A | 5toaA-2fw2A:undetectable | 5toaA-2fw2A:23.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ALA A 272MET A 306LEU A 309ILE A 438LEU A 345 | OHT A 500 (-3.5A)OHT A 500 (-3.9A)OHT A 500 ( 4.0A)NoneOHT A 500 (-4.3A) | 0.99A | 5toaA-2gpvA:27.4 | 5toaA-2gpvA:37.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 268LEU A 271ALA A 272GLU A 275MET A 306LEU A 309ARG A 316 | OHT A 500 (-4.1A)OHT A 500 ( 4.4A)OHT A 500 (-3.5A)OHT A 500 (-2.6A)OHT A 500 (-3.9A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A) | 0.37A | 5toaA-2gpvA:27.4 | 5toaA-2gpvA:37.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i71 | HYPOTHETICAL PROTEIN (Sulfolobussolfataricus) |
PF09455(Cas_DxTHG) | 5 | ALA A 220LEU A 275LEU A 271LEU A 143LEU A 190 | None | 0.92A | 5toaA-2i71A:undetectable | 5toaA-2i71A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j9w | VPS28-PROV PROTEIN (Xenopus laevis) |
PF03997(VPS28) | 5 | ALA A 211MET A 204LEU A 205LEU A 143LEU A 160 | None | 0.89A | 5toaA-2j9wA:undetectable | 5toaA-2j9wA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jl4 | MALEYLPYRUVATEISOMERASE (Ralstonia sp.U2) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | LEU A 144ALA A 146LEU A 186ILE A 98LEU A 167 | None | 0.90A | 5toaA-2jl4A:undetectable | 5toaA-2jl4A:17.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | LEU A 346LEU A 349ALA A 350GLU A 353LEU A 387MET A 388LEU A 391ARG A 394LEU A 428LEU A 525 | EST A 596 (-4.4A)EST A 596 ( 4.1A)EST A 596 ( 3.9A)EST A 596 (-2.7A)EST A 596 ( 4.2A)NoneEST A 596 ( 4.6A)EST A 596 (-4.0A)NoneEST A 596 (-3.6A) | 0.46A | 5toaA-2ocfA:31.7 | 5toaA-2ocfA:53.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 349ALA A 350GLU A 353ARG A 394ILE A 424LEU A 525 | EST A 596 ( 4.1A)EST A 596 ( 3.9A)EST A 596 (-2.7A)EST A 596 (-4.0A)EST A 596 ( 4.7A)EST A 596 (-3.6A) | 1.32A | 5toaA-2ocfA:31.7 | 5toaA-2ocfA:53.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 6 | LEU A 32LEU A 35ALA A 36MET A 70LEU A 77ARG A 80 | 1CA A 247 (-4.0A)1CA A 247 ( 4.4A)1CA A 247 (-3.6A)1CA A 247 ( 3.8A)1CA A 247 ( 3.9A)1CA A 247 (-3.8A) | 0.27A | 5toaA-2q3yA:26.5 | 5toaA-2q3yA:29.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qq8 | TBC1 DOMAIN FAMILYMEMBER 14 (Homo sapiens) |
PF00566(RabGAP-TBC) | 5 | LEU A 605ALA A 604LEU A 568LEU A 562LEU A 630 | None | 1.02A | 5toaA-2qq8A:undetectable | 5toaA-2qq8A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qr4 | PEPTIDASE M3B,OLIGOENDOPEPTIDASE F (Enterococcusfaecium) |
PF01432(Peptidase_M3)PF08439(Peptidase_M3_N) | 5 | LEU A 537MET A 334LEU A 549ILE A 420LEU A 556 | None | 1.04A | 5toaA-2qr4A:undetectable | 5toaA-2qr4A:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhh | CG3027-PA (Drosophilamelanogaster) |
PF00795(CN_hydrolase) | 5 | LEU A 229ALA A 251LEU A 345ARG A 71LEU A 343 | None | 1.01A | 5toaA-2vhhA:undetectable | 5toaA-2vhhA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afl | OLIGO ALGINATE LYASE (Agrobacteriumfabrum) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 6 | LEU A 338ALA A 334LEU A 327ILE A 380LEU A 142LEU A 320 | None | 1.29A | 5toaA-3aflA:undetectable | 5toaA-3aflA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bhq | TRANSCRIPTIONALREGULATOR (Mesorhizobiumjaponicum) |
PF00440(TetR_N)PF14246(TetR_C_7) | 5 | LEU A 91LEU A 94ALA A 95LEU A 169MET A 168 | None | 0.97A | 5toaA-3bhqA:undetectable | 5toaA-3bhqA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnr | TYPE IV FIMBRIAEASSEMBLY PROTEIN (Xanthomonascitri) |
PF07238(PilZ) | 5 | LEU A 52LEU A 13ALA A 14LEU A 21LEU A 103 | None | 0.95A | 5toaA-3cnrA:undetectable | 5toaA-3cnrA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dsg | TYPE IV FIMBRIAEASSEMBLY PROTEIN (Xanthomonascampestris) |
PF07238(PilZ) | 5 | LEU A 52LEU A 13ALA A 14LEU A 21LEU A 103 | None | 0.86A | 5toaA-3dsgA:undetectable | 5toaA-3dsgA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3erv | PUTATIVE C39-LIKEPEPTIDASE (Bacillusanthracis) |
PF13529(Peptidase_C39_2) | 6 | LEU A 134LEU A 137ALA A 138MET A 80LEU A 81ILE A 170 | None | 1.10A | 5toaA-3ervA:undetectable | 5toaA-3ervA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hee | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | LEU A 117ALA A 116LEU A 14ILE A 3LEU A 104 | None | 1.05A | 5toaA-3heeA:undetectable | 5toaA-3heeA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0s | DNA MISMATCH REPAIRPROTEIN MUTS (Escherichiacoli) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 5 | LEU A 352ALA A 356LEU A 536LEU A 535LEU A 403 | None | 1.03A | 5toaA-3k0sA:undetectable | 5toaA-3k0sA:16.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 718LEU A 721MET A 756LEU A 763ARG A 766 | WOW A 1 (-4.2A)WOW A 1 ( 4.3A)WOW A 1 ( 4.1A)WOW A 1 ( 4.0A)WOW A 1 (-3.8A) | 0.32A | 5toaA-3kbaA:25.4 | 5toaA-3kbaA:30.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3meb | ASPARTATEAMINOTRANSFERASE (Giardiaintestinalis) |
PF00155(Aminotran_1_2) | 5 | LEU A 249LEU A 268ALA A 251LEU A 111ILE A 216 | None | 1.05A | 5toaA-3mebA:undetectable | 5toaA-3mebA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3obw | PROTEIN PELOTAHOMOLOG (Sulfolobussolfataricus) |
PF03463(eRF1_1)PF03465(eRF1_3) | 5 | LEU A 190LEU A 191LEU A 132ILE A 236LEU A 227 | None | 1.06A | 5toaA-3obwA:undetectable | 5toaA-3obwA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph3 | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | LEU A 117ALA A 116LEU A 14ILE A 3LEU A 104 | None | 1.02A | 5toaA-3ph3A:undetectable | 5toaA-3ph3A:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppl | ASPARTATEAMINOTRANSFERASE (Corynebacteriumglutamicum) |
PF12897(Aminotran_MocR) | 5 | LEU A 418ALA A 419GLU A 422ILE A 373LEU A 393 | None | 1.05A | 5toaA-3pplA:undetectable | 5toaA-3pplA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qay | ENDOLYSIN (Clostridiumvirus phiCD27) |
PF01520(Amidase_3) | 5 | LEU A 85LEU A 33ILE A 111LEU A 37LEU A 142 | None | 0.97A | 5toaA-3qayA:undetectable | 5toaA-3qayA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35MET A 70LEU A 77ARG A 80 | 1CA A 249 (-3.9A)1CA A 249 ( 4.4A)1CA A 249 ( 3.8A)1CA A 249 ( 4.1A)1CA A 249 (-3.5A) | 0.27A | 5toaA-3ry9A:25.9 | 5toaA-3ry9A:29.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uar | GLUTATHIONES-TRANSFERASE (Methylococcuscapsulatus) |
PF00043(GST_C)PF02798(GST_N) | 6 | LEU A 70LEU A 73ALA A 74LEU A 82ILE A 101LEU A 94 | None | 1.33A | 5toaA-3uarA:undetectable | 5toaA-3uarA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wh7 | BETA-GLUCOSIDASE (metagenomes) |
PF00232(Glyco_hydro_1) | 5 | LEU A 252LEU A 255ALA A 256ILE A 335LEU A 348 | NoneNoneNoneNHE A 502 (-4.4A)None | 0.91A | 5toaA-3wh7A:undetectable | 5toaA-3wh7A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 5 | ALA B 347LEU B 343LEU B 341ILE B 151LEU B 134 | None | 1.05A | 5toaA-4cakB:undetectable | 5toaA-4cakB:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ejs | ELONGATOR COMPLEXPROTEIN 6 (Saccharomycescerevisiae) |
no annotation | 5 | ALA C 131LEU C 126ILE C 148LEU C 154LEU C 106 | None | 0.97A | 5toaA-4ejsC:undetectable | 5toaA-4ejsC:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ga6 | PUTATIVE THYMIDINEPHOSPHORYLASE (Thermococcuskodakarensis) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | LEU A 338ALA A 340LEU A 177ILE A 394LEU A 231 | None | 0.99A | 5toaA-4ga6A:undetectable | 5toaA-4ga6A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ged | ASCORBATE PEROXIDASE (Leishmaniamajor) |
PF00141(peroxidase) | 5 | LEU A 62LEU A 65ALA A 66LEU A 123ILE A 52 | None | 0.94A | 5toaA-4gedA:undetectable | 5toaA-4gedA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvl | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | ALA A 266LEU A 338ILE A 306LEU A 303LEU A 328 | None | 1.00A | 5toaA-4gvlA:undetectable | 5toaA-4gvlA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 12 (Thermusthermophilus) |
PF00361(Proton_antipo_M)PF00662(Proton_antipo_N) | 5 | LEU L 116LEU L 67LEU L 69LEU L 47LEU L 8 | None | 0.96A | 5toaA-4heaL:undetectable | 5toaA-4heaL:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxc | FEFE-HYDROGENASEMATURASE (Thermotogamaritima) |
PF04055(Radical_SAM)PF06968(BATS) | 5 | LEU A 35LEU A 38ALA A 39LEU A 214LEU A 250 | None | 0.86A | 5toaA-4jxcA:undetectable | 5toaA-4jxcA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4liy | FIBER PROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 5 | LEU A 173MET A 286LEU A 210ILE A 159LEU A 214 | None | 1.04A | 5toaA-4liyA:undetectable | 5toaA-4liyA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4me7 | MRNA INTERFERASEENDOA (Bacillussubtilis) |
PF02452(PemK_toxin) | 5 | LEU A 106ALA A 105MET A 98ILE A 46LEU A 94 | None | 1.04A | 5toaA-4me7A:undetectable | 5toaA-4me7A:17.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 7 | LEU A 283LEU A 286ALA A 287GLU A 290MET A 321LEU A 324ARG A 331 | None | 0.42A | 5toaA-4n1yA:28.6 | 5toaA-4n1yA:38.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ol0 | TRANSPORTIN-3 (Homo sapiens) |
PF08389(Xpo1) | 5 | LEU B 612LEU B 615ALA B 616LEU B 666ILE B 658 | None | 0.99A | 5toaA-4ol0B:undetectable | 5toaA-4ol0B:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6w | GLUCOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 563LEU A 566MET A 601LEU A 608ARG A 611 | MOF A 801 (-3.9A)MOF A 801 ( 4.6A)MOF A 801 (-3.7A)MOF A 801 ( 4.6A)MOF A 801 (-4.2A) | 0.71A | 5toaA-4p6wA:25.6 | 5toaA-4p6wA:29.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptf | DNA POLYMERASEEPSILON CATALYTICSUBUNIT A (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | ALA A 524LEU A 531ARG A 252LEU A 188LEU A 175 | None | 1.04A | 5toaA-4ptfA:undetectable | 5toaA-4ptfA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgy | ESTERASE (unculturedbacterium FLS12) |
PF00756(Esterase) | 6 | LEU A 148LEU A 124LEU A 48LEU A 47LEU A 45LEU A 132 | None | 1.46A | 5toaA-4rgyA:undetectable | 5toaA-4rgyA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 769LEU A 772ALA A 773MET A 807LEU A 810LEU A 814ARG A 817 | CV7 A1987 (-4.1A)CV7 A1987 ( 4.5A)CV7 A1987 (-3.5A)CV7 A1987 ( 3.9A)CV7 A1987 (-4.0A)CV7 A1987 ( 4.0A)CV7 A1987 (-3.7A) | 0.42A | 5toaA-4udbA:25.9 | 5toaA-4udbA:27.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uvk | ZYRO0D15994P (Zygosaccharomycesrouxii) |
PF08514(STAG) | 5 | LEU A 773LEU A 776ALA A 777LEU A 825LEU A 826 | None | 1.05A | 5toaA-4uvkA:undetectable | 5toaA-4uvkA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxm | TRANSCRIPTIONALREGULATOR FLEQ (Pseudomonasaeruginosa) |
PF06490(FleQ) | 6 | LEU A 118ALA A 121LEU A 102ILE A 10LEU A 84LEU A 80 | None | 1.43A | 5toaA-4wxmA:undetectable | 5toaA-4wxmA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z26 | PUTATIVE GMC-TYPEOXIDOREDUCTASE R135 (Acanthamoebapolyphagamimivirus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | LEU A 21LEU A 20ILE A 9LEU A 633LEU A 255 | None | 0.92A | 5toaA-4z26A:undetectable | 5toaA-4z26A:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3k | SEPIAPTERINREDUCTASE (Homo sapiens) |
PF00106(adh_short) | 5 | LEU A 238LEU A 23LEU A 24ILE A 152LEU A 9 | NoneNoneNoneNAP A 801 (-4.5A)None | 0.86A | 5toaA-4z3kA:undetectable | 5toaA-4z3kA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpx | ATP-DEPENDENTPROTEASE LON (Thermococcusonnurineus) |
PF01078(Mg_chelatase)PF13654(AAA_32) | 5 | LEU A 292LEU A 242MET A 80ILE A 312LEU A 65 | None | 1.03A | 5toaA-4zpxA:undetectable | 5toaA-4zpxA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5avo | HOMOSERINEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 5 | ALA A 289LEU A 18ILE A 68LEU A 27LEU A 5 | None | 1.01A | 5toaA-5avoA:undetectable | 5toaA-5avoA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c0u | ALKYLMERCURY LYASE (Escherichiacoli) |
PF03243(MerB)PF12324(HTH_15) | 5 | LEU A 28LEU A 31ALA A 32LEU A 92ILE A 102 | None | 1.05A | 5toaA-5c0uA:undetectable | 5toaA-5c0uA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwe | CYTOCHROME P450HYDROXYLASE (Streptomycesavermitilis) |
PF00067(p450) | 5 | ALA A 311LEU A 335ILE A 294LEU A 57LEU A 46 | None | 1.02A | 5toaA-5cweA:undetectable | 5toaA-5cweA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dpd | PROTEIN LYSINEMETHYLTRANSFERASE 1 (Rickettsiaprowazekii) |
PF10119(MethyTransf_Reg)PF13847(Methyltransf_31) | 5 | LEU A 56LEU A 59ALA A 60LEU A 277ILE A 144 | None | 1.04A | 5toaA-5dpdA:undetectable | 5toaA-5dpdA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esy | SAL1 PHOSPHATASE (Arabidopsisthaliana) |
PF00459(Inositol_P) | 5 | LEU A 152ALA A 151LEU A 165LEU A 191LEU A 205 | None | 1.05A | 5toaA-5esyA:undetectable | 5toaA-5esyA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ggy | IRON(III) ABCTRANSPORTER,PERIPLASMICIRON-COMPOUND-BINDING PROTEIN (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 5 | LEU A 226LEU A 184LEU A 313LEU A 258LEU A 196 | None | 0.97A | 5toaA-5ggyA:undetectable | 5toaA-5ggyA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqr | LEUCINE-RICH REPEATRECEPTOR-LIKEPROTEIN KINASE TDR (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | LEU B 42LEU B 39LEU B 107ILE B 97LEU B 128 | None | 0.91A | 5toaA-5gqrB:undetectable | 5toaA-5gqrB:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hw3 | BETA-LACTAMASE (Burkholderiavietnamiensis) |
PF13354(Beta-lactamase2) | 6 | LEU A 76ALA A 77MET A 210LEU A 128ILE A 185LEU A 192 | None | 1.50A | 5toaA-5hw3A:undetectable | 5toaA-5hw3A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jij | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00982(Glyco_transf_20) | 6 | LEU A 303LEU A 304ALA A 301LEU A 281LEU A 379LEU A 428 | NoneNoneEDO A 505 ( 3.7A)NoneNoneEDO A 504 (-4.5A) | 1.39A | 5toaA-5jijA:undetectable | 5toaA-5jijA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjq | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Streptomycessp. ML694-90F3) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | LEU A 120LEU A 73LEU A 93ILE A 146LEU A 65 | None | 0.92A | 5toaA-5jjqA:undetectable | 5toaA-5jjqA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lfn | CHONDROADHERIN (Homo sapiens) |
PF00560(LRR_1)PF01462(LRRNT)PF13855(LRR_8) | 5 | LEU A 275LEU A 297ALA A 296LEU A 292LEU A 270 | None | 0.97A | 5toaA-5lfnA:undetectable | 5toaA-5lfnA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlv | - (-) |
no annotation | 5 | LEU G 219ALA G 223LEU G 177MET G 176ILE G 428 | None | 0.95A | 5toaA-5mlvG:undetectable | 5toaA-5mlvG:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 6 | LEU A 769LEU A 772ALA A 773MET A 807LEU A 814ARG A 817 | ECV A1101 (-4.7A)ECV A1101 ( 3.9A)ECV A1101 (-3.8A)ECV A1101 (-3.6A)ECV A1101 (-4.1A)ECV A1101 (-4.0A) | 0.32A | 5toaA-5mwpA:25.6 | 5toaA-5mwpA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | ALA A4641LEU A4643LEU A4563LEU A4511LEU A4618 | None | 1.04A | 5toaA-5nugA:undetectable | 5toaA-5nugA:4.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9g | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | LEU A 818LEU A 817ALA A 816ILE A 784LEU A 843 | None | 1.03A | 5toaA-5t9gA:undetectable | 5toaA-5t9gA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tz8 | GLYCOSYL TRANSFERASE (Staphylococcusaureus) |
PF00535(Glycos_transf_2) | 5 | LEU A 20LEU A 23ALA A 24LEU A 59ILE A 49 | None | 0.97A | 5toaA-5tz8A:undetectable | 5toaA-5tz8A:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2p | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Treponemapallidum) |
PF01547(SBP_bac_1) | 5 | LEU A 317LEU A 139ALA A 138LEU A 101ILE A 46 | None | 1.00A | 5toaA-5u2pA:undetectable | 5toaA-5u2pA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uc1 | GLUCOCORTICOIDRECEPTOR (Heterocephalusglaber) |
no annotation | 5 | LEU A 559LEU A 562MET A 597LEU A 604ARG A 607 | 486 A 801 (-4.7A)486 A 801 ( 4.8A)CPS A 803 ( 3.9A)486 A 801 ( 3.8A)486 A 801 (-3.5A) | 0.80A | 5toaA-5uc1A:22.9 | 5toaA-5uc1A:16.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ufs | ANCESTRALGLUCOCORTICOIDRECEPTOR2 (unidentified) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35MET A 70LEU A 77ARG A 80 | 1TA A 301 (-3.5A)1TA A 301 ( 3.6A)1TA A 301 ( 3.1A)1TA A 301 ( 3.4A)1TA A 301 (-3.5A) | 0.47A | 5toaA-5ufsA:26.4 | 5toaA-5ufsA:30.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5van | BETA-KLOTHO (Homo sapiens) |
no annotation | 5 | LEU A 716LEU A 715ALA A 718LEU A 740LEU A 813 | None | 1.05A | 5toaA-5vanA:undetectable | 5toaA-5vanA:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1y | MERCURIC REDUCTASE (Lysinibacillussphaericus) |
no annotation | 5 | LEU B 264LEU B 134LEU B 133ILE B 248LEU B 163 | FAD B 601 ( 4.9A)NoneNoneNoneNone | 0.95A | 5toaA-5x1yB:undetectable | 5toaA-5x1yB:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yv5 | ATPASE RIL (Pyrococcusfuriosus) |
no annotation | 5 | ALA A 495LEU A 468LEU A 469ILE A 444LEU A 420 | None | 1.05A | 5toaA-5yv5A:undetectable | 5toaA-5yv5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cn7 | AEROBACTIN SYNTHASEIUCC (Klebsiellapneumoniae) |
no annotation | 5 | ALA A 140LEU A 13ILE A 39LEU A 65LEU A 81 | None | 1.02A | 5toaA-6cn7A:undetectable | 5toaA-6cn7A:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6et0 | PQSB (Pseudomonasaeruginosa) |
no annotation | 5 | ALA B 278LEU B 2MET B 1LEU B 275LEU B 107 | None | 0.97A | 5toaA-6et0B:undetectable | 5toaA-6et0B:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eti | ATP-BINDING CASSETTESUB-FAMILY G MEMBER2 (Homo sapiens) |
no annotation | 5 | LEU A 225LEU A 226ALA A 223ILE A 242LEU A 216 | None | 0.98A | 5toaA-6etiA:undetectable | 5toaA-6etiA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ez8 | HUNTINGTIN (Homo sapiens) |
no annotation | 6 | LEU A1776LEU A1747LEU A1748ILE A1835LEU A1814LEU A1740 | None | 1.47A | 5toaA-6ez8A:undetectable | 5toaA-6ez8A:7.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fg8 | PROBABLE INACTIVERECEPTOR KINASEAT1G27190 (Arabidopsisthaliana) |
no annotation | 5 | LEU B 34LEU B 31LEU B 98ILE B 88LEU B 120 | None | 1.03A | 5toaA-6fg8B:undetectable | 5toaA-6fg8B:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g3w | PROBABLE INACTIVERECEPTOR KINASEAT1G27190 (Arabidopsisthaliana) |
no annotation | 5 | LEU B 34LEU B 31LEU B 98ILE B 88LEU B 120 | None | 1.03A | 5toaA-6g3wB:undetectable | 5toaA-6g3wB:16.46 |