SIMILAR PATTERNS OF AMINO ACIDS FOR 5TIX_B_OQRB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		5 ILE A 117
LEU A 281
LEU A 266
ASP A 216
PHE A 214
 None
None
None
LLP  A 253 ( 2.8A)
None
 1.33A 5tixB-1bw0A:
1.2		 5tixB-1bw0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		5 ILE A  90
LEU A  71
ASP A  55
PHE A  58
GLU A  64
 None
 1.24A 5tixB-1c1kA:
undetectable		 5tixB-1c1kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		5 ILE A  90
VAL A  19
ASP A  55
PHE A  58
GLU A  64
 None
 1.45A 5tixB-1c1kA:
undetectable		 5tixB-1c1kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		5 ILE A 654
VAL A 671
PHE A 652
SER A 699
GLU A 695
 None
 1.44A 5tixB-1d0nA:
undetectable		 5tixB-1d0nA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		5 ILE A 140
VAL A 180
LEU A 179
PHE A 157
GLU A 108
 None
 1.34A 5tixB-1kzlA:
undetectable		 5tixB-1kzlA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 459
VAL A 406
LEU A 405
PHE A 465
GLU A 401
 None
 1.29A 5tixB-1m2wA:
undetectable		 5tixB-1m2wA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PRO A 544
ILE A 720
LEU A 711
VAL A 657
LEU A 656
 None
 1.16A 5tixB-1ofeA:
0.0		 5tixB-1ofeA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0v TRNA-INTRON
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		5 ILE A 184
LEU A 190
VAL A 158
LEU A 153
GLU A 204
 None
 1.42A 5tixB-1r0vA:
undetectable		 5tixB-1r0vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 ILE A 158
LEU A 178
VAL A 216
LEU A 207
GLU A 197
 None
 1.39A 5tixB-1rf5A:
undetectable		 5tixB-1rf5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE

(Pyrococcus
furiosus) 		PF03070
(TENA_THI-4) 		5 ILE A 204
VAL A 106
LEU A 109
PHE A 201
GLU A 128
 None
None
None
MP5  A1213 (-3.3A)
MP5  A1213 (-3.8A)
 1.46A 5tixB-1rtwA:
undetectable		 5tixB-1rtwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 PRO B 233
ILE B  82
LEU B  76
LEU B  64
PHE B  55
 None
 1.30A 5tixB-1skyB:
undetectable		 5tixB-1skyB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9n MALATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF02615
(Ldh_2) 		5 PRO A  76
ILE A  90
VAL A  99
LEU A  96
SER A 125
 None
 1.41A 5tixB-1v9nA:
undetectable		 5tixB-1v9nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Escherichia
coli) 		PF02540
(NAD_synthase) 		5 ILE A 181
LEU A  59
LEU A 187
PHE A  29
GLU A  22
 None
 1.32A 5tixB-1wxfA:
undetectable		 5tixB-1wxfA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq8 MINOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF08949
(DUF1860) 		5 MET A 261
ILE A 332
LEU A 274
PHE A 225
SER A 319
 None
 1.42A 5tixB-1yq8A:
undetectable		 5tixB-1yq8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 PRO A 170
ILE A 179
LEU A 222
VAL A 117
LEU A 118
 None
 1.48A 5tixB-2e9yA:
2.6		 5tixB-2e9yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		5 PRO A 124
ILE A 162
LEU A 209
LEU A 234
PHE A 181
 None
 1.40A 5tixB-2eekA:
undetectable		 5tixB-2eekA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 265
VAL A 410
PHE A 414
SER A 356
GLU A 355
 None
 1.45A 5tixB-2gp6A:
undetectable		 5tixB-2gp6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		5 LEU A 119
VAL A  31
LEU A  32
PHE A  66
GLU A  34
 None
 1.47A 5tixB-2he3A:
undetectable		 5tixB-2he3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		5 ILE A 183
LEU A  30
LEU A 140
ASP A 176
GLU A 143
 None
 1.42A 5tixB-2jssA:
undetectable		 5tixB-2jssA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		5 PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
 None
 1.31A 5tixB-2mkiA:
undetectable		 5tixB-2mkiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4

(Phytolacca
dioica) 		PF00161
(RIP) 		5 PRO A  38
ILE A 210
LEU A 250
PHE A 179
GLU A 183
 None
 1.36A 5tixB-2qesA:
undetectable		 5tixB-2qesA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 ILE A 347
LEU A  22
VAL A 350
LEU A  45
GLU A 364
 None
 1.30A 5tixB-2w8sA:
undetectable		 5tixB-2w8sA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wql MAJOR ALLERGEN DAU C
1

(Daucus carota) 		PF00407
(Bet_v_1) 		5 ILE A 147
LEU A  25
LEU A  79
SER A  21
GLU A  17
 None
 1.28A 5tixB-2wqlA:
undetectable		 5tixB-2wqlA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		5 PRO A 127
MET A 101
ILE A  28
LEU A 125
LEU A 109
 None
 1.32A 5tixB-2wtnA:
2.2		 5tixB-2wtnA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA

(Rhodococcus
erythropolis) 		PF02979
(NHase_alpha) 		5 PRO A 172
MET A 169
ILE A 119
LEU A 171
VAL A 190
 None
 1.36A 5tixB-2zpbA:
undetectable		 5tixB-2zpbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 MET A 278
LEU A 313
LEU A 187
PHE A 202
GLU A 183
 None
 1.42A 5tixB-3a31A:
undetectable		 5tixB-3a31A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 PRO A 191
ILE A 295
LEU A 189
SER A 152
GLU A 151
 None
None
None
None
LLP  A 205 ( 3.8A)
 1.40A 5tixB-3aczA:
undetectable		 5tixB-3aczA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 PRO A 168
ILE A 247
VAL A 205
LEU A 202
GLU A 237
 None
 1.31A 5tixB-3bc8A:
undetectable		 5tixB-3bc8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		5 PRO A  98
ILE A  19
VAL A 218
PHE A 210
SER A 106
 None
 1.27A 5tixB-3e8jA:
undetectable		 5tixB-3e8jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ear HERA

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		5 PRO A 367
LEU A 232
VAL A 372
SER A 230
GLU A 227
 None
 1.30A 5tixB-3earA:
undetectable		 5tixB-3earA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ILE A 161
VAL A 107
LEU A 108
PHE A  56
GLU A 110
 None
None
BTN  A2001 ( 4.1A)
None
None
 1.30A 5tixB-3efsA:
undetectable		 5tixB-3efsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 PRO A  70
VAL A 107
LEU A 108
PHE A  56
GLU A 110
 None
None
BTN  A2001 ( 4.1A)
None
None
 1.34A 5tixB-3efsA:
undetectable		 5tixB-3efsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		5 PRO A  41
ILE A 116
LEU A  23
SER A 109
GLU A 107
 None
 1.44A 5tixB-3grnA:
undetectable		 5tixB-3grnA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 PRO A  81
ILE A 367
LEU A 411
LEU A  66
PHE A 401
 None
 1.24A 5tixB-3h5cA:
undetectable		 5tixB-3h5cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 PRO A 496
LEU A 522
LEU A 605
ASP A 600
SER A 523
 None
 1.42A 5tixB-3hmjA:
undetectable		 5tixB-3hmjA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmq NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Salmonella
enterica) 		PF02540
(NAD_synthase) 		5 ILE A 181
LEU A  59
LEU A 187
PHE A  29
GLU A  22
 None
 1.33A 5tixB-3hmqA:
undetectable		 5tixB-3hmqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		5 PRO A 367
LEU A 232
VAL A 372
SER A 230
GLU A 227
 None
 1.43A 5tixB-3i32A:
undetectable		 5tixB-3i32A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		5 MET A 446
LEU A 443
VAL A 377
LEU A 380
ASP A 372
 None
 1.24A 5tixB-3ihpA:
undetectable		 5tixB-3ihpA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 PRO A  58
ILE A 136
LEU A  61
VAL A 115
PHE A 151
 None
 1.41A 5tixB-3j31A:
undetectable		 5tixB-3j31A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		5 PRO A 270
ILE A 266
VAL A 233
LEU A 236
ASP A 248
 None
 1.26A 5tixB-3lfvA:
undetectable		 5tixB-3lfvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ILE A 124
LEU A 116
VAL A  46
LEU A  49
GLU A 111
 None
 1.41A 5tixB-3myvA:
undetectable		 5tixB-3myvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 PRO A  84
LEU A 151
VAL A 113
LEU A  86
ASP A 277
 None
 1.30A 5tixB-3n05A:
undetectable		 5tixB-3n05A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6o HEAT SHOCK PROTEIN
83

(Trypanosoma
brucei) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 MET A  15
ILE A  11
PHE A   7
SER A 149
GLU A 148
 None
 1.34A 5tixB-3o6oA:
undetectable		 5tixB-3o6oA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 ILE A 433
LEU A 439
VAL A 404
LEU A 402
SER A 440
 None
 1.47A 5tixB-3qxmA:
undetectable		 5tixB-3qxmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 MET A  30
ILE A  26
PHE A  22
SER A 164
GLU A 163
 None
 1.31A 5tixB-3r92A:
undetectable		 5tixB-3r92A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnk PROGRAMMED CELL
DEATH 1 LIGAND 2

(Mus musculus) 		PF07679
(I-set) 		5 ILE B  55
LEU B  82
LEU B  86
PHE B  44
GLU B  41
 None
 1.45A 5tixB-3rnkB:
undetectable		 5tixB-3rnkB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 MET A 330
ILE A 334
LEU A 324
ASP A 270
GLU A 319
 None
 1.18A 5tixB-3v1vA:
undetectable		 5tixB-3v1vA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		5 PRO B 106
LEU B 447
VAL B  86
LEU B  87
GLU B 450
 None
 1.42A 5tixB-3v4vB:
undetectable		 5tixB-3v4vB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		5 MET A 705
ILE A 704
LEU A 714
LEU A 198
PHE A 225
 None
 1.24A 5tixB-3wonA:
undetectable		 5tixB-3wonA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		5 LEU A  77
VAL A  12
LEU A  13
ASP A  62
GLU A  83
 None
 1.46A 5tixB-4aodA:
undetectable		 5tixB-4aodA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 PRO A 163
MET A 154
ILE A 149
LEU A 165
PHE A 168
 None
 1.24A 5tixB-4bhdA:
undetectable		 5tixB-4bhdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 MET A  33
ILE A  18
VAL A 278
SER A 254
GLU A 255
 None
 1.35A 5tixB-4c7vA:
undetectable		 5tixB-4c7vA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		5 ILE A  55
VAL A 236
PHE A  87
SER A  86
GLU A  47
 None
 1.36A 5tixB-4cn8A:
2.4		 5tixB-4cn8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrobaculum
neutrophilum) 		PF00215
(OMPdecase) 		5 PRO A 202
ILE A  85
VAL A   8
LEU A   7
GLU A 175
 None
 1.42A 5tixB-4df1A:
undetectable		 5tixB-4df1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo sapiens;
Homo sapiens) 		PF12678
(zf-rbx1)
PF08568
(Kinetochor_Ybp2) 		5 MET E 472
ILE E 568
VAL E 575
LEU E 578
GLU B  55
 None
 1.46A 5tixB-4f52E:
undetectable		 5tixB-4f52E:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 PRO A  25
ILE A  13
LEU A  61
VAL A  30
PHE A  42
 None
 1.45A 5tixB-4i9fA:
undetectable		 5tixB-4i9fA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		5 PRO A  82
ILE A 132
VAL A 128
LEU A 127
GLU A 123
 None
 1.41A 5tixB-4jj6A:
2.6		 5tixB-4jj6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 ILE A 303
LEU A 203
VAL A 300
LEU A 298
GLU A 294
 None
None
None
None
UDP  A 401 (-2.7A)
 1.14A 5tixB-4nesA:
undetectable		 5tixB-4nesA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 PRO A 173
MET A 502
ILE A 499
PHE A 479
GLU A 491
 None
None
None
AKR  A 609 (-4.6A)
None
 1.39A 5tixB-4ph9A:
undetectable		 5tixB-4ph9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 ILE A 639
LEU A 636
VAL A 502
SER A 635
GLU A 507
 None
 1.40A 5tixB-4qi4A:
1.5		 5tixB-4qi4A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens) 		no annotation 5 LEU A 161
VAL A 387
LEU A 391
PHE A 330
GLU A 168
 None
 1.34A 5tixB-4qikA:
undetectable		 5tixB-4qikA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 PRO L 352
ILE L 297
VAL L 499
LEU L 498
PHE L 299
 None
 0.96A 5tixB-4u9iL:
undetectable		 5tixB-4u9iL:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 ILE A 111
LEU A  94
VAL A 138
LEU A 139
SER A  95
 None
 1.29A 5tixB-4uqmA:
undetectable		 5tixB-4uqmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xat NOELIN

(Homo sapiens) 		PF02191
(OLF) 		5 PRO A 253
MET A 250
VAL A 359
LEU A 364
ASP A 356
 None
None
None
None
CA  A 501 ( 2.7A)
 1.29A 5tixB-4xatA:
undetectable		 5tixB-4xatA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z31 ROQUIN-2

(Homo sapiens) 		no annotation 5 LEU A 158
VAL A 384
LEU A 388
PHE A 327
GLU A 165
 None
 1.39A 5tixB-4z31A:
undetectable		 5tixB-4z31A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PRO A 480
ILE A 539
LEU A 483
LEU A 470
PHE A 552
 None
 1.43A 5tixB-4z64A:
undetectable		 5tixB-4z64A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus) 		no annotation 5 PRO D  84
ILE D 121
LEU D   4
VAL D 118
LEU D 116
 None
 0.94A 5tixB-4zg5D:
undetectable		 5tixB-4zg5D:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus) 		no annotation 5 PRO D  84
LEU D   4
VAL D 118
LEU D 116
GLU D 112
 None
 0.96A 5tixB-4zg5D:
undetectable		 5tixB-4zg5D:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 ILE A 114
LEU A  67
VAL A 150
LEU A 151
GLU A 160
 None
 1.36A 5tixB-5advA:
2.5		 5tixB-5advA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 ILE A 886
LEU A1001
VAL A 986
ASP A 882
SER A1000
 None
 1.47A 5tixB-5aorA:
undetectable		 5tixB-5aorA:
11.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 9 PRO A  16
MET A  38
ILE A  42
LEU A  92
VAL A 128
LEU A 129
ASP A 144
PHE A 153
GLU A 158
 OAQ  A 302 (-4.4A)
OAQ  A 302 (-4.3A)
None
OAQ  A 302 (-4.0A)
OAQ  A 302 (-4.0A)
None
OAQ  A 302 (-3.3A)
OAQ  A 302 ( 4.8A)
None
 0.55A 5tixB-5bykA:
39.6		 5tixB-5bykA:
75.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftg CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 ILE A 343
LEU A 219
LEU A 326
PHE A 378
SER A 225
 None
EDO  A1459 (-4.5A)
None
None
None
 1.46A 5tixB-5ftgA:
undetectable		 5tixB-5ftgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 MET A 208
ILE A  56
LEU A 204
VAL A  75
PHE A  58
 None
 1.46A 5tixB-5g37A:
undetectable		 5tixB-5g37A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan PRE-MRNA-PROCESSING
FACTOR 31

(Saccharomyces
cerevisiae) 		PF01798
(Nop)
PF09785
(Prp31_C) 		5 ILE F 105
LEU F  47
LEU F  80
PHE F  54
SER F  50
 None
 1.18A 5tixB-5ganF:
undetectable		 5tixB-5ganF:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		5 PRO A 433
ILE A 425
VAL A 401
LEU A 396
ASP A 416
 None
 1.40A 5tixB-5gl7A:
undetectable		 5tixB-5gl7A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 346
LEU A 280
PHE A 309
SER A 347
GLU A 349
 None
None
None
None
PO4  A 802 (-3.6A)
 1.41A 5tixB-5gslA:
undetectable		 5tixB-5gslA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		5 LEU A 344
LEU A 278
PHE A 307
SER A 345
GLU A 347
 None
None
None
None
GCS  A 801 (-2.7A)
 1.35A 5tixB-5gsmA:
undetectable		 5tixB-5gsmA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 ILE A 156
LEU A 138
LEU A 148
PHE A 240
GLU A 144
 None
 1.46A 5tixB-5hdjA:
undetectable		 5tixB-5hdjA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huj NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptococcus
pyogenes) 		PF02540
(NAD_synthase) 		5 ILE A 189
LEU A  67
LEU A 195
PHE A  37
GLU A  30
 None
 1.28A 5tixB-5hujA:
undetectable		 5tixB-5hujA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE

(Saccharomyces
cerevisiae) 		PF04752
(ChaC) 		5 ILE A  99
LEU A  11
LEU A 157
SER A 159
GLU A 123
 None
 1.37A 5tixB-5hwiA:
undetectable		 5tixB-5hwiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0k DESIGNED PROTEIN
2L4HC2_23

(synthetic
construct) 		no annotation 5 ILE A  57
LEU A  13
LEU A  67
SER A  12
GLU A   8
 None
 1.44A 5tixB-5j0kA:
undetectable		 5tixB-5j0kA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 5 MET B 696
ILE B 692
VAL B 515
PHE B 713
GLU B 509
 None
 1.46A 5tixB-5kdjB:
undetectable		 5tixB-5kdjB:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		5 MET A 696
ILE A 692
VAL A 515
PHE A 713
GLU A 509
 None
 1.42A 5tixB-5kdsA:
undetectable		 5tixB-5kdsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Trichormus
variabilis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 MET A 103
ILE A  71
LEU A  68
VAL A  94
LEU A  92
 None
 1.46A 5tixB-5kt0A:
2.8		 5tixB-5kt0A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb3 PHYCOERYTHRIN BETA
SUBUNIT,PHYCOERYTHRI
N BETA SUBUNIT

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		5 VAL M  91
LEU M  95
ASP M 104
SER M 174
GLU M 171
 None
 1.24A 5tixB-5nb3M:
undetectable		 5tixB-5nb3M:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 10 PRO A  31
MET A  53
ILE A  57
LEU A 101
VAL A 137
LEU A 138
ASP A 153
PHE A 162
SER A 166
GLU A 167
 OAQ  A 302 (-4.7A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 ( 4.1A)
OAQ  A 302 (-4.0A)
None
OAQ  A 302 (-3.1A)
OAQ  A 302 (-4.6A)
OAQ  A 302 (-3.5A)
None
 0.31A 5tixB-5tiwA:
43.0		 5tixB-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 7 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 124
LEU A 125
PHE A 149
 None
 0.62A 5tixB-5tizA:
36.0		 5tixB-5tizA:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		5 PRO A 299
LEU A 171
PHE A 157
SER A 174
GLU A 173
 None
 1.29A 5tixB-5u2pA:
undetectable		 5tixB-5u2pA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 5 PRO B 401
MET B 399
ILE B 395
SER B 222
GLU B 223
 None
 1.46A 5tixB-5uanB:
undetectable		 5tixB-5uanB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 110
LEU A  83
VAL A  90
LEU A  88
GLU A  87
 None
 1.46A 5tixB-5vmtA:
undetectable		 5tixB-5vmtA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		5 ILE A  18
LEU A 108
VAL A  34
LEU A 161
PHE A  20
 None
 0.75A 5tixB-5vvwA:
3.4		 5tixB-5vvwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3v APOBEC3H

(Macaca
nemestrina) 		no annotation 5 ILE B 173
LEU B  80
VAL B 133
LEU B 126
SER B  83
 None
 1.27A 5tixB-5w3vB:
undetectable		 5tixB-5w3vB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 MET A  60
ILE A  59
VAL A 100
LEU A 101
PHE A 189
 None
 1.11A 5tixB-5wbfA:
undetectable		 5tixB-5wbfA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 182
LEU A 137
VAL A 185
LEU A  98
GLU A 101
 None
 1.40A 5tixB-5wx3A:
undetectable		 5tixB-5wx3A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 PRO A 429
ILE A 325
VAL A   5
LEU A 220
GLU A 222
 None
 1.43A 5tixB-6bs7A:
undetectable		 5tixB-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Enterococcus
faecalis) 		no annotation 5 ILE A 182
LEU A  60
LEU A 188
PHE A  30
GLU A  23
 None
 1.37A 5tixB-6c8qA:
undetectable		 5tixB-6c8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 5 ILE A  30
LEU A 107
VAL A  95
LEU A  94
ASP A  47
 None
 1.32A 5tixB-6cjqA:
undetectable		 5tixB-6cjqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 ILE M  60
LEU M  98
VAL M   8
LEU M  16
GLU M 100
 None
 1.32A 5tixB-6criM:
undetectable		 5tixB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 ILE M 109
LEU M  65
PHE M  95
SER M 102
GLU M  99
 None
 1.35A 5tixB-6criM:
undetectable		 5tixB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC2
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 ILE G  13
LEU G  59
LEU F  99
ASP G  16
PHE G  18
 None
 1.41A 5tixB-6f42G:
undetectable		 5tixB-6f42G:
undetectable