SIMILAR PATTERNS OF AMINO ACIDS FOR 5T8S_B_SAMB402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.17A 5t8sB-1cenA:
undetectable		 5t8sB-1cenA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		4 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.23A 5t8sB-1ee6A:
undetectable		 5t8sB-1ee6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		4 PRO A 194
ASP A 196
PHE A 233
ASP A 200
 None
 1.09A 5t8sB-1iipA:
undetectable		 5t8sB-1iipA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.12A 5t8sB-1kcxA:
undetectable		 5t8sB-1kcxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.15A 5t8sB-1lf9A:
undetectable		 5t8sB-1lf9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.05A 5t8sB-1ltzA:
undetectable		 5t8sB-1ltzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 PRO A 192
SER A 133
THR A  83
PHE A 135
 None
 1.21A 5t8sB-1mnnA:
undetectable		 5t8sB-1mnnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 HIS B 213
PRO B 214
SER B 381
THR B  97
 None
 1.14A 5t8sB-1n60B:
undetectable		 5t8sB-1n60B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 HIS A 339
PRO A 337
THR A 556
ASP A 551
 None
 1.21A 5t8sB-1pd1A:
undetectable		 5t8sB-1pd1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psz PROTEIN (SURFACE
ANTIGEN PSAA)

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		4 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
 1.21A 5t8sB-1pszA:
undetectable		 5t8sB-1pszA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 HIS A 354
ASP A 345
THR A 195
ASP A 154
 None
 1.20A 5t8sB-1pvjA:
undetectable		 5t8sB-1pvjA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 HIS A 158
ASP A 126
SER A  98
ASP A 134
 None
 1.23A 5t8sB-1qmhA:
undetectable		 5t8sB-1qmhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
 None
 1.14A 5t8sB-1rajA:
undetectable		 5t8sB-1rajA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
 None
 1.11A 5t8sB-1rdrA:
undetectable		 5t8sB-1rdrA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		4 HIS A 212
PRO A 211
SER A 179
THR A 373
 None
 1.16A 5t8sB-1t3iA:
undetectable		 5t8sB-1t3iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyo NALP

(Neisseria
meningitidis) 		PF03797
(Autotransporter) 		4 ASP X1050
SER X 993
THR X1005
PHE X1003
 None
 1.15A 5t8sB-1uyoX:
undetectable		 5t8sB-1uyoX:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 HIS A  41
PRO A 127
SER A  38
ASP A 150
 None
 1.20A 5t8sB-1v26A:
undetectable		 5t8sB-1v26A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		4 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 0.97A 5t8sB-1vtkA:
undetectable		 5t8sB-1vtkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.15A 5t8sB-1xngA:
undetectable		 5t8sB-1xngA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 HIS A 422
PRO A 389
PHE A 460
ASP A 215
 None
 1.12A 5t8sB-1xr5A:
undetectable		 5t8sB-1xr5A:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  14
PRO A  15
ASP A 163
LYS A 165
SER A 186
THR A 227
PHE A 230
ASP A 238
 None
 0.73A 5t8sB-1xrcA:
58.3		 5t8sB-1xrcA:
67.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		4 HIS A 201
ASP A 483
THR A 211
ASP A 481
 None
 1.18A 5t8sB-2f1zA:
undetectable		 5t8sB-2f1zA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00018
(SH3_1) 		4 LYS A  18
SER A  26
THR A  51
ASP A  23
 None
 1.19A 5t8sB-2gqiA:
undetectable		 5t8sB-2gqiA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 HIS A  49
PRO A  48
ASP A  47
ASP A 142
 None
 1.03A 5t8sB-2gzbA:
undetectable		 5t8sB-2gzbA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PRO A2797
THR A3072
PHE A3112
ASP A2981
 None
 1.17A 5t8sB-2h84A:
undetectable		 5t8sB-2h84A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 HIS 1 606
PRO 1 573
PHE 1 644
ASP 1 398
 None
 1.12A 5t8sB-2ijd1:
undetectable		 5t8sB-2ijd1:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3t FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 HIS A2506
PRO A2511
LYS A2500
SER A2463
 None
 0.77A 5t8sB-2k3tA:
undetectable		 5t8sB-2k3tA:
15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.7A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.6A)
 0.21A 5t8sB-2obvA:
55.3		 5t8sB-2obvA:
56.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.86A 5t8sB-2v28A:
undetectable		 5t8sB-2v28A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 HIS A 266
ASP A 221
THR A 260
PHE A 262
 MES  A 504 (-4.0A)
None
None
None
 1.17A 5t8sB-2zm2A:
undetectable		 5t8sB-2zm2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 HIS A 439
PRO A 481
ASP A 438
LYS A 436
 None
 1.01A 5t8sB-3d45A:
undetectable		 5t8sB-3d45A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		4 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.20A 5t8sB-3h1gA:
undetectable		 5t8sB-3h1gA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		4 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 FE  A 401 (-3.3A)
None
None
FE  A 401 (-2.1A)
 1.16A 5t8sB-3hh8A:
undetectable		 5t8sB-3hh8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i86 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00877
(NLPC_P60) 		4 PRO A 171
THR A 235
PHE A 196
ASP A 176
 None
 1.21A 5t8sB-3i86A:
undetectable		 5t8sB-3i86A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 HIS A 225
ASP A 228
LYS A 224
ASP A 191
 None
 1.03A 5t8sB-3ij6A:
undetectable		 5t8sB-3ij6A:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  16
PRO A  17
ASP A 167
LYS A 169
SER A 190
THR A 231
ASP A 242
 None
 0.92A 5t8sB-3imlA:
58.4		 5t8sB-3imlA:
73.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  16
PRO A  17
ASP A 167
LYS A 169
SER A 190
THR A 231
PHE A 234
 None
 0.60A 5t8sB-3imlA:
58.4		 5t8sB-3imlA:
73.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		4 ASP A 201
LYS A 168
THR A  80
ASP A 240
 FE  A 334 ( 3.2A)
UNL  A 337 ( 2.9A)
UNL  A 337 ( 3.8A)
FE  A 333 (-2.5A)
 1.09A 5t8sB-3ktcA:
undetectable		 5t8sB-3ktcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.09A 5t8sB-3lscA:
undetectable		 5t8sB-3lscA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.17A 5t8sB-3n6nA:
undetectable		 5t8sB-3n6nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		4 PRO A 388
ASP A 387
LYS A 391
THR A 193
 None
 1.17A 5t8sB-3pplA:
undetectable		 5t8sB-3pplA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 HIS A 175
SER A 190
THR A 215
ASP A 236
 HEM  A 338 (-3.3A)
None
None
None
 1.23A 5t8sB-3q3uA:
undetectable		 5t8sB-3q3uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyg CO-TYPE NITRILE
HYDRATASE BETA
SUBUNIT

(Pseudomonas
putida) 		PF02211
(NHase_beta) 		4 HIS B 147
PRO B 171
ASP B 172
THR B 154
 None
 1.15A 5t8sB-3qygB:
undetectable		 5t8sB-3qygB:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  17
PRO A  18
ASP A 179
LYS A 181
SER A 202
THR A 248
PHE A 251
ASP A 259
 None
None
None
None
None
None
None
CA  A 404 (-3.4A)
 0.85A 5t8sB-3rv2A:
52.3		 5t8sB-3rv2A:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.10A 5t8sB-3rxzA:
undetectable		 5t8sB-3rxzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbc PEROXIREDOXIN TSA1

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PRO A   9
THR A  73
PHE A  38
ASP A 110
 None
 0.96A 5t8sB-3sbcA:
undetectable		 5t8sB-3sbcA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  16
PRO A  17
ASP A 166
LYS A 168
SER A 193
PHE A 237
ASP A 245
 None
None
None
ACT  A 400 ( 4.9A)
None
None
None
 0.60A 5t8sB-3so4A:
55.2		 5t8sB-3so4A:
51.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA

(Pyrococcus
furiosus) 		PF09376
(NurA) 		4 ASP A 268
LYS A  87
SER A  88
ASP A 264
 None
 1.20A 5t8sB-3talA:
undetectable		 5t8sB-3talA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		4 LYS B 173
THR B 165
PHE B   9
ASP B   6
 None
 1.15A 5t8sB-3tw8B:
undetectable		 5t8sB-3tw8B:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 HIS A 143
ASP A 161
PHE A 217
ASP A 221
 None
 0.87A 5t8sB-3v8uA:
undetectable		 5t8sB-3v8uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 PRO A 442
ASP A 472
SER A 458
PHE A 470
 None
None
FRU  A 601 (-2.9A)
None
 1.10A 5t8sB-3vssA:
undetectable		 5t8sB-3vssA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		4 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.22A 5t8sB-4ag6A:
undetectable		 5t8sB-4ag6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 ASP A  99
SER A 251
PHE A 209
ASP A 244
 None
 1.03A 5t8sB-4c9mA:
undetectable		 5t8sB-4c9mA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.07A 5t8sB-4dmgA:
undetectable		 5t8sB-4dmgA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.10A 5t8sB-4e1oA:
undetectable		 5t8sB-4e1oA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fh8 ACEPRX-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.97A 5t8sB-4fh8A:
undetectable		 5t8sB-4fh8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6u EC869 CDIA-CT
EC869 CDII

(Escherichia
coli;
Escherichia
coli) 		no annotation
PF07262
(CdiI) 		4 PRO A 185
ASP A 187
THR B  64
ASP A 201
 None
 1.14A 5t8sB-4g6uA:
undetectable		 5t8sB-4g6uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 5t8sB-4hjwA:
undetectable		 5t8sB-4hjwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.38A 5t8sB-4hpvA:
27.7		 5t8sB-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.96A 5t8sB-4hpvA:
27.7		 5t8sB-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 HIS A  83
PRO A  82
ASP A  81
SER A 154
 None
 1.20A 5t8sB-4i0nA:
undetectable		 5t8sB-4i0nA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		4 HIS A 224
ASP A 265
PHE A 172
ASP A 291
 None
None
None
ZN  A 401 (-3.0A)
 0.95A 5t8sB-4igmA:
undetectable		 5t8sB-4igmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA) 		4 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.93A 5t8sB-4kw6A:
undetectable		 5t8sB-4kw6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.58A 5t8sB-4l4qA:
28.3		 5t8sB-4l4qA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.18A 5t8sB-4lanA:
undetectable		 5t8sB-4lanA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  13
PRO A  14
ASP A 168
LYS A 170
SER A 197
THR A 239
ASP A 250
 None
 0.88A 5t8sB-4le5A:
50.6		 5t8sB-4le5A:
39.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 HIS A 425
PRO A 393
PHE A 459
ASP A 215
 None
 1.13A 5t8sB-4nz0A:
undetectable		 5t8sB-4nz0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		5 HIS A 177
PRO A 175
SER A 150
THR A 145
ASP A 115
 None
None
None
DLY  A 403 (-4.6A)
None
 1.27A 5t8sB-4nz6A:
undetectable		 5t8sB-4nz6A:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  34
PRO A  35
ASP A 187
LYS A 189
SER A 214
PHE A 258
ASP A 266
 SAM  A 500 ( 3.8A)
SAM  A 500 (-4.3A)
SAM  A 500 (-2.8A)
3PO  A 501 ( 2.7A)
SAM  A 500 ( 4.0A)
SAM  A 500 (-3.5A)
SAM  A 500 (-3.3A)
 0.15A 5t8sB-4odjA:
55.3		 5t8sB-4odjA:
50.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		4 PRO A 300
THR A 261
PHE A 165
ASP A 168
 None
 1.02A 5t8sB-4opmA:
undetectable		 5t8sB-4opmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		4 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 1.05A 5t8sB-4q3rA:
undetectable		 5t8sB-4q3rA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo6 ADENYLATE
CYCLASE-LIKE PROTEIN

(Chlamydia
trachomatis) 		PF04972
(BON) 		4 ASP A 568
SER A 613
PHE A 614
ASP A 564
 None
 1.16A 5t8sB-4qo6A:
undetectable		 5t8sB-4qo6A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		4 PRO A 163
ASP A 193
THR A 259
ASP A 219
 None
 1.20A 5t8sB-4qrjA:
undetectable		 5t8sB-4qrjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rft COAT PROTEIN

(Redspotted
grouper nervous
necrosis virus) 		no annotation 4 SER A 211
THR A 169
PHE A  99
ASP A  54
 None
 1.18A 5t8sB-4rftA:
undetectable		 5t8sB-4rftA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.01A 5t8sB-4s17A:
undetectable		 5t8sB-4s17A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		4 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.20A 5t8sB-4uzjA:
undetectable		 5t8sB-4uzjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		4 HIS B 795
ASP B 792
SER B 598
THR B 625
 None
 1.16A 5t8sB-4wwxB:
undetectable		 5t8sB-4wwxB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		4 HIS A 220
ASP A 218
PHE A 336
ASP A 271
 None
 0.88A 5t8sB-4xdtA:
undetectable		 5t8sB-4xdtA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.13A 5t8sB-4zpdA:
undetectable		 5t8sB-4zpdA:
23.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.19A 5t8sB-5a1iA:
54.9		 5t8sB-5a1iA:
56.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1

(Bacillus phage
SPP1) 		PF06199
(Phage_tail_2) 		4 ASP H 105
SER H 154
THR H  22
ASP H  95
 None
 1.13A 5t8sB-5a20H:
undetectable		 5t8sB-5a20H:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 HIS M 339
ASP M 221
SER M 337
THR M 318
 None
 1.13A 5t8sB-5a5tM:
undetectable		 5t8sB-5a5tM:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn LIGHT CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO L  40
ASP L  85
SER L   9
THR L 145
 None
 1.23A 5t8sB-5awnL:
undetectable		 5t8sB-5awnL:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		4 HIS A  22
ASP A  10
SER A  19
PHE A  12
 None
 1.05A 5t8sB-5cz3A:
undetectable		 5t8sB-5cz3A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ept PEROXIREDOXIN TSA2

(Saccharomyces
cerevisiae) 		no annotation 4 PRO H  10
THR H  74
PHE H  39
ASP H 111
 None
 1.16A 5t8sB-5eptH:
undetectable		 5t8sB-5eptH:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fll 6-CARBOXYHEXANOATE-C
OA LIGASE

(Bacillus
subtilis) 		PF03744
(BioW) 		4 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.06A 5t8sB-5fllA:
undetectable		 5t8sB-5fllA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g47 SFTSV GC

(SFTS
phlebovirus) 		PF07245
(Phlebovirus_G2) 		4 HIS A 663
PRO A 661
SER A 685
ASP A 655
 None
 1.17A 5t8sB-5g47A:
undetectable		 5t8sB-5g47A:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 6 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
 None
 0.65A 5t8sB-5h9uC:
57.4		 5t8sB-5h9uC:
57.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 5 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
 None
 1.13A 5t8sB-5h9uC:
57.4		 5t8sB-5h9uC:
57.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		4 HIS A  67
PRO A  66
ASP A  65
ASP A 281
 MN  A 501 (-3.4A)
None
None
MN  A 501 (-2.0A)
 1.23A 5t8sB-5i4kA:
undetectable		 5t8sB-5i4kA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Thermus
thermophilus) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.23A 5t8sB-5t3oA:
undetectable		 5t8sB-5t3oA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ASP A 166
LYS A 168
SER A 191
THR A 232
PHE A 235
 None
 0.81A 5t8sB-5t8tA:
61.8		 5t8sB-5t8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  15
PRO A  16
ASP A 166
SER A 191
THR A 232
PHE A 235
 None
 0.58A 5t8sB-5t8tA:
61.8		 5t8sB-5t8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  15
PRO A  16
ASP A 166
THR A 232
PHE A 235
ASP A 243
 None
 0.90A 5t8sB-5t8tA:
61.8		 5t8sB-5t8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		4 SER A 469
THR A 532
PHE A 467
ASP A 505
 None
 1.11A 5t8sB-5txeA:
undetectable		 5t8sB-5txeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 HIS A  63
SER A  89
THR A 139
ASP A 250
 None
 1.20A 5t8sB-5x9gA:
undetectable		 5t8sB-5x9gA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 HIS A  20
LYS A  23
SER A  85
THR A 114
 None
 1.03A 5t8sB-5x9wA:
undetectable		 5t8sB-5x9wA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 HIS A 419
PRO A 386
PHE A 457
ASP A 211
 None
 1.16A 5t8sB-5xe0A:
undetectable		 5t8sB-5xe0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 HIS A 392
ASP A 389
THR A 285
PHE A 333
 None
 1.14A 5t8sB-5yimA:
undetectable		 5t8sB-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 HIS A 630
SER A 425
PHE A 476
ASP A 483
 None
 1.12A 5t8sB-5z0uA:
undetectable		 5t8sB-5z0uA:
undetectable