SIMILAR PATTERNS OF AMINO ACIDS FOR 5TE0_A_XINA401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		4 LEU A  64
VAL A  60
MET A 108
CYH A 111
 None
None
SO3  A1374 ( 4.7A)
None
 1.44A 5te0A-1okgA:
undetectable		 5te0A-1okgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 624
CYH A 694
CYH A 828
 None
 0.58A 5te0A-1rjbA:
21.8		 5te0A-1rjbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmd RAG1

(Mus musculus) 		PF00097
(zf-C3HC4)
PF10426
(zf-RAG1)
PF12560
(RAG1_imp_bd) 		4 LEU A  44
VAL A  37
CYH A  41
CYH A  68
 None
None
ZN  A 119 (-2.3A)
None
 1.46A 5te0A-1rmdA:
undetectable		 5te0A-1rmdA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		4 LEU A 396
VAL A 392
MET A 423
CYH A 444
 None
 1.22A 5te0A-1sxjA:
undetectable		 5te0A-1sxjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 603
CYH A 673
CYH A 809
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.5A)
 0.52A 5te0A-1t46A:
18.0		 5te0A-1t46A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REPLICATION PROTEIN
E1

(Alphapapillomavirus
7) 		PF00519
(PPV_E1_C) 		4 LEU A 528
MET A 543
CYH A 479
CYH A 566
 None
 1.40A 5te0A-1tueA:
undetectable		 5te0A-1tueA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo7 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		4 LEU A 117
MET A  11
CYH A  52
CYH A  69
 None
 1.49A 5te0A-1yo7A:
undetectable		 5te0A-1yo7A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 605
VAL A 613
MET A 788
CYH A 791
 None
None
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.3A)
 0.32A 5te0A-1zy4A:
21.7		 5te0A-1zy4A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		4 LEU A 143
VAL A 140
MET A 201
CYH A 220
 None
 1.30A 5te0A-2horA:
undetectable		 5te0A-2horA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C  55
VAL C  63
MET C 129
CYH C 132
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
None
ANP  C   2 (-4.5A)
 0.94A 5te0A-2wtkC:
25.7		 5te0A-2wtkC:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 LEU B 179
VAL B 175
MET B 211
CYH B 189
 None
 1.49A 5te0A-3aeqB:
undetectable		 5te0A-3aeqB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		4 LEU A 176
VAL A 172
MET A 135
CYH A 159
 None
 1.34A 5te0A-3dxiA:
undetectable		 5te0A-3dxiA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
MET A 117
CYH A 184
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.8A)
DRK  A 384 ( 3.8A)
 0.74A 5te0A-3eb0A:
24.1		 5te0A-3eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 212
VAL A 213
MET A 132
CYH A 188
 None
 1.29A 5te0A-3fcjA:
undetectable		 5te0A-3fcjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
VAL A  67
MET A 129
CYH A 196
 STU  A   1 (-3.8A)
None
STU  A   1 ( 3.8A)
STU  A   1 ( 3.7A)
 0.62A 5te0A-3fmeA:
21.4		 5te0A-3fmeA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkm OS03G0854200 PROTEIN

(Oryza sativa) 		PF01138
(RNase_PH) 		4 LEU A  84
VAL A  64
CYH A 124
CYH A  92
 None
 1.50A 5te0A-3hkmA:
undetectable		 5te0A-3hkmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 833
VAL A 841
CYH A 912
CYH A1039
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.2A)
 0.42A 5te0A-3hngA:
22.9		 5te0A-3hngA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4u ATP-DEPENDENT RNA
HELICASE DHX8

(Homo sapiens) 		PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 LEU A1006
VAL A1009
MET A 992
CYH A1001
 None
 1.37A 5te0A-3i4uA:
undetectable		 5te0A-3i4uA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A 141
VAL A 149
MET A 210
CYH A 213
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.6A)
ANP  A   1 (-4.3A)
 0.45A 5te0A-3is5A:
24.8		 5te0A-3is5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxe TRYPTOPHANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 LEU A 247
VAL A 276
CYH A 301
CYH A 332
 None
 1.38A 5te0A-3jxeA:
undetectable		 5te0A-3jxeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		4 LEU A  21
VAL A  29
MET A  96
CYH A  99
 None
 0.61A 5te0A-3qa8A:
19.3		 5te0A-3qa8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 LEU A 498
VAL A 502
MET A 512
CYH A 477
 None
 1.34A 5te0A-3s51A:
undetectable		 5te0A-3s51A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 LEU A 630
VAL A 763
MET A 621
CYH A 604
 None
 1.42A 5te0A-3uelA:
undetectable		 5te0A-3uelA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		4 LEU A 701
VAL A 730
CYH A 713
CYH A 735
 None
 1.40A 5te0A-3un9A:
undetectable		 5te0A-3un9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
CYH A 919
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-4.3A)
None
 0.49A 5te0A-3vidA:
22.0		 5te0A-3vidA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 LEU A 543
VAL A 517
CYH A 498
CYH A 466
 None
 1.33A 5te0A-3wbkA:
undetectable		 5te0A-3wbkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
CYH A 919
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-4.1A)
GOL  A1210 ( 3.3A)
 0.38A 5te0A-3wzdA:
22.5		 5te0A-3wzdA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
CYH A 919
CYH A1045
 B49  A2000 (-3.7A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 4.1A)
 0.59A 5te0A-4agdA:
22.3		 5te0A-4agdA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 LEU A 440
MET A 460
CYH A 418
CYH A 413
 None
 1.32A 5te0A-4b8jA:
undetectable		 5te0A-4b8jA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		4 LEU A 160
VAL A 192
CYH A 145
CYH A 138
 None
None
BME  A 502 (-2.0A)
None
 1.28A 5te0A-4da1A:
undetectable		 5te0A-4da1A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
MET A  86
CYH A  89
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-4.5A)
BX7  A 401 (-4.1A)
 0.83A 5te0A-4eutA:
21.6		 5te0A-4eutA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
MET A  86
CYH A  89
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.7A)
BX7  A 401 (-4.1A)
 0.64A 5te0A-4euuA:
24.7		 5te0A-4euuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		4 LEU A 627
VAL A 760
MET A 618
CYH A 601
 None
 1.48A 5te0A-4fc2A:
undetectable		 5te0A-4fc2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4git LON PROTEASE

(Brevibacillus
thermoruber) 		PF05362
(Lon_C) 		4 LEU A 577
VAL A 574
MET A 523
CYH A 552
 None
 1.09A 5te0A-4gitA:
undetectable		 5te0A-4gitA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 406
VAL A 414
MET A 469
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-2.6A)
T28  A 701 (-3.7A)
 0.85A 5te0A-4idtA:
23.5		 5te0A-4idtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		4 LEU A 284
VAL A 131
MET A  87
CYH A 236
 None
None
None
PYC  A 402 (-3.6A)
 1.42A 5te0A-4j9wA:
undetectable		 5te0A-4j9wA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 LEU A 207
VAL A 201
MET A 141
CYH A 148
 None
 1.39A 5te0A-4jjaA:
undetectable		 5te0A-4jjaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
MET A  86
CYH A  89
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.8A)
 0.48A 5te0A-4jlcA:
18.8		 5te0A-4jlcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia) 		PF01979
(Amidohydro_1) 		4 LEU A  93
VAL A 116
MET A 144
CYH A 137
 None
KCX  A 117 ( 3.0A)
None
None
 1.07A 5te0A-4lfyA:
undetectable		 5te0A-4lfyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  33
VAL A  41
MET A  99
CYH A 102
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 (-2.7A)
GOL  A 403 (-4.0A)
 0.52A 5te0A-4lg4A:
19.0		 5te0A-4lg4A:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  78
VAL A  86
MET A 146
CYH A 149
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.2A)
 0.45A 5te0A-4mvfA:
22.9		 5te0A-4mvfA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 LEU A 729
VAL A 644
CYH A 734
CYH A 526
 None
 1.45A 5te0A-4ncnA:
undetectable		 5te0A-4ncnA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  46
VAL A  54
CYH A 126
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 (-4.3A)
None
 0.52A 5te0A-4o38A:
26.9		 5te0A-4o38A:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 624
CYH A 694
CYH A 828
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-4.1A)
 0.44A 5te0A-4rt7A:
23.0		 5te0A-4rt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 4 LEU B 729
VAL B 644
CYH B 734
CYH B 526
 None
 1.46A 5te0A-4tmzB:
undetectable		 5te0A-4tmzB:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  52
VAL A  60
MET A 126
CYH A 129
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.4A)
 0.57A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 624
CYH A 694
CYH A 828
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-4.2A)
P30  A1001 (-4.8A)
 0.58A 5te0A-4xufA:
22.6		 5te0A-4xufA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum) 		no annotation 4 LEU A 196
VAL A 200
CYH A 125
CYH A  46
 None
None
None
ZN  A 500 (-2.2A)
 1.35A 5te0A-5b5zA:
undetectable		 5te0A-5b5zA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erm FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		no annotation 4 LEU A 205
VAL A 201
MET A 309
CYH A 217
 None
 1.42A 5te0A-5ermA:
undetectable		 5te0A-5ermA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
VAL A 607
CYH A 677
CYH A 835
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.5A)
748  A1001 (-4.5A)
 0.56A 5te0A-5grnA:
16.3		 5te0A-5grnA:
24.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
MET A 130
CYH A 133
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
 0.68A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irr SEPTIN-LIKE PROTEIN

(Chlamydomonas
reinhardtii) 		PF00735
(Septin) 		4 LEU A 368
VAL A 364
CYH A 231
CYH A 234
 None
 0.99A 5te0A-5irrA:
undetectable		 5te0A-5irrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 LEU A 112
VAL A 109
CYH A  20
CYH A 121
 None
 1.27A 5te0A-5tukA:
undetectable		 5te0A-5tukA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B  50
VAL B  10
MET B  16
CYH B  91
 None
 1.50A 5te0A-5y58B:
undetectable		 5te0A-5y58B:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 4 LEU A  33
VAL A  41
MET A  99
CYH A 102
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 (-2.5A)
ANP  A 501 (-4.2A)
 0.72A 5te0A-6ao5A:
9.9		 5te0A-6ao5A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 4 LEU A 206
VAL A 202
MET A 151
CYH A 143
 None
 1.17A 5te0A-6byqA:
undetectable		 5te0A-6byqA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 LEU A 366
VAL A 374
MET A 438
CYH A 441
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 ( 3.8A)
EE4  A 701 (-4.6A)
 0.62A 5te0A-6c0tA:
16.3		 5te0A-6c0tA:
13.45