SIMILAR PATTERNS OF AMINO ACIDS FOR 5TDM_A_ADNA904_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		4 THR A  54
ASP A 285
ARG A  51
LEU A 286
 None
 1.28A 5tdmA-1mtpA:
0.0		 5tdmA-1mtpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 THR A  67
ASP A  70
ARG A  63
LEU A  64
 None
 1.07A 5tdmA-1r3nA:
0.1		 5tdmA-1r3nA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		4 THR A 456
ASP A 457
ARG A 542
LEU A 543
 None
 1.43A 5tdmA-1vg0A:
0.3		 5tdmA-1vg0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeb HYPOTHETICAL PROTEIN
PA0115

(Pseudomonas
aeruginosa) 		PF13673
(Acetyltransf_10) 		4 THR A  49
ASP A  68
ARG A  71
LEU A  67
 None
 1.07A 5tdmA-1xebA:
0.0		 5tdmA-1xebA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 THR A 268
ASP A 269
ARG A 273
LEU A 272
 None
 1.35A 5tdmA-1yirA:
0.9		 5tdmA-1yirA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 THR A 273
ASP A 265
ARG A 271
LEU A 266
 None
 1.01A 5tdmA-2ew2A:
0.0		 5tdmA-2ew2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7a CALPAIN 13

(Homo sapiens) 		no annotation 4 THR A 599
ASP A 600
ARG A 603
LEU A 602
 None
 1.49A 5tdmA-2i7aA:
undetectable		 5tdmA-2i7aA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9m FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA

(Homo sapiens) 		no annotation 4 THR A 108
ASP A 111
ARG A  73
LEU A  76
 None
 1.08A 5tdmA-2m9mA:
3.0		 5tdmA-2m9mA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 THR A 129
ASP A 131
ARG A 132
LEU A 133
 None
 1.43A 5tdmA-2y6cA:
undetectable		 5tdmA-2y6cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3b 30S RIBOSOMAL
PROTEIN S10

(Escherichia
coli) 		PF00338
(Ribosomal_S10) 		4 THR J  62
ASP J  64
ARG J  68
LEU J  66
 None
 1.28A 5tdmA-3d3bJ:
undetectable		 5tdmA-3d3bJ:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 THR A  13
ASP A  11
ARG A  15
LEU A  14
 None
None
None
SAM  A 221 (-4.4A)
 1.49A 5tdmA-3e23A:
undetectable		 5tdmA-3e23A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 THR A 101
ASP A 103
ARG A 106
LEU A 107
 None
 1.30A 5tdmA-3f11A:
undetectable		 5tdmA-3f11A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		4 THR A 324
ASP A 323
ARG A 305
LEU A 306
 None
 1.19A 5tdmA-3fipA:
undetectable		 5tdmA-3fipA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go5 MULTIDOMAIN PROTEIN
WITH S1 RNA-BINDING
DOMAINS

(Streptococcus
pneumoniae) 		PF13509
(S1_2) 		4 THR A  51
ASP A  52
ARG A  58
LEU A  57
 None
 1.25A 5tdmA-3go5A:
undetectable		 5tdmA-3go5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 THR A  45
ASP A  46
ARG A 274
LEU A 277
 None
 1.07A 5tdmA-3hgqA:
undetectable		 5tdmA-3hgqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 THR A 108
ASP A 110
ARG A 114
LEU A 112
 None
 1.37A 5tdmA-3mjfA:
4.1		 5tdmA-3mjfA:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF16114
(Citrate_bind) 		4 THR A  38
ASP A  39
ARG A  42
LEU A  43
 None
 0.72A 5tdmA-3mweA:
52.4		 5tdmA-3mweA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgh REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Thermoanaerobacter
ethanolicus) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		4 THR A 162
ASP A 164
ARG A 168
LEU A 166
 NAI  A 301 (-3.7A)
None
None
None
 1.00A 5tdmA-3wghA:
4.3		 5tdmA-3wghA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cah DYSFERLIN

(Homo sapiens) 		PF06398
(Pex24p) 		4 THR B1001
ASP B1002
ARG B1005
LEU B1003
 None
 1.03A 5tdmA-4cahB:
undetectable		 5tdmA-4cahB:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		4 THR A 136
ASP A 138
ARG A 141
LEU A 142
 None
 0.98A 5tdmA-4cv7A:
undetectable		 5tdmA-4cv7A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 THR A 549
ASP A 534
ARG A 550
LEU A 551
 None
ZN  A1613 ( 4.2A)
None
None
 1.47A 5tdmA-4cvcA:
undetectable		 5tdmA-4cvcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq7 MEMBRANE PROTEIN
PHI6 P5

(Pseudomonas
virus phi6) 		PF10464
(Peptidase_U40) 		4 THR A 121
ASP A 123
ARG A 127
LEU A 125
 None
 1.12A 5tdmA-4dq7A:
undetectable		 5tdmA-4dq7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf0 GLUTATHIONE
S-TRANSFERASE

(Sulfitobacter
sp. NAS-14.1) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 THR A  62
ASP A  61
ARG A  57
LEU A  58
 None
 0.97A 5tdmA-4gf0A:
undetectable		 5tdmA-4gf0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		4 THR A 561
ASP A 596
ARG A 560
LEU A 557
 None
 1.44A 5tdmA-4pjuA:
undetectable		 5tdmA-4pjuA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 THR A 130
ASP A 132
ARG A 136
LEU A 134
 None
 1.08A 5tdmA-4q48A:
undetectable		 5tdmA-4q48A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 THR A 292
ASP A 297
ARG A 359
LEU A 298
 None
None
SO4  A 907 (-3.2A)
None
 1.47A 5tdmA-4qnlA:
4.8		 5tdmA-4qnlA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 THR A 556
ASP A 500
ARG A 509
LEU A 502
 None
 1.14A 5tdmA-4um8A:
undetectable		 5tdmA-4um8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 THR A  40
ASP A  43
ARG A  36
LEU A  37
 None
 1.25A 5tdmA-4wjbA:
1.8		 5tdmA-4wjbA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 4 THR A  88
ASP A  89
ARG A  31
LEU A  27
 None
 1.08A 5tdmA-4yubA:
2.4		 5tdmA-4yubA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 THR A 111
ASP A 112
ARG A 139
LEU A 142
 None
 1.40A 5tdmA-4z5yA:
undetectable		 5tdmA-4z5yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		4 THR A 213
ASP A 215
ARG A 216
LEU A 217
 None
 1.27A 5tdmA-4zxoA:
1.4		 5tdmA-4zxoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 THR A 643
ASP A 639
ARG A 620
LEU A 638
 None
 1.22A 5tdmA-5hy7A:
undetectable		 5tdmA-5hy7A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		4 THR 5 347
ASP 5 295
ARG 5 173
LEU 5 294
 None
None
A  A2395 ( 3.0A)
None
 1.44A 5tdmA-5ool5:
undetectable		 5tdmA-5ool5:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		4 THR 5 347
ASP 5 348
ARG 5 173
LEU 5 294
 None
None
A  A2395 ( 3.0A)
None
 1.30A 5tdmA-5ool5:
undetectable		 5tdmA-5ool5:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 THR A  38
ASP A  39
ARG A  42
LEU A  43
 None
 0.66A 5tdmA-5te1A:
36.3		 5tdmA-5te1A:
72.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 THR A  48
ASP A  51
ARG A  44
LEU A  45
 None
 1.38A 5tdmA-5thwA:
1.3		 5tdmA-5thwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		4 THR A  36
ASP A  39
ARG A  32
LEU A  33
 None
 1.37A 5tdmA-5tp4A:
1.8		 5tdmA-5tp4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 THR A 268
ASP A  85
ARG A  86
LEU A 270
 None
 1.22A 5tdmA-5u47A:
undetectable		 5tdmA-5u47A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 THR A 495
ASP A 508
ARG A 511
LEU A 512
 None
 1.05A 5tdmA-5xfaA:
2.2		 5tdmA-5xfaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 4 THR A 177
ASP A 178
ARG A 175
LEU A 176
 None
 1.34A 5tdmA-6c8gA:
undetectable		 5tdmA-6c8gA:
13.50