SIMILAR PATTERNS OF AMINO ACIDS FOR 5TIY_A_OAQA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 ILE A 216
ASP A 100
PHE A 212
SER A  92
LEU A 183
 None
 1.46A 5tiyA-1cptA:
undetectable		 5tiyA-1cptA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 PRO A 123
ILE A 300
ASP A 122
LEU A 293
THR A 277
 None
None
None
HG  A 501 (-4.9A)
HG  A 501 ( 4.8A)
 1.35A 5tiyA-1dkpA:
undetectable		 5tiyA-1dkpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmg RIBOSOMAL PROTEIN L4

(Thermotoga
maritima) 		PF00573
(Ribosomal_L4) 		5 PRO A 185
ILE A 180
MET A 217
LEU A 213
THR A 214
 CIT  A 510 (-3.5A)
None
None
None
None
 1.20A 5tiyA-1dmgA:
0.0		 5tiyA-1dmgA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A 140
VAL A 214
PHE A 144
SER A 254
LEU A 171
 None
 1.24A 5tiyA-1pg5A:
1.5		 5tiyA-1pg5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzw PROTEIN AF2095(GR4)

(Archaeoglobus
fulgidus) 		PF01981
(PTH2) 		5 VAL A  95
ASP A  99
SER A  35
LEU A  53
THR A 108
 None
 1.39A 5tiyA-1rzwA:
undetectable		 5tiyA-1rzwA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 207
VAL A  26
MET A 108
LEU A 137
THR A 138
 None
 1.14A 5tiyA-1w5fA:
1.2		 5tiyA-1w5fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9j SEC1 FAMILY DOMAIN
CONTAINING PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		5 PRO A  89
ILE A  50
VAL A 141
MET A  21
LEU A  22
 None
 1.16A 5tiyA-1y9jA:
0.0		 5tiyA-1y9jA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 MET A 262
ASP A 263
VAL A 237
SER A 269
MET A 217
 None
 1.45A 5tiyA-1zczA:
0.6		 5tiyA-1zczA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ILE A1142
VAL A1280
PHE A1153
LEU A1284
THR A1254
 None
 1.33A 5tiyA-2bruA:
1.1		 5tiyA-2bruA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		5 ILE A 200
VAL A 230
SER A 194
LEU A 180
THR A 176
 None
 1.45A 5tiyA-2d1gA:
undetectable		 5tiyA-2d1gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 PRO X 453
ILE X 570
ASP X 449
PHE X 529
LEU X 498
 None
 1.23A 5tiyA-2epkX:
undetectable		 5tiyA-2epkX:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 PRO A 160
ILE A 180
ASP A 446
PHE A 135
THR A  96
 None
 1.48A 5tiyA-2j2mA:
undetectable		 5tiyA-2j2mA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PRO A 312
MET A 289
ILE A 264
LEU A 272
THR A 273
 None
 1.39A 5tiyA-2qddA:
undetectable		 5tiyA-2qddA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 5 PRO A 317
ILE A 275
VAL A 320
LEU A 241
THR A 240
 None
 1.45A 5tiyA-3e05A:
undetectable		 5tiyA-3e05A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 207
ILE A 234
PHE A 271
MET A 178
LEU A 220
 None
 1.18A 5tiyA-3gdcA:
undetectable		 5tiyA-3gdcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 374
VAL A 405
SER A 446
MET A 338
THR A 334
 None
 1.50A 5tiyA-3ho8A:
undetectable		 5tiyA-3ho8A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgf FLUORESCENT PROTEIN

(Verrillofungia
concinna) 		PF01353
(GFP) 		5 ILE A 195
VAL A 160
SER A 145
LEU A 156
THR A 150
 None
None
CFY  A  66 ( 2.4A)
None
None
 1.17A 5tiyA-3mgfA:
undetectable		 5tiyA-3mgfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe7 OLIGOGALACTURONATE
LYASE

(Yersinia
enterocolitica) 		PF14583
(Pectate_lyase22) 		5 PRO A 356
VAL A 298
PHE A 244
MET A 282
THR A 280
 None
 1.48A 5tiyA-3pe7A:
undetectable		 5tiyA-3pe7A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		5 PRO A 344
ILE A 107
VAL A 349
PHE A  53
LEU A 398
 None
 1.43A 5tiyA-3q33A:
undetectable		 5tiyA-3q33A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix UBIQUITIN-LIKE
PROTEIN
SMT3,RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3
CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe;
Saccharomyces
cerevisiae;
Schizosaccharomyces
pombe) 		PF11976
(Rad60-SLD)
no annotation 		5 PRO B 707
ILE B 685
VAL A  66
LEU A  48
THR A  44
 None
None
None
None
CL  A1001 ( 3.9A)
 1.43A 5tiyA-3tixB:
undetectable		 5tiyA-3tixB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 ILE A 287
VAL A 257
PHE A 175
LEU A 310
THR A 309
 None
 1.48A 5tiyA-3wq1A:
undetectable		 5tiyA-3wq1A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4et7 EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 MET A 153
ILE A 177
VAL A 226
LEU A 134
THR A 133
 None
 1.47A 5tiyA-4et7A:
undetectable		 5tiyA-4et7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III CHAPERONE
PROTEIN SHCA

(Pseudomonas
syringae group
genomosp. 3) 		PF05932
(CesT) 		5 PRO A  21
VAL A  23
MET A  32
LEU A  40
THR A  41
 None
 1.22A 5tiyA-4g6tA:
undetectable		 5tiyA-4g6tA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 PRO A 217
ASP A 185
SER A 123
LEU A 107
THR A 106
 None
 1.42A 5tiyA-4iw7A:
undetectable		 5tiyA-4iw7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE A 165
ASP A 130
VAL A 177
LEU A 143
THR A 144
 None
 1.40A 5tiyA-4tnmA:
undetectable		 5tiyA-4tnmA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 5 ILE C 358
VAL C 369
SER C 364
LEU C 338
THR C 339
 None
 1.48A 5tiyA-4wzsC:
undetectable		 5tiyA-4wzsC:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05861
(PhnI)
PF06007
(PhnJ) 		5 PRO D 189
ILE D  69
ASP D 192
VAL C 335
SER D 267
 None
 1.42A 5tiyA-4xb6D:
undetectable		 5tiyA-4xb6D:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 PRO A 676
ILE A1098
PHE A 740
SER A 713
LEU A 352
 None
 1.33A 5tiyA-5a0zA:
undetectable		 5tiyA-5a0zA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ako TSE2

(Pseudomonas
aeruginosa) 		no annotation 5 PRO C  44
MET C 138
ASP C 142
PHE C  50
THR C 125
 None
 1.48A 5tiyA-5akoC:
undetectable		 5tiyA-5akoC:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 10 PRO A  16
MET A  38
ILE A  42
ASP A  91
VAL A 128
ASP A 144
PHE A 153
MET A 233
LEU A 236
THR A 237
 OAQ  A 302 (-4.4A)
OAQ  A 302 (-4.3A)
None
OAQ  A 302 (-2.7A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-3.3A)
OAQ  A 302 ( 4.8A)
None
None
OAQ  A 302 (-3.8A)
 0.38A 5tiyA-5bykA:
39.7		 5tiyA-5bykA:
75.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		5 ILE A 127
ASP A 180
VAL A 153
SER A 185
THR A 257
 None
 1.41A 5tiyA-5ex2A:
undetectable		 5tiyA-5ex2A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff8 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		5 MET A 192
ILE A 137
VAL A 216
PHE A 229
LEU A 128
 None
 1.38A 5tiyA-5ff8A:
undetectable		 5tiyA-5ff8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		5 ILE A 384
ASP A 497
PHE A 505
SER A 509
LEU A 492
 None
 1.36A 5tiyA-5h5mA:
undetectable		 5tiyA-5h5mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 PRO A 115
ILE A 162
PHE A 141
SER A 145
LEU A 219
 None
 1.48A 5tiyA-5ns8A:
undetectable		 5tiyA-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbk IMPORTIN SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 PRO A 129
VAL A 173
SER A 168
LEU A 139
THR A 140
 None
 1.31A 5tiyA-5tbkA:
undetectable		 5tiyA-5tbkA:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 10 MET A  53
ILE A  57
ASP A 100
VAL A 137
ASP A 153
PHE A 162
SER A 166
MET A 242
LEU A 245
THR A 246
 OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 (-2.5A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-3.1A)
OAQ  A 302 (-4.6A)
OAQ  A 302 (-3.5A)
OAQ  A 302 ( 4.0A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.5A)
 0.50A 5tiyA-5tiwA:
43.0		 5tiyA-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 10 PRO A  31
MET A  53
ILE A  57
ASP A 100
VAL A 137
ASP A 153
PHE A 162
MET A 242
LEU A 245
THR A 246
 OAQ  A 302 (-4.7A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 (-2.5A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-3.1A)
OAQ  A 302 (-4.6A)
OAQ  A 302 ( 4.0A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.5A)
 0.22A 5tiyA-5tiwA:
43.0		 5tiyA-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 7 PRO A  16
MET A  38
ILE A  42
ASP A  87
VAL A 124
LEU A 232
THR A 233
 None
 0.61A 5tiyA-5tizA:
35.8		 5tiyA-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 7 PRO A  16
MET A  38
ILE A  42
ASP A  87
VAL A 124
PHE A 149
THR A 233
 None
 0.66A 5tiyA-5tizA:
35.8		 5tiyA-5tizA:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Escherichia
coli) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 ILE A  81
VAL A  64
SER A  69
MET A 142
LEU A 102
 None
 1.33A 5tiyA-5uagA:
undetectable		 5tiyA-5uagA:
22.15