SIMILAR PATTERNS OF AMINO ACIDS FOR 5TIW_A_OAQA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 PRO A 360
ILE A 441
ILE A 377
LEU A 338
LEU A 431
 None
 1.26A 5tiwA-1amoA:
2.0		 5tiwA-1amoA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 ILE A 220
VAL A 202
LEU A 237
LEU A 213
LEU A 235
 None
 1.28A 5tiwA-1d0bA:
undetectable		 5tiwA-1d0bA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		5 ILE A  74
LEU A  68
VAL A  46
LEU A  39
LEU A 101
 None
TRS  A2001 ( 4.7A)
CA  A 501 (-4.8A)
None
None
 1.10A 5tiwA-1fhfA:
undetectable		 5tiwA-1fhfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		5 PRO A 263
ILE A 249
LEU A 262
VAL A 289
LEU A  15
 None
 1.25A 5tiwA-1j93A:
0.4		 5tiwA-1j93A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN

(Thermotoga
maritima) 		PF01975
(SurE) 		5 PRO A  34
VAL A  31
VAL A  32
LEU A  89
LEU A  23
 None
 1.31A 5tiwA-1j9lA:
2.1		 5tiwA-1j9lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		5 LEU A 641
LEU A 465
PHE A 467
THR A 458
LEU A 457
 None
 1.30A 5tiwA-1kehA:
undetectable		 5tiwA-1kehA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  67
VAL A 128
ILE A 102
LEU A  62
LEU A  60
 None
 1.03A 5tiwA-1kkhA:
undetectable		 5tiwA-1kkhA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 305
VAL A 138
LEU A 324
LEU A 179
LEU A 146
 PLM  A 328 (-4.5A)
None
None
PLM  A 328 ( 4.6A)
None
 1.26A 5tiwA-1lv2A:
undetectable		 5tiwA-1lv2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		5 ILE A 220
VAL A 202
LEU A 237
LEU A 213
LEU A 235
 None
 1.28A 5tiwA-1m9sA:
undetectable		 5tiwA-1m9sA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1e KV CHANNEL
INTERACTING PROTEIN
1

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 MET A 158
ILE A 154
VAL A 215
LEU A  94
LEU A 133
 None
 1.21A 5tiwA-1s1eA:
undetectable		 5tiwA-1s1eA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 ILE A  84
VAL A  19
LEU A 146
THR A 143
LEU A 142
 None
 1.25A 5tiwA-1tzbA:
2.5		 5tiwA-1tzbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		5 PRO A  58
ILE A  81
LEU A  78
LEU A  91
LEU A 106
 None
 1.26A 5tiwA-1w0mA:
undetectable		 5tiwA-1w0mA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wym TRANSGELIN-2

(Homo sapiens) 		PF00307
(CH) 		5 ILE A  85
ILE A 102
LEU A 108
LEU A 121
THR A 120
 None
 1.09A 5tiwA-1wymA:
undetectable		 5tiwA-1wymA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yax VIRULENCE SENSOR
PROTEIN PHOQ, SENSOR
DOMAIN

(Salmonella
enterica) 		PF08918
(PhoQ_Sensor) 		5 LEU A  74
ILE A  70
LEU A  87
PHE A  59
LEU A  95
 None
 1.28A 5tiwA-1yaxA:
undetectable		 5tiwA-1yaxA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		5 ILE A  76
VAL A   7
LEU A 112
LEU A  17
LEU A  21
 None
 1.15A 5tiwA-1zh4A:
undetectable		 5tiwA-1zh4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		5 ILE A 158
VAL A 142
LEU A 154
LEU A 127
LEU A 123
 None
 1.18A 5tiwA-2a33A:
2.5		 5tiwA-2a33A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 PRO A 269
LEU A 642
PHE A 263
LEU A 591
LEU A 574
 None
 1.24A 5tiwA-2a3lA:
undetectable		 5tiwA-2a3lA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		5 ILE A 320
VAL A 390
ILE A 506
LEU A 331
LEU A 547
 None
 1.08A 5tiwA-2bllA:
undetectable		 5tiwA-2bllA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 ILE A 162
LEU A 276
LEU A 163
LEU A 205
LEU A 179
 None
 1.14A 5tiwA-2cdaA:
undetectable		 5tiwA-2cdaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 ILE A 325
VAL A 416
VAL A 419
LEU A 588
LEU A 592
 None
 1.19A 5tiwA-2dfsA:
undetectable		 5tiwA-2dfsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 PRO A 291
ILE A   7
VAL A 299
ILE A 303
THR A 307
 None
 1.20A 5tiwA-2e28A:
undetectable		 5tiwA-2e28A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 ILE A 294
VAL A 273
ILE A 267
LEU A 279
LEU A 264
 None
 0.86A 5tiwA-2eo5A:
undetectable		 5tiwA-2eo5A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE

(Plasmodium
falciparum) 		PF00574
(CLP_protease) 		5 PRO A 291
ILE A 237
LEU A 292
ILE A 269
LEU A 241
 None
 1.14A 5tiwA-2f6iA:
undetectable		 5tiwA-2f6iA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fin RABBITPOX ENCODED CC
CHEMOKINE INHIBITOR

(Vaccinia virus) 		PF02250
(Orthopox_35kD) 		5 ILE A  30
VAL A 144
ILE A 180
LEU A 193
THR A 183
 None
 1.21A 5tiwA-2finA:
undetectable		 5tiwA-2finA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		5 ILE A 102
ILE A  88
LEU A  63
LEU A  55
LEU A  59
 None
 1.23A 5tiwA-2h4uA:
undetectable		 5tiwA-2h4uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL A 117
ILE A 119
LEU A  72
LEU A  61
LEU A  63
 None
 1.28A 5tiwA-2hr7A:
undetectable		 5tiwA-2hr7A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Homo sapiens) 		PF14580
(LRR_9) 		5 ILE A 100
VAL A 135
LEU A  95
LEU A 109
LEU A  93
 None
 1.18A 5tiwA-2je1A:
undetectable		 5tiwA-2je1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A1139
LEU A1156
ILE A1403
LEU A1132
LEU A1408
 None
 1.29A 5tiwA-2nlkA:
undetectable		 5tiwA-2nlkA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 ILE A  34
VAL A  67
LEU A  36
PHE A   8
LEU A   3
 None
 1.31A 5tiwA-2olaA:
undetectable		 5tiwA-2olaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		5 ILE A 225
ILE A 219
LEU A 193
LEU A 235
LEU A 239
 PE5  A 407 ( 4.4A)
None
None
None
None
 1.20A 5tiwA-2r09A:
undetectable		 5tiwA-2r09A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbi RIBONUCLEASE

(Bacillus
intermedius) 		PF00545
(Ribonuclease) 		5 ILE A  75
VAL A   2
LEU A  87
LEU A  19
LEU A  13
 None
 1.23A 5tiwA-2rbiA:
undetectable		 5tiwA-2rbiA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 ILE A 220
LEU A 215
PHE A 311
LEU A 204
LEU A 213
 None
 0.99A 5tiwA-2wqwA:
undetectable		 5tiwA-2wqwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wws COAT PROTEIN

(Physalis mottle
virus) 		PF00983
(Tymo_coat) 		5 ILE A  60
LEU A 154
LEU A  63
PHE A  38
LEU A  34
 None
 0.89A 5tiwA-2wwsA:
undetectable		 5tiwA-2wwsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdh COHESIN

(Archaeoglobus
fulgidus) 		PF00963
(Cohesin) 		5 ILE A  36
VAL A 143
LEU A  38
THR A 147
LEU A 130
 None
 1.03A 5tiwA-2xdhA:
undetectable		 5tiwA-2xdhA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 VAL A 340
ILE A 337
LEU A 329
THR A 365
LEU A 364
 None
 1.16A 5tiwA-2xtsA:
undetectable		 5tiwA-2xtsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5q INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 ILE A 220
VAL A 202
LEU A 237
LEU A 213
LEU A 235
 None
 1.29A 5tiwA-2y5qA:
undetectable		 5tiwA-2y5qA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 LEU A  88
LEU A 113
PHE A  97
LEU A 124
LEU A 221
 None
 1.29A 5tiwA-2yysA:
undetectable		 5tiwA-2yysA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 LEU A 851
ILE A 883
LEU A 923
PHE A 877
LEU A 965
 None
 1.13A 5tiwA-3a6pA:
undetectable		 5tiwA-3a6pA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq7 GROUP 1 TRUNCATED
HEMOGLOBIN

(Tetrahymena
pyriformis) 		PF01152
(Bac_globin) 		5 ILE A  87
LEU A  81
VAL A  28
THR A  93
LEU A  94
 None
 1.29A 5tiwA-3aq7A:
undetectable		 5tiwA-3aq7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PRO A   8
ILE A 112
VAL A 152
VAL A 151
LEU A 160
 None
 0.86A 5tiwA-3d46A:
undetectable		 5tiwA-3d46A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e98 GAF DOMAIN OF
UNKNOWN FUNCTION

(Pseudomonas
aeruginosa) 		PF04340
(DUF484) 		5 VAL A 181
VAL A 180
LEU A 123
LEU A 218
LEU A 222
 None
EDO  A 236 ( 4.8A)
None
None
None
 1.12A 5tiwA-3e98A:
undetectable		 5tiwA-3e98A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		5 MET B 178
LEU B 180
VAL B 356
LEU B 383
LEU B 410
 None
 0.95A 5tiwA-3egwB:
undetectable		 5tiwA-3egwB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikb UNCHARACTERIZED
CONSERVED PROTEIN

(Streptococcus
mutans) 		PF03167
(UDG) 		5 ILE A 123
VAL A 180
VAL A 181
LEU A 121
LEU A 153
 None
 1.26A 5tiwA-3ikbA:
undetectable		 5tiwA-3ikbA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		5 ILE A2153
ILE A2228
LEU A2174
LEU A2016
LEU A2172
 None
 1.04A 5tiwA-3jbzA:
undetectable		 5tiwA-3jbzA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		5 ILE A 276
LEU A 268
ILE A 234
LEU A 280
LEU A  54
 None
 1.03A 5tiwA-3na8A:
undetectable		 5tiwA-3na8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 ILE A 256
LEU A 214
LEU A 286
LEU A 310
LEU A 290
 None
 1.17A 5tiwA-3nowA:
undetectable		 5tiwA-3nowA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 MET A 393
ILE A 395
VAL A 420
LEU A 397
LEU A 448
 None
 1.25A 5tiwA-3pigA:
undetectable		 5tiwA-3pigA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 PRO A 363
ILE A 444
ILE A 380
LEU A 341
LEU A 434
 None
 1.20A 5tiwA-3qfsA:
undetectable		 5tiwA-3qfsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		5 ILE A 217
LEU A 260
LEU A 214
THR A 174
LEU A 177
 None
 1.25A 5tiwA-3qokA:
undetectable		 5tiwA-3qokA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp8 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		5 ILE A  47
LEU A  48
LEU A 178
THR A 175
LEU A 154
 None
 1.22A 5tiwA-3qp8A:
undetectable		 5tiwA-3qp8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ILE A 218
LEU A 209
LEU A 173
THR A 140
LEU A 139
 None
 1.15A 5tiwA-3so4A:
undetectable		 5tiwA-3so4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 ILE A  50
VAL A  30
ILE A   8
THR A  19
LEU A  18
 None
 1.29A 5tiwA-3u9lA:
undetectable		 5tiwA-3u9lA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 ILE A 101
ILE A 236
LEU A  99
THR A 229
LEU A 232
 None
 0.85A 5tiwA-3vr0A:
1.7		 5tiwA-3vr0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w11 INSULIN RECEPTOR
DOMAINS L1-CR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
 None
 1.26A 5tiwA-3w11E:
undetectable		 5tiwA-3w11E:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd6 OMEGA-CLASS
GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ILE A  83
VAL A  94
LEU A  30
THR A  44
LEU A  48
 None
 1.26A 5tiwA-3wd6A:
undetectable		 5tiwA-3wd6A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		5 ILE A 275
VAL A  12
LEU A 271
LEU A  85
LEU A 242
 None
 1.31A 5tiwA-3zfcA:
undetectable		 5tiwA-3zfcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		5 LEU A 156
VAL A 146
ILE A 115
THR A 113
LEU A 112
 None
 1.29A 5tiwA-3zs7A:
undetectable		 5tiwA-3zs7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		5 MET A 230
ILE A 226
ILE A 217
LEU A 335
LEU A 260
 None
 1.18A 5tiwA-4ae0A:
undetectable		 5tiwA-4ae0A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bcx AP-1 COMPLEX SUBUNIT
GAMMA-LIKE 2

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 ILE A 696
LEU A 748
VAL A 717
LEU A 682
LEU A 759
 None
None
IMD  A1786 ( 4.8A)
None
None
 1.22A 5tiwA-4bcxA:
undetectable		 5tiwA-4bcxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 MET A 187
ILE A 219
VAL A 156
VAL A 157
LEU A  95
 None
 1.26A 5tiwA-4bkmA:
undetectable		 5tiwA-4bkmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 ILE A 532
LEU A 503
LEU A 459
LEU A 515
LEU A 463
 None
 1.29A 5tiwA-4bqhA:
undetectable		 5tiwA-4bqhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chm IMC SUB-COMPARTMENT
PROTEIN ISP1

(Toxoplasma
gondii) 		no annotation 5 ILE A 117
VAL A 168
LEU A 101
LEU A 156
LEU A  92
 None
 1.09A 5tiwA-4chmA:
undetectable		 5tiwA-4chmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		5 ILE C  43
VAL C 227
LEU C 208
THR C 240
LEU C 241
 None
 1.15A 5tiwA-4g1uC:
undetectable		 5tiwA-4g1uC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		5 ILE A 176
LEU A 143
ILE A 116
LEU A 191
THR A 110
 None
 1.26A 5tiwA-4i5sA:
undetectable		 5tiwA-4i5sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib2 PUTATIVE LIPOPROTEIN

([Ruminococcus]
gnavus) 		PF03180
(Lipoprotein_9) 		5 ILE A  51
ILE A  58
LEU A  52
LEU A 253
LEU A  66
 None
 1.19A 5tiwA-4ib2A:
undetectable		 5tiwA-4ib2A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdl ABSCISIC ACID
RECEPTOR PYL5

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		5 ILE A 134
LEU A 101
VAL A  85
LEU A 196
LEU A 193
 None
 1.05A 5tiwA-4jdlA:
undetectable		 5tiwA-4jdlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaj DISKS LARGE HOMOLOG
1

(Mus musculus) 		PF00595
(PDZ) 		5 MET A 318
ILE A 320
VAL A 350
ILE A 353
LEU A 329
 None
 1.17A 5tiwA-4oajA:
undetectable		 5tiwA-4oajA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 ILE A 285
LEU A 245
LEU A 288
LEU A 298
LEU A 291
 None
 1.23A 5tiwA-4ow2A:
undetectable		 5tiwA-4ow2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 ILE A 345
LEU A 305
LEU A 348
LEU A 358
LEU A 351
 None
 1.25A 5tiwA-4ow2A:
undetectable		 5tiwA-4ow2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 ILE A 405
LEU A 365
LEU A 408
LEU A 418
LEU A 411
 None
 1.26A 5tiwA-4ow2A:
undetectable		 5tiwA-4ow2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 5 ILE B 395
ILE B 374
LEU B 369
LEU B 172
LEU B 176
 None
 1.02A 5tiwA-4p37B:
undetectable		 5tiwA-4p37B:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 PRO A 186
VAL A  15
VAL A   8
LEU A  31
THR A  61
 None
 1.17A 5tiwA-4qwwA:
1.8		 5tiwA-4qwwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 5 MET A 385
ILE A 381
LEU A 377
LEU A 334
LEU A 321
 None
 1.16A 5tiwA-4rxxA:
undetectable		 5tiwA-4rxxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 ILE A 240
LEU A 220
LEU A 244
THR A 265
LEU A 266
 None
 1.21A 5tiwA-4uvkA:
undetectable		 5tiwA-4uvkA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 ILE A 407
ILE A 386
LEU A 381
LEU A 172
LEU A 176
 None
 0.94A 5tiwA-4wseA:
undetectable		 5tiwA-4wseA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 353
LEU A 348
VAL A 334
VAL A 333
LEU A 355
 None
 1.09A 5tiwA-4xg0A:
4.7		 5tiwA-4xg0A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 140
VAL A 177
PHE A 184
LEU A 129
LEU A 131
 None
 1.27A 5tiwA-4z64A:
undetectable		 5tiwA-4z64A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
 None
 1.28A 5tiwA-4zxbE:
undetectable		 5tiwA-4zxbE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ILE A 464
VAL A1025
ILE A 985
LEU A1032
LEU A 495
 None
 1.21A 5tiwA-5a22A:
undetectable		 5tiwA-5a22A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 546
LEU A 542
LEU A 589
LEU A 605
LEU A 618
 None
 1.28A 5tiwA-5b7iA:
undetectable		 5tiwA-5b7iA:
11.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 12 PRO A  16
MET A  38
ILE A  42
LEU A  92
VAL A 127
VAL A 128
ILE A 140
LEU A 147
PHE A 153
LEU A 236
THR A 237
LEU A 240
 OAQ  A 302 (-4.4A)
OAQ  A 302 (-4.3A)
None
OAQ  A 302 (-4.0A)
OAQ  A 302 (-4.9A)
OAQ  A 302 (-4.0A)
None
None
OAQ  A 302 ( 4.8A)
None
OAQ  A 302 (-3.8A)
None
 0.27A 5tiwA-5bykA:
39.8		 5tiwA-5bykA:
75.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		5 ILE A 133
VAL A  44
LEU A 129
LEU A  62
LEU A 152
 None
 1.31A 5tiwA-5cxuA:
undetectable		 5tiwA-5cxuA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		5 ILE A 355
ILE A 336
LEU A 522
LEU A 348
LEU A 325
 None
 1.15A 5tiwA-5ed7A:
undetectable		 5tiwA-5ed7A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 ILE D 539
LEU D 462
PHE D 378
LEU D 499
LEU D 477
 None
 1.30A 5tiwA-5exrD:
undetectable		 5tiwA-5exrD:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw9 GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Homo sapiens) 		PF16647
(GCSF) 		5 LEU A  51
ILE A  96
LEU A  90
PHE A 141
LEU A 107
 None
 1.25A 5tiwA-5gw9A:
undetectable		 5tiwA-5gw9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF11976
(Rad60-SLD)
PF14324
(PINIT) 		5 ILE A 189
VAL A 311
LEU A 211
THR A 281
LEU A 284
 None
 1.21A 5tiwA-5jneA:
undetectable		 5tiwA-5jneA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
 None
 1.29A 5tiwA-5kqvE:
undetectable		 5tiwA-5kqvE:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 LEU A 401
VAL A 414
ILE A 416
LEU A 544
LEU A 386
 None
 1.12A 5tiwA-5l3dA:
undetectable		 5tiwA-5l3dA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 LEU A 401
VAL A 415
VAL A 414
LEU A 544
LEU A 386
 None
 0.89A 5tiwA-5l3dA:
undetectable		 5tiwA-5l3dA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE B 150
LEU B 334
PHE B 362
LEU B 120
LEU B 102
 None
 1.24A 5tiwA-5l3sB:
3.6		 5tiwA-5l3sB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		5 ILE A2466
LEU A2479
VAL A2326
LEU A2350
PHE A2318
 None
 1.31A 5tiwA-5mc9A:
undetectable		 5tiwA-5mc9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 ILE A 245
ILE A 212
LEU A 219
THR A 216
LEU A 252
 None
 1.24A 5tiwA-5nckA:
undetectable		 5tiwA-5nckA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 12 PRO A  31
MET A  53
ILE A  57
LEU A 101
VAL A 136
VAL A 137
ILE A 149
LEU A 156
PHE A 162
LEU A 245
THR A 246
LEU A 249
 OAQ  A 302 (-4.7A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 ( 4.1A)
None
OAQ  A 302 (-4.0A)
OAQ  A 302 ( 4.4A)
None
OAQ  A 302 (-4.6A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.5A)
None
 0.01A 5tiwA-5tiwA:
45.7		 5tiwA-5tiwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 10 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
PHE A 149
THR A 233
LEU A 236
 None
 0.61A 5tiwA-5tizA:
35.9		 5tiwA-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 8 PRO A  16
MET A  38
LEU A  88
VAL A 123
LEU A 143
LEU A 232
THR A 233
LEU A 236
 None
 0.62A 5tiwA-5tizA:
35.9		 5tiwA-5tizA:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7w APRATAXIN AND
PNK-LIKE FACTOR

(Homo sapiens) 		no annotation 5 ILE T  54
LEU T  73
LEU T  45
LEU T   7
LEU T  18
 None
 1.25A 5tiwA-5w7wT:
undetectable		 5tiwA-5w7wT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US2
RIBOSOMAL PROTEIN
ES21

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e) 		5 PRO A 120
ILE A 146
LEU A  76
VAL A 143
LEU V  68
 None
 1.15A 5tiwA-5xxuA:
undetectable		 5tiwA-5xxuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2

(Homo sapiens) 		no annotation 5 PRO A  94
ILE A  83
LEU A  40
LEU A  56
LEU A  78
 None
 1.18A 5tiwA-6axfA:
undetectable		 5tiwA-6axfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 ILE A 225
ILE A 219
LEU A 193
LEU A 235
LEU A 239
 None
 1.20A 5tiwA-6bbpA:
3.5		 5tiwA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu9 RETINOIC ACID
RECEPTOR

(Platynereis
dumerilii) 		no annotation 5 ILE A 437
LEU A 420
ILE A 397
PHE A 430
LEU A 512
 None
 1.27A 5tiwA-6eu9A:
undetectable		 5tiwA-6eu9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 TYR A  94
ASP A  93
ASP A 231
SER A  35
 None
 1.42A 5tiwA-3h6eA:
0.0		 5tiwA-3h6eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 TYR A  39
ASP A 391
ASP A 259
SER A 365
 ATP  A 801 (-4.8A)
None
ATP  A 801 ( 4.9A)
ATP  A 801 (-3.8A)
 1.40A 5tiwA-5e84A:
0.0		 5tiwA-5e84A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		4 TYR A  69
ASP A  66
ASP A 161
SER A 270
 None
 1.27A 5tiwA-5ix8A:
0.0		 5tiwA-5ix8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 TYR A  39
ASP A 391
ASP A 259
SER A 365
 ADP  A 603 (-4.9A)
ADP  A 603 (-3.6A)
None
ADP  A 603 (-3.6A)
 1.31A 5tiwA-6eoeA:
0.0		 5tiwA-6eoeA:
18.57