SIMILAR PATTERNS OF AMINO ACIDS FOR 5TJY_A_BEZA304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		3 MET A 194
GLU A 209
ARG A 205
 None
 1.12A 5tjyA-1chkA:
undetectable		 5tjyA-1chkA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		3 MET A 128
GLU A 167
ARG A 125
 None
 1.09A 5tjyA-1dm0A:
undetectable		 5tjyA-1dm0A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7u 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		3 MET A 267
GLU A 223
ARG A 226
 None
 1.13A 5tjyA-1g7uA:
undetectable		 5tjyA-1g7uA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		3 MET A 308
GLU A 318
ARG A 321
 None
 0.93A 5tjyA-1gm5A:
undetectable		 5tjyA-1gm5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 MET A 927
GLU A 939
ARG A 942
 None
 1.01A 5tjyA-1n5xA:
undetectable		 5tjyA-1n5xA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		3 MET A 267
GLU A 223
ARG A 226
 None
 1.03A 5tjyA-1o60A:
undetectable		 5tjyA-1o60A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		3 MET A1483
GLU A1582
ARG A1583
 None
 1.13A 5tjyA-1qhmA:
undetectable		 5tjyA-1qhmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		3 MET A 128
GLU A 167
ARG A 125
 None
 1.00A 5tjyA-1r4pA:
undetectable		 5tjyA-1r4pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to9 THI-4 PROTEIN

(Bacillus
subtilis) 		PF03070
(TENA_THI-4) 		3 MET B 194
GLU B 184
ARG B 191
 None
 1.03A 5tjyA-1to9B:
undetectable		 5tjyA-1to9B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 MET A 331
GLU A 156
ARG A 285
 None
None
FAD  A 480 (-3.8A)
 1.10A 5tjyA-1v59A:
undetectable		 5tjyA-1v59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		3 MET A 237
GLU A  39
ARG A  40
 None
 1.13A 5tjyA-1vrgA:
undetectable		 5tjyA-1vrgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z4e TRANSCRIPTIONAL
REGULATOR

(Bacillus
halodurans) 		PF00583
(Acetyltransf_1) 		3 MET A  69
GLU A  32
ARG A  92
 None
 1.06A 5tjyA-1z4eA:
undetectable		 5tjyA-1z4eA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 MET A 314
GLU A 337
ARG A 338
 None
 1.03A 5tjyA-2aj4A:
undetectable		 5tjyA-2aj4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 MET A 115
GLU A 121
ARG A 136
 None
 1.12A 5tjyA-2b3oA:
undetectable		 5tjyA-2b3oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		3 MET I 252
GLU I 374
ARG I 322
 None
 1.11A 5tjyA-2b4xI:
undetectable		 5tjyA-2b4xI:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Helicobacter
pylori) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 MET A  55
GLU A   2
ARG A   4
 None
 0.76A 5tjyA-2b7nA:
4.7		 5tjyA-2b7nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 MET A 126
GLU A 366
ARG A 264
 None
 0.94A 5tjyA-2ca4A:
undetectable		 5tjyA-2ca4A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		3 MET A 323
GLU A  41
ARG A  48
 None
 0.99A 5tjyA-2cwfA:
undetectable		 5tjyA-2cwfA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
TOB1 PROTEIN

(Homo sapiens;
Homo sapiens) 		PF04857
(CAF1)
PF07742
(BTG) 		3 MET B  25
GLU A 247
ARG B  80
 None
 0.96A 5tjyA-2d5rB:
undetectable		 5tjyA-2d5rB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dnx SYNTAXIN-12

(Homo sapiens) 		PF14523
(Syntaxin_2) 		3 MET A  37
GLU A 116
ARG A 113
 None
 0.77A 5tjyA-2dnxA:
undetectable		 5tjyA-2dnxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 MET A 387
GLU A 368
ARG A 398
 None
 1.08A 5tjyA-2e6kA:
2.0		 5tjyA-2e6kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edf OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		3 MET A  62
GLU A  27
ARG A  29
 None
 0.96A 5tjyA-2edfA:
undetectable		 5tjyA-2edfA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		3 MET A 103
GLU A 143
ARG A 144
 None
 0.77A 5tjyA-2fiqA:
2.4		 5tjyA-2fiqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 MET A 126
GLU A 151
ARG A 152
 None
 1.12A 5tjyA-2fwrA:
undetectable		 5tjyA-2fwrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 MET A 389
GLU A 234
ARG A 393
 None
 1.01A 5tjyA-2ibuA:
undetectable		 5tjyA-2ibuA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF04289
(DUF447) 		3 MET A 185
GLU A 167
ARG A 166
 None
 1.12A 5tjyA-2imlA:
undetectable		 5tjyA-2imlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		3 MET A 169
GLU A 144
ARG A 175
 None
 1.07A 5tjyA-2iy9A:
2.9		 5tjyA-2iy9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		3 MET A 113
GLU A 105
ARG A 109
 None
 1.01A 5tjyA-2jh9A:
2.5		 5tjyA-2jh9A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jml DNA BINDING
DOMAIN/TRANSCRIPTION
AL REGULATOR

(Myxococcus
xanthus) 		PF13411
(MerR_1) 		3 MET A  11
GLU A  48
ARG A  51
 None
 1.07A 5tjyA-2jmlA:
undetectable		 5tjyA-2jmlA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kj8 PUTATIVE PROPHAGE
CPS-53 INTEGRASE

(Escherichia
coli) 		PF14659
(Phage_int_SAM_3) 		3 MET A  33
GLU A  69
ARG A  70
 None
 1.10A 5tjyA-2kj8A:
undetectable		 5tjyA-2kj8A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9f CALE8

(Micromonospora
echinospora) 		no annotation 3 MET A  46
GLU A  25
ARG A  26
 None
 1.01A 5tjyA-2l9fA:
undetectable		 5tjyA-2l9fA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 MET A 321
GLU A 147
ARG A 274
 None
None
FAD  A 480 (-3.9A)
 0.96A 5tjyA-2qaeA:
4.4		 5tjyA-2qaeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 MET A   1
GLU A  22
ARG A  20
 None
 1.06A 5tjyA-2vwqA:
6.4		 5tjyA-2vwqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjg FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		3 MET A 107
GLU A  70
ARG A  74
 None
 0.84A 5tjyA-2wjgA:
7.1		 5tjyA-2wjgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		3 MET A 190
GLU A 158
ARG A 165
 None
 1.06A 5tjyA-2wl3A:
undetectable		 5tjyA-2wl3A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wt8 MICROCEPHALIN

(Homo sapiens) 		PF12738
(PTCB-BRCT) 		3 MET A  35
GLU A  77
ARG A  80
 None
 1.12A 5tjyA-2wt8A:
4.9		 5tjyA-2wt8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		3 MET A  62
GLU A  25
ARG A  24
 None
 1.00A 5tjyA-2wyrA:
undetectable		 5tjyA-2wyrA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		3 MET A 192
GLU A 161
ARG A 165
 None
 1.13A 5tjyA-2xvaA:
4.4		 5tjyA-2xvaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 MET A 130
GLU A   5
ARG A   6
 None
 1.08A 5tjyA-2zsgA:
undetectable		 5tjyA-2zsgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1t IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		3 MET A 120
GLU A  83
ARG A  87
 None
 1.07A 5tjyA-3a1tA:
7.4		 5tjyA-3a1tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b12 FLUOROACETATE
DEHALOGENASE

(Burkholderia
sp.) 		PF00561
(Abhydrolase_1) 		3 MET A 113
GLU A  88
ARG A  87
 None
 1.02A 5tjyA-3b12A:
4.7		 5tjyA-3b12A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzt D7 PROTEIN

(Aedes aegypti) 		PF01395
(PBP_GOBP) 		3 MET A 294
GLU A 268
ARG A 176
 None
TRS  A 306 ( 4.5A)
None
 1.01A 5tjyA-3dztA:
undetectable		 5tjyA-3dztA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		3 MET A   4
GLU A  61
ARG A  49
 None
 0.70A 5tjyA-3e48A:
7.3		 5tjyA-3e48A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		3 MET A 149
GLU A 184
ARG A 181
 None
 0.86A 5tjyA-3ec1A:
undetectable		 5tjyA-3ec1A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 MET A 358
GLU A 376
ARG A 379
 None
 1.00A 5tjyA-3g79A:
6.5		 5tjyA-3g79A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 MET A 226
GLU A 258
ARG A 222
 None
 0.88A 5tjyA-3i1iA:
3.5		 5tjyA-3i1iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		3 MET A  98
GLU A 104
ARG A 103
 None
 1.12A 5tjyA-3iu0A:
undetectable		 5tjyA-3iu0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		3 MET A 107
GLU A  70
ARG A  74
 None
 0.74A 5tjyA-3k53A:
7.7		 5tjyA-3k53A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		3 MET A 191
GLU A 141
ARG A 143
 None
 0.86A 5tjyA-3kcxA:
undetectable		 5tjyA-3kcxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 MET A 431
GLU A 110
ARG A 403
 None
 1.01A 5tjyA-3l84A:
4.1		 5tjyA-3l84A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 MET A 304
GLU A 480
ARG A 498
 None
 1.04A 5tjyA-3qfsA:
undetectable		 5tjyA-3qfsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 MET A 523
GLU A 567
ARG A 545
 None
 0.95A 5tjyA-3sbqA:
undetectable		 5tjyA-3sbqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 MET A 267
GLU A 255
ARG A 258
 None
 0.93A 5tjyA-3t57A:
undetectable		 5tjyA-3t57A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		3 MET A 511
GLU A 585
ARG A 566
 None
 1.12A 5tjyA-3tlmA:
2.4		 5tjyA-3tlmA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 MET A 433
GLU A 343
ARG A 385
 None
 1.09A 5tjyA-3u9sA:
4.5		 5tjyA-3u9sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubw 14-3-3 PROTEIN
EPSILON

(Homo sapiens) 		PF00244
(14-3-3) 		3 MET A  33
GLU A   5
ARG A   4
 None
 1.07A 5tjyA-3ubwA:
undetectable		 5tjyA-3ubwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 MET A 306
GLU A 329
ARG A 330
 None
None
SO4  A   1 (-3.9A)
 1.09A 5tjyA-3v5rA:
undetectable		 5tjyA-3v5rA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		3 MET A 279
GLU A 275
ARG A 277
 None
 1.12A 5tjyA-3vvjA:
undetectable		 5tjyA-3vvjA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckt PIH1
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF08190
(PIH1) 		3 MET A 132
GLU A 140
ARG A 139
 None
 1.05A 5tjyA-4cktA:
undetectable		 5tjyA-4cktA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		3 MET A 226
GLU A 270
ARG A 271
 None
 0.96A 5tjyA-4cswA:
undetectable		 5tjyA-4cswA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eu2 PROTEASOME COMPONENT
C7-ALPHA

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 MET A 121
GLU A 103
ARG A  96
 None
 0.96A 5tjyA-4eu2A:
undetectable		 5tjyA-4eu2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		3 MET A 360
GLU A 259
ARG A 356
 None
 1.00A 5tjyA-4fl0A:
3.7		 5tjyA-4fl0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fso PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 MET A 328
GLU A 349
ARG A 330
 None
 0.92A 5tjyA-4fsoA:
undetectable		 5tjyA-4fsoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 MET A 323
GLU A 344
ARG A 325
 None
 0.89A 5tjyA-4fspA:
undetectable		 5tjyA-4fspA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 MET A 413
GLU A 377
ARG A 380
 None
 1.08A 5tjyA-4fyeA:
undetectable		 5tjyA-4fyeA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN

(Salmonella
enterica) 		PF01261
(AP_endonuc_2) 		3 MET A  42
GLU A  37
ARG A  39
 None
 1.06A 5tjyA-4hgxA:
2.1		 5tjyA-4hgxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 MET A 360
GLU A 308
ARG A 309
 None
 0.99A 5tjyA-4hr3A:
undetectable		 5tjyA-4hr3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		3 MET A 794
GLU A 944
ARG A 875
 None
 0.92A 5tjyA-4knhA:
undetectable		 5tjyA-4knhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		3 MET A 106
GLU A 137
ARG A 138
 None
 0.83A 5tjyA-4mupA:
undetectable		 5tjyA-4mupA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 MET A 110
GLU A 130
ARG A 131
 None
None
GLY  A1001 (-2.8A)
 1.13A 5tjyA-4nf8A:
undetectable		 5tjyA-4nf8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		3 MET A 102
GLU A  85
ARG A  88
 None
 1.12A 5tjyA-4p1lA:
undetectable		 5tjyA-4p1lA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		3 MET A 105
GLU A 306
ARG A 305
 None
 0.99A 5tjyA-4xfeA:
3.0		 5tjyA-4xfeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		3 MET A 317
GLU A 262
ARG A 265
 None
 1.05A 5tjyA-4xuvA:
undetectable		 5tjyA-4xuvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwx SHC-TRANSFORMING
PROTEIN 1

(Homo sapiens) 		PF00640
(PID) 		3 MET A 147
GLU A 199
ARG A 201
 None
 1.11A 5tjyA-4xwxA:
undetectable		 5tjyA-4xwxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 MET A 198
GLU A 148
ARG A 151
 None
None
ST9  A 403 (-2.7A)
 0.81A 5tjyA-4ymkA:
undetectable		 5tjyA-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpk GAMMA-GLUTAMYLTRANSP
EPTIDASE (GGT)

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		3 MET C 540
GLU C 511
ARG C 475
 None
 1.10A 5tjyA-5bpkC:
undetectable		 5tjyA-5bpkC:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE

(Rhizomucor
miehei) 		PF00291
(PALP) 		3 MET A 330
GLU A 272
ARG A 326
 None
 1.11A 5tjyA-5c3uA:
undetectable		 5tjyA-5c3uA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		3 MET A 546
GLU A 508
ARG A 572
 None
ZN  A 801 (-2.2A)
None
 0.94A 5tjyA-5e3cA:
undetectable		 5tjyA-5e3cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epa SNOK

(Streptomyces
nogalater) 		PF05721
(PhyH) 		3 MET A 229
GLU A 254
ARG A 101
 None
 1.03A 5tjyA-5epaA:
undetectable		 5tjyA-5epaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		3 MET A 180
GLU A 236
ARG A 237
 None
 0.98A 5tjyA-5f0kA:
undetectable		 5tjyA-5f0kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 3 MET A 514
GLU A 558
ARG A 536
 None
 1.11A 5tjyA-5i5jA:
undetectable		 5tjyA-5i5jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		3 MET A 368
GLU A 362
ARG A 363
 None
GNL  A 601 (-3.4A)
None
 0.98A 5tjyA-5l7vA:
undetectable		 5tjyA-5l7vA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5low SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25

(Rattus
norvegicus;
Rattus
norvegicus) 		no annotation
no annotation 		3 MET D  71
GLU E 194
ARG E 191
 None
 0.97A 5tjyA-5lowD:
undetectable		 5tjyA-5lowD:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oow CHAPERONE PROTEIN
DNAK

(Escherichia
coli) 		no annotation 3 MET A 259
GLU A 242
ARG A 253
 None
 1.13A 5tjyA-5oowA:
undetectable		 5tjyA-5oowA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 3 MET A  59
GLU A  82
ARG A  83
 BEZ  A 302 ( 4.9A)
BEZ  A 302 ( 4.8A)
BEZ  A 302 (-3.4A)
 0.20A 5tjyA-5tjzA:
42.0		 5tjyA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5un1 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A

(Xenopus laevis) 		no annotation 3 MET G 500
GLU G 520
ARG G 521
 None
None
GLY  G1001 (-2.7A)
 1.06A 5tjyA-5un1G:
undetectable		 5tjyA-5un1G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgm DIHYDROOROTASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		3 MET A  72
GLU A  57
ARG A  56
 None
 0.93A 5tjyA-5vgmA:
2.5		 5tjyA-5vgmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5waq OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMD

(Neisseria
gonorrhoeae) 		no annotation 3 MET A 108
GLU A  96
ARG A  99
 None
 0.92A 5tjyA-5waqA:
undetectable		 5tjyA-5waqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wco NS2

(Salmon isavirus) 		no annotation 3 MET A 156
GLU A 167
ARG A 153
 None
 1.06A 5tjyA-5wcoA:
undetectable		 5tjyA-5wcoA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 3 MET A 540
GLU A 501
ARG A 566
 None
ZN  A 801 (-2.0A)
None
 0.70A 5tjyA-5yfbA:
undetectable		 5tjyA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 3 MET A1821
GLU A1608
ARG A1607
 None
 1.06A 5tjyA-5zalA:
2.2		 5tjyA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 3 MET A 386
GLU A 398
ARG A 401
 None
 1.10A 5tjyA-5zb3A:
undetectable		 5tjyA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 3 MET A 352
GLU A 199
ARG A 356
 None
 0.96A 5tjyA-6bj9A:
undetectable		 5tjyA-6bj9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 3 MET A 181
GLU A 212
ARG A 211
 None
 1.10A 5tjyA-6bk7A:
5.1		 5tjyA-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 3 MET A 321
GLU A 690
ARG A 419
 None
 0.95A 5tjyA-6bogA:
2.7		 5tjyA-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btp -

(-) 		no annotation 3 MET A  35
GLU A  48
ARG A  32
 None
 1.09A 5tjyA-6btpA:
2.1		 5tjyA-6btpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvp 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		no annotation 3 MET A 117
GLU A  57
ARG A 113
 None
FE2  A 202 (-2.2A)
None
 0.98A 5tjyA-6bvpA:
undetectable		 5tjyA-6bvpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 3 MET P 258
GLU P 269
ARG P 255
 None
 1.07A 5tjyA-6c1dP:
undetectable		 5tjyA-6c1dP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 3 MET A 316
GLU A 149
ARG A 271
 None
None
FAD  A 502 (-3.8A)
 0.89A 5tjyA-6cmzA:
3.2		 5tjyA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 MET A 162
GLU A 203
ARG A 180
 None
 1.08A 5tjyA-6fc0A:
undetectable		 5tjyA-6fc0A:
undetectable