SIMILAR PATTERNS OF AMINO ACIDS FOR 5TL8_A_X2NA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnk PROTEIN
(3-METHYLADENINE DNA
GLYCOSYLASE)

(Homo sapiens) 		PF02245
(Pur_DNA_glyco) 		4 PRO A 283
PRO A 186
LEU A 187
LEU A 214
 None
 1.19A 5tl8A-1bnkA:
0.0		 5tl8A-1bnkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		4 PRO A 271
LEU A 280
PHE A 165
LEU A 172
 None
 0.98A 5tl8A-1cn3A:
0.0		 5tl8A-1cn3A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1h PRECORRIN-8X
METHYLMUTASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF02570
(CbiC) 		4 PRO A 156
LEU A 160
PHE A 185
LEU A 142
 None
 0.96A 5tl8A-1i1hA:
0.3		 5tl8A-1i1hA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 TYR A 143
PRO A 147
LEU A 151
PHE A 150
 None
 1.03A 5tl8A-1jmyA:
0.0		 5tl8A-1jmyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 PRO A 261
PRO A 257
LEU A 256
LEU A  27
 None
 1.13A 5tl8A-1nytA:
0.0		 5tl8A-1nytA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		4 PRO A 151
LEU A 154
PHE A 153
LEU A 204
 None
 1.18A 5tl8A-1p33A:
0.0		 5tl8A-1p33A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		4 PRO A 172
LEU A 178
PHE A 180
LEU A  59
 None
 1.16A 5tl8A-1qmyA:
undetectable		 5tl8A-1qmyA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PRO A 270
TYR A 416
PHE A 401
LEU A 567
 None
 1.13A 5tl8A-1qonA:
0.0		 5tl8A-1qonA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		4 TYR A 165
LEU A 391
PHE A 145
LEU A 149
 None
 1.15A 5tl8A-1rq1A:
0.0		 5tl8A-1rq1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 TYR A  93
PRO A  58
LEU A  57
LEU A  96
 None
 1.18A 5tl8A-1s9cA:
undetectable		 5tl8A-1s9cA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		4 PRO A 181
LEU A 356
PHE A 172
LEU A 168
 None
OMN  A 601 ( 4.7A)
TON  A 603 (-3.9A)
TON  A 603 (-4.5A)
 1.21A 5tl8A-1sezA:
undetectable		 5tl8A-1sezA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		4 TYR C  61
PRO C 168
LEU C 167
PHE C 170
 None
 1.17A 5tl8A-1sr4C:
undetectable		 5tl8A-1sr4C:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00270
(DEAD) 		4 PRO A 246
LEU A 195
PHE A 227
LEU A 231
 None
 1.18A 5tl8A-1t6nA:
undetectable		 5tl8A-1t6nA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 TYR A 164
PRO A 168
LEU A 172
PHE A 171
 None
 1.12A 5tl8A-1thgA:
undetectable		 5tl8A-1thgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 PRO A 246
LEU A 327
PHE A 317
LEU A 335
 None
 1.10A 5tl8A-1v43A:
undetectable		 5tl8A-1v43A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 PRO A 237
LEU A 240
PHE A 238
LEU A 190
 None
 1.17A 5tl8A-1vcwA:
undetectable		 5tl8A-1vcwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg7 DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF00169
(PH) 		4 PRO A  69
LEU A  57
PHE A  74
LEU A  50
 None
 1.22A 5tl8A-1wg7A:
undetectable		 5tl8A-1wg7A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 292
PRO A 131
LEU A 110
LEU A 299
 None
 1.18A 5tl8A-1zr6A:
undetectable		 5tl8A-1zr6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 TYR A  54
LEU A 415
PHE A  47
LEU A 418
 None
 1.19A 5tl8A-2d1gA:
undetectable		 5tl8A-2d1gA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 TYR X 444
PRO X 597
LEU X 596
PHE X 598
 None
 1.12A 5tl8A-2epkX:
1.2		 5tl8A-2epkX:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		4 TYR A   5
PRO A 187
LEU A 186
LEU A 191
 None
 1.09A 5tl8A-2ezvA:
undetectable		 5tl8A-2ezvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2f CYTOLETHAL
DISTENDING TOXIN C

(Aggregatibacter
actinomycetemcomitans) 		PF03498
(CDtoxinA) 		4 TYR C  61
PRO C 168
LEU C 167
PHE C 170
 None
 1.12A 5tl8A-2f2fC:
undetectable		 5tl8A-2f2fC:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		4 PRO B 158
LEU B 157
PHE B 159
LEU B 196
 None
 1.09A 5tl8A-2f9iB:
undetectable		 5tl8A-2f9iB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A 198
PRO A 378
LEU A 377
LEU A 428
 None
 1.18A 5tl8A-2np0A:
undetectable		 5tl8A-2np0A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 PRO A 151
LEU A 154
PHE A 153
LEU A 204
 None
 1.16A 5tl8A-2qhxA:
undetectable		 5tl8A-2qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		4 PRO A 162
LEU A 189
PHE A 164
LEU A 125
 None
 1.15A 5tl8A-2rliA:
undetectable		 5tl8A-2rliA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 247
PRO A  87
PHE A  90
LEU A  86
 None
 1.07A 5tl8A-2v7bA:
undetectable		 5tl8A-2v7bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 PRO A  20
TYR A  44
PRO A  40
LEU A  39
 None
 0.93A 5tl8A-2vg2A:
undetectable		 5tl8A-2vg2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 PRO A  55
TYR A 235
LEU A 104
LEU A 121
 None
 1.23A 5tl8A-2wxuA:
undetectable		 5tl8A-2wxuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zah COAT PROTEIN

(Melon necrotic
spot virus) 		PF00729
(Viral_coat) 		4 PRO A 307
TYR A 252
LEU A 248
LEU A 134
 None
 1.16A 5tl8A-2zahA:
undetectable		 5tl8A-2zahA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PRO A 452
PRO A 333
LEU A 336
PHE A 334
 None
 1.02A 5tl8A-3a31A:
undetectable		 5tl8A-3a31A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 4 PRO B  13
TYR B 192
PRO B 219
LEU B 222
 None
 1.04A 5tl8A-3c6qB:
undetectable		 5tl8A-3c6qB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch8 FUSION PROTEIN
PDZ-FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3)
PF00595
(PDZ) 		4 PRO A  21
TYR A 134
PRO A 131
LEU A 130
 None
 1.02A 5tl8A-3ch8A:
undetectable		 5tl8A-3ch8A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 TYR A 179
LEU A 758
PHE A 195
LEU A 197
 None
 0.96A 5tl8A-3fqdA:
undetectable		 5tl8A-3fqdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		4 PRO A  58
PRO A 224
LEU A 223
PHE A 225
 None
None
None
ACT  A   7 (-4.4A)
 0.94A 5tl8A-3hbzA:
undetectable		 5tl8A-3hbzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 TYR A1190
LEU A1492
PHE A1493
LEU A1482
 None
 1.17A 5tl8A-3jroA:
undetectable		 5tl8A-3jroA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 PRO A 159
LEU A 207
PHE A 160
LEU A 183
 None
 1.18A 5tl8A-3lm8A:
undetectable		 5tl8A-3lm8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 PRO A   4
PRO A  88
LEU A  87
LEU A 112
 None
 0.95A 5tl8A-3memA:
undetectable		 5tl8A-3memA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 PRO A 799
LEU A1007
PHE A1105
LEU A1053
 None
 1.11A 5tl8A-3n3kA:
undetectable		 5tl8A-3n3kA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		4 TYR B 353
LEU B  26
PHE B  27
LEU B  68
 None
 1.15A 5tl8A-3o0rB:
0.0		 5tl8A-3o0rB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 PRO B 836
LEU B 835
PHE B 152
LEU B 825
 None
 1.20A 5tl8A-3ohmB:
undetectable		 5tl8A-3ohmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		4 PRO A   6
LEU A   7
PHE A 234
LEU A   3
 None
 1.12A 5tl8A-3pnuA:
undetectable		 5tl8A-3pnuA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 PRO A1032
PRO A1037
LEU A1039
PHE A1041
 NX3  A2001 (-4.0A)
None
None
NX3  A2001 (-4.1A)
 1.22A 5tl8A-3qciA:
undetectable		 5tl8A-3qciA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfi TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF03816
(LytR_cpsA_psr) 		4 PRO A 289
LEU A 316
PHE A 318
LEU A 292
 None
 1.16A 5tl8A-3qfiA:
undetectable		 5tl8A-3qfiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PRO A 224
LEU A  64
PHE A  26
LEU A  30
 None
 1.20A 5tl8A-3swlA:
undetectable		 5tl8A-3swlA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpa HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 PRO A 425
LEU A 271
PHE A 317
LEU A 269
 None
 1.04A 5tl8A-3tpaA:
undetectable		 5tl8A-3tpaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 122
PRO A 651
LEU A 650
PHE A 653
 None
 1.08A 5tl8A-3v8xA:
undetectable		 5tl8A-3v8xA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vg8 HYPOTHETICAL PROTEIN
TTHB210

(Thermus
thermophilus) 		no annotation 4 PRO G  12
LEU G  34
PHE G  33
LEU G  18
 None
 1.21A 5tl8A-3vg8G:
undetectable		 5tl8A-3vg8G:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 TYR A 240
PRO A 548
LEU A 547
LEU A 301
 None
 1.08A 5tl8A-3wfaA:
undetectable		 5tl8A-3wfaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 PRO A 245
PRO A 165
PHE A 170
LEU A 195
 None
CL  A1430 (-3.8A)
None
None
 1.22A 5tl8A-3zjkA:
undetectable		 5tl8A-3zjkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 TYR A 199
PRO A 379
LEU A 378
LEU A 429
 None
 1.16A 5tl8A-3zuqA:
0.0		 5tl8A-3zuqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 4 PRO A 348
TYR A 515
PRO A 505
LEU A 506
 None
HEM  A 701 (-4.7A)
None
HEM  A 701 (-4.6A)
 1.18A 5tl8A-4b2nA:
undetectable		 5tl8A-4b2nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF09663
(Amido_AtzD_TrzD) 		4 TYR A 192
PRO A 125
LEU A 124
LEU A 166
 None
 1.17A 5tl8A-4bvtA:
undetectable		 5tl8A-4bvtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		4 TYR A 551
PRO A 139
LEU A 138
LEU A   6
 None
 1.15A 5tl8A-4ccaA:
undetectable		 5tl8A-4ccaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 PRO A 240
LEU A 300
PHE A 302
LEU A 294
 None
 1.20A 5tl8A-4eziA:
undetectable		 5tl8A-4eziA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PRO A 897
TYR A 951
PRO A 907
LEU A 906
 None
 0.72A 5tl8A-4fxdA:
undetectable		 5tl8A-4fxdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5
AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens) 		PF04106
(APG5)
no annotation 		4 PRO C  11
PRO B 250
LEU B 254
LEU B 212
 None
 1.07A 5tl8A-4gdlC:
undetectable		 5tl8A-4gdlC:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 PRO A 168
LEU A 171
PHE A 170
LEU A 160
 None
 1.14A 5tl8A-4jc8A:
0.6		 5tl8A-4jc8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		4 PRO D 309
LEU D 293
PHE D 297
LEU D 299
 None
 1.22A 5tl8A-4jghD:
undetectable		 5tl8A-4jghD:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		4 PRO A  98
LEU A  97
PHE A  99
LEU A 104
 None
 0.87A 5tl8A-4joqA:
undetectable		 5tl8A-4joqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING

(Bacteroides
vulgatus) 		PF12771
(SusD-like_2) 		4 PRO A 433
PRO A 423
LEU A 422
PHE A 425
 None
 1.06A 5tl8A-4lerA:
undetectable		 5tl8A-4lerA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE

(Amycolatopsis
mediterranei) 		PF14765
(PS-DH) 		4 PRO A 244
LEU A 243
PHE A 245
LEU A 290
 None
 1.16A 5tl8A-4ln9A:
undetectable		 5tl8A-4ln9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbz MAJOR CAPSID PROTEIN
VP1

(African green
monkey
polyomavirus) 		PF00718
(Polyoma_coat) 		4 PRO A 253
LEU A 262
PHE A 153
LEU A 160
 EDO  A 403 (-4.2A)
None
IPA  A 405 (-4.6A)
None
 1.01A 5tl8A-4mbzA:
undetectable		 5tl8A-4mbzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		4 PRO A 133
TYR A 331
PRO A 323
LEU A 321
 None
 1.21A 5tl8A-4n91A:
undetectable		 5tl8A-4n91A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 TYR A  55
LEU A 204
PHE A 202
LEU A  53
 None
None
None
PGE  A 503 ( 3.7A)
 1.18A 5tl8A-4ogzA:
undetectable		 5tl8A-4ogzA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pot VP1

(Human
polyomavirus 9) 		PF00718
(Polyoma_coat) 		4 PRO A 256
LEU A 265
PHE A 156
LEU A 163
 None
None
IPA  A 404 (-4.6A)
None
 1.03A 5tl8A-4potA:
undetectable		 5tl8A-4potA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 PRO B 836
LEU B 835
PHE B 152
LEU B 825
 None
 1.18A 5tl8A-4qj4B:
undetectable		 5tl8A-4qj4B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		4 TYR A 156
PRO A 144
LEU A 145
LEU A  53
 None
 1.08A 5tl8A-4r2vA:
undetectable		 5tl8A-4r2vA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 PRO A 208
LEU A 175
PHE A 209
LEU A 238
 None
 1.18A 5tl8A-4rkcA:
undetectable		 5tl8A-4rkcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuu CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00571
(CBS) 		4 PRO A 407
LEU A 540
PHE A 542
LEU A 499
 None
None
EDO  A1551 (-3.7A)
None
 1.11A 5tl8A-4uuuA:
undetectable		 5tl8A-4uuuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 PRO A 306
LEU A  29
PHE A 276
LEU A 278
 None
 1.03A 5tl8A-4v15A:
undetectable		 5tl8A-4v15A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PRO A 641
PRO A 587
PHE A 589
LEU A 584
 None
 0.98A 5tl8A-4z0cA:
undetectable		 5tl8A-4z0cA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 TYR A1601
PRO A1401
LEU A1404
PHE A1403
 None
 1.11A 5tl8A-5a31A:
0.3		 5tl8A-5a31A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 TYR D 443
PRO D 596
LEU D 595
PHE D 597
 None
 1.12A 5tl8A-5a6bD:
1.0		 5tl8A-5a6bD:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4

(Mus musculus) 		PF01852
(START) 		4 TYR A 188
LEU A 145
PHE A 172
LEU A 185
 None
 1.15A 5tl8A-5brlA:
undetectable		 5tl8A-5brlA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvi INTERFERON
REGULATORY FACTOR 4

(Mus musculus) 		PF10401
(IRF-3) 		4 PRO A 339
PRO A 407
LEU A 409
LEU A 252
 None
 1.17A 5tl8A-5bviA:
undetectable		 5tl8A-5bviA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 PRO A  98
LEU A  97
PHE A  99
LEU A 123
 None
 1.02A 5tl8A-5bz3A:
undetectable		 5tl8A-5bz3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2

(Homo sapiens) 		PF00616
(RasGAP) 		4 PRO E 987
TYR E1105
LEU E1068
LEU E 981
 None
 1.06A 5tl8A-5cjpE:
undetectable		 5tl8A-5cjpE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 PRO A 406
TYR A 233
LEU A 226
PHE A 221
 None
 1.15A 5tl8A-5g4iA:
undetectable		 5tl8A-5g4iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		4 PRO A 236
TYR A 221
LEU A 211
LEU A 261
 None
 1.16A 5tl8A-5givA:
undetectable		 5tl8A-5givA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 PRO A 529
PRO A 525
PHE A 526
LEU A 522
 None
 1.10A 5tl8A-5gz4A:
undetectable		 5tl8A-5gz4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		4 PRO A 385
PRO A 534
PHE A 535
LEU A 530
 None
 0.88A 5tl8A-5haxA:
undetectable		 5tl8A-5haxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 PRO A1969
LEU A2127
PHE A2125
LEU A2131
 None
 0.99A 5tl8A-5j6oA:
undetectable		 5tl8A-5j6oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PRO B 904
LEU B 930
PHE B 920
LEU B 922
 None
 1.19A 5tl8A-5kyuB:
undetectable		 5tl8A-5kyuB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		4 PRO A 181
PRO A 231
LEU A 232
LEU A 167
 None
 1.15A 5tl8A-5l2pA:
undetectable		 5tl8A-5l2pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N)
PF06444
(NADH_dehy_S2_C) 		4 PRO N 255
LEU M 117
PHE M 118
LEU M 164
 None
 1.09A 5tl8A-5lc5N:
undetectable		 5tl8A-5lc5N:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 TYR A1601
PRO A1401
LEU A1404
PHE A1403
 None
 1.08A 5tl8A-5lcwA:
0.2		 5tl8A-5lcwA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 PRO A  97
PRO A 110
LEU A 108
LEU A 346
 None
 1.17A 5tl8A-5mifA:
undetectable		 5tl8A-5mifA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 PRO B 360
PRO B 274
LEU B 291
LEU B 275
 None
 1.04A 5tl8A-5n5nB:
undetectable		 5tl8A-5n5nB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 PRO A  64
LEU A  65
PHE A  67
LEU A  91
 None
 0.89A 5tl8A-5od2A:
undetectable		 5tl8A-5od2A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 PRO A 382
TYR A 125
PRO A 117
LEU A 168
 None
 1.17A 5tl8A-5oglA:
undetectable		 5tl8A-5oglA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 PRO T 326
LEU T 328
PHE T 324
LEU T 367
 None
 1.22A 5tl8A-5ojsT:
undetectable		 5tl8A-5ojsT:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 4 PRO A  46
PRO A 109
LEU A 110
PHE A 112
 None
 0.75A 5tl8A-5oq3A:
undetectable		 5tl8A-5oq3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 TYR A 137
PRO A 141
LEU A 145
PHE A 144
 None
 1.06A 5tl8A-5thmA:
undetectable		 5tl8A-5thmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tup PROLIFERATING CELL
NUCLEAR ANTIGEN

(Aspergillus
fumigatus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 TYR A 239
LEU A  47
PHE A 248
LEU A 236
 None
 1.22A 5tl8A-5tupA:
undetectable		 5tl8A-5tupA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 TYR B  70
LEU B  88
PHE B  90
LEU B  14
 None
 1.09A 5tl8A-5wwpB:
undetectable		 5tl8A-5wwpB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus) 		no annotation 4 PRO D 257
PRO D 244
LEU D 243
PHE D 245
 None
 1.05A 5tl8A-5ybbD:
undetectable		 5tl8A-5ybbD:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 6 PRO A  57
TYR A 107
PRO A 213
LEU A 214
PHE A 216
LEU A 467
 None
TPF  A 506 (-4.2A)
None
None
None
EDO  A 503 (-4.2A)
 0.67A 5tl8A-6ay4A:
63.0		 5tl8A-6ay4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA
COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		no annotation 4 PRO B 126
PRO A 130
LEU A 137
PHE A 132
 None
 1.14A 5tl8A-6conB:
undetectable		 5tl8A-6conB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 PRO A 550
PRO A 546
PHE A 547
LEU A 543
 None
 0.96A 5tl8A-6f2tA:
undetectable		 5tl8A-6f2tA:
undetectable