SIMILAR PATTERNS OF AMINO ACIDS FOR 5TE8_C_08JC602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 ALA A 142
THR A 145
ILE A 212
LEU A 535
 None
 0.85A 5te8C-1c0aA:
0.0		 5te8C-1c0aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 135
ALA A 163
ILE A   5
LEU A 166
 None
 0.94A 5te8C-1eblA:
0.0		 5te8C-1eblA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ARG B 765
SER B 805
ALA B 885
ILE B 631
LEU B 581
 None
 1.40A 5te8C-1ej6B:
undetectable		 5te8C-1ej6B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5q GAMMA HERPESVIRUS
CYCLIN

(Murid
gammaherpesvirus
4) 		PF00134
(Cyclin_N) 		4 SER B 136
ALA B  98
ILE B 111
LEU B 116
 None
 0.97A 5te8C-1f5qB:
0.0		 5te8C-1f5qB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A1269
ALA A1293
ILE A1237
LEU A1267
 None
 0.86A 5te8C-1foeA:
0.0		 5te8C-1foeA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpz CYCLIN-DEPENDENT
KINASE INHIBITOR 3

(Homo sapiens) 		PF05706
(CDKN3) 		4 LEU A 155
ALA A 151
ILE A 180
LEU A 189
 None
 0.92A 5te8C-1fpzA:
0.0		 5te8C-1fpzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		4 ARG A 238
THR A 219
ILE A 202
LEU A 221
 None
 0.87A 5te8C-1g6oA:
0.1		 5te8C-1g6oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		4 SER A 106
LEU A 104
ILE A 128
LEU A 118
 None
 0.80A 5te8C-1g6oA:
0.1		 5te8C-1g6oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 ARG A 231
LEU A 195
ILE A 272
LEU A 279
 None
 0.98A 5te8C-1gjvA:
0.0		 5te8C-1gjvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpr GLUCOSE PERMEASE

(Bacillus
subtilis) 		PF00358
(PTS_EIIA_1) 		4 LEU A  81
ALA A  69
ILE A  60
LEU A  72
 None
 0.95A 5te8C-1gprA:
undetectable		 5te8C-1gprA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 SER A 507
LEU A 560
ALA A 541
THR A 554
ILE A 471
 None
 1.50A 5te8C-1ikpA:
undetectable		 5te8C-1ikpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 ARG C 158
LEU C 156
ALA C 153
ILE C  99
LEU C  42
 None
 1.34A 5te8C-1ixrC:
undetectable		 5te8C-1ixrC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 ARG A 139
LEU A 577
THR A   9
ILE A  42
LEU A  69
 NAP  A1000 ( 4.6A)
None
None
None
None
 1.09A 5te8C-1j1wA:
1.5		 5te8C-1j1wA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A  11
THR A  13
ILE A 336
LEU A 339
 None
 0.90A 5te8C-1j3nA:
undetectable		 5te8C-1j3nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 LEU A 161
ALA A  27
ILE A 285
LEU A 238
 None
 0.94A 5te8C-1jihA:
0.4		 5te8C-1jihA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 LEU A 185
ALA A 152
ILE A 180
LEU A 189
 None
 0.97A 5te8C-1k82A:
undetectable		 5te8C-1k82A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7y HYPOTHETICAL PROTEIN
ZK652.3

(Caenorhabditis
elegans) 		PF03671
(Ufm1) 		4 SER A  57
LEU A  43
ALA A  47
LEU A  31
 None
 0.97A 5te8C-1l7yA:
undetectable		 5te8C-1l7yA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		4 SER A 172
LEU A 143
ALA A  94
ILE A 325
 None
 0.89A 5te8C-1musA:
undetectable		 5te8C-1musA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 SER A 127
LEU A 291
ALA A 287
ILE A 244
 None
HEM  A 500 (-4.4A)
None
None
 0.81A 5te8C-1nr6A:
34.8		 5te8C-1nr6A:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 4 LEU A 144
ALA A 140
ILE A 156
LEU A 166
 None
 0.84A 5te8C-1oy1A:
undetectable		 5te8C-1oy1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 4 SER A 105
THR A 162
ILE A 156
LEU A 166
 None
 0.96A 5te8C-1oy1A:
undetectable		 5te8C-1oy1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4x STAPHYLOCOCCAL
ACCESSORY REGULATOR
A HOMOLOGUE

(Staphylococcus
aureus) 		no annotation 4 SER A 157
ALA A 194
ILE A 167
LEU A 204
 None
 0.94A 5te8C-1p4xA:
undetectable		 5te8C-1p4xA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 SER H 170
LEU H 150
ALA H 138
ILE H 120
 None
 0.92A 5te8C-1q5rH:
0.8		 5te8C-1q5rH:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 ARG A 243
SER A 153
ALA A 240
LEU A 226
 None
 0.95A 5te8C-1q6yA:
undetectable		 5te8C-1q6yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)

(Rattus
norvegicus) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU A1107
ALA A1150
ILE A1169
LEU A1165
 None
 0.83A 5te8C-1qqfA:
undetectable		 5te8C-1qqfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 ARG A 230
ALA A  36
ILE A 318
LEU A 309
 None
 0.88A 5te8C-1s0uA:
undetectable		 5te8C-1s0uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sed HYPOTHETICAL PROTEIN
YHAI

(Bacillus
subtilis) 		PF08963
(DUF1878) 		4 LEU A  72
ALA A  76
ILE A  49
LEU A  53
 MPD  A 702 ( 4.8A)
MPD  A 703 (-4.4A)
None
None
 0.97A 5te8C-1sedA:
undetectable		 5te8C-1sedA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A  66
ALA A  62
ILE A  81
LEU A  85
 None
 0.81A 5te8C-1t4bA:
undetectable		 5te8C-1t4bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		4 ALA A 175
THR A 178
ILE A 180
LEU A 141
 None
 0.94A 5te8C-1ta3A:
undetectable		 5te8C-1ta3A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1th8 ANTI-SIGMA F FACTOR
ANTAGONIST

(Geobacillus
stearothermophilus) 		PF01740
(STAS) 		4 ARG B  67
ALA B  27
ILE B   5
LEU B  18
 None
 0.96A 5te8C-1th8B:
undetectable		 5te8C-1th8B:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 ARG A  80
THR A  92
ILE A  58
LEU A  90
 None
 0.95A 5te8C-1twdA:
undetectable		 5te8C-1twdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		4 ARG A 213
ALA A 174
ILE A 236
LEU A 209
 None
 0.93A 5te8C-1txkA:
undetectable		 5te8C-1txkA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 ARG A 310
ALA A 300
ILE A 315
LEU A 316
 None
 0.73A 5te8C-1u5qA:
undetectable		 5te8C-1u5qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A  71
ALA A  37
ILE A  50
LEU A  79
 None
 0.92A 5te8C-1uaaA:
undetectable		 5te8C-1uaaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 ALA A  63
THR A  66
ILE A 129
LEU A  77
 None
 0.68A 5te8C-1uz5A:
undetectable		 5te8C-1uz5A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE

(Neisseria
gonorrhoeae) 		PF01128
(IspD) 		4 ARG A 112
ALA A 208
ILE A 221
LEU A 225
 None
 0.83A 5te8C-1vgwA:
undetectable		 5te8C-1vgwA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A  70
ALA A  68
ILE A 141
LEU A 143
 None
 0.82A 5te8C-1vj0A:
undetectable		 5te8C-1vj0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 LEU A 155
ALA A 151
ILE A 127
LEU A 160
 None
 0.85A 5te8C-1w8gA:
undetectable		 5te8C-1w8gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 SER A 359
ALA A 151
THR A 154
ILE A 217
 None
 0.92A 5te8C-1wopA:
undetectable		 5te8C-1wopA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 SER A  69
LEU A 102
ALA A  98
ILE A 134
 None
 0.96A 5te8C-1zkdA:
undetectable		 5te8C-1zkdA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A 228
ALA A 274
ILE A 198
LEU A 196
 None
 0.93A 5te8C-1zu4A:
undetectable		 5te8C-1zu4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 278
ALA A 190
ILE A 224
LEU A 206
 None
 0.92A 5te8C-2ac5A:
undetectable		 5te8C-2ac5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		4 ARG P  82
ALA P  73
ILE P  79
LEU P  44
 None
 0.96A 5te8C-2aieP:
undetectable		 5te8C-2aieP:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 ARG A 137
LEU A 573
THR A   7
ILE A  40
LEU A  67
 None
 1.02A 5te8C-2b0tA:
0.6		 5te8C-2b0tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU A1106
ALA A1149
ILE A1168
LEU A1164
 None
 0.82A 5te8C-2b39A:
undetectable		 5te8C-2b39A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 SER A 415
THR A 157
ILE A 182
LEU A 177
 None
 0.95A 5te8C-2cxeA:
undetectable		 5te8C-2cxeA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 SER A 162
LEU A  87
ALA A 114
LEU A  50
 None
 0.97A 5te8C-2cy7A:
undetectable		 5te8C-2cy7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 LEU A  41
ALA A 124
THR A  90
LEU A 170
 None
 0.98A 5te8C-2d42A:
undetectable		 5te8C-2d42A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		4 SER A 143
LEU A 149
ILE A 156
LEU A 153
 GDP  A 501 (-4.3A)
None
None
None
 0.89A 5te8C-2dykA:
undetectable		 5te8C-2dykA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 203
ALA A 194
ILE A 387
LEU A 470
 None
 0.96A 5te8C-2e5vA:
undetectable		 5te8C-2e5vA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 LEU A 249
ALA A 245
ILE A 183
LEU A 260
 None
 0.89A 5te8C-2eg5A:
undetectable		 5te8C-2eg5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ARG A 139
ALA A 131
ILE A 210
LEU A 178
 None
 0.97A 5te8C-2hcbA:
undetectable		 5te8C-2hcbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi9 PLASMA SERINE
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 SER A  52
ALA A 332
ILE A 165
LEU A 168
 None
 0.97A 5te8C-2hi9A:
undetectable		 5te8C-2hi9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		4 ALA A 118
THR A 122
ILE A 137
LEU A  87
 None
 0.92A 5te8C-2hq1A:
undetectable		 5te8C-2hq1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 175
ALA A 180
THR A 225
ILE A 241
 None
 0.87A 5te8C-2htvA:
undetectable		 5te8C-2htvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 243
ALA A 155
ILE A 189
LEU A 171
 None
 0.88A 5te8C-2hw6A:
undetectable		 5te8C-2hw6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		4 SER A 248
ALA A 199
ILE A 239
LEU A  42
 None
 0.87A 5te8C-2i62A:
undetectable		 5te8C-2i62A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LEU A  61
ALA A  28
ILE A  37
LEU A  47
 None
 0.94A 5te8C-2ip2A:
undetectable		 5te8C-2ip2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ARG A 314
LEU A 729
THR A 770
LEU A 774
 None
 0.92A 5te8C-2iukA:
undetectable		 5te8C-2iukA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 LEU A   4
ALA A  27
ILE A  11
LEU A  35
 None
 0.95A 5te8C-2jjyA:
undetectable		 5te8C-2jjyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 SER A 124
ALA A  84
ILE A  88
LEU A  92
 None
 0.80A 5te8C-2nq5A:
undetectable		 5te8C-2nq5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os1 PEPTIDE DEFORMYLASE

(Enterococcus
faecalis) 		PF01327
(Pep_deformylase) 		4 ARG A  71
ALA A  62
ILE A  68
LEU A  33
 None
 0.95A 5te8C-2os1A:
undetectable		 5te8C-2os1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		5 ARG A 335
LEU A 302
ALA A 329
ILE A 259
LEU A 300
 None
 1.45A 5te8C-2pg8A:
undetectable		 5te8C-2pg8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB

(Nitrosomonas
europaea) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		4 LEU A 102
ALA A  98
ILE A  89
LEU A  76
 None
 0.75A 5te8C-2pn0A:
undetectable		 5te8C-2pn0A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 SER A  91
ALA A 361
ILE A 403
LEU A 458
 None
 0.90A 5te8C-2pyxA:
undetectable		 5te8C-2pyxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q04 ACETOIN UTILIZATION
PROTEIN

(Exiguobacterium
sibiricum) 		PF00583
(Acetyltransf_1) 		4 LEU A  97
ALA A  99
ILE A  54
LEU A  78
 None
CA  A 211 ( 4.8A)
None
None
 0.82A 5te8C-2q04A:
undetectable		 5te8C-2q04A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q66 POLY(A) POLYMERASE

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 ARG A 127
THR A 103
ILE A 153
LEU A 155
 None
 0.98A 5te8C-2q66A:
1.4		 5te8C-2q66A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		4 SER A 205
ALA A 280
ILE A 260
LEU A 264
 None
 0.97A 5te8C-2qi9A:
undetectable		 5te8C-2qi9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN

(Homo sapiens) 		PF00782
(DSPc) 		4 SER A  43
LEU A 117
ILE A  32
LEU A  36
 None
 0.78A 5te8C-2r0bA:
undetectable		 5te8C-2r0bA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7h PUTATIVE D-ALANINE
N-ACETYLTRANSFERASE
OF GNAT FAMILY

(Desulfovibrio
alaskensis) 		PF00583
(Acetyltransf_1) 		4 ARG A  23
ALA A 116
ILE A  99
LEU A  96
 None
 0.79A 5te8C-2r7hA:
undetectable		 5te8C-2r7hA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 SER A 604
ALA A 419
ILE A 350
LEU A 347
 None
 0.88A 5te8C-2v26A:
undetectable		 5te8C-2v26A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vec PIRIN-LIKE PROTEIN
YHAK

(Escherichia
coli) 		PF02678
(Pirin) 		4 LEU A 202
ALA A 192
ILE A 164
LEU A 224
 None
 0.96A 5te8C-2vecA:
undetectable		 5te8C-2vecA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6l COBE

(Pseudomonas
aeruginosa) 		PF01890
(CbiG_C) 		4 SER A  98
ALA A 131
THR A  31
LEU A  27
 SO4  A1138 (-2.5A)
None
None
None
 0.82A 5te8C-2w6lA:
undetectable		 5te8C-2w6lA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 ARG A  49
LEU A  46
ILE A  60
LEU A 113
 None
 0.92A 5te8C-2wsmA:
undetectable		 5te8C-2wsmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 LEU A  39
THR A  93
ILE A  60
LEU A  34
 None
 0.74A 5te8C-2ylkA:
undetectable		 5te8C-2ylkA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvh TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		5 ARG A  48
LEU A  51
ALA A  13
THR A  34
LEU A  41
 None
 1.32A 5te8C-2yvhA:
undetectable		 5te8C-2yvhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		4 ALA A 250
THR A 253
ILE A 368
LEU A 365
 None
 0.81A 5te8C-2zbzA:
27.8		 5te8C-2zbzA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		4 LEU A 140
ALA A 135
ILE A  49
LEU A  20
 None
 0.96A 5te8C-3b1fA:
undetectable		 5te8C-3b1fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b78 EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly) 		5 SER B 507
LEU B 560
ALA B 541
THR B 554
ILE B 471
 None
 1.40A 5te8C-3b78B:
undetectable		 5te8C-3b78B:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		4 LEU A  30
ALA A  19
ILE A 332
LEU A 329
 None
 0.84A 5te8C-3cerA:
undetectable		 5te8C-3cerA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuo UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YGAV

(Escherichia
coli) 		PF01022
(HTH_5) 		4 ARG A  63
ALA A  41
ILE A  29
LEU A  33
 None
 0.87A 5te8C-3cuoA:
undetectable		 5te8C-3cuoA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwz RAB6-INTERACTING
PROTEIN 1

(Mus musculus) 		PF01477
(PLAT)
PF02759
(RUN) 		4 LEU B 784
ALA B 792
ILE B 779
LEU B 897
 None
 0.93A 5te8C-3cwzB:
undetectable		 5te8C-3cwzB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 ARG A  25
ALA A 278
ILE A 289
LEU A  37
 None
 0.78A 5te8C-3dwiA:
undetectable		 5te8C-3dwiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		5 LEU G 115
ALA F  11
THR F  15
ILE F  63
LEU F  51
 None
 1.21A 5te8C-3dwlG:
undetectable		 5te8C-3dwlG:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 561
THR A 475
ILE A 531
LEU A 629
 None
 0.92A 5te8C-3e9yA:
undetectable		 5te8C-3e9yA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 SER A 149
LEU A  76
ALA A  72
ILE A  31
 None
 0.89A 5te8C-3ed3A:
undetectable		 5te8C-3ed3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fm0 PROTEIN CIAO1

(Homo sapiens) 		PF00400
(WD40) 		4 LEU A   7
ALA A 329
ILE A 276
LEU A   5
 None
 0.91A 5te8C-3fm0A:
undetectable		 5te8C-3fm0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6n PEPTIDE DEFORMYLASE

(Enterococcus
faecium) 		PF01327
(Pep_deformylase) 		4 ARG A  71
ALA A  62
ILE A  68
LEU A  33
 None
 0.96A 5te8C-3g6nA:
undetectable		 5te8C-3g6nA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 LEU A 130
ALA A 172
ILE A 151
LEU A 137
 None
 0.93A 5te8C-3g77A:
undetectable		 5te8C-3g77A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ARG A 197
ALA A 177
THR A 154
ILE A 149
 None
 0.91A 5te8C-3g79A:
undetectable		 5te8C-3g79A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		no annotation 4 SER D  99
LEU D  97
ILE D 138
LEU D 139
 NAD  D6686 (-4.7A)
None
None
None
 0.93A 5te8C-3gggD:
undetectable		 5te8C-3gggD:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 SER A 117
ALA A 123
ILE A 146
LEU A  14
 None
 0.96A 5te8C-3gl1A:
undetectable		 5te8C-3gl1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 ALA A 138
THR A 142
ILE A 157
LEU A 107
 None
 0.96A 5te8C-3gvcA:
undetectable		 5te8C-3gvcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		4 ARG A  66
SER A  77
LEU A  73
ILE A  21
 None
 0.79A 5te8C-3gwfA:
undetectable		 5te8C-3gwfA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h79 THIOREDOXIN-LIKE
PROTEIN

(Trypanosoma
cruzi) 		PF00085
(Thioredoxin) 		4 SER A  15
ALA A  73
ILE A  28
LEU A  20
 None
 0.84A 5te8C-3h79A:
undetectable		 5te8C-3h79A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 SER A 268
ALA A 338
ILE A 417
LEU A  57
 None
 0.75A 5te8C-3hjrA:
undetectable		 5te8C-3hjrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 SER A 271
ALA A 338
THR A 342
ILE A 213
LEU A 256
 None
 1.44A 5te8C-3hjrA:
undetectable		 5te8C-3hjrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 4 LEU A 120
ALA A 122
ILE A  36
LEU A  18
 None
 0.92A 5te8C-3hm2A:
undetectable		 5te8C-3hm2A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		4 LEU A 178
ALA A 107
ILE A 132
LEU A 144
 None
 0.86A 5te8C-3hvyA:
0.3		 5te8C-3hvyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9x MUTT/NUDIX FAMILY
PROTEIN

(Listeria
innocua) 		PF00293
(NUDIX) 		4 ARG A 110
ALA A  68
ILE A  31
LEU A 163
 GOL  A 186 (-2.8A)
None
None
None
 0.93A 5te8C-3i9xA:
undetectable		 5te8C-3i9xA:
17.42