SIMILAR PATTERNS OF AMINO ACIDS FOR 5T8S_B_SAMB402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae)
PF00224
(PK)
PF02887
(PK_C)
4 ALA A 263
GLU A 242
ASP A 220
ILE A 237
PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
0.75A 5t8sA-1a3xA:
undetectable
5t8sA-1a3xA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens)
PF02333
(Phytase)
4 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.81A 5t8sA-1cvmA:
undetectable
5t8sA-1cvmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba)
PF00232
(Glyco_hydro_1)
4 GLN M  80
ASP M  82
ILE M  83
ILE M 133
None
0.91A 5t8sA-1dwaM:
0.0
5t8sA-1dwaM:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT


(Methanopyrus
kandleri)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 ALA B 160
ASP B  78
ILE B  79
ILE B  86
None
0.75A 5t8sA-1e6vB:
undetectable
5t8sA-1e6vB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT


(Methanosarcina
barkeri)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 ALA B2156
ASP B2074
ILE B2075
ILE B2082
None
0.89A 5t8sA-1e6yB:
undetectable
5t8sA-1e6yB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1


(Saccharomyces
cerevisiae)
PF00156
(Pribosyltran)
4 ALA A  54
ASP A  61
ILE A  60
ILE A  63
None
0.84A 5t8sA-1g2pA:
undetectable
5t8sA-1g2pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
4 ALA A 402
GLN A 393
ILE A 389
ILE A 409
None
0.92A 5t8sA-1hp1A:
undetectable
5t8sA-1hp1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
4 ALA X  12
GLU X 313
ILE X 142
ILE X 147
None
0.95A 5t8sA-1mw9X:
undetectable
5t8sA-1mw9X:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT


(Mycobacterium
tuberculosis)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
4 ALA A 369
ASP A 138
ILE A 127
ILE A 173
None
0.76A 5t8sA-1nl3A:
undetectable
5t8sA-1nl3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE


(Acinetobacter
calcoaceticus)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
4 GLN A 127
ASP A 177
ILE A 181
ILE A 184
None
0.72A 5t8sA-1q5nA:
undetectable
5t8sA-1q5nA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tsj CONSERVED
HYPOTHETICAL PROTEIN


(Staphylococcus
aureus)
PF06983
(3-dmu-9_3-mt)
4 ALA A 130
ASP A   2
ILE A   3
ILE A  53
None
0.77A 5t8sA-1tsjA:
undetectable
5t8sA-1tsjA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN


(Arachis
hypogaea)
PF00139
(Lectin_legB)
4 ALA A 208
GLN A 216
ASP A  80
ASP A 123
None
None
None
CA  A1237 ( 2.4A)
0.92A 5t8sA-1v6mA:
undetectable
5t8sA-1v6mA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN


(Caulobacter
vibrioides)
PF00072
(Response_reg)
PF00990
(GGDEF)
4 ALA A 351
ASP A 329
ILE A 328
ILE A 334
None
0.96A 5t8sA-1w25A:
undetectable
5t8sA-1w25A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN


(Bacillus
subtilis)
PF02113
(Peptidase_S13)
4 ALA A  24
ASP A 450
ILE A 451
ILE A  14
None
0.80A 5t8sA-1w5dA:
undetectable
5t8sA-1w5dA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA


(Bacillus
subtilis)
PF00496
(SBP_bac_5)
4 ALA A 494
ASP A 236
ILE A 237
ILE A 222
None
0.82A 5t8sA-1xocA:
undetectable
5t8sA-1xocA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 ALA A 258
ASP A 241
ILE A 239
ILE A 263
None
0.89A 5t8sA-1ykwA:
undetectable
5t8sA-1ykwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE


(Pseudomonas
aeruginosa)
PF00581
(Rhodanese)
4 ALA A 228
GLU A 135
GLN A 138
ILE A 149
None
0.79A 5t8sA-1yt8A:
undetectable
5t8sA-1yt8A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE


(Klebsiella
aerogenes)
PF00144
(Beta-lactamase)
4 ALA A 337
ASP A  14
ILE A  17
ILE A 353
None
ZN  A 514 (-3.1A)
None
None
0.90A 5t8sA-1zkjA:
undetectable
5t8sA-1zkjA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus)
PF00089
(Trypsin)
4 GLU A 168
ILE A 170
ASP A 115
ILE A 139
None
0.76A 5t8sA-2as9A:
undetectable
5t8sA-2as9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus)
PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2)
4 GLN A  52
ASP A  64
ILE A  14
ILE A  18
None
0.91A 5t8sA-2au3A:
undetectable
5t8sA-2au3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE


(Thermotoga
maritima)
PF00696
(AA_kinase)
4 ALA A 117
ASP A  45
ILE A  46
ILE A  26
None
0.86A 5t8sA-2btyA:
undetectable
5t8sA-2btyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT


(Klebsiella
oxytoca)
PF08841
(DDR)
4 ALA A 579
ASP A 548
ILE A 549
ILE A 423
None
0.88A 5t8sA-2d0oA:
undetectable
5t8sA-2d0oA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT


(Thermus
aquaticus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
4 GLU A 306
ASP A 408
ILE A 405
ILE A 581
None
0.85A 5t8sA-2hpiA:
undetectable
5t8sA-2hpiA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida)
PF11477
(PM0188)
4 ALA A 208
ASP A 156
ILE A 157
ILE A 184
None
0.94A 5t8sA-2iy8A:
undetectable
5t8sA-2iy8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli)
PF01261
(AP_endonuc_2)
4 ASP A 135
ILE A 132
ASP A  89
ILE A  92
None
0.85A 5t8sA-2nq9A:
undetectable
5t8sA-2nq9A:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1


(Homo sapiens)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
None
0.21A 5t8sA-2obvA:
57.4
5t8sA-2obvA:
56.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE


(Lactobacillus
plantarum)
PF01643
(Acyl-ACP_TE)
4 ALA A  68
GLN A  66
ILE A 115
ILE A 145
GOL  A 271 (-3.7A)
SO4  A 266 (-3.3A)
None
None
0.91A 5t8sA-2ownA:
undetectable
5t8sA-2ownA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2


(Rhodopseudomonas
palustris)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 ALA A 258
ASP A 241
ILE A 239
ILE A 263
None
0.90A 5t8sA-2qygA:
undetectable
5t8sA-2qygA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli)
PF00575
(S1)
PF10150
(RNase_E_G)
4 ALA A  74
GLU A  76
ILE A 101
ILE A  41
None
0.96A 5t8sA-2vrtA:
undetectable
5t8sA-2vrtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0i MALATE DEHYDROGENASE

(Archaeoglobus
fulgidus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ALA A 202
ASP A 304
ILE A 305
ILE A 268
None
0.92A 5t8sA-2x0iA:
undetectable
5t8sA-2x0iA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4


(Caenorhabditis
elegans)
no annotation 4 GLU A 259
ASP A 240
ILE A 244
ILE A 204
None
0.88A 5t8sA-2yv9A:
undetectable
5t8sA-2yv9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105


(Mesorhizobium
japonicum)
PF02627
(CMD)
4 ALA A 147
ASP A 156
ILE A 157
ILE A  72
None
0.95A 5t8sA-3c1lA:
undetectable
5t8sA-3c1lA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Rhodospirillum
rubrum)
PF00440
(TetR_N)
4 ALA A 162
ASP A  96
ILE A  97
ILE A  72
None
0.86A 5t8sA-3cwrA:
undetectable
5t8sA-3cwrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR


(Klebsiella
pneumoniae)
PF13407
(Peripla_BP_4)
4 ALA A 272
ASP A 132
ASP A 127
ILE A 309
None
0.82A 5t8sA-3d02A:
undetectable
5t8sA-3d02A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
4 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.89A 5t8sA-3degC:
undetectable
5t8sA-3degC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES


(Salmonella
enterica)
PF01380
(SIS)
4 GLN A  19
ASP A  14
ILE A  15
ILE A 101
None
0.86A 5t8sA-3fkjA:
undetectable
5t8sA-3fkjA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus)
PF00210
(Ferritin)
4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
IMD  A 171 (-3.4A)
FE  A 164 ( 2.5A)
None
None
0.94A 5t8sA-3fvbA:
undetectable
5t8sA-3fvbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides)
PF00210
(Ferritin)
4 ALA A  97
GLU A 127
ASP A 132
ASP A  90
None
FE  A 163 (-2.0A)
None
None
0.85A 5t8sA-3gvyA:
undetectable
5t8sA-3gvyA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides)
PF00210
(Ferritin)
4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
None
FE  A 163 (-2.0A)
None
None
0.86A 5t8sA-3gvyA:
undetectable
5t8sA-3gvyA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108


(Bacillus
thuringiensis)
PF08241
(Methyltransf_11)
4 ALA A 161
GLN A  26
ASP A  24
ASP A 172
None
0.91A 5t8sA-3hnrA:
undetectable
5t8sA-3hnrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6


(Saccharomyces
cerevisiae)
PF01918
(Alba)
4 GLU A 131
ASP A 119
ILE A 120
ILE A  16
A  R  71 ( 4.0A)
None
None
None
0.92A 5t8sA-3iabA:
undetectable
5t8sA-3iabA:
17.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE


(Burkholderia
pseudomallei)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 ALA A  42
GLU A  57
ASP A 122
LYS A 273
None
0.43A 5t8sA-3imlA:
56.8
5t8sA-3imlA:
73.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1


(Cypovirus 1)
no annotation 4 GLU B1143
ASP B1167
ILE B1141
ILE B1155
None
0.91A 5t8sA-3iz3B:
undetectable
5t8sA-3iz3B:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA


(Methanothermobacter
marburgensis)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 ALA B 159
ASP B  77
ILE B  78
ILE B  85
None
0.89A 5t8sA-3m2rB:
undetectable
5t8sA-3m2rB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME


([Candida]
glabrata)
PF02110
(HK)
PF02581
(TMP-TENI)
4 ALA A 413
ASP A 444
ILE A 445
ILE A 427
None
0.63A 5t8sA-3nm1A:
undetectable
5t8sA-3nm1A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT


(Vibrio
parahaemolyticus)
PF00532
(Peripla_BP_1)
4 ALA B 240
ASP B 221
ILE B 246
ILE B 223
None
0.89A 5t8sA-3o1hB:
undetectable
5t8sA-3o1hB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
4 GLU A   6
GLN A   7
ASP A 431
ILE A  60
None
0.79A 5t8sA-3oksA:
undetectable
5t8sA-3oksA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyo HEMOPEXIN FOLD
PROTEIN CP4


(Vigna
unguiculata)
PF00045
(Hemopexin)
4 ALA A 185
ASP A 121
ILE A 173
ILE A 157
None
0.89A 5t8sA-3oyoA:
undetectable
5t8sA-3oyoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
4 ALA A 287
GLU A  59
ASP A 347
ILE A 269
None
0.66A 5t8sA-3snxA:
undetectable
5t8sA-3snxA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE


(Entamoeba
histolytica)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 ALA A  42
ASP A 121
LYS A 276
ILE A 309
None
0.59A 5t8sA-3so4A:
54.0
5t8sA-3so4A:
51.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE


(Entamoeba
histolytica)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 GLU A  57
ASP A 121
LYS A 276
ILE A 309
None
0.85A 5t8sA-3so4A:
54.0
5t8sA-3so4A:
51.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN


(Rhodobacteraceae
bacterium KLH11)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLU A 119
ASP A 113
ASP A 142
ILE A 145
None
0.61A 5t8sA-3sszA:
undetectable
5t8sA-3sszA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE


(Labrenzia
aggregata)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLU A  96
ASP A  90
ASP A 119
ILE A 122
None
0.60A 5t8sA-3stpA:
undetectable
5t8sA-3stpA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN


(Mus musculus)
PF00271
(Helicase_C)
PF04851
(ResIII)
4 GLU A 703
ASP A 706
ILE A 705
ILE A 632
None
0.75A 5t8sA-3tbkA:
undetectable
5t8sA-3tbkA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Coxiella
burnetii)
PF00215
(OMPdecase)
4 ALA A 202
ASP A 230
ILE A 229
ILE A 216
None
0.96A 5t8sA-3tr2A:
undetectable
5t8sA-3tr2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II


(Burkholderia
pseudomallei)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 ALA A 197
GLU A 389
ASP A 218
ILE A 221
None
0.81A 5t8sA-3tv2A:
undetectable
5t8sA-3tv2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 ALA A 354
GLN A 239
ILE A 199
ILE A 203
None
0.84A 5t8sA-3u3xA:
undetectable
5t8sA-3u3xA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus)
PF00089
(Trypsin)
4 GLU A 164
ILE A 166
ASP A 111
ILE A 135
None
0.77A 5t8sA-3ufaA:
undetectable
5t8sA-3ufaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA


(Salmonella
enterica)
PF03193
(RsgA_GTPase)
4 ALA V 261
ASP V 132
ILE V 131
ILE V 134
None
0.94A 5t8sA-4a2iV:
undetectable
5t8sA-4a2iV:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am2 BACTERIOFERRITIN

(Blastochloris
viridis)
PF00210
(Ferritin)
4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
None
FE  A1161 ( 2.6A)
None
None
0.93A 5t8sA-4am2A:
undetectable
5t8sA-4am2A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE


(Paenarthrobacter
aurescens)
PF00202
(Aminotran_3)
4 ALA A  80
ASP A  60
ILE A  58
ILE A 417
None
0.90A 5t8sA-4atqA:
undetectable
5t8sA-4atqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE


(Gelatoporia
subvermispora)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
4 ALA A 135
GLU A  74
ASP A  84
ILE A  91
None
CA  A1371 ( 4.5A)
None
None
0.94A 5t8sA-4czpA:
undetectable
5t8sA-4czpA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Paraburkholderia
xenovorans)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 ALA A  72
ASP A  84
ILE A  83
ILE A 110
None
0.81A 5t8sA-4dfeA:
undetectable
5t8sA-4dfeA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans)
PF02274
(Amidinotransf)
4 GLN A 381
ASP A 383
ILE A 384
ILE A 374
None
0.93A 5t8sA-4e4jA:
undetectable
5t8sA-4e4jA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1


(Rattus
norvegicus)
PF00928
(Adap_comp_sub)
4 GLU A 185
ASP A 188
ILE A 187
ILE A 272
GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
0.87A 5t8sA-4iknA:
undetectable
5t8sA-4iknA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana)
PF00491
(Arginase)
4 ALA A 140
GLU A 197
ASP A 165
ILE A 160
None
S2C  A 405 ( 4.2A)
None
None
0.95A 5t8sA-4iu4A:
undetectable
5t8sA-4iu4A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE


(Saccharomyces
cerevisiae)
PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N)
4 ALA A 791
ASP A 404
ILE A 400
ILE A 411
None
0.91A 5t8sA-4j5tA:
undetectable
5t8sA-4j5tA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE


(Campylobacter
jejuni)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
6 ALA A  39
GLU A  54
GLN A 105
ASP A 124
LYS A 281
ILE A 314
None
0.47A 5t8sA-4le5A:
51.1
5t8sA-4le5A:
39.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1


(Rattus
norvegicus)
PF00777
(Glyco_transf_29)
4 ALA A 187
GLU A 339
ASP A 336
ILE A 325
None
0.71A 5t8sA-4mpsA:
undetectable
5t8sA-4mpsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n58 PECTOCIN M2

(Pectobacterium
carotovorum)
PF00111
(Fer2)
PF14859
(Colicin_M)
4 ALA A 132
ASP A 150
ILE A 146
ILE A 259
None
0.95A 5t8sA-4n58A:
undetectable
5t8sA-4n58A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL


(Homo sapiens)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
4 GLN D 949
ASP D 951
ILE D 952
ILE D 885
None
None
None
MLY  D 884 ( 4.0A)
0.94A 5t8sA-4ngeD:
undetectable
5t8sA-4ngeD:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 ALA A 105
ASP A  72
ILE A  73
ILE A  63
None
0.75A 5t8sA-4nhdA:
undetectable
5t8sA-4nhdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Caldalkalibacillus
thermarum)
PF07992
(Pyr_redox_2)
4 ALA A  18
ASP A  32
ILE A   6
ILE A 334
None
0.94A 5t8sA-4nwzA:
undetectable
5t8sA-4nwzA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE


(Geobacillus
stearothermophilus)
PF16499
(Melibiase_2)
4 GLU A 173
ASP A 169
ILE A 152
ILE A 131
SO4  A 502 (-2.5A)
CIT  A 513 ( 4.9A)
None
None
0.94A 5t8sA-4nxkA:
undetectable
5t8sA-4nxkA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE


(Cryptosporidium
hominis)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
7 ALA A  60
GLU A  75
GLN A 118
ILE A 122
ASP A 139
LYS A 297
ILE A 330
None
0.18A 5t8sA-4odjA:
57.9
5t8sA-4odjA:
50.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2


(Mycolicibacterium
smegmatis)
PF13452
(MaoC_dehydrat_N)
4 ALA A 131
GLU A 133
ASP A 101
ILE A  97
None
0.91A 5t8sA-4rv2A:
undetectable
5t8sA-4rv2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Listeria
monocytogenes)
PF00574
(CLP_protease)
4 ALA H  96
ASP H 187
ILE H 186
ILE H 189
None
0.93A 5t8sA-4ryfH:
undetectable
5t8sA-4ryfH:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toc BACTERIOFERRITIN

(Pseudomonas
aeruginosa)
PF00210
(Ferritin)
4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
None
FE2  A 203 ( 2.5A)
None
None
0.89A 5t8sA-4tocA:
undetectable
5t8sA-4tocA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17484
(TbpB_A)
4 ALA A  46
ASP A  85
ILE A  86
ILE A 329
None
0.75A 5t8sA-4u9cA:
undetectable
5t8sA-4u9cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)


(Agrobacterium
vitis)
PF13407
(Peripla_BP_4)
4 GLN A 111
ASP A 120
ILE A 119
ASP A  91
None
0.77A 5t8sA-4wt7A:
undetectable
5t8sA-4wt7A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2


(Mus musculus)
no annotation 4 ALA A 573
ASP A 550
ILE A 551
ILE A 594
None
0.94A 5t8sA-4yomA:
undetectable
5t8sA-4yomA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 ALA A 476
ASP A 398
ILE A 399
ASP A 408
None
0.88A 5t8sA-4z0vA:
undetectable
5t8sA-4z0vA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2


(Homo sapiens)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
None
0.21A 5t8sA-5a1iA:
56.9
5t8sA-5a1iA:
56.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
4 ALA A1403
ASP A1394
ILE A1353
ILE A1347
None
0.88A 5t8sA-5cslA:
undetectable
5t8sA-5cslA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi)
PF01400
(Astacin)
4 ALA A 112
GLN A  93
ILE A  54
ILE A  82
None
0.96A 5t8sA-5czwA:
undetectable
5t8sA-5czwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans)
PF01039
(Carboxyl_trans)
4 ALA A 204
ASP A 241
ILE A 242
ILE A 229
None
0.84A 5t8sA-5fifA:
undetectable
5t8sA-5fifA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 ALA A  25
GLU A 290
ASP A 221
ILE A 135
None
None
PO4  A 401 ( 2.9A)
None
0.91A 5t8sA-5giuA:
undetectable
5t8sA-5giuA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta)
PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 ALA A 412
ILE A 505
ASP A 512
ILE A 508
None
0.96A 5t8sA-5gmhA:
undetectable
5t8sA-5gmhA:
16.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE


(Thermus
thermophilus)
no annotation 4 ALA C  42
GLU C  57
ASP C 130
LYS C 282
None
0.71A 5t8sA-5h9uC:
57.9
5t8sA-5h9uC:
57.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1


(Mus musculus)
no annotation 4 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.84A 5t8sA-5iriA:
undetectable
5t8sA-5iriA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Trichormus
variabilis)
PF01113
(DapB_N)
PF05173
(DapB_C)
4 GLU A 198
GLN A 263
ILE A 196
ILE A 249
None
0.94A 5t8sA-5kt0A:
undetectable
5t8sA-5kt0A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE


(Giardia
intestinalis)
PF07992
(Pyr_redox_2)
4 ALA A  28
GLU A 307
ILE A   9
ILE A  11
None
0.87A 5t8sA-5m5jA:
undetectable
5t8sA-5m5jA:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE


(Neisseria
gonorrhoeae)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
8 ALA A  41
GLU A  56
GLN A  99
ASP A 102
ILE A 103
ASP A 121
LYS A 274
ILE A 307
None
0.30A 5t8sA-5t8tA:
64.1
5t8sA-5t8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1


(Streptomyces
coelicolor)
PF00128
(Alpha-amylase)
PF11896
(DUF3416)
4 ALA A 136
GLU A 133
ASP A 127
ILE A 122
None
0.81A 5t8sA-5vsjA:
undetectable
5t8sA-5vsjA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF04446
(Thg1)
PF14413
(Thg1C)
4 ALA A  58
ASP A  68
ILE A  69
ILE A  70
None
0.86A 5t8sA-5xoxA:
undetectable
5t8sA-5xoxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xx9 BACTERIOFERRITIN

(Streptomyces
coelicolor)
no annotation 4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
None
FE2  A 201 (-2.2A)
None
None
0.92A 5t8sA-5xx9A:
undetectable
5t8sA-5xx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli)
no annotation 4 ALA A 339
ASP A  13
ILE A  16
ILE A 355
None
0.93A 5t8sA-5za2A:
undetectable
5t8sA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD


(Helicobacter
pylori)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
4 ALA A 228
ASP A 246
ILE A 219
ILE A 199
None
GOL  A 303 ( 4.8A)
None
None
0.92A 5t8sA-6apeA:
undetectable
5t8sA-6apeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Campylobacter
jejuni)
no annotation 4 ALA A 182
ASP A 170
ILE A 168
ILE A 187
None
0.88A 5t8sA-6bmaA:
undetectable
5t8sA-6bmaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans)
no annotation 4 ALA A 254
ASP A 199
ILE A 200
ILE A 142
None
0.86A 5t8sA-6d3uA:
undetectable
5t8sA-6d3uA:
undetectable