SIMILAR PATTERNS OF AMINO ACIDS FOR 5TE8_A_08JA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 SER A  89
LEU A 113
ILE A 170
LEU A  69
 None
 1.01A 5te8A-1ac5A:
0.0		 5te8A-1ac5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ARG A 501
ALA A 477
ILE A 481
LEU A 484
 None
 0.91A 5te8A-1c30A:
0.0		 5te8A-1c30A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 SER B 115
ALA B  94
ILE B   4
LEU B 341
 None
 0.83A 5te8A-1e4eB:
0.0		 5te8A-1e4eB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 SER A 320
ALA A 277
ILE A 409
LEU A 369
 None
 1.05A 5te8A-1ezvA:
0.0		 5te8A-1ezvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A  72
ALA A  76
THR A  80
ILE A  83
LEU A 317
 None
 1.43A 5te8A-1imvA:
0.1		 5te8A-1imvA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 262
ALA A 332
THR A 364
ILE A 363
 None
None
None
FAD  A 399 (-4.7A)
 1.03A 5te8A-1jqiA:
0.0		 5te8A-1jqiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 262
ALA A 361
THR A 364
ILE A 251
 None
 0.87A 5te8A-1jqiA:
0.0		 5te8A-1jqiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 LEU A 465
ALA A 404
ILE A 512
LEU A 504
 None
 1.00A 5te8A-1oa1A:
0.0		 5te8A-1oa1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 SER A 466
LEU A 342
ILE A 369
LEU A 453
 None
 0.97A 5te8A-1p31A:
0.0		 5te8A-1p31A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		4 SER A 375
ALA A 267
ILE A 191
LEU A 192
 None
 0.98A 5te8A-1pffA:
0.0		 5te8A-1pffA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ARG A 371
ALA A 130
ILE A  65
LEU A 342
 None
 0.78A 5te8A-1pojA:
undetectable		 5te8A-1pojA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 ARG A 525
THR A 613
ILE A 616
LEU A 553
 None
 0.84A 5te8A-1pxyA:
undetectable		 5te8A-1pxyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 LEU A 144
THR A 126
ILE A 136
LEU A 147
 None
 0.93A 5te8A-1rf5A:
undetectable		 5te8A-1rf5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		4 LEU A 137
ALA A  47
ILE A 125
LEU A 129
 None
 0.92A 5te8A-1rp0A:
undetectable		 5te8A-1rp0A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 SER A 484
THR A 373
ILE A 364
LEU A 468
 None
 1.04A 5te8A-1wd3A:
undetectable		 5te8A-1wd3A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		4 LEU A  54
THR A  40
ILE A  78
LEU A  76
 None
 0.84A 5te8A-1wmrA:
undetectable		 5te8A-1wmrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 ARG A 179
ALA A 254
ILE A 129
LEU A 118
 None
 0.87A 5te8A-2axcA:
undetectable		 5te8A-2axcA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 SER A 162
LEU A  87
ALA A 114
LEU A  50
 None
 1.05A 5te8A-2cy7A:
undetectable		 5te8A-2cy7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 LEU A  41
ALA A 124
THR A  90
LEU A 170
 None
 0.96A 5te8A-2d42A:
undetectable		 5te8A-2d42A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER A 283
LEU A 304
ALA A 396
LEU A 272
 None
 1.03A 5te8A-2d4wA:
undetectable		 5te8A-2d4wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ARG A  69
SER A 100
ALA A  64
ILE A 446
 None
 0.94A 5te8A-2ihtA:
undetectable		 5te8A-2ihtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 SER B 310
ALA B 323
ILE B 355
LEU B 356
 None
 1.05A 5te8A-2jgzB:
undetectable		 5te8A-2jgzB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muu UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 28

(Homo sapiens) 		no annotation 4 SER A  47
LEU A  57
THR A  32
ILE A  34
 None
 0.92A 5te8A-2muuA:
undetectable		 5te8A-2muuA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqm HYPOTHETICAL PROTEIN

(Shewanella
denitrificans) 		PF09351
(DUF1993) 		4 ARG A  91
LEU A  88
ILE A 143
LEU A  17
 None
 0.87A 5te8A-2oqmA:
undetectable		 5te8A-2oqmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou3 TELLURITE RESISTANCE
PROTEIN OF COG3793

(Nostoc
punctiforme) 		PF05099
(TerB) 		4 SER A  46
ALA A 106
ILE A 101
LEU A 110
 None
 0.83A 5te8A-2ou3A:
undetectable		 5te8A-2ou3A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 SER A 186
LEU A 273
ILE A 234
LEU A 269
 None
 0.87A 5te8A-2oucA:
undetectable		 5te8A-2oucA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT
PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin)
no annotation 		4 ARG A  95
SER B  70
ALA A  87
ILE A 145
 None
 1.04A 5te8A-2p5tA:
undetectable		 5te8A-2p5tA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 LEU A 150
ALA A 178
ILE A 458
LEU A 462
 EDO  A 477 (-4.3A)
None
None
None
 0.95A 5te8A-2qneA:
undetectable		 5te8A-2qneA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ARG A  60
SER A  97
ALA A  52
THR A 139
 None
 0.94A 5te8A-2qnyA:
undetectable		 5te8A-2qnyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 SER A 604
ALA A 419
ILE A 350
LEU A 347
 None
 1.02A 5te8A-2v26A:
undetectable		 5te8A-2v26A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus) 		PF06745
(ATPase) 		4 ARG A  68
THR A  37
ILE A  38
LEU A  41
 None
POP  A1240 (-3.6A)
POP  A1240 (-4.1A)
None
 0.93A 5te8A-2w0mA:
undetectable		 5te8A-2w0mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6l COBE

(Pseudomonas
aeruginosa) 		PF01890
(CbiG_C) 		4 SER A  98
ALA A 131
THR A  31
LEU A  27
 SO4  A1138 (-2.5A)
None
None
None
 0.84A 5te8A-2w6lA:
undetectable		 5te8A-2w6lA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 SER X 533
ALA X 631
ILE X 517
LEU X 469
 None
 1.03A 5te8A-2y9eX:
undetectable		 5te8A-2y9eX:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6-F
COMPLEX SUBUNIT 4

(Nostoc sp. PCC
7120) 		PF00032
(Cytochrom_B_C) 		4 SER B  90
LEU B 155
ILE B 145
LEU B 157
 None
 0.88A 5te8A-2zt9B:
undetectable		 5te8A-2zt9B:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		4 SER A1202
LEU A1479
ILE A1362
LEU A1475
 None
 1.04A 5te8A-3b13A:
undetectable		 5te8A-3b13A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida) 		PF03349
(Toluene_X) 		4 ARG A 376
ALA A 336
ILE A 333
LEU A   6
 None
C8E  A 502 (-3.3A)
None
None
 0.97A 5te8A-3brzA:
undetectable		 5te8A-3brzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byh FIMBRIN ABD2

(Homo sapiens) 		PF00307
(CH) 		4 ARG B 525
THR B 613
ILE B 616
LEU B 553
 None
 0.85A 5te8A-3byhB:
undetectable		 5te8A-3byhB:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ARG A 354
ALA A 373
ILE A 337
LEU A 356
 None
 1.02A 5te8A-3cb5A:
undetectable		 5te8A-3cb5A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 SER A 153
THR A 114
ILE A 111
LEU A 175
 None
 0.97A 5te8A-3cf4A:
undetectable		 5te8A-3cf4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh) 		4 SER G  58
ALA G  82
ILE G  85
LEU G 102
 None
 0.99A 5te8A-3cf4G:
undetectable		 5te8A-3cf4G:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		4 LEU B 172
ALA B 170
THR A 268
ILE A 269
 None
 0.94A 5te8A-3chxB:
undetectable		 5te8A-3chxB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 SER A 821
ALA A 948
ILE A 955
LEU A 592
 None
 1.01A 5te8A-3egwA:
undetectable		 5te8A-3egwA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 179
THR A 182
ILE A  49
LEU A  43
 None
 0.87A 5te8A-3fk5A:
undetectable		 5te8A-3fk5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 LEU A 298
ALA A 124
THR A 127
LEU A 285
 None
 0.81A 5te8A-3g0tA:
undetectable		 5te8A-3g0tA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		4 ALA A 237
THR A 241
ILE A 246
LEU A 313
 None
 0.89A 5te8A-3godA:
undetectable		 5te8A-3godA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 ALA A1753
THR A1490
ILE A1493
LEU A1467
 None
 1.00A 5te8A-3hmjA:
undetectable		 5te8A-3hmjA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 SER A  59
ALA A  53
ILE A  48
LEU A  79
 None
 0.96A 5te8A-3hurA:
undetectable		 5te8A-3hurA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 LEU B1945
ALA B1877
ILE B1921
LEU B1880
 None
 0.97A 5te8A-3j2sB:
undetectable		 5te8A-3j2sB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 LEU A 247
ALA A 249
THR A 229
LEU A 325
 None
 1.00A 5te8A-3lpdA:
undetectable		 5te8A-3lpdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		4 SER A  68
LEU A 307
ALA A 303
LEU A 268
 None
 1.05A 5te8A-3m1rA:
undetectable		 5te8A-3m1rA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 287
ALA A 269
ILE A 277
LEU A 243
 None
 1.03A 5te8A-3mwcA:
undetectable		 5te8A-3mwcA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA

(Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ALA A  28
THR A 157
ILE A 160
LEU A  34
 None
 0.91A 5te8A-3myrA:
undetectable		 5te8A-3myrA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ALA A  50
THR B1011
ILE B1010
LEU B1546
 None
 0.95A 5te8A-3myrA:
undetectable		 5te8A-3myrA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5y SENSOR PROTEIN

(Bacillus
halodurans) 		PF13492
(GAF_3) 		4 LEU A 102
THR A 138
ILE A 106
LEU A 116
 None
 1.01A 5te8A-3o5yA:
undetectable		 5te8A-3o5yA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN

(Brucella
abortus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ALA A 178
THR A 195
ILE A 181
LEU A 455
 EDO  A 475 ( 4.0A)
None
None
None
 0.98A 5te8A-3oceA:
0.2		 5te8A-3oceA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 SER A 463
ALA A 267
ILE A 453
LEU A 448
 None
 0.75A 5te8A-3r6kA:
undetectable		 5te8A-3r6kA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		4 LEU A 149
THR A 131
ILE A 141
LEU A 152
 None
 0.82A 5te8A-3rmtA:
undetectable		 5te8A-3rmtA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		4 ALA A   8
THR A 218
ILE A  20
LEU A  24
 None
 1.01A 5te8A-3tfxA:
undetectable		 5te8A-3tfxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 LEU A 247
ALA A 249
THR A 229
LEU A 325
 None
 1.02A 5te8A-3ti7A:
undetectable		 5te8A-3ti7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ARG A 514
SER A 181
ALA A 291
ILE A 296
 None
 0.96A 5te8A-3tv2A:
0.1		 5te8A-3tv2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A 282
LEU A 279
ILE A 224
LEU A 241
 None
 1.06A 5te8A-3uj2A:
undetectable		 5te8A-3uj2A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 ARG X 281
ALA X 183
ILE X 268
LEU X 272
 None
 0.95A 5te8A-3utnX:
undetectable		 5te8A-3utnX:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrv TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		4 LEU A 138
ALA A 134
ILE A 146
LEU A 164
 None
 0.95A 5te8A-3wrvA:
undetectable		 5te8A-3wrvA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 101
ALA A 126
ILE A 147
LEU A 123
 None
NDP  A 601 (-3.4A)
None
None
 0.84A 5te8A-3zhyA:
undetectable		 5te8A-3zhyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		4 SER A 225
LEU A 189
ALA A 411
ILE A 179
 None
 0.97A 5te8A-3zm8A:
undetectable		 5te8A-3zm8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etm LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YFKJ

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 SER A  39
ALA A  18
ILE A  58
LEU A  59
 K  A 203 (-3.5A)
None
None
None
 1.02A 5te8A-4etmA:
undetectable		 5te8A-4etmA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		4 LEU A  62
THR A 269
ILE A  94
LEU A 350
 None
 0.85A 5te8A-4gdnA:
undetectable		 5te8A-4gdnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Drosophila
melanogaster) 		PF13091
(PLDc_2) 		4 ARG A 102
ALA A 223
THR A 228
ILE A 174
 None
 0.77A 5te8A-4gelA:
undetectable		 5te8A-4gelA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1

(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		no annotation 4 LEU B 287
ALA B 201
ILE B 309
LEU B  53
 None
 1.00A 5te8A-4h2xB:
undetectable		 5te8A-4h2xB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Pseudomonas
aeruginosa) 		PF13360
(PQQ_2) 		4 LEU A 359
ALA A  63
ILE A  81
LEU A 374
 None
 1.02A 5te8A-4hdjA:
undetectable		 5te8A-4hdjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ALA A 410
THR A 354
ILE A 390
LEU A 391
 None
 0.81A 5te8A-4jkmA:
undetectable		 5te8A-4jkmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A3231
ALA A3412
ILE A3073
LEU A3063
 None
 1.05A 5te8A-4kc5A:
undetectable		 5te8A-4kc5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		4 SER A 208
ALA A 200
ILE A 195
LEU A  15
 None
 1.05A 5te8A-4mdvA:
undetectable		 5te8A-4mdvA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A  95
ALA A  91
ILE A 116
LEU A 119
 None
 1.05A 5te8A-4mn8A:
undetectable		 5te8A-4mn8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mso SERINE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
cenocepacia) 		PF00464
(SHMT) 		4 LEU A 198
ALA A 173
ILE A 117
LEU A 170
 None
 0.86A 5te8A-4msoA:
undetectable		 5te8A-4msoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 ARG A 289
LEU A 284
ILE A 295
LEU A 292
 None
 1.00A 5te8A-4n78A:
undetectable		 5te8A-4n78A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU B 247
ALA B 213
ILE B 124
LEU B 125
 None
 0.81A 5te8A-4o27B:
undetectable		 5te8A-4o27B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF00575
(S1)
PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N) 		4 SER F  44
LEU E  46
ALA F  17
LEU E  49
 None
 0.79A 5te8A-4qiwF:
undetectable		 5te8A-4qiwF:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7b MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 ARG A 142
LEU A 139
ILE A 326
LEU A 329
 None
 0.92A 5te8A-4u7bA:
undetectable		 5te8A-4u7bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7b MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 LEU A 280
ALA A 274
ILE A 138
LEU A 139
 None
 1.04A 5te8A-4u7bA:
undetectable		 5te8A-4u7bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 136
ALA A 164
ILE A   8
LEU A 167
 None
 0.98A 5te8A-4x0oA:
undetectable		 5te8A-4x0oA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrf HYPOTHETICAL
THIOESTERASE PROTEIN
SP_1851

(Streptococcus
pneumoniae) 		PF03061
(4HBT) 		4 ARG A 111
ALA A  78
ILE A 105
LEU A  85
 None
 0.95A 5te8A-4zrfA:
undetectable		 5te8A-4zrfA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		4 ARG A 367
ALA A 307
ILE A 302
LEU A  91
 None
 0.97A 5te8A-5b3jA:
undetectable		 5te8A-5b3jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		4 SER A 378
LEU A 398
ILE A 368
LEU A 402
 None
 0.98A 5te8A-5b5rA:
undetectable		 5te8A-5b5rA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 ARG A 185
ALA A 292
ILE A  32
LEU A  83
 None
 0.94A 5te8A-5bn4A:
undetectable		 5te8A-5bn4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A 141
ALA A  88
ILE A 253
LEU A 244
 None
 1.00A 5te8A-5dfaA:
undetectable		 5te8A-5dfaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 SER A 434
ALA A 490
ILE A 108
LEU A 106
 None
 1.05A 5te8A-5gwnA:
undetectable		 5te8A-5gwnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 390
THR A 345
ILE A 397
LEU A 418
 None
 1.01A 5te8A-5kyvA:
undetectable		 5te8A-5kyvA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 SER A 810
ALA A 911
ILE A 878
LEU A 932
 None
 0.86A 5te8A-5l5gA:
undetectable		 5te8A-5l5gA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 SER A 579
LEU A 549
ALA A 547
THR A 448
 None
 0.90A 5te8A-5lp4A:
undetectable		 5te8A-5lp4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 ARG A 440
LEU A 442
ALA A 421
ILE A 321
 None
 0.99A 5te8A-5mkfA:
undetectable		 5te8A-5mkfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-9

(Caenorhabditis
elegans) 		no annotation 4 LEU D  79
ALA D  75
ILE D  72
LEU D 339
 None
 0.81A 5te8A-5nkmD:
undetectable		 5te8A-5nkmD:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		4 ALA A 239
THR A 243
ILE A 149
LEU A 199
 None
 0.84A 5te8A-5tprA:
undetectable		 5te8A-5tprA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3

(Homo sapiens) 		no annotation 4 LEU A  22
THR A  87
ILE A  88
LEU A  25
 None
 1.02A 5te8A-5ukeA:
undetectable		 5te8A-5ukeA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		4 ALA A 419
THR A 422
ILE A 454
LEU A 451
 None
 0.98A 5te8A-5vatA:
undetectable		 5te8A-5vatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 247
THR A 225
ILE A 226
LEU A 257
 None
 0.89A 5te8A-5vm2A:
undetectable		 5te8A-5vm2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF

(Shewanella
oneidensis) 		no annotation 4 ALA B 262
THR B 266
ILE B 284
LEU B 251
 None
 1.00A 5te8A-5vrfB:
undetectable		 5te8A-5vrfB:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 ARG A 457
LEU A 460
ALA A 389
LEU A 472
 None
 1.00A 5te8A-6bfiA:
0.0		 5te8A-6bfiA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 248
SER B 147
THR B 114
LEU B 139
 None
 1.03A 5te8A-6c6lA:
0.2		 5te8A-6c6lA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 LEU A 286
ALA A 261
ILE A 199
LEU A 258
 None
 0.98A 5te8A-6cczA:
undetectable		 5te8A-6cczA:
10.68