SIMILAR PATTERNS OF AMINO ACIDS FOR 5TL8_A_X2NA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		5 ALA A  32
ALA A 185
ALA A 169
THR A 131
LEU A 104
 None
 1.17A 5tl8A-1bg6A:
undetectable		 5tl8A-1bg6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct8 LONG CHAIN
7C8 FAB FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA B  16
PHE B 146
TYR B 145
LEU B 108
THR B  83
 None
 1.10A 5tl8A-1ct8B:
undetectable		 5tl8A-1ct8B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emt IGG ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 149
TYR H 148
LEU H 111
THR H  87
 None
 1.15A 5tl8A-1emtH:
undetectable		 5tl8A-1emtH:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA C  16
PHE C 151
TYR C 150
LEU C 113
THR C  87
 None
 1.15A 5tl8A-1fskC:
undetectable		 5tl8A-1fskC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		5 PHE A 198
ALA A 199
ALA A   2
ALA A   6
THR A 179
 None
 1.20A 5tl8A-1fvfA:
0.0		 5tl8A-1fvfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 ALA A 317
ALA A 550
THR A 584
LEU A 581
MET A 561
 None
 1.23A 5tl8A-1h39A:
undetectable		 5tl8A-1h39A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		5 ALA A  32
ALA A  82
ALA A  40
THR A  12
THR A  26
 None
 1.25A 5tl8A-1jxiA:
0.0		 5tl8A-1jxiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5d RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN

(Homo sapiens) 		PF00638
(Ran_BP1) 		5 PHE B 142
ALA B 148
ALA B  85
MET B  90
THR B 153
 PHE  B 142 ( 1.3A)
ALA  B 148 ( 0.0A)
ALA  B  85 ( 0.0A)
MET  B  90 ( 0.0A)
THR  B 153 ( 0.8A)
 1.25A 5tl8A-1k5dB:
undetectable		 5tl8A-1k5dB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk3 9D7 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 152
ALA H 174
LEU H 114
THR H  87
 None
 1.17A 5tl8A-1lk3H:
undetectable		 5tl8A-1lk3H:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mj8 IMMUNOGLOBULIN
MS6-126

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 148
TYR H 147
LEU H 108
THR H  83
 None
 1.11A 5tl8A-1mj8H:
undetectable		 5tl8A-1mj8H:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 232
ALA A 174
PHE A 349
PHE A 363
ALA A 308
 None
 1.19A 5tl8A-1navA:
undetectable		 5tl8A-1navA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		6 ALA A  47
PHE A 114
ALA A 113
ALA A 294
THR A 298
LEU A 359
 None
DIF  A 501 (-4.5A)
DIF  A 501 (-3.6A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 1.38A 5tl8A-1nr6A:
34.9		 5tl8A-1nr6A:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q87 39 KDA INITIATOR
BINDING PROTEIN

(Trichomonas
vaginalis) 		PF11422
(IBP39) 		5 PHE A 276
ALA A 212
ALA A 209
LEU A 245
THR A 236
 None
 1.16A 5tl8A-1q87A:
undetectable		 5tl8A-1q87A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qju PROTEIN VP1

(Rhinovirus A) 		PF00073
(Rhv) 		5 PHE 1 118
ALA 1 116
THR 1 208
MET 1 103
THR 1 216
 None
 1.27A 5tl8A-1qju1:
undetectable		 5tl8A-1qju1:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr5 PHOSPHOCARRIER
PROTEIN HPR

(Staphylococcus
carnosus) 		PF00381
(PTS-HPr) 		5 ALA A  71
ALA A  65
LEU A  44
MET A  21
THR A   7
 None
 1.22A 5tl8A-1qr5A:
undetectable		 5tl8A-1qr5A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 PHE A 237
PHE A 158
ALA A 176
ALA A 180
THR A 184
 None
VIV  A 301 (-3.9A)
None
None
None
 1.24A 5tl8A-1r5lA:
undetectable		 5tl8A-1r5lA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		5 PHE A 266
ALA A 190
LEU A 182
MET A 209
THR A  76
 None
 1.16A 5tl8A-1svvA:
undetectable		 5tl8A-1svvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ALA C 148
ALA C 240
ALA C 244
THR C 248
LEU C 213
 None
 1.12A 5tl8A-1t3qC:
undetectable		 5tl8A-1t3qC:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  44
PHE A 306
ALA A 218
THR A  36
LEU A 154
 None
 1.26A 5tl8A-1ub7A:
undetectable		 5tl8A-1ub7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ALA A 290
PHE A  16
ALA A  14
THR A 304
LEU A 338
 None
 1.03A 5tl8A-1w07A:
undetectable		 5tl8A-1w07A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		5 ALA A 110
PHE A  50
ALA A  49
ALA A  92
THR A 294
 None
MET  A1298 (-3.8A)
None
None
None
 1.25A 5tl8A-1wkmA:
undetectable		 5tl8A-1wkmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ALA A 244
THR A  28
LEU A 285
MET A 283
THR A 275
 None
 1.18A 5tl8A-1x0lA:
undetectable		 5tl8A-1x0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 641
ALA A 481
ALA A 479
THR A 448
LEU A 527
 None
 1.25A 5tl8A-2bklA:
undetectable		 5tl8A-2bklA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9e PERIDININ-CHLOROPHYL
L A PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		5 PHE A 109
ALA A 110
PHE A  21
ALA A  30
THR A 114
 PID  A1330 ( 3.5A)
PID  A1331 ( 3.8A)
PID  A1329 (-4.1A)
PID  A1329 (-3.9A)
None
 1.23A 5tl8A-2c9eA:
undetectable		 5tl8A-2c9eA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 TYR A 308
ALA A 316
ALA A 320
LEU A 185
MET A 286
 None
 1.23A 5tl8A-2cb1A:
undetectable		 5tl8A-2cb1A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF01965
(DJ-1_PfpI) 		5 ALA A  58
PHE A 161
ALA A 153
ALA A 104
THR A  36
 None
 1.26A 5tl8A-2fexA:
undetectable		 5tl8A-2fexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE

(Pseudomonas
putida) 		PF04909
(Amidohydro_2) 		5 PHE A 277
PHE A 182
ALA A 221
LEU A 231
MET A 232
 None
 1.25A 5tl8A-2ffiA:
undetectable		 5tl8A-2ffiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ALA A 290
PHE A  16
ALA A  14
THR A 304
LEU A 338
 None
 1.04A 5tl8A-2fonA:
undetectable		 5tl8A-2fonA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqa MINOR AMPULLATE
FIBROIN 1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 ALA A  47
PHE A  20
ALA A 116
ALA A 119
THR A  52
 None
 1.23A 5tl8A-2mqaA:
undetectable		 5tl8A-2mqaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 147
TYR H 146
LEU H 109
THR H  87
 None
 1.20A 5tl8A-2oz4H:
undetectable		 5tl8A-2oz4H:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 5 ALA A 302
PHE A  30
ALA A  91
ALA A  86
THR A 200
 None
NO3  A 501 (-4.7A)
None
None
None
 1.21A 5tl8A-2q9uA:
undetectable		 5tl8A-2q9uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 PHE A 276
ALA A 277
ALA A 426
ALA A  10
THR A 286
 None
 1.23A 5tl8A-2qfqA:
undetectable		 5tl8A-2qfqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 PHE A 199
ALA A 117
LEU A 298
MET A 300
MET A 304
 None
 1.04A 5tl8A-2qytA:
undetectable		 5tl8A-2qytA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A  81
ALA A 395
ALA A 365
THR A 367
LEU A 341
 None
 1.26A 5tl8A-2vosA:
undetectable		 5tl8A-2vosA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr3 CLUMPING FACTOR A

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 ALA A 528
TYR A 261
ALA A 361
ALA A 353
LEU A 283
 None
 1.23A 5tl8A-2vr3A:
undetectable		 5tl8A-2vr3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ALA A 299
PHE A 438
ALA A 595
ALA A 591
THR A 587
 None
 1.11A 5tl8A-2vxoA:
undetectable		 5tl8A-2vxoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqu 3H6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA D  16
PHE D 157
TYR D 156
LEU D 117
THR D  87
 None
 1.16A 5tl8A-3bquD:
undetectable		 5tl8A-3bquD:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		5 ALA A  10
PHE A 281
ALA A 239
ALA A 243
MET A 352
 None
 1.24A 5tl8A-3c3jA:
2.3		 5tl8A-3c3jA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d85 FAB OF ANTIBODY
7G10, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA B  16
PHE B 148
TYR B 147
LEU B 110
THR B  87
 None
 1.09A 5tl8A-3d85B:
undetectable		 5tl8A-3d85B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 ALA A 290
PHE A 251
ALA A 315
LEU A 110
THR A 104
 None
 1.25A 5tl8A-3if2A:
undetectable		 5tl8A-3if2A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		5 ALA A 287
ALA A 291
THR A 295
MET A 358
MET A 360
 VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 1.18A 5tl8A-3kswA:
38.1		 5tl8A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		5 PHE A  48
ALA A 291
LEU A 356
MET A 358
MET A 360
 None
VNF  A 490 ( 4.0A)
None
None
None
 1.11A 5tl8A-3kswA:
38.1		 5tl8A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		5 PHE A  48
ALA A 291
THR A 295
MET A 358
MET A 360
 None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 1.08A 5tl8A-3kswA:
38.1		 5tl8A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		7 PHE A  48
ALA A 286
ALA A 290
THR A 294
LEU A 355
MET A 357
MET A 359
 None
TPF  A 490 (-3.4A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
None
None
 1.09A 5tl8A-3l4dA:
46.7		 5tl8A-3l4dA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		9 PHE A 104
PHE A 109
TYR A 115
ALA A 286
ALA A 290
THR A 294
LEU A 355
MET A 357
MET A 359
 None
TPF  A 490 (-4.5A)
HEM  A 481 ( 4.9A)
TPF  A 490 (-3.4A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
None
None
 1.03A 5tl8A-3l4dA:
46.7		 5tl8A-3l4dA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Yersinia pestis) 		PF04166
(PdxA) 		5 PHE A 114
ALA A  46
ALA A  48
LEU A  74
THR A 119
 None
 1.25A 5tl8A-3lxyA:
undetectable		 5tl8A-3lxyA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PHE C1013
PHE C1009
ALA C1079
THR C 803
LEU C 648
 None
None
RMO  C1317 ( 3.6A)
None
None
 1.13A 5tl8A-3sr6C:
undetectable		 5tl8A-3sr6C:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt1 MOUSE MONOCLONAL
1GG2A FAB FRAGMENT,
KAPPA LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 154
TYR H 153
THR H  41
THR H  87
 None
 1.19A 5tl8A-3tt1H:
undetectable		 5tl8A-3tt1H:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt3 MOUSE MONOCLONAL
1GG1 FAB FRAGMENT,
KAPPA LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 152
TYR H 151
LEU H 114
THR H  87
 None
 1.16A 5tl8A-3tt3H:
undetectable		 5tl8A-3tt3H:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujt AB-52 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 146
TYR H 145
LEU H 108
THR H  83
 None
 1.17A 5tl8A-3ujtH:
undetectable		 5tl8A-3ujtH:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		5 ALA A 101
ALA A 161
ALA A 159
LEU A  24
THR A  96
 None
 0.92A 5tl8A-3zgqA:
0.5		 5tl8A-3zgqA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		5 ALA A 372
PHE A  10
ALA A 255
ALA A 259
THR A 263
 None
 1.03A 5tl8A-3zytA:
undetectable		 5tl8A-3zytA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		5 ALA A 218
ALA A 174
ALA A 172
THR A 133
THR A 140
 None
None
None
None
MLI  A1466 ( 4.9A)
 1.22A 5tl8A-4cp8A:
undetectable		 5tl8A-4cp8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 PHE A 255
ALA A 251
ALA A 277
ALA A 281
MET A 216
 None
 1.07A 5tl8A-4dnxA:
undetectable		 5tl8A-4dnxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		5 PHE A 320
ALA A 294
THR A 133
MET A 331
THR A 119
 None
 1.08A 5tl8A-4e7wA:
undetectable		 5tl8A-4e7wA:
24.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		9 PHE A  48
PHE A 110
TYR A 116
ALA A 287
ALA A 291
THR A 295
LEU A 356
MET A 358
MET A 360
 VNT  A 502 (-4.2A)
VNT  A 502 (-4.4A)
HEM  A 501 ( 4.5A)
VNT  A 502 ( 3.9A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
VNT  A 502 (-4.9A)
VNT  A 502 (-4.5A)
 1.26A 5tl8A-4g3jA:
29.2		 5tl8A-4g3jA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		8 PHE A 105
PHE A 110
TYR A 116
ALA A 287
ALA A 291
THR A 295
LEU A 356
MET A 360
 VNT  A 502 (-4.8A)
VNT  A 502 (-4.4A)
HEM  A 501 ( 4.5A)
VNT  A 502 ( 3.9A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
VNT  A 502 (-4.5A)
 0.90A 5tl8A-4g3jA:
29.2		 5tl8A-4g3jA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		6 PHE A 110
TYR A 103
ALA A 287
ALA A 291
THR A 295
LEU A 356
 VNT  A 502 (-4.4A)
VNT  A 502 ( 4.8A)
VNT  A 502 ( 3.9A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
 1.05A 5tl8A-4g3jA:
29.2		 5tl8A-4g3jA:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		5 PHE A 240
ALA A 241
ALA A  82
THR A 106
THR A  64
 None
 1.13A 5tl8A-4gn2A:
undetectable		 5tl8A-4gn2A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		5 ALA A 102
ALA A 162
ALA A 160
LEU A  25
THR A  97
 None
 1.10A 5tl8A-4houA:
undetectable		 5tl8A-4houA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 PHE A  18
ALA A  19
ALA A 219
LEU A 117
THR A 104
 None
 0.80A 5tl8A-4iwmA:
undetectable		 5tl8A-4iwmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre IMMUNOGLOBULIN
GAMMA-2A, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE B  95
PHE B 151
TYR B 180
ALA B 119
THR B  88
 None
 1.24A 5tl8A-4jreB:
undetectable		 5tl8A-4jreB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		5 ALA A 261
ALA A 139
ALA A 136
LEU A 299
THR A 244
 None
 1.26A 5tl8A-4kjdA:
undetectable		 5tl8A-4kjdA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		5 PHE A 352
PHE A 269
ALA A 128
ALA A 143
LEU A 110
 None
 1.15A 5tl8A-4mnrA:
undetectable		 5tl8A-4mnrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ALA A 139
ALA A  74
THR A 169
LEU A 148
THR A 134
 None
 1.15A 5tl8A-4mrmA:
undetectable		 5tl8A-4mrmA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A 537
ALA A 233
ALA A 231
THR A 154
LEU A 149
 None
 1.21A 5tl8A-4mz0A:
undetectable		 5tl8A-4mz0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		5 ALA A 195
PHE A  66
ALA A  37
ALA A  40
LEU A  57
 None
 1.22A 5tl8A-4nnqA:
undetectable		 5tl8A-4nnqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oii HEAVY CHAIN OF FAB
FRAGMENT OF 22NS1
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  16
PHE H 148
TYR H 147
LEU H 108
THR H  83
 None
 1.10A 5tl8A-4oiiH:
undetectable		 5tl8A-4oiiH:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		5 ALA A 295
ALA A 150
ALA A 153
LEU A  80
MET A 166
 None
 1.12A 5tl8A-4okoA:
undetectable		 5tl8A-4okoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 ALA A 738
PHE A 544
ALA A 665
THR A 669
THR A 696
 None
None
None
None
2U4  A 901 (-3.7A)
 1.22A 5tl8A-4oonA:
undetectable		 5tl8A-4oonA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A  52
ALA A  75
ALA A 259
ALA A 216
THR A 371
 None
 1.16A 5tl8A-4oqjA:
undetectable		 5tl8A-4oqjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 PHE A  34
ALA A  35
ALA A 107
ALA A 104
LEU A 136
 None
 1.27A 5tl8A-4p47A:
undetectable		 5tl8A-4p47A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5p THIJ/PFPI FAMILY
PROTEIN

(Francisella
tularensis) 		PF01965
(DJ-1_PfpI) 		5 PHE A 215
ALA A 212
PHE A 108
LEU A   5
THR A  29
 None
 0.87A 5tl8A-4p5pA:
undetectable		 5tl8A-4p5pA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj 8G12 HEAVY CHAIN

(Mus musculus) 		no annotation 5 ALA H  14
PHE H 156
TYR H 155
LEU H 116
THR H  85
 None
 1.10A 5tl8A-4pljH:
undetectable		 5tl8A-4pljH:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhz CRY23AA1
CRY37AA1

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2)
no annotation 		5 TYR B 121
ALA B  29
THR A 247
LEU A 249
THR A  55
 None
 1.16A 5tl8A-4rhzB:
undetectable		 5tl8A-4rhzB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 ALA A  42
ALA A 189
ALA A 194
THR A 197
THR A 240
 None
 1.15A 5tl8A-4ryeA:
undetectable		 5tl8A-4ryeA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA A  16
PHE A 152
TYR A 151
LEU A 114
THR A  87
 None
 1.10A 5tl8A-4u6hA:
undetectable		 5tl8A-4u6hA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1g UNCHARACTERIZED
PROTEIN SAV1875

(Staphylococcus
aureus) 		PF01965
(DJ-1_PfpI) 		5 ALA A  39
ALA A  28
ALA A  24
LEU A  69
THR A  52
 None
 1.22A 5tl8A-4y1gA:
undetectable		 5tl8A-4y1gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ALA A 282
ALA A 162
THR A 218
LEU A 222
MET A 223
 None
None
None
GOL  A 301 (-4.5A)
None
 1.23A 5tl8A-4zrsA:
undetectable		 5tl8A-4zrsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA B  16
PHE B 151
TYR B 150
LEU B 113
THR B  87
 None
 1.11A 5tl8A-5cmaB:
undetectable		 5tl8A-5cmaB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		5 ALA A 146
ALA A 187
ALA A 183
THR A 153
THR A 148
 None
 1.18A 5tl8A-5dk6A:
undetectable		 5tl8A-5dk6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		5 PHE A 336
PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 1.10A 5tl8A-5f2oA:
undetectable		 5tl8A-5f2oA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF02465
(FliD_N)
PF07195
(FliD_C) 		5 PHE A 289
ALA A  53
THR A  55
LEU A 398
THR A 388
 None
 1.10A 5tl8A-5h5vA:
undetectable		 5tl8A-5h5vA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 PHE A 134
TYR A 140
THR A 318
LEU A 380
THR A 507
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.86A 5tl8A-5hs1A:
43.0		 5tl8A-5hs1A:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ALA A 276
ALA A 307
ALA A 305
THR A 266
LEU A 613
 None
 1.25A 5tl8A-5ic7A:
undetectable		 5tl8A-5ic7A:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 PHE A 135
TYR A 141
THR A 319
LEU A 381
THR A 510
 1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.8A)
 0.93A 5tl8A-5jlcA:
42.4		 5tl8A-5jlcA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 PHE A 126
ALA A 275
ALA A 121
THR A 118
LEU A 379
 None
 1.13A 5tl8A-5ldfA:
undetectable		 5tl8A-5ldfA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 PHE A 237
PHE A 158
ALA A 176
ALA A 180
THR A 184
 None
VIV  A 302 (-3.9A)
None
None
None
 1.25A 5tl8A-5mueA:
undetectable		 5tl8A-5mueA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 ALA A 119
ALA A  56
ALA A 177
LEU A 145
MET A 147
 None
 1.08A 5tl8A-5n0gA:
undetectable		 5tl8A-5n0gA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 5 PHE A 137
PHE A  72
ALA A  70
LEU A 202
THR A 134
 NAG  A 304 ( 4.3A)
None
None
None
None
 1.16A 5tl8A-5ndlA:
undetectable		 5tl8A-5ndlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 5 ALA A 183
ALA A 363
ALA A 365
MET A  91
THR A 334
 None
 0.84A 5tl8A-5nhbA:
undetectable		 5tl8A-5nhbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		5 PHE A 768
ALA A 765
TYR A1025
ALA A 920
THR A 952
 None
 1.22A 5tl8A-5tj6A:
undetectable		 5tl8A-5tj6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqa DH270.6 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 ALA H  16
PHE H 160
TYR H 159
LEU H 122
THR H  87
 None
 1.25A 5tl8A-5tqaH:
undetectable		 5tl8A-5tqaH:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybp PRHA

(Penicillium
brasilianum) 		no annotation 5 PHE A 244
PHE A 160
TYR A 206
ALA A 166
ALA A 216
 None
None
None
None
AKG  A 302 (-3.3A)
 1.09A 5tl8A-5ybpA:
undetectable		 5tl8A-5ybpA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybp PRHA

(Penicillium
brasilianum) 		no annotation 5 PHE A 244
PHE A 160
TYR A 206
ALA A 166
THR A  70
 None
 1.25A 5tl8A-5ybpA:
undetectable		 5tl8A-5ybpA:
9.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 12 PHE A  53
ALA A  54
PHE A 109
PHE A 114
TYR A 120
ALA A 289
ALA A 293
THR A 297
LEU A 358
MET A 360
MET A 362
THR A 465
 None
None
None
TPF  A 506 (-4.4A)
None
TPF  A 506 (-3.5A)
TPF  A 506 ( 3.2A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
None
None
None
 0.49A 5tl8A-6ay4A:
63.0		 5tl8A-6ay4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 5 ALA A 104
ALA A 164
ALA A 162
LEU A  27
THR A  99
 None
 1.06A 5tl8A-6c6kA:
undetectable		 5tl8A-6c6kA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 PHE A  75
ALA A  76
ALA A 263
ALA A 278
LEU A 291
 None
 1.21A 5tl8A-6c7sA:
undetectable		 5tl8A-6c7sA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyn -

(-) 		no annotation 5 ALA H  16
PHE H 152
TYR H 151
LEU H 114
THR H  87
 None
 1.11A 5tl8A-6eynH:
undetectable		 5tl8A-6eynH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 ALA A2317
PHE A2350
TYR A2364
ALA A2115
THR A2315
 None
 1.07A 5tl8A-6fb3A:
undetectable		 5tl8A-6fb3A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnk PROTEIN
(3-METHYLADENINE DNA
GLYCOSYLASE)

(Homo sapiens) 		PF02245
(Pur_DNA_glyco) 		4 PRO A 283
PRO A 186
LEU A 187
LEU A 214
 None
 1.19A 5tl8A-1bnkA:
0.0		 5tl8A-1bnkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		4 PRO A 271
LEU A 280
PHE A 165
LEU A 172
 None
 0.98A 5tl8A-1cn3A:
0.0		 5tl8A-1cn3A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1h PRECORRIN-8X
METHYLMUTASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF02570
(CbiC) 		4 PRO A 156
LEU A 160
PHE A 185
LEU A 142
 None
 0.96A 5tl8A-1i1hA:
0.3		 5tl8A-1i1hA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 TYR A 143
PRO A 147
LEU A 151
PHE A 150
 None
 1.03A 5tl8A-1jmyA:
0.0		 5tl8A-1jmyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 PRO A 261
PRO A 257
LEU A 256
LEU A  27
 None
 1.13A 5tl8A-1nytA:
0.0		 5tl8A-1nytA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		4 PRO A 151
LEU A 154
PHE A 153
LEU A 204
 None
 1.18A 5tl8A-1p33A:
0.0		 5tl8A-1p33A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		4 PRO A 172
LEU A 178
PHE A 180
LEU A  59
 None
 1.16A 5tl8A-1qmyA:
undetectable		 5tl8A-1qmyA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PRO A 270
TYR A 416
PHE A 401
LEU A 567
 None
 1.13A 5tl8A-1qonA:
0.0		 5tl8A-1qonA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		4 TYR A 165
LEU A 391
PHE A 145
LEU A 149
 None
 1.15A 5tl8A-1rq1A:
0.0		 5tl8A-1rq1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 TYR A  93
PRO A  58
LEU A  57
LEU A  96
 None
 1.18A 5tl8A-1s9cA:
undetectable		 5tl8A-1s9cA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		4 PRO A 181
LEU A 356
PHE A 172
LEU A 168
 None
OMN  A 601 ( 4.7A)
TON  A 603 (-3.9A)
TON  A 603 (-4.5A)
 1.21A 5tl8A-1sezA:
undetectable		 5tl8A-1sezA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		4 TYR C  61
PRO C 168
LEU C 167
PHE C 170
 None
 1.17A 5tl8A-1sr4C:
undetectable		 5tl8A-1sr4C:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00270
(DEAD) 		4 PRO A 246
LEU A 195
PHE A 227
LEU A 231
 None
 1.18A 5tl8A-1t6nA:
undetectable		 5tl8A-1t6nA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 TYR A 164
PRO A 168
LEU A 172
PHE A 171
 None
 1.12A 5tl8A-1thgA:
undetectable		 5tl8A-1thgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 PRO A 246
LEU A 327
PHE A 317
LEU A 335
 None
 1.10A 5tl8A-1v43A:
undetectable		 5tl8A-1v43A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 PRO A 237
LEU A 240
PHE A 238
LEU A 190
 None
 1.17A 5tl8A-1vcwA:
undetectable		 5tl8A-1vcwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg7 DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF00169
(PH) 		4 PRO A  69
LEU A  57
PHE A  74
LEU A  50
 None
 1.22A 5tl8A-1wg7A:
undetectable		 5tl8A-1wg7A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 292
PRO A 131
LEU A 110
LEU A 299
 None
 1.18A 5tl8A-1zr6A:
undetectable		 5tl8A-1zr6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 TYR A  54
LEU A 415
PHE A  47
LEU A 418
 None
 1.19A 5tl8A-2d1gA:
undetectable		 5tl8A-2d1gA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 TYR X 444
PRO X 597
LEU X 596
PHE X 598
 None
 1.12A 5tl8A-2epkX:
1.2		 5tl8A-2epkX:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		4 TYR A   5
PRO A 187
LEU A 186
LEU A 191
 None
 1.09A 5tl8A-2ezvA:
undetectable		 5tl8A-2ezvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2f CYTOLETHAL
DISTENDING TOXIN C

(Aggregatibacter
actinomycetemcomitans) 		PF03498
(CDtoxinA) 		4 TYR C  61
PRO C 168
LEU C 167
PHE C 170
 None
 1.12A 5tl8A-2f2fC:
undetectable		 5tl8A-2f2fC:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		4 PRO B 158
LEU B 157
PHE B 159
LEU B 196
 None
 1.09A 5tl8A-2f9iB:
undetectable		 5tl8A-2f9iB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A 198
PRO A 378
LEU A 377
LEU A 428
 None
 1.18A 5tl8A-2np0A:
undetectable		 5tl8A-2np0A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 PRO A 151
LEU A 154
PHE A 153
LEU A 204
 None
 1.16A 5tl8A-2qhxA:
undetectable		 5tl8A-2qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		4 PRO A 162
LEU A 189
PHE A 164
LEU A 125
 None
 1.15A 5tl8A-2rliA:
undetectable		 5tl8A-2rliA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 247
PRO A  87
PHE A  90
LEU A  86
 None
 1.07A 5tl8A-2v7bA:
undetectable		 5tl8A-2v7bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 PRO A  20
TYR A  44
PRO A  40
LEU A  39
 None
 0.93A 5tl8A-2vg2A:
undetectable		 5tl8A-2vg2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 PRO A  55
TYR A 235
LEU A 104
LEU A 121
 None
 1.23A 5tl8A-2wxuA:
undetectable		 5tl8A-2wxuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zah COAT PROTEIN

(Melon necrotic
spot virus) 		PF00729
(Viral_coat) 		4 PRO A 307
TYR A 252
LEU A 248
LEU A 134
 None
 1.16A 5tl8A-2zahA:
undetectable		 5tl8A-2zahA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PRO A 452
PRO A 333
LEU A 336
PHE A 334
 None
 1.02A 5tl8A-3a31A:
undetectable		 5tl8A-3a31A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 4 PRO B  13
TYR B 192
PRO B 219
LEU B 222
 None
 1.04A 5tl8A-3c6qB:
undetectable		 5tl8A-3c6qB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch8 FUSION PROTEIN
PDZ-FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3)
PF00595
(PDZ) 		4 PRO A  21
TYR A 134
PRO A 131
LEU A 130
 None
 1.02A 5tl8A-3ch8A:
undetectable		 5tl8A-3ch8A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 TYR A 179
LEU A 758
PHE A 195
LEU A 197
 None
 0.96A 5tl8A-3fqdA:
undetectable		 5tl8A-3fqdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		4 PRO A  58
PRO A 224
LEU A 223
PHE A 225
 None
None
None
ACT  A   7 (-4.4A)
 0.94A 5tl8A-3hbzA:
undetectable		 5tl8A-3hbzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 TYR A1190
LEU A1492
PHE A1493
LEU A1482
 None
 1.17A 5tl8A-3jroA:
undetectable		 5tl8A-3jroA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 PRO A 159
LEU A 207
PHE A 160
LEU A 183
 None
 1.18A 5tl8A-3lm8A:
undetectable		 5tl8A-3lm8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 PRO A   4
PRO A  88
LEU A  87
LEU A 112
 None
 0.95A 5tl8A-3memA:
undetectable		 5tl8A-3memA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 PRO A 799
LEU A1007
PHE A1105
LEU A1053
 None
 1.11A 5tl8A-3n3kA:
undetectable		 5tl8A-3n3kA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		4 TYR B 353
LEU B  26
PHE B  27
LEU B  68
 None
 1.15A 5tl8A-3o0rB:
0.0		 5tl8A-3o0rB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 PRO B 836
LEU B 835
PHE B 152
LEU B 825
 None
 1.20A 5tl8A-3ohmB:
undetectable		 5tl8A-3ohmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		4 PRO A   6
LEU A   7
PHE A 234
LEU A   3
 None
 1.12A 5tl8A-3pnuA:
undetectable		 5tl8A-3pnuA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 PRO A1032
PRO A1037
LEU A1039
PHE A1041
 NX3  A2001 (-4.0A)
None
None
NX3  A2001 (-4.1A)
 1.22A 5tl8A-3qciA:
undetectable		 5tl8A-3qciA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfi TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF03816
(LytR_cpsA_psr) 		4 PRO A 289
LEU A 316
PHE A 318
LEU A 292
 None
 1.16A 5tl8A-3qfiA:
undetectable		 5tl8A-3qfiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PRO A 224
LEU A  64
PHE A  26
LEU A  30
 None
 1.20A 5tl8A-3swlA:
undetectable		 5tl8A-3swlA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpa HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 PRO A 425
LEU A 271
PHE A 317
LEU A 269
 None
 1.04A 5tl8A-3tpaA:
undetectable		 5tl8A-3tpaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 122
PRO A 651
LEU A 650
PHE A 653
 None
 1.08A 5tl8A-3v8xA:
undetectable		 5tl8A-3v8xA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vg8 HYPOTHETICAL PROTEIN
TTHB210

(Thermus
thermophilus) 		no annotation 4 PRO G  12
LEU G  34
PHE G  33
LEU G  18
 None
 1.21A 5tl8A-3vg8G:
undetectable		 5tl8A-3vg8G:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 TYR A 240
PRO A 548
LEU A 547
LEU A 301
 None
 1.08A 5tl8A-3wfaA:
undetectable		 5tl8A-3wfaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 PRO A 245
PRO A 165
PHE A 170
LEU A 195
 None
CL  A1430 (-3.8A)
None
None
 1.22A 5tl8A-3zjkA:
undetectable		 5tl8A-3zjkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 TYR A 199
PRO A 379
LEU A 378
LEU A 429
 None
 1.16A 5tl8A-3zuqA:
0.0		 5tl8A-3zuqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 4 PRO A 348
TYR A 515
PRO A 505
LEU A 506
 None
HEM  A 701 (-4.7A)
None
HEM  A 701 (-4.6A)
 1.18A 5tl8A-4b2nA:
undetectable		 5tl8A-4b2nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF09663
(Amido_AtzD_TrzD) 		4 TYR A 192
PRO A 125
LEU A 124
LEU A 166
 None
 1.17A 5tl8A-4bvtA:
undetectable		 5tl8A-4bvtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		4 TYR A 551
PRO A 139
LEU A 138
LEU A   6
 None
 1.15A 5tl8A-4ccaA:
undetectable		 5tl8A-4ccaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 PRO A 240
LEU A 300
PHE A 302
LEU A 294
 None
 1.20A 5tl8A-4eziA:
undetectable		 5tl8A-4eziA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PRO A 897
TYR A 951
PRO A 907
LEU A 906
 None
 0.72A 5tl8A-4fxdA:
undetectable		 5tl8A-4fxdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5
AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens) 		PF04106
(APG5)
no annotation 		4 PRO C  11
PRO B 250
LEU B 254
LEU B 212
 None
 1.07A 5tl8A-4gdlC:
undetectable		 5tl8A-4gdlC:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 PRO A 168
LEU A 171
PHE A 170
LEU A 160
 None
 1.14A 5tl8A-4jc8A:
0.6		 5tl8A-4jc8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		4 PRO D 309
LEU D 293
PHE D 297
LEU D 299
 None
 1.22A 5tl8A-4jghD:
undetectable		 5tl8A-4jghD:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		4 PRO A  98
LEU A  97
PHE A  99
LEU A 104
 None
 0.87A 5tl8A-4joqA:
undetectable		 5tl8A-4joqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING

(Bacteroides
vulgatus) 		PF12771
(SusD-like_2) 		4 PRO A 433
PRO A 423
LEU A 422
PHE A 425
 None
 1.06A 5tl8A-4lerA:
undetectable		 5tl8A-4lerA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE

(Amycolatopsis
mediterranei) 		PF14765
(PS-DH) 		4 PRO A 244
LEU A 243
PHE A 245
LEU A 290
 None
 1.16A 5tl8A-4ln9A:
undetectable		 5tl8A-4ln9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbz MAJOR CAPSID PROTEIN
VP1

(African green
monkey
polyomavirus) 		PF00718
(Polyoma_coat) 		4 PRO A 253
LEU A 262
PHE A 153
LEU A 160
 EDO  A 403 (-4.2A)
None
IPA  A 405 (-4.6A)
None
 1.01A 5tl8A-4mbzA:
undetectable		 5tl8A-4mbzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		4 PRO A 133
TYR A 331
PRO A 323
LEU A 321
 None
 1.21A 5tl8A-4n91A:
undetectable		 5tl8A-4n91A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 TYR A  55
LEU A 204
PHE A 202
LEU A  53
 None
None
None
PGE  A 503 ( 3.7A)
 1.18A 5tl8A-4ogzA:
undetectable		 5tl8A-4ogzA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pot VP1

(Human
polyomavirus 9) 		PF00718
(Polyoma_coat) 		4 PRO A 256
LEU A 265
PHE A 156
LEU A 163
 None
None
IPA  A 404 (-4.6A)
None
 1.03A 5tl8A-4potA:
undetectable		 5tl8A-4potA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 PRO B 836
LEU B 835
PHE B 152
LEU B 825
 None
 1.18A 5tl8A-4qj4B:
undetectable		 5tl8A-4qj4B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		4 TYR A 156
PRO A 144
LEU A 145
LEU A  53
 None
 1.08A 5tl8A-4r2vA:
undetectable		 5tl8A-4r2vA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 PRO A 208
LEU A 175
PHE A 209
LEU A 238
 None
 1.18A 5tl8A-4rkcA:
undetectable		 5tl8A-4rkcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuu CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00571
(CBS) 		4 PRO A 407
LEU A 540
PHE A 542
LEU A 499
 None
None
EDO  A1551 (-3.7A)
None
 1.11A 5tl8A-4uuuA:
undetectable		 5tl8A-4uuuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 PRO A 306
LEU A  29
PHE A 276
LEU A 278
 None
 1.03A 5tl8A-4v15A:
undetectable		 5tl8A-4v15A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PRO A 641
PRO A 587
PHE A 589
LEU A 584
 None
 0.98A 5tl8A-4z0cA:
undetectable		 5tl8A-4z0cA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 TYR A1601
PRO A1401
LEU A1404
PHE A1403
 None
 1.11A 5tl8A-5a31A:
0.3		 5tl8A-5a31A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 TYR D 443
PRO D 596
LEU D 595
PHE D 597
 None
 1.12A 5tl8A-5a6bD:
1.0		 5tl8A-5a6bD:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4

(Mus musculus) 		PF01852
(START) 		4 TYR A 188
LEU A 145
PHE A 172
LEU A 185
 None
 1.15A 5tl8A-5brlA:
undetectable		 5tl8A-5brlA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvi INTERFERON
REGULATORY FACTOR 4

(Mus musculus) 		PF10401
(IRF-3) 		4 PRO A 339
PRO A 407
LEU A 409
LEU A 252
 None
 1.17A 5tl8A-5bviA:
undetectable		 5tl8A-5bviA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 PRO A  98
LEU A  97
PHE A  99
LEU A 123
 None
 1.02A 5tl8A-5bz3A:
undetectable		 5tl8A-5bz3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2

(Homo sapiens) 		PF00616
(RasGAP) 		4 PRO E 987
TYR E1105
LEU E1068
LEU E 981
 None
 1.06A 5tl8A-5cjpE:
undetectable		 5tl8A-5cjpE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 PRO A 406
TYR A 233
LEU A 226
PHE A 221
 None
 1.15A 5tl8A-5g4iA:
undetectable		 5tl8A-5g4iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		4 PRO A 236
TYR A 221
LEU A 211
LEU A 261
 None
 1.16A 5tl8A-5givA:
undetectable		 5tl8A-5givA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 PRO A 529
PRO A 525
PHE A 526
LEU A 522
 None
 1.10A 5tl8A-5gz4A:
undetectable		 5tl8A-5gz4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		4 PRO A 385
PRO A 534
PHE A 535
LEU A 530
 None
 0.88A 5tl8A-5haxA:
undetectable		 5tl8A-5haxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 PRO A1969
LEU A2127
PHE A2125
LEU A2131
 None
 0.99A 5tl8A-5j6oA:
undetectable		 5tl8A-5j6oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PRO B 904
LEU B 930
PHE B 920
LEU B 922
 None
 1.19A 5tl8A-5kyuB:
undetectable		 5tl8A-5kyuB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		4 PRO A 181
PRO A 231
LEU A 232
LEU A 167
 None
 1.15A 5tl8A-5l2pA:
undetectable		 5tl8A-5l2pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N)
PF06444
(NADH_dehy_S2_C) 		4 PRO N 255
LEU M 117
PHE M 118
LEU M 164
 None
 1.09A 5tl8A-5lc5N:
undetectable		 5tl8A-5lc5N:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 TYR A1601
PRO A1401
LEU A1404
PHE A1403
 None
 1.08A 5tl8A-5lcwA:
0.2		 5tl8A-5lcwA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 PRO A  97
PRO A 110
LEU A 108
LEU A 346
 None
 1.17A 5tl8A-5mifA:
undetectable		 5tl8A-5mifA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 PRO B 360
PRO B 274
LEU B 291
LEU B 275
 None
 1.04A 5tl8A-5n5nB:
undetectable		 5tl8A-5n5nB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 PRO A  64
LEU A  65
PHE A  67
LEU A  91
 None
 0.89A 5tl8A-5od2A:
undetectable		 5tl8A-5od2A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 PRO A 382
TYR A 125
PRO A 117
LEU A 168
 None
 1.17A 5tl8A-5oglA:
undetectable		 5tl8A-5oglA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 PRO T 326
LEU T 328
PHE T 324
LEU T 367
 None
 1.22A 5tl8A-5ojsT:
undetectable		 5tl8A-5ojsT:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 4 PRO A  46
PRO A 109
LEU A 110
PHE A 112
 None
 0.75A 5tl8A-5oq3A:
undetectable		 5tl8A-5oq3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 TYR A 137
PRO A 141
LEU A 145
PHE A 144
 None
 1.06A 5tl8A-5thmA:
undetectable		 5tl8A-5thmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tup PROLIFERATING CELL
NUCLEAR ANTIGEN

(Aspergillus
fumigatus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 TYR A 239
LEU A  47
PHE A 248
LEU A 236
 None
 1.22A 5tl8A-5tupA:
undetectable		 5tl8A-5tupA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 TYR B  70
LEU B  88
PHE B  90
LEU B  14
 None
 1.09A 5tl8A-5wwpB:
undetectable		 5tl8A-5wwpB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus) 		no annotation 4 PRO D 257
PRO D 244
LEU D 243
PHE D 245
 None
 1.05A 5tl8A-5ybbD:
undetectable		 5tl8A-5ybbD:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 6 PRO A  57
TYR A 107
PRO A 213
LEU A 214
PHE A 216
LEU A 467
 None
TPF  A 506 (-4.2A)
None
None
None
EDO  A 503 (-4.2A)
 0.67A 5tl8A-6ay4A:
63.0		 5tl8A-6ay4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA
COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		no annotation 4 PRO B 126
PRO A 130
LEU A 137
PHE A 132
 None
 1.14A 5tl8A-6conB:
undetectable		 5tl8A-6conB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 PRO A 550
PRO A 546
PHE A 547
LEU A 543
 None
 0.96A 5tl8A-6f2tA:
undetectable		 5tl8A-6f2tA:
undetectable