SIMILAR PATTERNS OF AMINO ACIDS FOR 5TE0_A_XINA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A   8
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 133
 None
 0.86A 5te0A-1h4lA:
25.3		 5te0A-1h4lA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 211
ALA A 220
GLU A 236
MET A 240
VAL A 249
GLY A 272
LEU A 321
 None
 0.55A 5te0A-1k9aA:
25.2		 5te0A-1k9aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
GLU A 305
MET A 309
VAL A 318
PHE A 336
GLY A 340
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.43A 5te0A-1opkA:
23.3		 5te0A-1opkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 379
ALA A 389
VAL A 419
PHE A 437
GLY A 441
LEU A 489
 None
 0.53A 5te0A-1snxA:
23.2		 5te0A-1snxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 379
MET A 410
VAL A 419
PHE A 437
GLY A 441
LEU A 489
 None
 0.76A 5te0A-1snxA:
23.2		 5te0A-1snxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.35A 5te0A-1u59A:
25.2		 5te0A-1u59A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  25
ALA A  36
GLU A  55
VAL A  68
GLY A  90
LEU A 137
 None
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-4.5A)
 0.49A 5te0A-1zltA:
24.7		 5te0A-1zltA:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  36
ALA A  47
GLU A  65
PHE A 100
GLY A 104
ASN A 108
LEU A 155
 None
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
 0.82A 5te0A-2bujA:
30.3		 5te0A-2bujA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
GLU X  54
MET X  58
VAL X  67
GLY X  88
LEU X 137
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.53A 5te0A-2dq7X:
25.7		 5te0A-2dq7X:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 LEU A  69
ALA A  80
MET A 104
VAL A 113
GLY A 134
LEU A 182
 None
 1.01A 5te0A-2hakA:
22.0		 5te0A-2hakA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 LEU A  69
ALA A  80
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.88A 5te0A-2hakA:
22.0		 5te0A-2hakA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
MET A 292
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.72A 5te0A-2hk5A:
18.5		 5te0A-2hk5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
GLU A 286
MET A 290
VAL A 299
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.49A 5te0A-2hz0A:
23.8		 5te0A-2hz0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.54A 5te0A-2j0jA:
23.9		 5te0A-2j0jA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
LEU A 553
 BII  A1687 (-3.5A)
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.78A 5te0A-2jkmA:
23.4		 5te0A-2jkmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU A 249
ALA A 271
GLU A 288
MET A 292
VAL A 301
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.76A 5te0A-2og8A:
22.5		 5te0A-2og8A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
GLU A 633
MET A 637
VAL A 647
GLY A 669
LEU A 785
 None
 0.69A 5te0A-2ogvA:
21.9		 5te0A-2ogvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  92
ALA A 103
GLU A 124
MET A 128
GLY A 158
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
None
None
ANP  A1480 ( 4.7A)
 1.13A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  92
ALA A 103
GLU A 124
MET A 128
GLY A 159
ASN A 163
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
None
None
None
ANP  A1480 ( 4.7A)
 1.05A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  92
ALA A 103
GLU A 124
VAL A 137
GLY A 158
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
 1.02A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  92
ALA A 103
GLU A 124
VAL A 137
GLY A 159
ASN A 163
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
None
ANP  A1480 ( 4.7A)
 1.00A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU B  87
GLU B 118
VAL B 131
PHE B 149
GLY B 153
LEU B 202
 None
None
None
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
 0.88A 5te0A-2wtkB:
24.9		 5te0A-2wtkB:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
ALA A  92
VAL A 125
PHE A 143
GLY A 146
LEU A 194
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
None
STU  A   1 (-4.6A)
 0.92A 5te0A-2z7rA:
24.1		 5te0A-2z7rA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
ALA A  92
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.37A 5te0A-2z7rA:
24.1		 5te0A-2z7rA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
MET A 294
VAL A 303
PHE A 321
GLY A 325
LEU A 374
 None
 0.77A 5te0A-2zv7A:
25.0		 5te0A-2zv7A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		6 ALA A 243
LEU A  75
ALA A  71
PHE A  49
GLY A  90
LEU A  53
 None
 1.18A 5te0A-3afeA:
undetectable		 5te0A-3afeA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A  16
ALA A  39
VAL A  75
PHE A  93
GLY A  96
LEU A 148
 None
3AM  A 338 (-3.3A)
None
3AM  A 338 ( 4.6A)
None
3AM  A 338 (-4.7A)
 0.84A 5te0A-3c0iA:
27.7		 5te0A-3c0iA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 494
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
 0.61A 5te0A-3c4fA:
22.5		 5te0A-3c4fA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 211
ALA A 220
GLU A 236
MET A 240
VAL A 249
GLY A 272
LEU A 321
 None
 0.55A 5te0A-3d7uA:
25.9		 5te0A-3d7uA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 LEU A  69
ALA A  80
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.60A 5te0A-3iecA:
27.0		 5te0A-3iecA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 LEU A  69
GLU A 100
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.69A 5te0A-3iecA:
27.0		 5te0A-3iecA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 LEU A 568
ALA A 579
GLU A 596
VAL A 614
GLY A 634
LEU A 684
 None
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.85A 5te0A-3lltA:
24.0		 5te0A-3lltA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
ALA A  70
GLU A  91
VAL A 104
GLY A 126
LEU A 173
 None
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.64A 5te0A-3mvjA:
25.5		 5te0A-3mvjA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 GLU A  27
ALA A  49
GLU A  69
VAL A  82
PHE A 100
LEU A 151
 None
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
 0.96A 5te0A-3nizA:
26.1		 5te0A-3nizA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  98
ALA A 109
GLU A 130
MET A 134
GLY A 165
LEU A 212
 None
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
 0.38A 5te0A-3nuuA:
26.3		 5te0A-3nuuA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  98
ALA A 109
GLU A 130
VAL A 143
GLY A 165
LEU A 212
 None
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
 0.61A 5te0A-3nuuA:
26.3		 5te0A-3nuuA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLU A 555
ALA A 576
GLU A 596
MET A 600
VAL A 609
GLY A 631
LEU A 683
 None
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.81A 5te0A-3ppzA:
26.5		 5te0A-3ppzA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  73
ALA A  84
GLU A 115
PHE A 146
GLY A 150
LEU A 197
 None
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.53A 5te0A-3q5iA:
25.1		 5te0A-3q5iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  73
ALA A  84
GLU A 115
VAL A 210
PHE A 146
GLY A 150
 None
ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.8A)
None
 1.38A 5te0A-3q5iA:
25.1		 5te0A-3q5iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 433
ALA A 443
MET A 464
VAL A 473
GLY A 495
LEU A 543
 None
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.59A 5te0A-3sxsA:
13.4		 5te0A-3sxsA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 494
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 None
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.53A 5te0A-3tt0A:
22.4		 5te0A-3tt0A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 371
ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
 None
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.58A 5te0A-3txoA:
17.2		 5te0A-3txoA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A  37
ALA A  48
VAL A  78
GLY A 100
LEU A 147
 None
 0.38A 5te0A-3ujgA:
20.2		 5te0A-3ujgA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 554
ALA A 570
GLU A 588
VAL A 601
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.71A 5te0A-3v5qA:
22.4		 5te0A-3v5qA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.44A 5te0A-3vidA:
22.0		 5te0A-3vidA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.61A 5te0A-3wzdA:
22.5		 5te0A-3wzdA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.57A 5te0A-4agdA:
22.3		 5te0A-4agdA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
GLU A  81
VAL A  94
PHE A 112
GLY A 116
LEU A 164
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.61A 5te0A-4bc6A:
22.3		 5te0A-4bc6A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU A 614
LEU A 626
ALA A 653
GLU A 672
MET A 676
GLY A 707
LEU A 773
 None
None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
 0.82A 5te0A-4ckrA:
22.2		 5te0A-4ckrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 673
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 None
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.39A 5te0A-4crsA:
26.9		 5te0A-4crsA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.72A 5te0A-4fieA:
25.5		 5te0A-4fieA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 ALA A 348
MET A 370
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-3.6A)
None
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.76A 5te0A-4fieA:
25.5		 5te0A-4fieA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 838
ALA A 853
GLU A 871
VAL A 884
GLY A 908
LEU A 956
 None
19S  A1201 (-3.3A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.54A 5te0A-4hviA:
25.2		 5te0A-4hviA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 423
ALA A 434
GLU A 452
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.73A 5te0A-4ks8A:
26.0		 5te0A-4ks8A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 423
ALA A 434
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.54A 5te0A-4ks8A:
26.0		 5te0A-4ks8A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A  40
ALA A  61
GLU A  77
VAL A  90
GLY A 110
ASN A 114
 None
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.4A)
 0.90A 5te0A-4l52A:
14.4		 5te0A-4l52A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A  40
ALA A  61
GLU A  77
VAL A  90
GLY A 110
LEU A 163
 None
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.72A 5te0A-4l52A:
14.4		 5te0A-4l52A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  54
GLU A  70
MET A  74
VAL A  83
GLY A 105
LEU A 153
 GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 1.01A 5te0A-4lg4A:
18.9		 5te0A-4lg4A:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A  31
ALA A  54
GLU A  70
MET A  74
VAL A  83
GLY A 105
 None
GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
 1.11A 5te0A-4lg4A:
18.9		 5te0A-4lg4A:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
ALA A  54
GLU A  70
MET A  74
VAL A  83
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
 1.42A 5te0A-4lg4A:
18.9		 5te0A-4lg4A:
29.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  47
ALA A  67
GLU A  85
VAL A  99
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.85A 5te0A-4o38A:
26.9		 5te0A-4o38A:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
GLU A  85
MET A  89
VAL A  99
GLY A 128
GLN A 129
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.79A 5te0A-4o38A:
26.9		 5te0A-4o38A:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 114
ALA A 125
GLU A 146
VAL A 159
GLY A 181
LEU A 228
 None
ATP  A 501 (-3.4A)
None
None
None
ATP  A 501 (-4.5A)
 0.58A 5te0A-4wb7A:
25.5		 5te0A-4wb7A:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		10 GLU A  50
ALA A  53
LEU A  62
ALA A  72
GLU A  90
MET A  94
VAL A 104
PHE A 128
GLY A 132
LEU A 183
 None
KSA  A 405 (-3.3A)
None
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.76A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU A  50
ALA A  53
LEU A  62
ALA A  72
MET A  94
VAL A 104
PHE A 128
GLY A 131
 None
KSA  A 405 (-3.3A)
None
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
None
 0.88A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLU A  50
LEU A  62
ALA A  72
MET A  94
VAL A 104
PHE A 128
GLY A 132
GLN A 133
LEU A 183
 None
None
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
 0.67A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		6 ALA A 348
MET A 370
VAL A 379
PHE A 397
GLY A 400
LEU A 447
 ATP  A 601 ( 3.7A)
None
None
ATP  A 601 (-4.6A)
None
None
 1.23A 5te0A-4xbrA:
20.5		 5te0A-4xbrA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		6 ALA A 348
MET A 370
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ATP  A 601 ( 3.7A)
None
None
ATP  A 601 (-4.6A)
None
None
 0.76A 5te0A-4xbrA:
20.5		 5te0A-4xbrA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 ALA B 288
MET B 309
VAL B 318
PHE B 336
GLY B 340
LEU B 389
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.58A 5te0A-4xeyB:
24.0		 5te0A-4xeyB:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 494
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 None
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.55A 5te0A-5a46A:
22.5		 5te0A-5a46A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A  29
ALA A  52
GLU A  69
PHE A 107
GLY A 111
LEU A 160
 GLU  A  29 ( 0.6A)
ALA  A  52 (-0.0A)
GLU  A  69 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
 0.65A 5te0A-5d7aA:
24.8		 5te0A-5d7aA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 LEU A  72
ALA A  83
GLU A 103
VAL A 116
GLY A 138
LEU A 185
 None
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
None
 0.62A 5te0A-5es1A:
27.3		 5te0A-5es1A:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 LEU A 109
ALA A 120
PHE A 172
GLY A 176
LEU A 223
 None
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.20A 5te0A-5eykA:
26.7		 5te0A-5eykA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
GLU A 644
MET A 648
VAL A 658
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.45A 5te0A-5grnA:
16.3		 5te0A-5grnA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A  96
ALA A 105
VAL A 134
GLY A 154
ASN A 158
LEU A 215
 None
 0.43A 5te0A-5gz8A:
19.1		 5te0A-5gz8A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 GLU A  18
ALA A  41
GLU A  61
VAL A  74
GLY A  96
LEU A 143
 None
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 (-4.7A)
 0.69A 5te0A-5hu3A:
28.3		 5te0A-5hu3A:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU A  55
ALA A  58
LEU A  67
ALA A  77
GLU A  95
MET A  99
VAL A 109
LEU A 187
 None
IDV  A 401 (-3.3A)
None
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-4.4A)
 0.93A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLU A  55
LEU A  67
ALA A  77
GLU A  95
MET A  99
VAL A 109
GLY A 136
GLN A 137
LEU A 187
 None
None
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 (-4.4A)
 0.85A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU A  55
LEU A  67
GLU A  95
VAL A 109
GLY A 136
GLN A 137
ASN A 140
LEU A 187
 None
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 ( 4.5A)
IDV  A 401 (-4.4A)
 0.99A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
GLU A  61
MET A  65
VAL A  74
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.50A 5te0A-5j5tA:
22.2		 5te0A-5j5tA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 297
GLU A 315
MET A 319
VAL A 328
GLY A 350
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.61A 5te0A-5kbrA:
23.7		 5te0A-5kbrA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF01180
(DHO_dh)
PF10418
(DHODB_Fe-S_bind) 		6 GLU A  65
ALA B  47
LEU B  51
ALA A 275
VAL A 279
GLY A 222
 FAD  B 301 ( 4.6A)
None
FAD  B 301 ( 4.2A)
None
None
FMN  A 401 (-3.5A)
 1.44A 5te0A-5kswA:
undetectable		 5te0A-5kswA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
LEU A1016
 ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
 0.66A 5te0A-5lpyA:
24.3		 5te0A-5lpyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
LEU A1016
 ADP  A1200 (-3.5A)
None
None
ADP  A1200 (-4.1A)
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.75A 5te0A-5lpzA:
24.2		 5te0A-5lpzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 LEU A 368
ALA A 379
VAL A 413
PHE A 431
GLY A 434
LEU A 482
 None
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 ( 4.9A)
None
ANP  A 801 (-4.8A)
 0.97A 5te0A-5nclA:
21.3		 5te0A-5nclA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 LEU A 368
ALA A 379
VAL A 413
PHE A 431
GLY A 435
LEU A 482
 None
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 ( 4.9A)
None
ANP  A 801 (-4.8A)
 0.51A 5te0A-5nclA:
21.3		 5te0A-5nclA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 6 ALA A 103
VAL A 134
PHE A 152
GLY A 156
ASN A 160
LEU A 209
 None
 0.62A 5te0A-5tosA:
19.7		 5te0A-5tosA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 108
ALA A 119
MET A 144
GLY A 175
ASN A 179
LEU A 221
 None
 1.06A 5te0A-5u7qA:
24.7		 5te0A-5u7qA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 108
ALA A 119
VAL A 153
GLY A 175
ASN A 179
LEU A 221
 None
 0.86A 5te0A-5u7qA:
24.7		 5te0A-5u7qA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 GLU A  15
LEU A  27
ALA A  38
GLU A  59
VAL A  72
GLY A  97
 None
GOL  A 307 ( 3.8A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
GOL  A 305 ( 4.3A)
 0.63A 5te0A-5u94A:
27.7		 5te0A-5u94A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 6 ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.60A 5te0A-5vefA:
25.4		 5te0A-5vefA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 ALA A 707
GLU A 725
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.32A 5te0A-5vilA:
25.1		 5te0A-5vilA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 141
ALA A 150
PHE A 192
GLY A 196
GLN A 197
LEU A 243
 None
9FS  A 501 (-3.4A)
9FS  A 501 (-4.3A)
9FS  A 501 (-3.6A)
9FS  A 501 ( 4.0A)
9FS  A 501 (-4.7A)
 0.69A 5te0A-5vo1A:
20.9		 5te0A-5vo1A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 GLU A  26
ALA A  49
GLU A  69
MET A  73
GLY A 102
LEU A 150
 None
VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
 0.90A 5te0A-5wnmA:
24.2		 5te0A-5wnmA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 GLU A 202
ALA A 225
GLU A 244
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.81A 5te0A-5xzwA:
21.2		 5te0A-5xzwA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 LEU A 376
ALA A 388
GLU A 409
MET A 413
VAL A 422
GLY A 444
 None
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
None
 0.71A 5te0A-6c0tA:
16.3		 5te0A-6c0tA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 891
ALA A 906
GLU A 925
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 None
ADP  A1201 (-3.4A)
None
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.65A 5te0A-6c7yA:
24.2		 5te0A-6c7yA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 LEU A  76
ALA A  87
GLU A 107
MET A 111
VAL A 120
GLY A 142
LEU A 189
 None
 0.65A 5te0A-6c9dA:
28.1		 5te0A-6c9dA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 LEU A 181
ALA A 192
GLU A 236
VAL A 249
GLY A 273
LEU A 319
 None
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
None
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
 0.65A 5te0A-6cmjA:
27.1		 5te0A-6cmjA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 GLU U  18
ALA U  42
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 None
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.71A 5te0A-6fdyU:
25.3		 5te0A-6fdyU:
undetectable