SIMILAR PATTERNS OF AMINO ACIDS FOR 5TEG_B_SAMB401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 LYS A 338
GLY A 339
TYR A 381
ASN A 409
HIS A 410
 None
 1.00A 5tegB-1mvhA:
11.7
5tegE-1mvhA:
undetectable		 5tegB-1mvhA:
21.07
5tegE-1mvhA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 160
TYR A 204
ASN A 241
HIS A 242
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.35A 5tegB-1pegA:
13.1
5tegE-1pegA:
undetectable		 5tegB-1pegA:
22.70
5tegE-1pegA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 GLY A  81
LEU A 240
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
None
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.33A 5tegB-2h21A:
6.1
5tegE-2h21A:
undetectable		 5tegB-2h21A:
19.73
5tegE-2h21A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 151
TYR A 193
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.35A 5tegB-2r3aA:
12.6
5tegE-2r3aA:
undetectable		 5tegB-2r3aA:
23.78
5tegE-2r3aA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
ARG A3841
TYR A3883
ASN A3906
HIS A3907
 SAH  A4971 ( 3.7A)
None
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
 0.86A 5tegB-2w5zA:
15.7
5tegE-2w5zA:
undetectable		 5tegB-2w5zA:
30.96
5tegE-2w5zA:
4.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.69A 5tegB-2w5zA:
15.7
5tegE-2w5zA:
undetectable		 5tegB-2w5zA:
30.96
5tegE-2w5zA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 LYS A 135
GLY A 136
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 None
SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.35A 5tegB-3bo5A:
13.3
5tegE-3bo5A:
undetectable		 5tegB-3bo5A:
22.41
5tegE-3bo5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 LYS A 135
LEU A 139
ASN A 209
HIS A 210
TYR A 248
 None
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 1.46A 5tegB-3bo5A:
13.3
5tegE-3bo5A:
undetectable		 5tegB-3bo5A:
22.41
5tegE-3bo5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 227
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.89A 5tegB-3cboA:
13.0
5tegE-3cboA:
undetectable		 5tegB-3cboA:
24.80
5tegE-3cboA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		5 LEU A 230
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 None
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 1.39A 5tegB-3cboA:
13.0
5tegE-3cboA:
undetectable		 5tegB-3cboA:
24.80
5tegE-3cboA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		6 GLY A  18
ARG A  19
LEU A 203
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.9A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.51A 5tegB-3n71A:
7.8
5tegE-3n71A:
undetectable		 5tegB-3n71A:
15.04
5tegE-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		6 LYS A  17
GLY A  18
ARG A  19
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.55A 5tegB-3n71A:
7.8
5tegE-3n71A:
undetectable		 5tegB-3n71A:
15.04
5tegE-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 LYS A  17
LEU A  21
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 1.19A 5tegB-3n71A:
7.8
5tegE-3n71A:
undetectable		 5tegB-3n71A:
15.04
5tegE-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.35A 5tegB-3ooiA:
14.3
5tegE-3ooiA:
undetectable		 5tegB-3ooiA:
23.53
5tegE-3ooiA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		6 LYS A2150
GLY A2151
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.46A 5tegB-3opeA:
14.3
5tegE-3opeA:
undetectable		 5tegB-3opeA:
22.87
5tegE-3opeA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 GLY A  74
TYR A 223
ASN A 251
HIS A 252
TYR A 285
 SAM  A 484 (-3.4A)
SAM  A 484 (-3.6A)
SAM  A 484 (-3.1A)
None
SAM  A 484 (-4.8A)
 0.79A 5tegB-3rc0A:
5.1
5tegE-3rc0A:
undetectable		 5tegB-3rc0A:
15.32
5tegE-3rc0A:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		5 LYS A1560
GLY A1561
TYR A1605
ASN A1628
HIS A1629
 None
0UM  A1804 (-3.5A)
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
 0.42A 5tegB-4fmuA:
13.6
5tegE-4fmuA:
undetectable		 5tegB-4fmuA:
23.60
5tegE-4fmuA:
4.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION

(Cryptosporidium
parvum) 		PF00856
(SET) 		5 GLY A 149
TYR A 193
LEU A 220
ASN A 222
HIS A 223
 None
 0.92A 5tegB-4ldgA:
15.9
5tegE-4ldgA:
undetectable		 5tegB-4ldgA:
30.58
5tegE-4ldgA:
5.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION

(Cryptosporidium
parvum) 		PF00856
(SET) 		5 TYR A 193
LEU A 220
ASN A 222
HIS A 223
TYR A 261
 None
 1.02A 5tegB-4ldgA:
15.9
5tegE-4ldgA:
undetectable		 5tegB-4ldgA:
30.58
5tegE-4ldgA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		6 LYS A 456
GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.56A 5tegB-4qeoA:
8.9
5tegE-4qeoA:
undetectable		 5tegB-4qeoA:
16.21
5tegE-4qeoA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		5 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
 0.57A 5tegB-4z4pA:
16.0
5tegE-4z4pA:
undetectable		 5tegB-4z4pA:
28.98
5tegE-4z4pA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		5 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
 0.78A 5tegB-5f59A:
15.9
5tegE-5f59A:
undetectable		 5tegB-5f59A:
29.52
5tegE-5f59A:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
 0.54A 5tegB-5f6lA:
17.0
5tegE-5f6lA:
undetectable		 5tegB-5f6lA:
35.33
5tegE-5f6lA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		6 LYS A  17
GLY A  18
ARG A  19
ASN A 206
HIS A 207
TYR A 240
 None
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.77A 5tegB-5kjmA:
8.6
5tegE-5kjmA:
undetectable		 5tegB-5kjmA:
17.03
5tegE-5kjmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		6 LYS A  17
GLY A  18
LEU A 204
ASN A 206
HIS A 207
TYR A 240
 None
SAM  A 501 ( 4.1A)
None
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
 0.90A 5tegB-5kjmA:
8.6
5tegE-5kjmA:
undetectable		 5tegB-5kjmA:
17.03
5tegE-5kjmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1074
TYR A1118
ASN A1141
HIS A1142
TYR A1179
 SAM  A1304 ( 3.2A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.24A 5tegB-5lsuA:
13.8
5tegE-5lsuA:
undetectable		 5tegB-5lsuA:
24.15
5tegE-5lsuA:
4.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo sapiens) 		PF00856
(SET) 		9 LYS A 226
GLY A 227
ARG A 228
TYR A 271
LEU A 296
ASN A 298
HIS A 299
TYR A 336
TRP A 349
 SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.1A)
SAM  A 401 (-4.6A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
 0.14A 5tegB-5tegA:
28.0
5tegE-5tegA:
undetectable		 5tegB-5tegA:
100.00
5tegE-5tegA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1049
TYR A1085
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.23A 5tegB-5tuyA:
12.8
5tegE-5tuyA:
undetectable		 5tegB-5tuyA:
23.38
5tegE-5tuyA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1137
TYR A1173
ASN A1200
HIS A1201
TYR A1242
 SAM  A3001 (-3.6A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
 0.24A 5tegB-5vsdA:
13.8
5tegE-5vsdA:
undetectable		 5tegB-5vsdA:
23.99
5tegE-5vsdA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 GLY A  15
LEU A 203
ASN A 205
HIS A 206
TYR A 239
 SAM  A 502 ( 3.9A)
None
SAM  A 502 (-3.1A)
None
8HR  A 501 ( 4.0A)
 0.51A 5tegB-5xxgA:
7.7
5tegE-5xxgA:
undetectable		 5tegB-5xxgA:
undetectable
5tegE-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 5 GLY A1156
TYR A1200
ASN A1223
HIS A1224
TYR A1261
 SAM  A1301 (-3.6A)
SAM  A1301 (-3.9A)
SAM  A1301 (-3.2A)
None
SAM  A1301 (-4.9A)
 0.26A 5tegB-6cenA:
14.3
5tegE-6cenA:
undetectable		 5tegB-6cenA:
undetectable
5tegE-6cenA:
undetectable