SIMILAR PATTERNS OF AMINO ACIDS FOR 5TE8_B_08JB602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bmt METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ALA A 818
ILE A 789
ALA A 786
LEU A 790
 None
 0.82A 5te8B-1bmtA:
0.0		 5te8B-1bmtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 SER B 115
ALA B  94
ILE B   4
LEU B 341
 None
 0.80A 5te8B-1e4eB:
undetectable		 5te8B-1e4eB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 LEU A 479
ILE A 443
ALA A 444
LEU A 489
 None
 0.69A 5te8B-1j2bA:
0.0		 5te8B-1j2bA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ALA A 216
ILE A  65
ALA A  66
LEU A 193
 None
 0.82A 5te8B-1khdA:
0.0		 5te8B-1khdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 SER A 337
ILE A  86
ALA A  85
LEU A  84
 None
 0.81A 5te8B-1m1cA:
undetectable		 5te8B-1m1cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN
(SUBUNIT S5)

(Bordetella
pertussis) 		PF09276
(Pertus-S5-tox) 		4 ALA F  16
ILE F  61
ALA F  60
LEU F  57
 None
 0.80A 5te8B-1ptoF:
undetectable		 5te8B-1ptoF:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 ARG A 525
THR A 613
ILE A 616
LEU A 553
 None
 0.74A 5te8B-1pxyA:
0.0		 5te8B-1pxyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 SER A 314
LEU A 354
ILE A 346
ALA A 347
 None
 0.83A 5te8B-1r0lA:
0.0		 5te8B-1r0lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 LEU A 246
ALA A 242
ILE A 257
LEU A 255
 None
 0.80A 5te8B-1u2eA:
undetectable		 5te8B-1u2eA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufb TT1696 PROTEIN

(Thermus
thermophilus) 		PF05168
(HEPN) 		4 ALA A  40
ILE A 119
ALA A 116
LEU A 120
 None
 0.84A 5te8B-1ufbA:
undetectable		 5te8B-1ufbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyi RNA POLYMERASE ALPHA
SUBUNIT

(Rabies
lyssavirus) 		PF03012
(PP_M1) 		4 ALA A 199
ILE A 205
ALA A 206
LEU A 234
 None
 0.72A 5te8B-1vyiA:
undetectable		 5te8B-1vyiA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		4 LEU A  54
THR A  40
ILE A  78
LEU A  76
 None
 0.77A 5te8B-1wmrA:
undetectable		 5te8B-1wmrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		4 LEU A  67
ILE A  48
ALA A  47
LEU A  44
 None
 0.80A 5te8B-1yfzA:
undetectable		 5te8B-1yfzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		4 LEU A1040
THR A1099
ILE A1035
ALA A1034
 None
 0.69A 5te8B-1yxoA:
undetectable		 5te8B-1yxoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgg PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YWLE

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 SER A  36
ALA A  17
ALA A  51
LEU A  55
 None
 0.69A 5te8B-1zggA:
undetectable		 5te8B-1zggA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 ARG A 179
ALA A 254
ILE A 129
LEU A 118
 None
 0.83A 5te8B-2axcA:
undetectable		 5te8B-2axcA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		4 ALA A  96
ILE A 102
ALA A 103
LEU A  60
 None
 0.83A 5te8B-2deoA:
undetectable		 5te8B-2deoA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ALA A 202
ILE A  52
ALA A  53
LEU A 179
 None
 0.65A 5te8B-2elcA:
undetectable		 5te8B-2elcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		4 SER A 207
LEU A 137
ILE A 129
ALA A 130
 None
 0.84A 5te8B-2g9dA:
undetectable		 5te8B-2g9dA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 ALA A 264
ILE A 187
ALA A 184
LEU A 188
 None
 0.82A 5te8B-2gnpA:
undetectable		 5te8B-2gnpA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huh PUTATIVE DNA
MISMATCH REPAIR
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09640
(DUF2027) 		4 SER A 118
ALA A 170
ILE A 179
ALA A 178
 None
 0.83A 5te8B-2huhA:
undetectable		 5te8B-2huhA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 SER A  51
ALA A  34
ILE A  40
ALA A  41
 None
 0.78A 5te8B-2ipfA:
undetectable		 5te8B-2ipfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ALA A 275
ILE A 424
ALA A 425
LEU A 250
 None
 0.61A 5te8B-2iu3A:
undetectable		 5te8B-2iu3A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A1075
ALA A 920
ILE A 922
ALA A 923
 None
 0.80A 5te8B-2nlkA:
1.2		 5te8B-2nlkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 ARG A  67
SER A  63
ALA A 274
ALA A  71
 None
 0.82A 5te8B-2o0rA:
undetectable		 5te8B-2o0rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Pectobacterium
atrosepticum) 		PF06508
(QueC) 		4 THR A 105
ILE A 146
ALA A 145
LEU A 142
 None
 0.78A 5te8B-2pg3A:
undetectable		 5te8B-2pg3A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6l COBE

(Pseudomonas
aeruginosa) 		PF01890
(CbiG_C) 		4 SER A  98
ALA A 131
THR A  31
LEU A  27
 SO4  A1138 (-2.5A)
None
None
None
 0.79A 5te8B-2w6lA:
undetectable		 5te8B-2w6lA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00731
(AIRC) 		4 ALA A  52
ILE A 122
ALA A 119
LEU A 123
 None
 0.77A 5te8B-2ywxA:
undetectable		 5te8B-2ywxA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byh FIMBRIN ABD2

(Homo sapiens) 		PF00307
(CH) 		4 ARG B 525
THR B 613
ILE B 616
LEU B 553
 None
 0.75A 5te8B-3byhB:
undetectable		 5te8B-3byhB:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5c RAS-LIKE PROTEIN 12

(Homo sapiens) 		PF00071
(Ras) 		4 ALA A 129
ILE A  25
ALA A  24
LEU A  23
 None
 0.80A 5te8B-3c5cA:
undetectable		 5te8B-3c5cA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz8 PUTATIVE
SPORULATION-SPECIFIC
GLYCOSYLASE YDHD

(Bacillus
subtilis) 		PF00704
(Glyco_hydro_18) 		4 LEU A 400
ILE A  99
ALA A 100
LEU A 402
 None
 0.76A 5te8B-3cz8A:
undetectable		 5te8B-3cz8A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 ALA A 320
ILE A 370
ALA A 372
LEU A 198
 None
 0.82A 5te8B-3f0nA:
undetectable		 5te8B-3f0nA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 ALA A  85
ILE A 320
ALA A 317
LEU A 321
 None
 0.84A 5te8B-3fpzA:
undetectable		 5te8B-3fpzA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 ARG A 215
ILE A  20
ALA A  19
LEU A  16
 None
 0.74A 5te8B-3gk3A:
undetectable		 5te8B-3gk3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae) 		4 LEU C  51
ALA C  20
ILE C  26
ALA C  27
 None
 0.81A 5te8B-3hjwC:
undetectable		 5te8B-3hjwC:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		4 ALA A 130
ILE A 159
ALA A 158
LEU A 155
 None
 0.76A 5te8B-3kljA:
undetectable		 5te8B-3kljA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf2 SHORT CHAIN
OXIDOREDUCTASE
Q9HYA2

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 ALA A  11
ILE A 141
ALA A 140
LEU A 133
 None
 0.84A 5te8B-3lf2A:
undetectable		 5te8B-3lf2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica) 		PF00923
(TAL_FSA) 		4 ALA A 117
ILE A 152
ALA A 149
LEU A 153
 None
 0.70A 5te8B-3m16A:
undetectable		 5te8B-3m16A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 289
ILE A 265
ALA A 264
LEU A 261
 None
 0.81A 5te8B-3mpiA:
undetectable		 5te8B-3mpiA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ARG A  50
ILE A 261
ALA A 258
LEU A 262
 None
 0.70A 5te8B-3ngxA:
undetectable		 5te8B-3ngxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu1 HEMIN-BINDING
PERIPLASMIC PROTEIN

(Yersinia pestis) 		PF01497
(Peripla_BP_2) 		4 ALA A 103
ILE A  79
ALA A  76
LEU A  80
 None
 0.81A 5te8B-3nu1A:
undetectable		 5te8B-3nu1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfe PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE FAMILY
PROTEIN

(Coccidioides
immitis) 		PF00701
(DHDPS) 		4 ALA A  63
ILE A  47
ALA A  81
LEU A  48
 None
 0.71A 5te8B-3qfeA:
undetectable		 5te8B-3qfeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		4 ALA A  47
ILE A 280
ALA A 277
LEU A 281
 None
 0.83A 5te8B-3qitA:
undetectable		 5te8B-3qitA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		4 ALA A 103
ILE A 109
ALA A 110
LEU A  96
 None
 0.84A 5te8B-3qitA:
undetectable		 5te8B-3qitA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		4 LEU A 149
THR A 131
ILE A 141
LEU A 152
 None
 0.75A 5te8B-3rmtA:
undetectable		 5te8B-3rmtA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		4 ALA A 205
ILE A 118
ALA A 119
LEU A 122
 None
 0.80A 5te8B-3tqgA:
undetectable		 5te8B-3tqgA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		no annotation 4 ALA B  10
ILE B 137
ALA B 136
LEU B 129
 None
 0.65A 5te8B-3tzqB:
undetectable		 5te8B-3tzqB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		4 SER A 203
ALA A 277
ILE A 376
ALA A 375
 None
 0.79A 5te8B-3uhjA:
undetectable		 5te8B-3uhjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ALA A   8
ILE A 137
ALA A 136
LEU A 129
 None
 0.76A 5te8B-3v8bA:
undetectable		 5te8B-3v8bA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 ALA A 288
ILE A 225
ALA A 222
LEU A 226
 None
 0.78A 5te8B-3wajA:
0.7		 5te8B-3wajA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A

(Methanosarcina
mazei) 		no annotation 4 ALA A 335
ILE A  85
ALA A  86
LEU A  89
 None
 0.83A 5te8B-3wnbA:
undetectable		 5te8B-3wnbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ALA A 344
ILE A 350
ALA A 351
LEU A 433
 None
 0.81A 5te8B-4cgyA:
undetectable		 5te8B-4cgyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE

(Flavobacterium
sp. 141-8) 		PF13561
(adh_short_C2) 		4 ALA A  61
ILE A  19
ALA A  18
LEU A  85
 None
 0.76A 5te8B-4cr6A:
undetectable		 5te8B-4cr6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Clostridioides
difficile) 		PF00590
(TP_methylase) 		4 SER A  86
THR A  18
ILE A  17
ALA A   9
 None
 0.80A 5te8B-4e16A:
undetectable		 5te8B-4e16A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		4 ARG A  22
ILE A 228
ALA A 225
LEU A 229
 None
 0.83A 5te8B-4e3zA:
undetectable		 5te8B-4e3zA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB

(Caldanaerobacter
subterraneus) 		PF01451
(LMWPc) 		4 SER A  36
ALA A  17
ALA A  51
LEU A  55
 SER  A  36 ( 0.0A)
ALA  A  17 ( 0.0A)
ALA  A  51 ( 0.0A)
LEU  A  55 ( 0.6A)
 0.69A 5te8B-4egsA:
undetectable		 5te8B-4egsA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 SER A 383
ALA A 184
ALA A 358
LEU A 362
 None
 0.64A 5te8B-4ga4A:
undetectable		 5te8B-4ga4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ALA A 410
THR A 354
ILE A 390
LEU A 391
 None
 0.74A 5te8B-4jkmA:
undetectable		 5te8B-4jkmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 275
ILE A 281
ALA A 282
LEU A 324
 SO4  A 614 ( 3.8A)
None
None
None
 0.78A 5te8B-4ksiA:
undetectable		 5te8B-4ksiA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 LEU A 377
ALA A 173
ILE A 127
ALA A 128
 None
None
None
FAD  A 501 (-3.4A)
 0.79A 5te8B-4kw5A:
undetectable		 5te8B-4kw5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		4 ALA A 305
ILE A 293
ALA A 292
LEU A 289
 None
 0.76A 5te8B-4mdyA:
undetectable		 5te8B-4mdyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3

(Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ALA A 232
ILE A 223
ALA A 222
LEU A 219
 None
 0.79A 5te8B-4n5qA:
undetectable		 5te8B-4n5qA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
SER A 119
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
 0.75A 5te8B-4ny4A:
51.5		 5te8B-4ny4A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A 106
THR A  26
ILE A  92
ALA A  89
 None
 0.81A 5te8B-4r0xA:
undetectable		 5te8B-4r0xA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Mycobacterium
tuberculosis) 		PF01180
(DHO_dh) 		4 ALA A  50
ILE A 332
ALA A 333
LEU A 336
 None
 0.82A 5te8B-4xq6A:
undetectable		 5te8B-4xq6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ALA A 519
ILE A 452
ALA A 453
LEU A 496
 None
None
None
GOL  A 705 ( 4.1A)
 0.79A 5te8B-4ye5A:
undetectable		 5te8B-4ye5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yme SENSORY BOX/GGDEF
FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00990
(GGDEF) 		4 ALA A 405
ILE A 394
ALA A 393
LEU A 390
 None
 0.78A 5te8B-4ymeA:
undetectable		 5te8B-4ymeA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ALA A 155
ILE A 161
ALA A 162
LEU A 215
 SEB  A 151 ( 4.0A)
None
None
None
 0.68A 5te8B-4zrsA:
undetectable		 5te8B-4zrsA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9t PUTATIVE
DEHYDROGENASE

(Amycolatopsis
orientalis) 		PF03446
(NAD_binding_2) 		4 LEU A 117
ILE A 121
ALA A 120
LEU A  94
 None
 0.68A 5te8B-5a9tA:
undetectable		 5te8B-5a9tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A  72
THR A 313
ALA A 332
LEU A 335
 None
 0.76A 5te8B-5b37A:
undetectable		 5te8B-5b37A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 ALA A 687
ILE A 836
ALA A 835
LEU A 717
 None
 0.81A 5te8B-5b7iA:
undetectable		 5te8B-5b7iA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 571
ILE A 476
ALA A 475
LEU A 474
 None
 0.77A 5te8B-5b7iA:
undetectable		 5te8B-5b7iA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23

(Homo sapiens) 		PF03097
(BRO1) 		4 ALA A 297
ILE A 284
ALA A 283
LEU A 280
 None
 0.71A 5te8B-5crvA:
0.6		 5te8B-5crvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvz COAT PROTEIN

(Panicum
papanivirus 1) 		no annotation 4 ALA A  87
ILE A 125
ALA A 124
LEU A 123
 None
 0.78A 5te8B-5cvzA:
undetectable		 5te8B-5cvzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE

(Salmonella
enterica) 		PF02664
(LuxS) 		4 ALA A 106
ILE A 146
ALA A 143
LEU A 147
 None
 0.75A 5te8B-5e68A:
undetectable		 5te8B-5e68A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 THR A 152
ILE A 122
ALA A 123
LEU A 148
 None
 0.56A 5te8B-5e78A:
37.8		 5te8B-5e78A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 SER A 103
THR A 240
ILE A 243
ALA A 218
 COI  A 601 (-2.4A)
None
None
COI  A 601 ( 4.3A)
 0.81A 5te8B-5ereA:
undetectable		 5te8B-5ereA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 LEU D 132
ALA D 134
ILE D 107
ALA D 108
 None
 0.83A 5te8B-5fmgD:
undetectable		 5te8B-5fmgD:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 SER B1274
ALA B1263
THR B1371
ALA B1356
 None
 0.78A 5te8B-5gztB:
undetectable		 5te8B-5gztB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 SER A1274
ALA A1263
THR A1371
ALA A1356
 None
 0.75A 5te8B-5gzuA:
undetectable		 5te8B-5gzuA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		4 ALA A 457
ILE A 425
ALA A 422
LEU A 426
 ALA  A 457 ( 0.0A)
ILE  A 425 ( 0.7A)
ALA  A 422 ( 0.0A)
LEU  A 426 ( 0.6A)
 0.78A 5te8B-5hiuA:
undetectable		 5te8B-5hiuA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 ALA A 183
ILE A 210
ALA A 209
LEU A 206
 None
 0.81A 5te8B-5hoeA:
undetectable		 5te8B-5hoeA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		4 LEU A  87
ALA A 230
ILE A 236
ALA A 237
 HEM  A 401 (-3.9A)
None
None
HEM  A 401 (-3.5A)
 0.56A 5te8B-5it1A:
12.9		 5te8B-5it1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 SER A  48
LEU A 339
ILE A 326
ALA A 323
 None
 0.81A 5te8B-5jrjA:
undetectable		 5te8B-5jrjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 579
LEU A 549
ALA A 547
THR A 448
ALA A 259
 None
 1.28A 5te8B-5lp4A:
undetectable		 5te8B-5lp4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 229
ALA A 225
ALA A 244
LEU A 245
 None
 0.84A 5te8B-5mfbA:
undetectable		 5te8B-5mfbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S21,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 ARG g  65
THR g  30
ILE g  29
ALA g  60
 C  E1548 ( 3.4A)
None
None
None
 0.82A 5te8B-5optg:
undetectable		 5te8B-5optg:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tva 6-CARBOXYHEXANOATE--
COA LIGASE

(Aquifex
aeolicus) 		PF03744
(BioW) 		4 ALA A 115
ILE A 100
ALA A  97
LEU A 101
 AMP  A 301 (-3.7A)
None
None
None
 0.80A 5te8B-5tvaA:
undetectable		 5te8B-5tvaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 ALA A   8
ILE A 126
ALA A 125
LEU A 119
 None
 0.65A 5te8B-5u4sA:
undetectable		 5te8B-5u4sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 ALA A 134
ILE A 219
ALA A 220
LEU A 223
 None
None
None
PO4  A 302 ( 4.3A)
 0.69A 5te8B-5u4sA:
undetectable		 5te8B-5u4sA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ARG A 105
ALA A 305
ALA A 370
LEU A 481
 HEM  A 601 (-2.8A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
None
 0.71A 5te8B-5veuA:
26.1		 5te8B-5veuA:
83.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ARG A 105
SER A 119
ALA A 370
LEU A 481
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 (-3.3A)
None
 0.80A 5te8B-5veuA:
26.1		 5te8B-5veuA:
83.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 4 SER A 357
LEU A 393
ILE A 406
ALA A 403
 None
 0.70A 5te8B-5wzkA:
undetectable		 5te8B-5wzkA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 4 THR A 124
ILE A 131
ALA A 132
LEU A 141
 None
 0.74A 5te8B-5wzkA:
undetectable		 5te8B-5wzkA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 4 ALA C 111
ILE C  79
ALA C  80
LEU C  83
 None
 0.66A 5te8B-5x6xC:
undetectable		 5te8B-5x6xC:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 4 ALA A 231
ILE A 169
ALA A 170
LEU A 255
 None
 0.70A 5te8B-5y2vA:
undetectable		 5te8B-5y2vA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 4 ALA B 607
ILE B 263
ALA B 262
LEU B 259
 None
 0.79A 5te8B-5zvtB:
undetectable		 5te8B-5zvtB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 4 SER A 186
ILE A  97
ALA A  98
LEU A 101
 None
OLA  A1210 (-4.2A)
None
OLA  A1209 ( 4.8A)
 0.83A 5te8B-6bqhA:
1.5		 5te8B-6bqhA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 LEU A 892
ALA A 894
ALA A 877
LEU A 890
 None
 0.81A 5te8B-6egtA:
undetectable		 5te8B-6egtA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens) 		no annotation 5 SER B 324
LEU B 340
ALA B 336
ILE B 364
LEU B 360
 None
 1.48A 5te8B-6ez8B:
undetectable		 5te8B-6ez8B:
10.99