SIMILAR PATTERNS OF AMINO ACIDS FOR 5TIW_B_OAQB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
5 PRO A 105
ILE A  95
LEU A 108
LEU A  48
THR A  45
None
1.25A 5tiwB-1j3eA:
undetectable
5tiwB-1j3eA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
5 ASP A 108
ILE A  48
PHE A  52
SER A 237
LEU A  96
None
1.29A 5tiwB-1kk0A:
1.2
5tiwB-1kk0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
5 PRO A 170
ILE A 160
LEU A 173
LEU A 113
THR A 110
None
1.20A 5tiwB-1lrrA:
undetectable
5tiwB-1lrrA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE


(Neurospora
crassa)
PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase)
5 LEU A 178
VAL A 665
ILE A 649
SER A 654
THR A 647
None
1.27A 5tiwB-1mhsA:
undetectable
5tiwB-1mhsA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE


(Sulfolobus
acidocaldarius)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ILE A 140
VAL A 214
PHE A 144
SER A 254
LEU A 171
None
1.20A 5tiwB-1pg5A:
2.0
5tiwB-1pg5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE


(Methanopyrus
kandleri)
PF02289
(MCH)
5 PRO A  10
MET A  15
ILE A  36
LEU A  11
THR A  33
None
1.21A 5tiwB-1qlmA:
undetectable
5tiwB-1qlmA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)


(Rhinovirus A)
PF00073
(Rhv)
5 MET 1 169
ILE 1 171
ILE 1 239
PHE 1 182
THR 1 237
None
1.05A 5tiwB-1r1a1:
undetectable
5tiwB-1r1a1:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL


(Rattus
norvegicus)
PF01323
(DSBA)
5 ILE A 125
ASP A  13
LEU A  44
ILE A  70
PHE A  87
None
None
GSH  A 301 ( 4.9A)
None
None
1.29A 5tiwB-1r4wA:
1.8
5tiwB-1r4wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans)
PF03598
(CdhC)
5 ILE A 387
LEU A 480
VAL A 390
ILE A 410
THR A 414
None
1.29A 5tiwB-1ru3A:
2.1
5tiwB-1ru3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1


(Saccharomyces
cerevisiae)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
5 MET A 184
LEU A 180
VAL A 192
ILE A 232
THR A 266
None
1.29A 5tiwB-1ry2A:
undetectable
5tiwB-1ry2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv1 CIRCADIAN CLOCK
PROTEIN KAIA


(Thermosynechococcus
elongatus)
PF07688
(KaiA)
5 ILE A  59
LEU A  13
ILE A  24
LEU A  88
THR A  87
None
1.13A 5tiwB-1sv1A:
undetectable
5tiwB-1sv1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT


(Thermus
thermophilus)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 PRO B 309
ILE B 290
ILE B 208
LEU B 205
THR B 206
None
1.20A 5tiwB-1umbB:
undetectable
5tiwB-1umbB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus)
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
5 PRO A  46
VAL A 104
ILE A 241
LEU A 250
THR A 246
None
1.20A 5tiwB-1w9xA:
undetectable
5tiwB-1w9xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ASP A 121
LEU A 119
VAL A 148
ILE A   5
THR A   3
None
1.24A 5tiwB-1xdiA:
undetectable
5tiwB-1xdiA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE


(Pyrococcus
furiosus)
PF00155
(Aminotran_1_2)
5 PRO A 220
ILE A 194
LEU A 188
VAL A 172
THR A 167
None
1.26A 5tiwB-1xi9A:
undetectable
5tiwB-1xi9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo7 REGULATORY PROTEIN
ROP


(Escherichia
coli)
PF01815
(Rop)
5 ILE A  68
LEU A  53
ILE A  15
LEU A 111
THR A 107
None
1.32A 5tiwB-1yo7A:
undetectable
5tiwB-1yo7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Staphylococcus
aureus)
PF00475
(IGPD)
5 LEU A 131
ILE A 149
PHE A 165
LEU A 145
THR A 147
None
1.31A 5tiwB-2ae8A:
undetectable
5tiwB-2ae8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus)
PF07652
(Flavi_DEAD)
5 PRO A 176
ILE A 182
ILE A 282
LEU A 216
THR A 218
None
1.22A 5tiwB-2bmfA:
undetectable
5tiwB-2bmfA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria))
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
5 PRO A  46
VAL A 104
ILE A 241
LEU A 250
THR A 246
None
1.24A 5tiwB-2dieA:
undetectable
5tiwB-2dieA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE


(Candida
albicans)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
5 ILE A 436
VAL A 248
ILE A 219
PHE A 289
LEU A 240
None
1.17A 5tiwB-2dkdA:
undetectable
5tiwB-2dkdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7g DNA TOPOISOMERASE 1

(Variola virus)
PF01028
(Topoisom_I)
PF09266
(VirDNA-topo-I_N)
5 MET X 121
ILE X  98
LEU X 117
PHE X 215
SER X 211
None
1.25A 5tiwB-2h7gX:
undetectable
5tiwB-2h7gX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
5 ILE A 470
ASP A 514
ILE A 355
SER A 266
LEU A 332
None
1.26A 5tiwB-2hjhA:
undetectable
5tiwB-2hjhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lab BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa)
PF03423
(CBM_25)
5 MET A 566
ILE A 549
ILE A 626
PHE A 591
LEU A 587
None
1.17A 5tiwB-2labA:
undetectable
5tiwB-2labA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzj UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1


(Mus musculus)
PF16190
(E1_FCCH)
5 MET A 265
ILE A 277
PHE A 250
LEU A 270
THR A 274
None
1.29A 5tiwB-2lzjA:
undetectable
5tiwB-2lzjA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4


(Homo sapiens)
PF16367
(RRM_7)
5 PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
None
1.28A 5tiwB-2mkiA:
undetectable
5tiwB-2mkiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)


(Candida
albicans)
PF01380
(SIS)
5 ILE A 636
LEU A 571
ILE A 649
LEU A 628
THR A 624
None
1.22A 5tiwB-2putA:
undetectable
5tiwB-2putA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnd FMR1 PROTEIN

(Homo sapiens)
PF00013
(KH_1)
5 ILE A  92
ASP A 137
VAL A  73
ILE A 103
PHE A 122
None
1.33A 5tiwB-2qndA:
undetectable
5tiwB-2qndA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE


(Thermoproteus
tenax)
PF00701
(DHDPS)
5 ASP A 248
LEU A 247
VAL A 202
SER A 217
THR A 182
None
1.17A 5tiwB-2r94A:
undetectable
5tiwB-2r94A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT


(Homo sapiens)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
5 LEU A 131
VAL A 176
ILE A 178
LEU A 205
THR A 204
None
1.27A 5tiwB-2wghA:
undetectable
5tiwB-2wghA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens)
PF00150
(Cellulase)
5 PRO A 183
ILE A 122
ASP A 182
LEU A 184
ILE A 107
None
1.10A 5tiwB-2whlA:
undetectable
5tiwB-2whlA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE


(Pyrococcus
horikoshii)
PF01177
(Asp_Glu_race)
5 PRO A 197
ILE A 102
ASP A 211
LEU A 191
THR A  10
None
1.31A 5tiwB-2zskA:
undetectable
5tiwB-2zskA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE


(Micrococcus
luteus)
PF00348
(polyprenyl_synt)
5 ILE B 123
LEU B  66
ILE B 134
SER B 185
THR B 138
None
1.19A 5tiwB-3aqcB:
undetectable
5tiwB-3aqcB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE


(Micrococcus
luteus)
PF00348
(polyprenyl_synt)
5 ILE B 123
LEU B  66
PHE B 131
SER B 185
THR B 138
None
1.27A 5tiwB-3aqcB:
undetectable
5tiwB-3aqcB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans)
PF00149
(Metallophos)
5 PRO A 409
ILE A 385
ILE A 369
LEU A 373
THR A 372
None
1.27A 5tiwB-3c9fA:
undetectable
5tiwB-3c9fA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Bacillus
halodurans)
PF01266
(DAO)
PF16901
(DAO_C)
5 PRO A 105
LEU A 151
VAL A 268
ILE A 282
PHE A 262
None
1.26A 5tiwB-3da1A:
undetectable
5tiwB-3da1A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima)
PF02230
(Abhydrolase_2)
5 PRO A 234
ILE A 280
LEU A 195
VAL A 262
PHE A 303
None
1.31A 5tiwB-3dohA:
undetectable
5tiwB-3dohA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3


(Campylobacter
jejuni)
PF13531
(SBP_bac_11)
5 ILE A 187
LEU A 209
ILE A 114
PHE A 160
THR A 106
None
1.20A 5tiwB-3fj7A:
2.1
5tiwB-3fj7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME


(Corynebacterium
glutamicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 PRO A 177
ILE A 199
ASP A 180
ILE A 240
THR A 244
PRO  A 177 ( 1.1A)
ILE  A 199 ( 0.4A)
ASP  A 180 ( 0.5A)
ILE  A 240 ( 0.6A)
THR  A 244 ( 0.8A)
1.27A 5tiwB-3i4kA:
undetectable
5tiwB-3i4kA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE


(Rhodopseudomonas
palustris)
PF00501
(AMP-binding)
5 LEU A 223
ILE A  74
PHE A  26
SER A 230
LEU A  79
None
1.08A 5tiwB-3ivrA:
undetectable
5tiwB-3ivrA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5)
PF00150
(Cellulase)
5 PRO A 214
ILE A 153
ASP A 213
LEU A 215
ILE A 138
None
1.30A 5tiwB-3jugA:
undetectable
5tiwB-3jugA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 PRO A 251
ILE A 143
LEU A 250
ILE A 161
PHE A 140
None
1.17A 5tiwB-3mn3A:
undetectable
5tiwB-3mn3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyf D-ARGININE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF01266
(DAO)
5 ILE A1145
ILE A1013
PHE A1069
SER A1065
THR A1042
None
FAD  A1500 (-4.8A)
None
None
FAD  A1500 (-3.5A)
1.22A 5tiwB-3nyfA:
undetectable
5tiwB-3nyfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY


(Bacteroides
ovatus)
PF09992
(NAGPA)
5 PRO A  33
ILE A  78
ASP A  53
VAL A  42
THR A 256
EDO  A 403 ( 4.9A)
None
None
EDO  A 403 ( 4.8A)
None
1.31A 5tiwB-3ohgA:
undetectable
5tiwB-3ohgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rft URONATE
DEHYDROGENASE


(Agrobacterium
fabrum)
PF01370
(Epimerase)
5 PRO A 201
ILE A 189
ILE A  68
LEU A  71
THR A   9
None
1.10A 5tiwB-3rftA:
2.1
5tiwB-3rftA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
5 ILE L 283
LEU L 128
VAL L 203
ASP L 279
LEU L 147
None
1.06A 5tiwB-3rgwL:
undetectable
5tiwB-3rgwL:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Shewanella
pealeana)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 367
VAL A  30
ILE A 307
LEU A 334
THR A 305
None
1.25A 5tiwB-3sjnA:
undetectable
5tiwB-3sjnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3son HYPOTHETICAL NUDIX
HYDROLASE


(Listeria
monocytogenes)
PF00293
(NUDIX)
5 ILE A  10
LEU A 123
VAL A 115
ILE A  13
LEU A 140
None
1.15A 5tiwB-3sonA:
undetectable
5tiwB-3sonA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 ILE A  82
LEU A  27
VAL A  12
ILE A  87
THR A 119
None
1.33A 5tiwB-3vc7A:
undetectable
5tiwB-3vc7A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5)
PF00544
(Pec_lyase_C)
5 ILE A  31
ILE A  84
PHE A  92
LEU A  48
THR A  49
None
1.31A 5tiwB-3vmwA:
undetectable
5tiwB-3vmwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF01423
(LSM)
PF01423
(LSM)
5 PRO A  75
ILE C  46
LEU C  85
VAL C  87
THR C  92
None
1.28A 5tiwB-4emkA:
undetectable
5tiwB-4emkA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09455
(Cas_DxTHG)
5 ILE A 434
LEU A 473
ILE A 347
PHE A 253
SER A 247
None
1.29A 5tiwB-4eogA:
undetectable
5tiwB-4eogA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL


(Homo sapiens)
PF00067
(p450)
5 PRO A  77
LEU A  93
ILE A 397
LEU A 402
THR A 401
None
1.05A 5tiwB-4fdhA:
undetectable
5tiwB-4fdhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1


(Bacteroides
thetaiotaomicron)
PF00328
(His_Phos_2)
5 ILE A 252
ILE A 246
PHE A  63
SER A 112
LEU A 256
None
1.30A 5tiwB-4fduA:
undetectable
5tiwB-4fduA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz2 TRNA INTRON
ENDONUCLEASE


(Candidatus
Micrarchaeum
acidiphilum)
PF01974
(tRNA_int_endo)
5 LEU A 256
ILE A 173
ASP A 172
LEU A 179
THR A 176
None
1.32A 5tiwB-4fz2A:
undetectable
5tiwB-4fz2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gps KLLA0E02245P

(Kluyveromyces
lactis)
no annotation 5 PRO A 302
ILE A 165
LEU A 301
VAL A 245
THR A 157
None
1.31A 5tiwB-4gpsA:
undetectable
5tiwB-4gpsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h20 HEAVY CHAIN OF FAB
FRAGMENT FROM THE
ANTI-RICIN
MONOCLONAL ANTIBODY
RAC18


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ILE H 199
LEU H 158
VAL H 169
SER H 185
THR H 190
None
1.33A 5tiwB-4h20H:
undetectable
5tiwB-4h20H:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN


(Streptococcus
mutans)
PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c)
5 ILE A 176
ASP A 145
LEU A 143
LEU A 191
THR A 110
None
1.32A 5tiwB-4i5sA:
undetectable
5tiwB-4i5sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
REGULATORY PROTEIN
SIR4


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
PF16991
(SIR4_SID)
5 PRO A 211
ILE C 832
ASP A 210
LEU A 212
ILE A 114
None
1.27A 5tiwB-4iaoA:
undetectable
5tiwB-4iaoA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB HEAVY CHAIN
FAB LIGHT CHAIN


(Homo sapiens;
Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
5 PRO L 113
MET L 175
VAL L 115
ILE L 117
LEU H 124
None
1.29A 5tiwB-4idjL:
undetectable
5tiwB-4idjL:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkj TRANSCOBALAMIN-1

(Homo sapiens)
PF01122
(Cobalamin_bind)
PF14478
(DUF4430)
5 ILE A   2
ASP A 278
LEU A 277
LEU A 246
THR A 245
None
1.18A 5tiwB-4kkjA:
undetectable
5tiwB-4kkjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE


(Coxiella
burnetii)
PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 ILE A  94
VAL A  43
ILE A 113
LEU A  39
THR A 115
None
0.99A 5tiwB-4nbqA:
undetectable
5tiwB-4nbqA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9l LIMONENE-1,2-EPOXIDE
HYDROLASE


(Rhodococcus
erythropolis)
PF07858
(LEH)
5 ASP A  33
LEU A  29
VAL A  85
ASP A 132
LEU A 103
None
None
None
HYH  A 201 (-4.2A)
HYH  A 201 ( 4.5A)
1.22A 5tiwB-4r9lA:
undetectable
5tiwB-4r9lA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rct RESTRICTION
ENDONUCLEASE
R.NGOVII


(Neisseria
gonorrhoeae)
PF09565
(RE_NgoFVII)
5 ILE A 297
ASP A 268
SER A 179
LEU A 318
THR A 317
None
1.30A 5tiwB-4rctA:
undetectable
5tiwB-4rctA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlr CYTOCHROME C, 1
HEME-BINDING SITE


(Geobacter
sulfurreducens)
no annotation 5 ILE A   9
ASP A  14
ILE A  55
LEU A  66
THR A  58
None
None
None
HEM  A 201 ( 4.8A)
None
1.27A 5tiwB-4rlrA:
undetectable
5tiwB-4rlrA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wip SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2


(Homo sapiens)
PF00778
(DIX)
5 ILE A  71
LEU A  89
ILE A  38
PHE A  57
SER A  87
None
1.32A 5tiwB-4wipA:
undetectable
5tiwB-4wipA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB HEAVY CHAIN
S4B6 FAB LIGHT CHAIN


(Mus musculus;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
5 PRO L 116
MET L 178
VAL L 118
ILE L 120
LEU H 137
None
1.30A 5tiwB-4yueL:
undetectable
5tiwB-4yueL:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywl CELL DIVISION
CONTROL PROTEIN 21


(Pyrococcus
furiosus)
PF14551
(MCM_N)
PF17207
(MCM_OB)
5 PRO A 217
ILE A 249
LEU A 216
VAL A 125
LEU A 244
None
1.09A 5tiwB-4ywlA:
undetectable
5tiwB-4ywlA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni)
no annotation 11 PRO A  16
MET A  38
ILE A  42
ASP A  91
LEU A  92
VAL A 128
ILE A 140
ASP A 144
PHE A 153
LEU A 236
THR A 237
OAQ  A 302 (-4.4A)
OAQ  A 302 (-4.3A)
None
OAQ  A 302 (-2.7A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-4.0A)
None
OAQ  A 302 (-3.3A)
OAQ  A 302 ( 4.8A)
None
OAQ  A 302 (-3.8A)
0.41A 5tiwB-5bykA:
39.2
5tiwB-5bykA:
75.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 HEAVY CHAIN
FAB CA33 LIGHT CHAIN


(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
no annotation
no annotation
5 PRO L 118
MET L 180
VAL L 120
ILE L 122
LEU H 131
None
1.33A 5tiwB-5c0nL:
undetectable
5tiwB-5c0nL:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1


(Saccharomyces
cerevisiae)
PF04252
(RNA_Me_trans)
5 ILE A   5
LEU A  82
ILE A  65
LEU A  37
THR A  58
None
1.26A 5tiwB-5c77A:
undetectable
5tiwB-5c77A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb5 O-ACETYL-ADP-RIBOSE
DEACETYLASE


(Escherichia
coli)
no annotation 5 PRO R 151
ILE R  67
LEU R 105
VAL R 116
ILE R  20
None
1.05A 5tiwB-5cb5R:
undetectable
5tiwB-5cb5R:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1


(Oryctolagus
cuniculus)
PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2)
5 PRO F 435
ILE F 359
PHE F 387
LEU F 285
THR F 284
None
1.28A 5tiwB-5gjwF:
undetectable
5tiwB-5gjwF:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385)
5 ILE A1118
LEU A1136
ILE A1155
PHE A1122
LEU A1111
None
1.33A 5tiwB-5h64A:
undetectable
5tiwB-5h64A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC


(Zea mays)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 PRO A 274
MET A 372
ILE A 373
ILE A 296
PHE A 381
None
1.22A 5tiwB-5h8yA:
undetectable
5tiwB-5h8yA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE


(Mus musculus)
PF01593
(Amino_oxidase)
5 ILE A 183
LEU A 357
VAL A 334
ILE A 106
PHE A 331
None
1.13A 5tiwB-5laeA:
undetectable
5tiwB-5laeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n47 FIBRONECTIN

(Homo sapiens)
no annotation 5 ILE B1336
VAL B1276
ILE B1278
SER B1274
LEU B1328
None
1.32A 5tiwB-5n47B:
undetectable
5tiwB-5n47B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nst LIGHT CHAIN OF
ANTIBODY MGD21
HEAVY CHAIN OF
ANTIBODY MGD21


(Homo sapiens;
Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
PF13895
(Ig_2)
5 PRO A 113
MET A 175
VAL A 115
ILE A 117
LEU B 261
None
1.29A 5tiwB-5nstA:
undetectable
5tiwB-5nstA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE


(Burkholderia
vietnamiensis)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
5 MET A  99
ASP A  96
LEU A  95
ASP A 309
THR A 241
None
None
None
EDO  A 406 (-3.6A)
EDO  A 406 (-3.7A)
1.26A 5tiwB-5td3A:
undetectable
5tiwB-5td3A:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium)
no annotation 10 MET A  53
ILE A  57
ASP A 100
VAL A 137
ILE A 149
ASP A 153
PHE A 162
SER A 166
LEU A 245
THR A 246
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 (-2.5A)
OAQ  A 302 (-4.0A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.1A)
OAQ  A 302 (-4.6A)
OAQ  A 302 (-3.5A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.5A)
0.56A 5tiwB-5tiwA:
43.0
5tiwB-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium)
no annotation 5 PRO A  31
ASP A 100
LEU A 101
SER A 169
LEU A 156
OAQ  A 302 (-4.7A)
OAQ  A 302 (-2.5A)
OAQ  A 302 ( 4.1A)
None
None
1.30A 5tiwB-5tiwA:
43.0
5tiwB-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium)
no annotation 5 PRO A  31
ILE A  56
ASP A 100
LEU A 101
SER A 169
OAQ  A 302 (-4.7A)
None
OAQ  A 302 (-2.5A)
OAQ  A 302 ( 4.1A)
None
1.19A 5tiwB-5tiwA:
43.0
5tiwB-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium)
no annotation 5 PRO A  31
LEU A 170
VAL A 137
ILE A 149
LEU A 156
OAQ  A 302 (-4.7A)
None
OAQ  A 302 (-4.0A)
OAQ  A 302 ( 4.4A)
None
1.33A 5tiwB-5tiwA:
43.0
5tiwB-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium)
no annotation 11 PRO A  31
MET A  53
ILE A  57
ASP A 100
LEU A 101
VAL A 137
ILE A 149
ASP A 153
PHE A 162
LEU A 245
THR A 246
OAQ  A 302 (-4.7A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 (-2.5A)
OAQ  A 302 ( 4.1A)
OAQ  A 302 (-4.0A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.1A)
OAQ  A 302 (-4.6A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.5A)
0.32A 5tiwB-5tiwA:
43.0
5tiwB-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium)
no annotation 5 PRO A  31
MET A  53
ILE A  57
LEU A 101
LEU A 265
OAQ  A 302 (-4.7A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 ( 4.1A)
None
1.31A 5tiwB-5tiwA:
43.0
5tiwB-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum)
no annotation 5 PRO A  16
ASP A  87
LEU A  88
SER A 156
LEU A 143
None
1.22A 5tiwB-5tizA:
35.7
5tiwB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum)
no annotation 5 PRO A  16
MET A  38
ASP A  87
LEU A  88
SER A 156
None
1.17A 5tiwB-5tizA:
35.7
5tiwB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum)
no annotation 8 PRO A  16
MET A  38
ILE A  42
ASP A  87
LEU A  88
VAL A 124
LEU A 232
THR A 233
None
0.66A 5tiwB-5tizA:
35.7
5tiwB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum)
no annotation 8 PRO A  16
MET A  38
ILE A  42
ASP A  87
LEU A  88
VAL A 124
PHE A 149
THR A 233
None
0.67A 5tiwB-5tizA:
35.7
5tiwB-5tizA:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY


(Burkholderia
ambifaria)
PF01546
(Peptidase_M20)
5 ILE A  81
VAL A 399
ILE A   7
LEU A 110
THR A 109
None
1.18A 5tiwB-5tp4A:
undetectable
5tiwB-5tp4A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV)
PF15892
(BNR_4)
5 MET A 194
ILE A 192
ASP A 195
ILE A 258
THR A 333
None
1.30A 5tiwB-5uamA:
undetectable
5tiwB-5uamA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE


(Aedes aegypti)
no annotation 5 PRO A 270
ILE A 250
LEU A 273
ILE A 188
THR A 190
None
1.30A 5tiwB-5vehA:
undetectable
5tiwB-5vehA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjd CG8481, ISOFORM B

(Drosophila
melanogaster)
no annotation 5 ILE A 104
VAL A  16
ILE A  18
LEU A  31
THR A  28
None
1.30A 5tiwB-5wjdA:
undetectable
5tiwB-5wjdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis)
no annotation 5 PRO A 452
MET A 457
ILE A  95
LEU A 453
ILE A 117
None
1.17A 5tiwB-5wvbA:
undetectable
5tiwB-5wvbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P

(Kluyveromyces
lactis)
no annotation 5 PRO A 526
ILE A 322
ILE A 379
PHE A 427
THR A 277
None
1.25A 5tiwB-5y5aA:
undetectable
5tiwB-5y5aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE


(Yersinia
enterocolitica)
no annotation 5 MET A  49
LEU A  46
VAL A 168
LEU A 159
THR A 158
None
1.07A 5tiwB-6b5fA:
undetectable
5tiwB-6b5fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4


(Homo sapiens)
no annotation 5 ILE A 186
LEU A 211
SER A 195
LEU A 236
THR A 269
None
1.18A 5tiwB-6c90A:
undetectable
5tiwB-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4


(Homo sapiens)
no annotation 5 ILE M 186
LEU M 211
SER M 195
LEU M 236
THR M 269
None
1.05A 5tiwB-6d6qM:
undetectable
5tiwB-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD


(Rhodothermus
marinus)
no annotation 5 ILE C 398
ILE C 266
PHE C 271
SER C 251
THR C 325
None
1.24A 5tiwB-6f0kC:
undetectable
5tiwB-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL


(Mus musculus)
no annotation 5 MET F  60
ILE F  56
LEU F  65
VAL F 230
THR F  45
None
1.18A 5tiwB-6g2jF:
undetectable
5tiwB-6g2jF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1


(Mus musculus;
Mus musculus)
no annotation
no annotation
5 PRO A  76
ILE A  69
ILE H 149
LEU H 298
THR H 297
None
0.89A 5tiwB-6g72A:
undetectable
5tiwB-6g72A:
undetectable