SIMILAR PATTERNS OF AMINO ACIDS FOR 5TIW_B_OAQB302_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3e | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 5 | PRO A 105ILE A 95LEU A 108LEU A 48THR A 45 | None | 1.25A | 5tiwB-1j3eA:undetectable | 5tiwB-1j3eA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kk0 | EIF2GAMMA (Pyrococcusabyssi) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 5 | ASP A 108ILE A 48PHE A 52SER A 237LEU A 96 | None | 1.29A | 5tiwB-1kk0A:1.2 | 5tiwB-1kk0A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 5 | PRO A 170ILE A 160LEU A 173LEU A 113THR A 110 | None | 1.20A | 5tiwB-1lrrA:undetectable | 5tiwB-1lrrA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhs | PLASMA MEMBRANEATPASE (Neurosporacrassa) |
PF00122(E1-E2_ATPase)PF00690(Cation_ATPase_N)PF00702(Hydrolase) | 5 | LEU A 178VAL A 665ILE A 649SER A 654THR A 647 | None | 1.27A | 5tiwB-1mhsA:undetectable | 5tiwB-1mhsA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pg5 | ASPARTATECARBAMOYLTRANSFERASE (Sulfolobusacidocaldarius) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ILE A 140VAL A 214PHE A 144SER A 254LEU A 171 | None | 1.20A | 5tiwB-1pg5A:2.0 | 5tiwB-1pg5A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlm | METHENYLTETRAHYDROMETHANOPTERINCYCLOHYDROLASE (Methanopyruskandleri) |
PF02289(MCH) | 5 | PRO A 10MET A 15ILE A 36LEU A 11THR A 33 | None | 1.21A | 5tiwB-1qlmA:undetectable | 5tiwB-1qlmA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP1) (Rhinovirus A) |
PF00073(Rhv) | 5 | MET 1 169ILE 1 171ILE 1 239PHE 1 182THR 1 237 | None | 1.05A | 5tiwB-1r1a1:undetectable | 5tiwB-1r1a1:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r4w | GLUTATHIONES-TRANSFERASE,MITOCHONDRIAL (Rattusnorvegicus) |
PF01323(DSBA) | 5 | ILE A 125ASP A 13LEU A 44ILE A 70PHE A 87 | NoneNoneGSH A 301 ( 4.9A)NoneNone | 1.29A | 5tiwB-1r4wA:1.8 | 5tiwB-1r4wA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ru3 | ACETYL-COA SYNTHASE (Carboxydothermushydrogenoformans) |
PF03598(CdhC) | 5 | ILE A 387LEU A 480VAL A 390ILE A 410THR A 414 | None | 1.29A | 5tiwB-1ru3A:2.1 | 5tiwB-1ru3A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry2 | ACETYL-COENZYME ASYNTHETASE 1 (Saccharomycescerevisiae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | MET A 184LEU A 180VAL A 192ILE A 232THR A 266 | None | 1.29A | 5tiwB-1ry2A:undetectable | 5tiwB-1ry2A:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sv1 | CIRCADIAN CLOCKPROTEIN KAIA (Thermosynechococcuselongatus) |
PF07688(KaiA) | 5 | ILE A 59LEU A 13ILE A 24LEU A 88THR A 87 | None | 1.13A | 5tiwB-1sv1A:undetectable | 5tiwB-1sv1A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umb | 2-OXO ACIDDEHYDROGENASE BETASUBUNIT (Thermusthermophilus) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | PRO B 309ILE B 290ILE B 208LEU B 205THR B 206 | None | 1.20A | 5tiwB-1umbB:undetectable | 5tiwB-1umbB:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w9x | ALPHA AMYLASE (Bacillushalmapalus) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | PRO A 46VAL A 104ILE A 241LEU A 250THR A 246 | None | 1.20A | 5tiwB-1w9xA:undetectable | 5tiwB-1w9xA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdi | RV3303C-LPDA (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ASP A 121LEU A 119VAL A 148ILE A 5THR A 3 | None | 1.24A | 5tiwB-1xdiA:undetectable | 5tiwB-1xdiA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xi9 | PUTATIVETRANSAMINASE (Pyrococcusfuriosus) |
PF00155(Aminotran_1_2) | 5 | PRO A 220ILE A 194LEU A 188VAL A 172THR A 167 | None | 1.26A | 5tiwB-1xi9A:undetectable | 5tiwB-1xi9A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yo7 | REGULATORY PROTEINROP (Escherichiacoli) |
PF01815(Rop) | 5 | ILE A 68LEU A 53ILE A 15LEU A 111THR A 107 | None | 1.32A | 5tiwB-1yo7A:undetectable | 5tiwB-1yo7A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ae8 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Staphylococcusaureus) |
PF00475(IGPD) | 5 | LEU A 131ILE A 149PHE A 165LEU A 145THR A 147 | None | 1.31A | 5tiwB-2ae8A:undetectable | 5tiwB-2ae8A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bmf | RNA HELICASE (Dengue virus) |
PF07652(Flavi_DEAD) | 5 | PRO A 176ILE A 182ILE A 282LEU A 216THR A 218 | None | 1.22A | 5tiwB-2bmfA:undetectable | 5tiwB-2bmfA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2die | AMYLASE (Bacillus sp.(in: Bacteria)) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | PRO A 46VAL A 104ILE A 241LEU A 250THR A 246 | None | 1.24A | 5tiwB-2dieA:undetectable | 5tiwB-2dieA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkd | PHOSPHOACETYLGLUCOSAMINE MUTASE (Candidaalbicans) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I) | 5 | ILE A 436VAL A 248ILE A 219PHE A 289LEU A 240 | None | 1.17A | 5tiwB-2dkdA:undetectable | 5tiwB-2dkdA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h7g | DNA TOPOISOMERASE 1 (Variola virus) |
PF01028(Topoisom_I)PF09266(VirDNA-topo-I_N) | 5 | MET X 121ILE X 98LEU X 117PHE X 215SER X 211 | None | 1.25A | 5tiwB-2h7gX:undetectable | 5tiwB-2h7gX:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjh | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 5 | ILE A 470ASP A 514ILE A 355SER A 266LEU A 332 | None | 1.26A | 5tiwB-2hjhA:undetectable | 5tiwB-2hjhA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lab | BETA/ALPHA-AMYLASE (Paenibacilluspolymyxa) |
PF03423(CBM_25) | 5 | MET A 566ILE A 549ILE A 626PHE A 591LEU A 587 | None | 1.17A | 5tiwB-2labA:undetectable | 5tiwB-2labA:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lzj | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME 1 (Mus musculus) |
PF16190(E1_FCCH) | 5 | MET A 265ILE A 277PHE A 250LEU A 270THR A 274 | None | 1.29A | 5tiwB-2lzjA:undetectable | 5tiwB-2lzjA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mki | CYTOPLASMICPOLYADENYLATIONELEMENT-BINDINGPROTEIN 4 (Homo sapiens) |
PF16367(RRM_7) | 5 | PRO A 73ILE A 151LEU A 72VAL A 139PHE A 85 | None | 1.28A | 5tiwB-2mkiA:undetectable | 5tiwB-2mkiA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2put | ISOMERASE DOMAIN OFGLUTAMINE-FRUCTOSE-6-PHOSPHATETRANSAMINASE(ISOMERIZING) (Candidaalbicans) |
PF01380(SIS) | 5 | ILE A 636LEU A 571ILE A 649LEU A 628THR A 624 | None | 1.22A | 5tiwB-2putA:undetectable | 5tiwB-2putA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qnd | FMR1 PROTEIN (Homo sapiens) |
PF00013(KH_1) | 5 | ILE A 92ASP A 137VAL A 73ILE A 103PHE A 122 | None | 1.33A | 5tiwB-2qndA:undetectable | 5tiwB-2qndA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r94 | 2-KETO-3-DEOXY-(6-PHOSPHO-)GLUCONATEALDOLASE (Thermoproteustenax) |
PF00701(DHDPS) | 5 | ASP A 248LEU A 247VAL A 202SER A 217THR A 182 | None | 1.17A | 5tiwB-2r94A:undetectable | 5tiwB-2r94A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wgh | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASELARGE SUBUNIT (Homo sapiens) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | LEU A 131VAL A 176ILE A 178LEU A 205THR A 204 | None | 1.27A | 5tiwB-2wghA:undetectable | 5tiwB-2wghA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whl | BETA-MANNANASE (Salipaludibacillusagaradhaerens) |
PF00150(Cellulase) | 5 | PRO A 183ILE A 122ASP A 182LEU A 184ILE A 107 | None | 1.10A | 5tiwB-2whlA:undetectable | 5tiwB-2whlA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsk | 226AA LONGHYPOTHETICALASPARTATE RACEMASE (Pyrococcushorikoshii) |
PF01177(Asp_Glu_race) | 5 | PRO A 197ILE A 102ASP A 211LEU A 191THR A 10 | None | 1.31A | 5tiwB-2zskA:undetectable | 5tiwB-2zskA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT B OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
PF00348(polyprenyl_synt) | 5 | ILE B 123LEU B 66ILE B 134SER B 185THR B 138 | None | 1.19A | 5tiwB-3aqcB:undetectable | 5tiwB-3aqcB:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT B OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
PF00348(polyprenyl_synt) | 5 | ILE B 123LEU B 66PHE B 131SER B 185THR B 138 | None | 1.27A | 5tiwB-3aqcB:undetectable | 5tiwB-3aqcB:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9f | 5'-NUCLEOTIDASE (Candidaalbicans) |
PF00149(Metallophos) | 5 | PRO A 409ILE A 385ILE A 369LEU A 373THR A 372 | None | 1.27A | 5tiwB-3c9fA:undetectable | 5tiwB-3c9fA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 5 | PRO A 105LEU A 151VAL A 268ILE A 282PHE A 262 | None | 1.26A | 5tiwB-3da1A:undetectable | 5tiwB-3da1A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3doh | ESTERASE (Thermotogamaritima) |
PF02230(Abhydrolase_2) | 5 | PRO A 234ILE A 280LEU A 195VAL A 262PHE A 303 | None | 1.31A | 5tiwB-3dohA:undetectable | 5tiwB-3dohA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj7 | MAJOR ANTIGENICPEPTIDE PEB3 (Campylobacterjejuni) |
PF13531(SBP_bac_11) | 5 | ILE A 187LEU A 209ILE A 114PHE A 160THR A 106 | None | 1.20A | 5tiwB-3fj7A:2.1 | 5tiwB-3fj7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4k | MUCONATE LACTONIZINGENZYME (Corynebacteriumglutamicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 177ILE A 199ASP A 180ILE A 240THR A 244 | PRO A 177 ( 1.1A)ILE A 199 ( 0.4A)ASP A 180 ( 0.5A)ILE A 240 ( 0.6A)THR A 244 ( 0.8A) | 1.27A | 5tiwB-3i4kA:undetectable | 5tiwB-3i4kA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivr | PUTATIVELONG-CHAIN-FATTY-ACID COA LIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding) | 5 | LEU A 223ILE A 74PHE A 26SER A 230LEU A 79 | None | 1.08A | 5tiwB-3ivrA:undetectable | 5tiwB-3ivrA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jug | BETA-MANNANASE (Bacillus sp.N16-5) |
PF00150(Cellulase) | 5 | PRO A 214ILE A 153ASP A 213LEU A 215ILE A 138 | None | 1.30A | 5tiwB-3jugA:undetectable | 5tiwB-3jugA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn3 | CARBONCATABOLITE-DEREPRESSING PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | PRO A 251ILE A 143LEU A 250ILE A 161PHE A 140 | None | 1.17A | 5tiwB-3mn3A:undetectable | 5tiwB-3mn3A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyf | D-ARGININEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF01266(DAO) | 5 | ILE A1145ILE A1013PHE A1069SER A1065THR A1042 | NoneFAD A1500 (-4.8A)NoneNoneFAD A1500 (-3.5A) | 1.22A | 5tiwB-3nyfA:undetectable | 5tiwB-3nyfA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohg | UNCHARACTERIZEDPROTEIN FROM DUF2233FAMILY (Bacteroidesovatus) |
PF09992(NAGPA) | 5 | PRO A 33ILE A 78ASP A 53VAL A 42THR A 256 | EDO A 403 ( 4.9A)NoneNoneEDO A 403 ( 4.8A)None | 1.31A | 5tiwB-3ohgA:undetectable | 5tiwB-3ohgA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rft | URONATEDEHYDROGENASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 5 | PRO A 201ILE A 189ILE A 68LEU A 71THR A 9 | None | 1.10A | 5tiwB-3rftA:2.1 | 5tiwB-3rftA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 5 | ILE L 283LEU L 128VAL L 203ASP L 279LEU L 147 | None | 1.06A | 5tiwB-3rgwL:undetectable | 5tiwB-3rgwL:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sjn | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 367VAL A 30ILE A 307LEU A 334THR A 305 | None | 1.25A | 5tiwB-3sjnA:undetectable | 5tiwB-3sjnA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3son | HYPOTHETICAL NUDIXHYDROLASE (Listeriamonocytogenes) |
PF00293(NUDIX) | 5 | ILE A 10LEU A 123VAL A 115ILE A 13LEU A 140 | None | 1.15A | 5tiwB-3sonA:undetectable | 5tiwB-3sonA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vc7 | PUTATIVEOXIDOREDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | ILE A 82LEU A 27VAL A 12ILE A 87THR A 119 | None | 1.33A | 5tiwB-3vc7A:undetectable | 5tiwB-3vc7A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vmw | PECTATE LYASE (Bacillus sp.N16-5) |
PF00544(Pec_lyase_C) | 5 | ILE A 31ILE A 84PHE A 92LEU A 48THR A 49 | None | 1.31A | 5tiwB-3vmwA:undetectable | 5tiwB-3vmwA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emk | U6 SNRNA-ASSOCIATEDSM-LIKE PROTEIN LSM5U6 SNRNA-ASSOCIATEDSM-LIKE PROTEIN LSM7 (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF01423(LSM)PF01423(LSM) | 5 | PRO A 75ILE C 46LEU C 85VAL C 87THR C 92 | None | 1.28A | 5tiwB-4emkA:undetectable | 5tiwB-4emkA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eog | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09455(Cas_DxTHG) | 5 | ILE A 434LEU A 473ILE A 347PHE A 253SER A 247 | None | 1.29A | 5tiwB-4eogA:undetectable | 5tiwB-4eogA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdh | CYTOCHROME P45011B2, MITOCHONDRIAL (Homo sapiens) |
PF00067(p450) | 5 | PRO A 77LEU A 93ILE A 397LEU A 402THR A 401 | None | 1.05A | 5tiwB-4fdhA:undetectable | 5tiwB-4fdhA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdu | PUTATIVE MULTIPLEINOSITOLPOLYPHOSPHATEHISTIDINEPHOSPHATASE 1 (Bacteroidesthetaiotaomicron) |
PF00328(His_Phos_2) | 5 | ILE A 252ILE A 246PHE A 63SER A 112LEU A 256 | None | 1.30A | 5tiwB-4fduA:undetectable | 5tiwB-4fduA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fz2 | TRNA INTRONENDONUCLEASE (CandidatusMicrarchaeumacidiphilum) |
PF01974(tRNA_int_endo) | 5 | LEU A 256ILE A 173ASP A 172LEU A 179THR A 176 | None | 1.32A | 5tiwB-4fz2A:undetectable | 5tiwB-4fz2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gps | KLLA0E02245P (Kluyveromyceslactis) |
no annotation | 5 | PRO A 302ILE A 165LEU A 301VAL A 245THR A 157 | None | 1.31A | 5tiwB-4gpsA:undetectable | 5tiwB-4gpsA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h20 | HEAVY CHAIN OF FABFRAGMENT FROM THE ANTI-RICINMONOCLONAL ANTIBODYRAC18 (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | ILE H 199LEU H 158VAL H 169SER H 185THR H 190 | None | 1.33A | 5tiwB-4h20H:undetectable | 5tiwB-4h20H:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i5s | PUTATIVE HISTIDINEKINASE COVS VICK-LIKE PROTEIN (Streptococcusmutans) |
PF00512(HisKA)PF00989(PAS)PF02518(HATPase_c) | 5 | ILE A 176ASP A 145LEU A 143LEU A 191THR A 110 | None | 1.32A | 5tiwB-4i5sA:undetectable | 5tiwB-4i5sA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iao | NAD-DEPENDENTHISTONE DEACETYLASESIR2REGULATORY PROTEINSIR4 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592)PF16991(SIR4_SID) | 5 | PRO A 211ILE C 832ASP A 210LEU A 212ILE A 114 | None | 1.27A | 5tiwB-4iaoA:undetectable | 5tiwB-4iaoA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4idj | FAB HEAVY CHAINFAB LIGHT CHAIN (Homo sapiens;Homo sapiens) |
PF07654(C1-set)PF07686(V-set)PF07654(C1-set)PF07686(V-set) | 5 | PRO L 113MET L 175VAL L 115ILE L 117LEU H 124 | None | 1.29A | 5tiwB-4idjL:undetectable | 5tiwB-4idjL:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kkj | TRANSCOBALAMIN-1 (Homo sapiens) |
PF01122(Cobalamin_bind)PF14478(DUF4430) | 5 | ILE A 2ASP A 278LEU A 277LEU A 246THR A 245 | None | 1.18A | 5tiwB-4kkjA:undetectable | 5tiwB-4kkjA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbq | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE (Coxiellaburnetii) |
PF00013(KH_1)PF00575(S1)PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | ILE A 94VAL A 43ILE A 113LEU A 39THR A 115 | None | 0.99A | 5tiwB-4nbqA:undetectable | 5tiwB-4nbqA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9l | LIMONENE-1,2-EPOXIDEHYDROLASE (Rhodococcuserythropolis) |
PF07858(LEH) | 5 | ASP A 33LEU A 29VAL A 85ASP A 132LEU A 103 | NoneNoneNoneHYH A 201 (-4.2A)HYH A 201 ( 4.5A) | 1.22A | 5tiwB-4r9lA:undetectable | 5tiwB-4r9lA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rct | RESTRICTIONENDONUCLEASER.NGOVII (Neisseriagonorrhoeae) |
PF09565(RE_NgoFVII) | 5 | ILE A 297ASP A 268SER A 179LEU A 318THR A 317 | None | 1.30A | 5tiwB-4rctA:undetectable | 5tiwB-4rctA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlr | CYTOCHROME C, 1HEME-BINDING SITE (Geobactersulfurreducens) |
no annotation | 5 | ILE A 9ASP A 14ILE A 55LEU A 66THR A 58 | NoneNoneNoneHEM A 201 ( 4.8A)None | 1.27A | 5tiwB-4rlrA:undetectable | 5tiwB-4rlrA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wip | SEGMENT POLARITYPROTEIN DISHEVELLEDHOMOLOG DVL-2 (Homo sapiens) |
PF00778(DIX) | 5 | ILE A 71LEU A 89ILE A 38PHE A 57SER A 87 | None | 1.32A | 5tiwB-4wipA:undetectable | 5tiwB-4wipA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yue | S4B6 FAB HEAVY CHAINS4B6 FAB LIGHT CHAIN (Mus musculus;Mus musculus) |
PF07654(C1-set)PF07686(V-set)PF07654(C1-set)PF07686(V-set) | 5 | PRO L 116MET L 178VAL L 118ILE L 120LEU H 137 | None | 1.30A | 5tiwB-4yueL:undetectable | 5tiwB-4yueL:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywl | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 5 | PRO A 217ILE A 249LEU A 216VAL A 125LEU A 244 | None | 1.09A | 5tiwB-4ywlA:undetectable | 5tiwB-4ywlA:18.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5byk | SULFOTRANSFERASE (Schistosomamansoni) |
no annotation | 11 | PRO A 16MET A 38ILE A 42ASP A 91LEU A 92VAL A 128ILE A 140ASP A 144PHE A 153LEU A 236THR A 237 | OAQ A 302 (-4.4A)OAQ A 302 (-4.3A)NoneOAQ A 302 (-2.7A)OAQ A 302 (-4.0A)OAQ A 302 (-4.0A)NoneOAQ A 302 (-3.3A)OAQ A 302 ( 4.8A)NoneOAQ A 302 (-3.8A) | 0.41A | 5tiwB-5bykA:39.2 | 5tiwB-5bykA:75.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c0n | FAB CA33 HEAVY CHAINFAB CA33 LIGHT CHAIN (Oryctolaguscuniculus;Oryctolaguscuniculus) |
no annotationno annotation | 5 | PRO L 118MET L 180VAL L 120ILE L 122LEU H 131 | None | 1.33A | 5tiwB-5c0nL:undetectable | 5tiwB-5c0nL:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c77 | PROTEIN ARGININEN-METHYLTRANSFERASESFM1 (Saccharomycescerevisiae) |
PF04252(RNA_Me_trans) | 5 | ILE A 5LEU A 82ILE A 65LEU A 37THR A 58 | None | 1.26A | 5tiwB-5c77A:undetectable | 5tiwB-5c77A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cb5 | O-ACETYL-ADP-RIBOSEDEACETYLASE (Escherichiacoli) |
no annotation | 5 | PRO R 151ILE R 67LEU R 105VAL R 116ILE R 20 | None | 1.05A | 5tiwB-5cb5R:undetectable | 5tiwB-5cb5R:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gjw | VOLTAGE-DEPENDENTCALCIUM CHANNELSUBUNITALPHA-2/DELTA-1 (Oryctolaguscuniculus) |
PF00092(VWA)PF08399(VWA_N)PF08473(VGCC_alpha2) | 5 | PRO F 435ILE F 359PHE F 387LEU F 285THR F 284 | None | 1.28A | 5tiwB-5gjwF:undetectable | 5tiwB-5gjwF:13.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h64 | SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08771(FRB_dom)PF11865(DUF3385) | 5 | ILE A1118LEU A1136ILE A1155PHE A1122LEU A1111 | None | 1.33A | 5tiwB-5h64A:undetectable | 5tiwB-5h64A:6.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8y | SULFITE REDUCTASE[FERREDOXIN],CHLOROPLASTIC (Zea mays) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | PRO A 274MET A 372ILE A 373ILE A 296PHE A 381 | None | 1.22A | 5tiwB-5h8yA:undetectable | 5tiwB-5h8yA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 5 | ILE A 183LEU A 357VAL A 334ILE A 106PHE A 331 | None | 1.13A | 5tiwB-5laeA:undetectable | 5tiwB-5laeA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n47 | FIBRONECTIN (Homo sapiens) |
no annotation | 5 | ILE B1336VAL B1276ILE B1278SER B1274LEU B1328 | None | 1.32A | 5tiwB-5n47B:undetectable | 5tiwB-5n47B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nst | LIGHT CHAIN OFANTIBODY MGD21HEAVY CHAIN OFANTIBODY MGD21 (Homo sapiens;Homo sapiens) |
PF07654(C1-set)PF07686(V-set)PF07654(C1-set)PF07686(V-set)PF13895(Ig_2) | 5 | PRO A 113MET A 175VAL A 115ILE A 117LEU B 261 | None | 1.29A | 5tiwB-5nstA:undetectable | 5tiwB-5nstA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td3 | CATECHOL1,2-DIOXYGENASE (Burkholderiavietnamiensis) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | MET A 99ASP A 96LEU A 95ASP A 309THR A 241 | NoneNoneNoneEDO A 406 (-3.6A)EDO A 406 (-3.7A) | 1.26A | 5tiwB-5td3A:undetectable | 5tiwB-5td3A:20.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 10 | MET A 53ILE A 57ASP A 100VAL A 137ILE A 149ASP A 153PHE A 162SER A 166LEU A 245THR A 246 | OAQ A 302 (-4.5A)OAQ A 302 ( 4.9A)OAQ A 302 (-2.5A)OAQ A 302 (-4.0A)OAQ A 302 ( 4.4A)OAQ A 302 (-3.1A)OAQ A 302 (-4.6A)OAQ A 302 (-3.5A)OAQ A 302 ( 4.4A)OAQ A 302 (-3.5A) | 0.56A | 5tiwB-5tiwA:43.0 | 5tiwB-5tiwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 5 | PRO A 31ASP A 100LEU A 101SER A 169LEU A 156 | OAQ A 302 (-4.7A)OAQ A 302 (-2.5A)OAQ A 302 ( 4.1A)NoneNone | 1.30A | 5tiwB-5tiwA:43.0 | 5tiwB-5tiwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 5 | PRO A 31ILE A 56ASP A 100LEU A 101SER A 169 | OAQ A 302 (-4.7A)NoneOAQ A 302 (-2.5A)OAQ A 302 ( 4.1A)None | 1.19A | 5tiwB-5tiwA:43.0 | 5tiwB-5tiwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 5 | PRO A 31LEU A 170VAL A 137ILE A 149LEU A 156 | OAQ A 302 (-4.7A)NoneOAQ A 302 (-4.0A)OAQ A 302 ( 4.4A)None | 1.33A | 5tiwB-5tiwA:43.0 | 5tiwB-5tiwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 11 | PRO A 31MET A 53ILE A 57ASP A 100LEU A 101VAL A 137ILE A 149ASP A 153PHE A 162LEU A 245THR A 246 | OAQ A 302 (-4.7A)OAQ A 302 (-4.5A)OAQ A 302 ( 4.9A)OAQ A 302 (-2.5A)OAQ A 302 ( 4.1A)OAQ A 302 (-4.0A)OAQ A 302 ( 4.4A)OAQ A 302 (-3.1A)OAQ A 302 (-4.6A)OAQ A 302 ( 4.4A)OAQ A 302 (-3.5A) | 0.32A | 5tiwB-5tiwA:43.0 | 5tiwB-5tiwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 5 | PRO A 31MET A 53ILE A 57LEU A 101LEU A 265 | OAQ A 302 (-4.7A)OAQ A 302 (-4.5A)OAQ A 302 ( 4.9A)OAQ A 302 ( 4.1A)None | 1.31A | 5tiwB-5tiwA:43.0 | 5tiwB-5tiwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiz | SULFOTRANSFERASE (Schistosomajaponicum) |
no annotation | 5 | PRO A 16ASP A 87LEU A 88SER A 156LEU A 143 | None | 1.22A | 5tiwB-5tizA:35.7 | 5tiwB-5tizA:61.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiz | SULFOTRANSFERASE (Schistosomajaponicum) |
no annotation | 5 | PRO A 16MET A 38ASP A 87LEU A 88SER A 156 | None | 1.17A | 5tiwB-5tizA:35.7 | 5tiwB-5tizA:61.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiz | SULFOTRANSFERASE (Schistosomajaponicum) |
no annotation | 8 | PRO A 16MET A 38ILE A 42ASP A 87LEU A 88VAL A 124LEU A 232THR A 233 | None | 0.66A | 5tiwB-5tizA:35.7 | 5tiwB-5tizA:61.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiz | SULFOTRANSFERASE (Schistosomajaponicum) |
no annotation | 8 | PRO A 16MET A 38ILE A 42ASP A 87LEU A 88VAL A 124PHE A 149THR A 233 | None | 0.67A | 5tiwB-5tizA:35.7 | 5tiwB-5tizA:61.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tp4 | AMIDASE,HYDANTOINASE/CARBAMOYLASE FAMILY (Burkholderiaambifaria) |
PF01546(Peptidase_M20) | 5 | ILE A 81VAL A 399ILE A 7LEU A 110THR A 109 | None | 1.18A | 5tiwB-5tp4A:undetectable | 5tiwB-5tp4A:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uam | ULVAN LYASE-PL25 (Pseudoalteromonassp. PLSV) |
PF15892(BNR_4) | 5 | MET A 194ILE A 192ASP A 195ILE A 258THR A 333 | None | 1.30A | 5tiwB-5uamA:undetectable | 5tiwB-5uamA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veh | KYNURENINEAMINOTRANSFERASE (Aedes aegypti) |
no annotation | 5 | PRO A 270ILE A 250LEU A 273ILE A 188THR A 190 | None | 1.30A | 5tiwB-5vehA:undetectable | 5tiwB-5vehA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjd | CG8481, ISOFORM B (Drosophilamelanogaster) |
no annotation | 5 | ILE A 104VAL A 16ILE A 18LEU A 31THR A 28 | None | 1.30A | 5tiwB-5wjdA:undetectable | 5tiwB-5wjdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wvb | CHITINASE (Ostriniafurnacalis) |
no annotation | 5 | PRO A 452MET A 457ILE A 95LEU A 453ILE A 117 | None | 1.17A | 5tiwB-5wvbA:undetectable | 5tiwB-5wvbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y5a | KLLA0F20702P (Kluyveromyceslactis) |
no annotation | 5 | PRO A 526ILE A 322ILE A 379PHE A 427THR A 277 | None | 1.25A | 5tiwB-5y5aA:undetectable | 5tiwB-5y5aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b5f | NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Yersiniaenterocolitica) |
no annotation | 5 | MET A 49LEU A 46VAL A 168LEU A 159THR A 158 | None | 1.07A | 5tiwB-6b5fA:undetectable | 5tiwB-6b5fA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c90 | EXOSOME RNA HELICASEMTR4,EXOSOME RNAHELICASE MTR4 (Homo sapiens) |
no annotation | 5 | ILE A 186LEU A 211SER A 195LEU A 236THR A 269 | None | 1.18A | 5tiwB-6c90A:undetectable | 5tiwB-6c90A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6q | EXOSOME RNA HELICASEMTR4 (Homo sapiens) |
no annotation | 5 | ILE M 186LEU M 211SER M 195LEU M 236THR M 269 | None | 1.05A | 5tiwB-6d6qM:undetectable | 5tiwB-6d6qM:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f0k | POLYSULPHIDEREDUCTASE NRFD (Rhodothermusmarinus) |
no annotation | 5 | ILE C 398ILE C 266PHE C 271SER C 251THR C 325 | None | 1.24A | 5tiwB-6f0kC:undetectable | 5tiwB-6f0kC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH DEHYDROGENASE[UBIQUINONE]FLAVOPROTEIN 1,MITOCHONDRIAL (Mus musculus) |
no annotation | 5 | MET F 60ILE F 56LEU F 65VAL F 230THR F 45 | None | 1.18A | 5tiwB-6g2jF:undetectable | 5tiwB-6g2jF:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN3NADH-UBIQUINONEOXIDOREDUCTASE CHAIN1 (Mus musculus;Mus musculus) |
no annotationno annotation | 5 | PRO A 76ILE A 69ILE H 149LEU H 298THR H 297 | None | 0.89A | 5tiwB-6g72A:undetectable | 5tiwB-6g72A:undetectable |