SIMILAR PATTERNS OF AMINO ACIDS FOR 5TIW_A_OAQA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 TYR A  94
ASP A  93
ASP A 231
SER A  35
 None
 1.42A 5tiwA-3h6eA:
0.0		 5tiwA-3h6eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 TYR A  39
ASP A 391
ASP A 259
SER A 365
 ATP  A 801 (-4.8A)
None
ATP  A 801 ( 4.9A)
ATP  A 801 (-3.8A)
 1.40A 5tiwA-5e84A:
0.0		 5tiwA-5e84A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		4 TYR A  69
ASP A  66
ASP A 161
SER A 270
 None
 1.27A 5tiwA-5ix8A:
0.0		 5tiwA-5ix8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 TYR A  39
ASP A 391
ASP A 259
SER A 365
 ADP  A 603 (-4.9A)
ADP  A 603 (-3.6A)
None
ADP  A 603 (-3.6A)
 1.31A 5tiwA-6eoeA:
0.0		 5tiwA-6eoeA:
18.57