SIMILAR PATTERNS OF AMINO ACIDS FOR 5T8S_B_SAMB402_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a3x | PYRUVATE KINASE (Saccharomycescerevisiae) |
PF00224(PK)PF02887(PK_C) | 4 | ALA A 263GLU A 242ASP A 220ILE A 237 | PGA A1005 (-2.1A) MN A1001 ( 2.9A)NoneNone | 0.75A | 5t8sA-1a3xA:undetectable | 5t8sA-1a3xA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvm | PHYTASE (Bacillusamyloliquefaciens) |
PF02333(Phytase) | 4 | ALA A 174ASP A 115ILE A 116ILE A 144 | None | 0.81A | 5t8sA-1cvmA:undetectable | 5t8sA-1cvmA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dwa | MYROSINASE MA1 (Sinapis alba) |
PF00232(Glyco_hydro_1) | 4 | GLN M 80ASP M 82ILE M 83ILE M 133 | None | 0.91A | 5t8sA-1dwaM:0.0 | 5t8sA-1dwaM:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I BETASUBUNIT (Methanopyruskandleri) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | ALA B 160ASP B 78ILE B 79ILE B 86 | None | 0.75A | 5t8sA-1e6vB:undetectable | 5t8sA-1e6vB:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6y | METHYL-COENZYME MREDUCTASE I BETASUBUNIT (Methanosarcinabarkeri) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | ALA B2156ASP B2074ILE B2075ILE B2082 | None | 0.89A | 5t8sA-1e6yB:undetectable | 5t8sA-1e6yB:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g2p | ADENINEPHOSPHORIBOSYLTRANSFERASE 1 (Saccharomycescerevisiae) |
PF00156(Pribosyltran) | 4 | ALA A 54ASP A 61ILE A 60ILE A 63 | None | 0.84A | 5t8sA-1g2pA:undetectable | 5t8sA-1g2pA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hp1 | 5'-NUCLEOTIDASE (Escherichiacoli) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 4 | ALA A 402GLN A 393ILE A 389ILE A 409 | None | 0.92A | 5t8sA-1hp1A:undetectable | 5t8sA-1hp1A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mw9 | DNA TOPOISOMERASE I (Escherichiacoli) |
PF01131(Topoisom_bac)PF01751(Toprim) | 4 | ALA X 12GLU X 313ILE X 142ILE X 147 | None | 0.95A | 5t8sA-1mw9X:undetectable | 5t8sA-1mw9X:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nl3 | PREPROTEINTRANSLOCASE SECA 1SUBUNIT (Mycobacteriumtuberculosis) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 4 | ALA A 369ASP A 138ILE A 127ILE A 173 | None | 0.76A | 5t8sA-1nl3A:undetectable | 5t8sA-1nl3A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5n | 3-CARBOXY-CIS,CIS-MUCONATECYCLOISOMERASE (Acinetobactercalcoaceticus) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | GLN A 127ASP A 177ILE A 181ILE A 184 | None | 0.72A | 5t8sA-1q5nA:undetectable | 5t8sA-1q5nA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tsj | CONSERVEDHYPOTHETICAL PROTEIN (Staphylococcusaureus) |
PF06983(3-dmu-9_3-mt) | 4 | ALA A 130ASP A 2ILE A 3ILE A 53 | None | 0.77A | 5t8sA-1tsjA:undetectable | 5t8sA-1tsjA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6m | GALACTOSE-BINDINGLECTIN (Arachishypogaea) |
PF00139(Lectin_legB) | 4 | ALA A 208GLN A 216ASP A 80ASP A 123 | NoneNoneNone CA A1237 ( 2.4A) | 0.92A | 5t8sA-1v6mA:undetectable | 5t8sA-1v6mA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w25 | STALKED-CELLDIFFERENTIATIONCONTROLLING PROTEIN (Caulobactervibrioides) |
PF00072(Response_reg)PF00990(GGDEF) | 4 | ALA A 351ASP A 329ILE A 328ILE A 334 | None | 0.96A | 5t8sA-1w25A:undetectable | 5t8sA-1w25A:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w5d | PENICILLIN-BINDINGPROTEIN (Bacillussubtilis) |
PF02113(Peptidase_S13) | 4 | ALA A 24ASP A 450ILE A 451ILE A 14 | None | 0.80A | 5t8sA-1w5dA:undetectable | 5t8sA-1w5dA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xoc | OLIGOPEPTIDE-BINDINGPROTEIN APPA (Bacillussubtilis) |
PF00496(SBP_bac_5) | 4 | ALA A 494ASP A 236ILE A 237ILE A 222 | None | 0.82A | 5t8sA-1xocA:undetectable | 5t8sA-1xocA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykw | RUBISCO-LIKE PROTEIN (Chlorobaculumtepidum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 4 | ALA A 258ASP A 241ILE A 239ILE A 263 | None | 0.89A | 5t8sA-1ykwA:undetectable | 5t8sA-1ykwA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yt8 | THIOSULFATESULFURTRANSFERASE (Pseudomonasaeruginosa) |
PF00581(Rhodanese) | 4 | ALA A 228GLU A 135GLN A 138ILE A 149 | None | 0.79A | 5t8sA-1yt8A:undetectable | 5t8sA-1yt8A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkj | EXTENDED-SPECTRUMBETA-LACTAMASE (Klebsiellaaerogenes) |
PF00144(Beta-lactamase) | 4 | ALA A 337ASP A 14ILE A 17ILE A 353 | None ZN A 514 (-3.1A)NoneNone | 0.90A | 5t8sA-1zkjA:undetectable | 5t8sA-1zkjA:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2as9 | SERINE PROTEASE (Staphylococcusaureus) |
PF00089(Trypsin) | 4 | GLU A 168ILE A 170ASP A 115ILE A 139 | None | 0.76A | 5t8sA-2as9A:undetectable | 5t8sA-2as9A:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2au3 | DNA PRIMASE (Aquifexaeolicus) |
PF01807(zf-CHC2)PF08275(Toprim_N)PF13155(Toprim_2) | 4 | GLN A 52ASP A 64ILE A 14ILE A 18 | None | 0.91A | 5t8sA-2au3A:undetectable | 5t8sA-2au3A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 4 | ALA A 117ASP A 45ILE A 46ILE A 26 | None | 0.86A | 5t8sA-2btyA:undetectable | 5t8sA-2btyA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 4 | ALA A 579ASP A 548ILE A 549ILE A 423 | None | 0.88A | 5t8sA-2d0oA:undetectable | 5t8sA-2d0oA:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpi | DNA POLYMERASE IIIALPHA SUBUNIT (Thermusaquaticus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 4 | GLU A 306ASP A 408ILE A 405ILE A 581 | None | 0.85A | 5t8sA-2hpiA:undetectable | 5t8sA-2hpiA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iy8 | PROTEIN PM0188 (Pasteurellamultocida) |
PF11477(PM0188) | 4 | ALA A 208ASP A 156ILE A 157ILE A 184 | None | 0.94A | 5t8sA-2iy8A:undetectable | 5t8sA-2iy8A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nq9 | ENDONUCLEASE 4 (Escherichiacoli) |
PF01261(AP_endonuc_2) | 4 | ASP A 135ILE A 132ASP A 89ILE A 92 | None | 0.85A | 5t8sA-2nq9A:undetectable | 5t8sA-2nq9A:22.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2obv | S-ADENOSYLMETHIONINESYNTHETASE ISOFORMTYPE-1 (Homo sapiens) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 8 | ALA A 55GLU A 70GLN A 113ASP A 116ILE A 117ASP A 134LYS A 289ILE A 322 | None | 0.21A | 5t8sA-2obvA:57.4 | 5t8sA-2obvA:56.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2own | PUTATIVEOLEOYL-[ACYL-CARRIERPROTEIN]THIOESTERASE (Lactobacillusplantarum) |
PF01643(Acyl-ACP_TE) | 4 | ALA A 68GLN A 66ILE A 115ILE A 145 | GOL A 271 (-3.7A)SO4 A 266 (-3.3A)NoneNone | 0.91A | 5t8sA-2ownA:undetectable | 5t8sA-2ownA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyg | RIBULOSEBISPHOSPHATECARBOXYLASE-LIKEPROTEIN 2 (Rhodopseudomonaspalustris) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 4 | ALA A 258ASP A 241ILE A 239ILE A 263 | None | 0.90A | 5t8sA-2qygA:undetectable | 5t8sA-2qygA:25.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrt | RIBONUCLEASE E (Escherichiacoli) |
PF00575(S1)PF10150(RNase_E_G) | 4 | ALA A 74GLU A 76ILE A 101ILE A 41 | None | 0.96A | 5t8sA-2vrtA:undetectable | 5t8sA-2vrtA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0i | MALATE DEHYDROGENASE (Archaeoglobusfulgidus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ALA A 202ASP A 304ILE A 305ILE A 268 | None | 0.92A | 5t8sA-2x0iA:undetectable | 5t8sA-2x0iA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv9 | CHLORIDEINTRACELLULARCHANNEL EXC-4 (Caenorhabditiselegans) |
no annotation | 4 | GLU A 259ASP A 240ILE A 244ILE A 204 | None | 0.88A | 5t8sA-2yv9A:undetectable | 5t8sA-2yv9A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c1l | PUTATIVE ANTIOXIDANTDEFENSE PROTEINMLR4105 (Mesorhizobiumjaponicum) |
PF02627(CMD) | 4 | ALA A 147ASP A 156ILE A 157ILE A 72 | None | 0.95A | 5t8sA-3c1lA:undetectable | 5t8sA-3c1lA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwr | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Rhodospirillumrubrum) |
PF00440(TetR_N) | 4 | ALA A 162ASP A 96ILE A 97ILE A 72 | None | 0.86A | 5t8sA-3cwrA:undetectable | 5t8sA-3cwrA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d02 | PUTATIVE LACI-TYPETRANSCRIPTIONALREGULATOR (Klebsiellapneumoniae) |
PF13407(Peripla_BP_4) | 4 | ALA A 272ASP A 132ASP A 127ILE A 309 | None | 0.82A | 5t8sA-3d02A:undetectable | 5t8sA-3d02A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3deg | GTP-BINDING PROTEINLEPA (Escherichiacoli) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF06421(LepA_C) | 4 | ALA C 119ASP C 154ILE C 153ILE C 147 | None | 0.89A | 5t8sA-3degC:undetectable | 5t8sA-3degC:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkj | PUTATIVEPHOSPHOSUGARISOMERASES (Salmonellaenterica) |
PF01380(SIS) | 4 | GLN A 19ASP A 14ILE A 15ILE A 101 | None | 0.86A | 5t8sA-3fkjA:undetectable | 5t8sA-3fkjA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvb | BACTERIOFERRITIN (Brucellaabortus) |
PF00210(Ferritin) | 4 | ALA A 97GLU A 127ASP A 132ILE A 131 | IMD A 171 (-3.4A) FE A 164 ( 2.5A)NoneNone | 0.94A | 5t8sA-3fvbA:undetectable | 5t8sA-3fvbA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvy | BACTERIOFERRITIN (Rhodobactersphaeroides) |
PF00210(Ferritin) | 4 | ALA A 97GLU A 127ASP A 132ASP A 90 | None FE A 163 (-2.0A)NoneNone | 0.85A | 5t8sA-3gvyA:undetectable | 5t8sA-3gvyA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvy | BACTERIOFERRITIN (Rhodobactersphaeroides) |
PF00210(Ferritin) | 4 | ALA A 97GLU A 127ASP A 132ILE A 131 | None FE A 163 (-2.0A)NoneNone | 0.86A | 5t8sA-3gvyA:undetectable | 5t8sA-3gvyA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hnr | PROBABLEMETHYLTRANSFERASEBT9727_4108 (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 4 | ALA A 161GLN A 26ASP A 24ASP A 172 | None | 0.91A | 5t8sA-3hnrA:undetectable | 5t8sA-3hnrA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iab | RIBONUCLEASES P/MRPPROTEIN SUBUNIT POP6 (Saccharomycescerevisiae) |
PF01918(Alba) | 4 | GLU A 131ASP A 119ILE A 120ILE A 16 | A R 71 ( 4.0A)NoneNoneNone | 0.92A | 5t8sA-3iabA:undetectable | 5t8sA-3iabA:17.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3iml | S-ADENOSYLMETHIONINESYNTHETASE (Burkholderiapseudomallei) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | ALA A 42GLU A 57ASP A 122LYS A 273 | None | 0.43A | 5t8sA-3imlA:56.8 | 5t8sA-3imlA:73.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iz3 | STRUCTURAL PROTEINVP1 (Cypovirus 1) |
no annotation | 4 | GLU B1143ASP B1167ILE B1141ILE B1155 | None | 0.91A | 5t8sA-3iz3B:undetectable | 5t8sA-3iz3B:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m2r | METHYL-COENZYME MREDUCTASE I SUBUNITBETA (Methanothermobactermarburgensis) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | ALA B 159ASP B 77ILE B 78ILE B 85 | None | 0.89A | 5t8sA-3m2rB:undetectable | 5t8sA-3m2rB:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nm1 | THIAMINEBIOSYNTHETICBIFUNCTIONAL ENZYME ([Candida]glabrata) |
PF02110(HK)PF02581(TMP-TENI) | 4 | ALA A 413ASP A 444ILE A 445ILE A 427 | None | 0.63A | 5t8sA-3nm1A:undetectable | 5t8sA-3nm1A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o1h | PERIPLASMIC PROTEINTORT (Vibrioparahaemolyticus) |
PF00532(Peripla_BP_1) | 4 | ALA B 240ASP B 221ILE B 246ILE B 223 | None | 0.89A | 5t8sA-3o1hB:undetectable | 5t8sA-3o1hB:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 4 | GLU A 6GLN A 7ASP A 431ILE A 60 | None | 0.79A | 5t8sA-3oksA:undetectable | 5t8sA-3oksA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oyo | HEMOPEXIN FOLDPROTEIN CP4 (Vignaunguiculata) |
PF00045(Hemopexin) | 4 | ALA A 185ASP A 121ILE A 173ILE A 157 | None | 0.89A | 5t8sA-3oyoA:undetectable | 5t8sA-3oyoA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3snx | PUTATIVE SUSD-LIKECARBOHYDRATE BINDINGPROTEIN (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | ALA A 287GLU A 59ASP A 347ILE A 269 | None | 0.66A | 5t8sA-3snxA:undetectable | 5t8sA-3snxA:23.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3so4 | METHIONINE-ADENOSYLTRANSFERASE (Entamoebahistolytica) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | ALA A 42ASP A 121LYS A 276ILE A 309 | None | 0.59A | 5t8sA-3so4A:54.0 | 5t8sA-3so4A:51.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3so4 | METHIONINE-ADENOSYLTRANSFERASE (Entamoebahistolytica) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | GLU A 57ASP A 121LYS A 276ILE A 309 | None | 0.85A | 5t8sA-3so4A:54.0 | 5t8sA-3so4A:51.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssz | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Rhodobacteraceaebacterium KLH11) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | GLU A 119ASP A 113ASP A 142ILE A 145 | None | 0.61A | 5t8sA-3sszA:undetectable | 5t8sA-3sszA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stp | GALACTONATEDEHYDRATASE,PUTATIVE (Labrenziaaggregata) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | GLU A 96ASP A 90ASP A 119ILE A 122 | None | 0.60A | 5t8sA-3stpA:undetectable | 5t8sA-3stpA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbk | RIG-I HELICASEDOMAIN (Mus musculus) |
PF00271(Helicase_C)PF04851(ResIII) | 4 | GLU A 703ASP A 706ILE A 705ILE A 632 | None | 0.75A | 5t8sA-3tbkA:undetectable | 5t8sA-3tbkA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr2 | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Coxiellaburnetii) |
PF00215(OMPdecase) | 4 | ALA A 202ASP A 230ILE A 229ILE A 216 | None | 0.96A | 5t8sA-3tr2A:undetectable | 5t8sA-3tr2A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tv2 | FUMARATE HYDRATASE,CLASS II (Burkholderiapseudomallei) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 4 | ALA A 197GLU A 389ASP A 218ILE A 221 | None | 0.81A | 5t8sA-3tv2A:undetectable | 5t8sA-3tv2A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u3x | OXIDOREDUCTASE (Sinorhizobiummeliloti) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ALA A 354GLN A 239ILE A 199ILE A 203 | None | 0.84A | 5t8sA-3u3xA:undetectable | 5t8sA-3u3xA:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufa | SERINE PROTEASE SPLA (Staphylococcusaureus) |
PF00089(Trypsin) | 4 | GLU A 164ILE A 166ASP A 111ILE A 135 | None | 0.77A | 5t8sA-3ufaA:undetectable | 5t8sA-3ufaA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2i | PUTATIVE RIBOSOMEBIOGENESIS GTPASERSGA (Salmonellaenterica) |
PF03193(RsgA_GTPase) | 4 | ALA V 261ASP V 132ILE V 131ILE V 134 | None | 0.94A | 5t8sA-4a2iV:undetectable | 5t8sA-4a2iV:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4am2 | BACTERIOFERRITIN (Blastochlorisviridis) |
PF00210(Ferritin) | 4 | ALA A 97GLU A 127ASP A 132ILE A 131 | None FE A1161 ( 2.6A)NoneNone | 0.93A | 5t8sA-4am2A:undetectable | 5t8sA-4am2A:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atq | 4-AMINOBUTYRATETRANSAMINASE (Paenarthrobacteraurescens) |
PF00202(Aminotran_3) | 4 | ALA A 80ASP A 60ILE A 58ILE A 417 | None | 0.90A | 5t8sA-4atqA:undetectable | 5t8sA-4atqA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | ALA A 135GLU A 74ASP A 84ILE A 91 | None CA A1371 ( 4.5A)NoneNone | 0.94A | 5t8sA-4czpA:undetectable | 5t8sA-4czpA:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dfe | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Paraburkholderiaxenovorans) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | ALA A 72ASP A 84ILE A 83ILE A 110 | None | 0.81A | 5t8sA-4dfeA:undetectable | 5t8sA-4dfeA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4j | ARGININE DEIMINASE (Mycoplasmapenetrans) |
PF02274(Amidinotransf) | 4 | GLN A 381ASP A 383ILE A 384ILE A 374 | None | 0.93A | 5t8sA-4e4jA:undetectable | 5t8sA-4e4jA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikn | AP-3 COMPLEX SUBUNITMU-1 (Rattusnorvegicus) |
PF00928(Adap_comp_sub) | 4 | GLU A 185ASP A 188ILE A 187ILE A 272 | GLU A 185 ( 0.6A)ASP A 188 ( 0.6A)ILE A 187 ( 0.6A)ILE A 272 ( 0.7A) | 0.87A | 5t8sA-4iknA:undetectable | 5t8sA-4iknA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu4 | ARGINASE (Leishmaniamexicana) |
PF00491(Arginase) | 4 | ALA A 140GLU A 197ASP A 165ILE A 160 | NoneS2C A 405 ( 4.2A)NoneNone | 0.95A | 5t8sA-4iu4A:undetectable | 5t8sA-4iu4A:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5t | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (Saccharomycescerevisiae) |
PF03200(Glyco_hydro_63)PF16923(Glyco_hydro_63N) | 4 | ALA A 791ASP A 404ILE A 400ILE A 411 | None | 0.91A | 5t8sA-4j5tA:undetectable | 5t8sA-4j5tA:19.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4le5 | S-ADENOSYLMETHIONINESYNTHETASE (Campylobacterjejuni) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 6 | ALA A 39GLU A 54GLN A 105ASP A 124LYS A 281ILE A 314 | None | 0.47A | 5t8sA-4le5A:51.1 | 5t8sA-4le5A:39.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mps | BETA-GALACTOSIDEALPHA-2,6-SIALYLTRANSFERASE 1 (Rattusnorvegicus) |
PF00777(Glyco_transf_29) | 4 | ALA A 187GLU A 339ASP A 336ILE A 325 | None | 0.71A | 5t8sA-4mpsA:undetectable | 5t8sA-4mpsA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n58 | PECTOCIN M2 (Pectobacteriumcarotovorum) |
PF00111(Fer2)PF14859(Colicin_M) | 4 | ALA A 132ASP A 150ILE A 146ILE A 259 | None | 0.95A | 5t8sA-4n58A:undetectable | 5t8sA-4n58A:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nge | PRESEQUENCEPROTEASE,MITOCHONDRIAL (Homo sapiens) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | GLN D 949ASP D 951ILE D 952ILE D 885 | NoneNoneNoneMLY D 884 ( 4.0A) | 0.94A | 5t8sA-4ngeD:undetectable | 5t8sA-4ngeD:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 1 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | ALA A 105ASP A 72ILE A 73ILE A 63 | None | 0.75A | 5t8sA-4nhdA:undetectable | 5t8sA-4nhdA:25.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwz | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE (Caldalkalibacillusthermarum) |
PF07992(Pyr_redox_2) | 4 | ALA A 18ASP A 32ILE A 6ILE A 334 | None | 0.94A | 5t8sA-4nwzA:undetectable | 5t8sA-4nwzA:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nxk | ABP, A GH27BETA-L-ARABINOPYRANOSIDASE (Geobacillusstearothermophilus) |
PF16499(Melibiase_2) | 4 | GLU A 173ASP A 169ILE A 152ILE A 131 | SO4 A 502 (-2.5A)CIT A 513 ( 4.9A)NoneNone | 0.94A | 5t8sA-4nxkA:undetectable | 5t8sA-4nxkA:20.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4odj | S-ADENOSYLMETHIONINESYNTHASE (Cryptosporidiumhominis) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 7 | ALA A 60GLU A 75GLN A 118ILE A 122ASP A 139LYS A 297ILE A 330 | None | 0.18A | 5t8sA-4odjA:57.9 | 5t8sA-4odjA:50.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv2 | UPF0336 PROTEINMSMEG_1340/MSMEI_1302 (Mycolicibacteriumsmegmatis) |
PF13452(MaoC_dehydrat_N) | 4 | ALA A 131GLU A 133ASP A 101ILE A 97 | None | 0.91A | 5t8sA-4rv2A:undetectable | 5t8sA-4rv2A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ryf | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Listeriamonocytogenes) |
PF00574(CLP_protease) | 4 | ALA H 96ASP H 187ILE H 186ILE H 189 | None | 0.93A | 5t8sA-4ryfH:undetectable | 5t8sA-4ryfH:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4toc | BACTERIOFERRITIN (Pseudomonasaeruginosa) |
PF00210(Ferritin) | 4 | ALA A 97GLU A 127ASP A 132ILE A 131 | NoneFE2 A 203 ( 2.5A)NoneNone | 0.89A | 5t8sA-4tocA:undetectable | 5t8sA-4tocA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9c | LACTOFERRIN-BINDINGPROTEIN B (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17484(TbpB_A) | 4 | ALA A 46ASP A 85ILE A 86ILE A 329 | None | 0.75A | 5t8sA-4u9cA:undetectable | 5t8sA-4u9cA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wt7 | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (RIBOSE) (Agrobacteriumvitis) |
PF13407(Peripla_BP_4) | 4 | GLN A 111ASP A 120ILE A 119ASP A 91 | None | 0.77A | 5t8sA-4wt7A:undetectable | 5t8sA-4wt7A:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yom | SERINE/THREONINE-PROTEIN KINASE BRSK2 (Mus musculus) |
no annotation | 4 | ALA A 573ASP A 550ILE A 551ILE A 594 | None | 0.94A | 5t8sA-4yomA:undetectable | 5t8sA-4yomA:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0v | 2',5'-PHOSPHODIESTERASE 12 (Homo sapiens) |
PF03372(Exo_endo_phos) | 4 | ALA A 476ASP A 398ILE A 399ASP A 408 | None | 0.88A | 5t8sA-4z0vA:undetectable | 5t8sA-4z0vA:22.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homo sapiens) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 8 | ALA A 55GLU A 70GLN A 113ASP A 116ILE A 117ASP A 134LYS A 289ILE A 322 | None | 0.21A | 5t8sA-5a1iA:56.9 | 5t8sA-5a1iA:56.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 4 | ALA A1403ASP A1394ILE A1353ILE A1347 | None | 0.88A | 5t8sA-5cslA:undetectable | 5t8sA-5cslA:11.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czw | MYROILYSIN (Myroidesprofundi) |
PF01400(Astacin) | 4 | ALA A 112GLN A 93ILE A 54ILE A 82 | None | 0.96A | 5t8sA-5czwA:undetectable | 5t8sA-5czwA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fif | CARBOXYLASE (Deinococcusradiodurans) |
PF01039(Carboxyl_trans) | 4 | ALA A 204ASP A 241ILE A 242ILE A 229 | None | 0.84A | 5t8sA-5fifA:undetectable | 5t8sA-5fifA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5giu | PROLINE DIPEPTIDASE (Deinococcusradiodurans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | ALA A 25GLU A 290ASP A 221ILE A 135 | NoneNonePO4 A 401 ( 2.9A)None | 0.91A | 5t8sA-5giuA:undetectable | 5t8sA-5giuA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gmh | TOLL-LIKE RECEPTOR 7 (Macaca mulatta) |
PF00560(LRR_1)PF13306(LRR_5)PF13855(LRR_8) | 4 | ALA A 412ILE A 505ASP A 512ILE A 508 | None | 0.96A | 5t8sA-5gmhA:undetectable | 5t8sA-5gmhA:16.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h9u | S-ADENOSYLMETHIONINESYNTHASE (Thermusthermophilus) |
no annotation | 4 | ALA C 42GLU C 57ASP C 130LYS C 282 | None | 0.71A | 5t8sA-5h9uC:57.9 | 5t8sA-5h9uC:57.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iri | SERINE/THREONINE-PROTEIN KINASE BRSK1 (Mus musculus) |
no annotation | 4 | ALA A 646ASP A 623ILE A 624ILE A 667 | None | 0.84A | 5t8sA-5iriA:undetectable | 5t8sA-5iriA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kt0 | 4-HYDROXY-TETRAHYDRODIPICOLINATEREDUCTASE (Trichormusvariabilis) |
PF01113(DapB_N)PF05173(DapB_C) | 4 | GLU A 198GLN A 263ILE A 196ILE A 249 | None | 0.94A | 5t8sA-5kt0A:undetectable | 5t8sA-5kt0A:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5j | THIOREDOXINREDUCTASE (Giardiaintestinalis) |
PF07992(Pyr_redox_2) | 4 | ALA A 28GLU A 307ILE A 9ILE A 11 | None | 0.87A | 5t8sA-5m5jA:undetectable | 5t8sA-5m5jA:24.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t8t | S-ADENOSYLMETHIONINESYNTHASE (Neisseriagonorrhoeae) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 8 | ALA A 41GLU A 56GLN A 99ASP A 102ILE A 103ASP A 121LYS A 274ILE A 307 | None | 0.30A | 5t8sA-5t8tA:64.1 | 5t8sA-5t8tA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsj | ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATEMALTOSYLTRANSFERASE1 (Streptomycescoelicolor) |
PF00128(Alpha-amylase)PF11896(DUF3416) | 4 | ALA A 136GLU A 133ASP A 127ILE A 122 | None | 0.81A | 5t8sA-5vsjA:undetectable | 5t8sA-5vsjA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xox | TRNA(HIS)GUANYLYLTRANSFERASE (Saccharomycescerevisiae) |
PF04446(Thg1)PF14413(Thg1C) | 4 | ALA A 58ASP A 68ILE A 69ILE A 70 | None | 0.86A | 5t8sA-5xoxA:undetectable | 5t8sA-5xoxA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xx9 | BACTERIOFERRITIN (Streptomycescoelicolor) |
no annotation | 4 | ALA A 97GLU A 127ASP A 132ILE A 131 | NoneFE2 A 201 (-2.2A)NoneNone | 0.92A | 5t8sA-5xx9A:undetectable | 5t8sA-5xx9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5za2 | BETA-LACTAMASE (Escherichiacoli) |
no annotation | 4 | ALA A 339ASP A 13ILE A 16ILE A 355 | None | 0.93A | 5t8sA-5za2A:undetectable | 5t8sA-5za2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ape | BIFUNCTIONAL PROTEINFOLD (Helicobacterpylori) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 4 | ALA A 228ASP A 246ILE A 219ILE A 199 | NoneGOL A 303 ( 4.8A)NoneNone | 0.92A | 5t8sA-6apeA:undetectable | 5t8sA-6apeA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bma | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Campylobacterjejuni) |
no annotation | 4 | ALA A 182ASP A 170ILE A 168ILE A 187 | None | 0.88A | 5t8sA-6bmaA:undetectable | 5t8sA-6bmaA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d3u | ULVAN LYASE (Nonlabensulvanivorans) |
no annotation | 4 | ALA A 254ASP A 199ILE A 200ILE A 142 | None | 0.86A | 5t8sA-6d3uA:undetectable | 5t8sA-6d3uA:undetectable |