SIMILAR PATTERNS OF AMINO ACIDS FOR 5T7B_A_IPHA902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 222
PRO A 189
LEU A  73
TYR A 194
 None
 1.02A 5t7bA-1cliA:
0.0		 5t7bA-1cliA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9)
PF02256
(Fe_hyd_SSU) 		4 LEU D  87
TYR A 214
LEU D  76
GLU D  77
 None
 0.87A 5t7bA-1e08D:
undetectable		 5t7bA-1e08D:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 LEU A  18
PRO A 135
LEU A 119
TYR A 120
 None
 1.00A 5t7bA-1hcyA:
0.0		 5t7bA-1hcyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jig DLP-2

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 LEU A  21
TYR A  54
LEU A 105
TYR A 102
 None
 1.00A 5t7bA-1jigA:
undetectable		 5t7bA-1jigA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 LYS A 528
PRO A 529
GLU A 566
TYR A 563
 None
 0.82A 5t7bA-1knbA:
undetectable		 5t7bA-1knbA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		4 LEU A 213
LYS A 231
GLU A 250
TYR A 256
 None
 0.88A 5t7bA-1m3uA:
undetectable		 5t7bA-1m3uA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.07A 5t7bA-1p9bA:
0.0		 5t7bA-1p9bA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvm CONSERVED
HYPOTHETICAL PROTEIN
TA0289

(Thermoplasma
acidophilum) 		PF00571
(CBS)
PF09151
(DUF1936) 		4 LEU A 100
PRO A  80
LEU A  95
TYR A  94
 None
 0.91A 5t7bA-1pvmA:
undetectable		 5t7bA-1pvmA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
 None
 0.96A 5t7bA-1qhvA:
undetectable		 5t7bA-1qhvA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob)
PF00608
(Adeno_shaft) 		4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
 None
 0.95A 5t7bA-1qiuA:
0.0		 5t7bA-1qiuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 LEU A 193
TYR A 241
LEU A 242
TYR A 245
 None
 0.99A 5t7bA-1up4A:
2.2		 5t7bA-1up4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 LEU A 315
LYS A 182
PRO A 183
GLU A 221
 None
 0.88A 5t7bA-1xi8A:
4.6		 5t7bA-1xi8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 461
LYS A 401
PRO A 402
TYR A 364
 None
 0.85A 5t7bA-1z1wA:
3.7		 5t7bA-1z1wA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 LEU A 383
PRO A 388
LEU A 195
TYR A 194
 None
 0.95A 5t7bA-2erqA:
4.2		 5t7bA-2erqA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli) 		PF00484
(Pro_CA) 		4 LEU A 134
LYS A 129
LEU A 149
GLU A 153
 None
 1.06A 5t7bA-2esfA:
undetectable		 5t7bA-2esfA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		4 LEU A 241
PRO A 261
LEU A 293
TYR A 279
 None
 0.75A 5t7bA-2g1sA:
undetectable		 5t7bA-2g1sA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq4 HYPOTHETICAL PROTEIN
PH1570

(Pyrococcus
horikoshii) 		PF09638
(Ph1570) 		4 LEU A  35
TYR A  39
LEU A  65
GLU A  66
 None
 0.88A 5t7bA-2hq4A:
undetectable		 5t7bA-2hq4A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 LEU A 335
LYS A  92
PRO A  93
GLU A 126
 None
 0.88A 5t7bA-2jjfA:
undetectable		 5t7bA-2jjfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbm TOP7 FOLD PROTEIN
TOP7M13

(synthetic
construct) 		no annotation 4 LEU A  25
TYR A  26
LEU A  33
GLU A  32
 None
 0.79A 5t7bA-2mbmA:
undetectable		 5t7bA-2mbmA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE

(Streptomyces
virginiae) 		PF00550
(PP-binding) 		4 LEU A6750
TYR A6751
LEU A6772
GLU A6775
 None
 1.02A 5t7bA-2mf4A:
undetectable		 5t7bA-2mf4A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 168
PRO A  48
LEU A 189
GLU A 188
 None
 1.06A 5t7bA-2qaeA:
undetectable		 5t7bA-2qaeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT GAMMA

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF04358
(DsrC) 		4 LEU C  53
TYR C  56
LEU C  98
GLU B 223
 None
 1.02A 5t7bA-2v4jC:
undetectable		 5t7bA-2v4jC:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 LEU A 372
TYR A 376
PRO A 383
LEU A 403
 None
 0.89A 5t7bA-2wzsA:
undetectable		 5t7bA-2wzsA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		4 LEU A 438
PRO A 378
LEU A 418
TYR A 417
 None
 1.02A 5t7bA-2x1iA:
undetectable		 5t7bA-2x1iA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		4 LEU A  38
PRO A  48
LEU A 123
TYR A 120
 None
 1.03A 5t7bA-2z3kA:
undetectable		 5t7bA-2z3kA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		4 LYS A 330
PRO A 331
LEU A 319
GLU A 320
 None
 0.72A 5t7bA-2zc0A:
2.2		 5t7bA-2zc0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 240
TYR A 241
LEU A 235
TYR A 176
 None
 1.08A 5t7bA-2zufA:
3.6		 5t7bA-2zufA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 LEU A 171
PRO A 174
LEU A  55
GLU A  56
 None
 0.95A 5t7bA-3ffrA:
2.3		 5t7bA-3ffrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 477
TYR A 479
LEU A 274
TYR A 276
 None
 1.01A 5t7bA-3h11A:
undetectable		 5t7bA-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 LEU A  13
PRO A 149
LEU A 136
TYR A 140
 None
 0.94A 5t7bA-3i5gA:
2.2		 5t7bA-3i5gA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		4 LEU A 183
LYS A 206
PRO A 207
GLU A 181
 None
 0.81A 5t7bA-3jr7A:
undetectable		 5t7bA-3jr7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 174
PRO A  55
LEU A 195
GLU A 194
 None
 1.02A 5t7bA-3ladA:
undetectable		 5t7bA-3ladA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PRO A  28
LEU A 534
GLU A 535
TYR A 619
 None
 1.03A 5t7bA-3ldrA:
undetectable		 5t7bA-3ldrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		4 LEU A 288
TYR A 287
PRO A 204
LEU A 201
 None
 0.93A 5t7bA-3lwuA:
2.0		 5t7bA-3lwuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 249
PRO A 237
LEU A 217
GLU A 216
 None
 0.82A 5t7bA-3mwcA:
undetectable		 5t7bA-3mwcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oad RENIN

(Homo sapiens) 		PF00026
(Asp) 		4 LEU B 246
PRO B 266
LEU B 298
TYR B 284
 None
 0.72A 5t7bA-3oadB:
undetectable		 5t7bA-3oadB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omz HUMAN VDELTA1 GAMMA
DELTA T CELL
RECEPTOR DELTA1A/B-3

(Homo sapiens) 		PF07686
(V-set) 		4 LEU A  38
TYR A  37
LEU A  48
GLU A  61
 None
 1.07A 5t7bA-3omzA:
undetectable		 5t7bA-3omzA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 222
PRO A 190
LEU A  74
TYR A 195
 None
 0.99A 5t7bA-3p4eA:
undetectable		 5t7bA-3p4eA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		4 LEU A 190
PRO A 168
LEU A 195
TYR A 198
 None
 1.06A 5t7bA-3phgA:
3.7		 5t7bA-3phgA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU A 303
TYR A 304
LEU A 223
TYR A 222
 None
 0.84A 5t7bA-3qr1A:
2.4		 5t7bA-3qr1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 LEU M 244
LYS M 234
PRO M 236
LEU M 259
 None
 1.00A 5t7bA-3rkoM:
undetectable		 5t7bA-3rkoM:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		4 LEU A 909
TYR A1016
LEU A 885
GLU A 886
 None
 0.85A 5t7bA-3tadA:
undetectable		 5t7bA-3tadA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 177
PRO A 273
LEU A 297
TYR A 263
 None
 1.08A 5t7bA-3tl2A:
undetectable		 5t7bA-3tl2A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 TYR A 193
PRO A 195
LEU A 200
GLU A 201
 None
SAH  A 258 (-4.1A)
None
None
 1.01A 5t7bA-3tosA:
3.2		 5t7bA-3tosA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 169
PRO A  48
LEU A 190
GLU A 189
 None
None
None
FAD  A 500 ( 4.5A)
 1.08A 5t7bA-3urhA:
undetectable		 5t7bA-3urhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 LEU A 203
TYR A 199
PRO A  69
LEU A  60
 None
 1.03A 5t7bA-3vgfA:
1.6		 5t7bA-3vgfA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 LEU A 145
TYR A 104
PRO A 103
TYR A 122
 None
 1.05A 5t7bA-3wg6A:
undetectable		 5t7bA-3wg6A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzf ACETYLGLUTAMATE
KINASE

(Saccharomyces
cerevisiae) 		PF00696
(AA_kinase) 		4 LEU A 120
TYR A 124
PRO A 130
LEU A 183
 None
 0.87A 5t7bA-3zzfA:
3.5		 5t7bA-3zzfA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzi ACETYLGLUTAMATE
KINASE

(Saccharomyces
cerevisiae) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 LEU A 120
TYR A 124
PRO A 130
LEU A 183
 None
 0.91A 5t7bA-3zziA:
3.4		 5t7bA-3zziA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 LEU A 289
PRO A 309
LEU A 341
TYR A 327
 None
 0.94A 5t7bA-4amtA:
undetectable		 5t7bA-4amtA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 TYR A 753
PRO A 757
LEU A 728
GLU A 729
 None
 1.07A 5t7bA-4cekA:
undetectable		 5t7bA-4cekA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		4 LEU A 476
PRO A 441
LEU A 446
TYR A 462
 None
 1.07A 5t7bA-4e2oA:
undetectable		 5t7bA-4e2oA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 405
PRO A 435
GLU A 398
TYR A 401
 None
 0.96A 5t7bA-4eq5A:
undetectable		 5t7bA-4eq5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
23

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A  39
PRO A  47
LEU A  56
TYR A  28
 None
 1.01A 5t7bA-4ercA:
undetectable		 5t7bA-4ercA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 4 LEU A  99
PRO A  58
LEU A  68
TYR A  67
 None
 0.86A 5t7bA-4fekA:
undetectable		 5t7bA-4fekA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3a CLIP-ASSOCIATING
PROTEIN

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 LEU A 192
TYR A 196
LEU A 221
GLU A 222
 None
 0.93A 5t7bA-4g3aA:
undetectable		 5t7bA-4g3aA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 LEU A  79
PRO A 105
LEU A 120
TYR A 116
 None
 1.04A 5t7bA-4gn2A:
undetectable		 5t7bA-4gn2A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		4 LEU A  29
PRO A 135
LEU A 117
GLU A 120
 None
 0.72A 5t7bA-4guzA:
undetectable		 5t7bA-4guzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikh GLUTATHIONE
S-TRANSFERASE

(Pseudomonas
protegens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  23
PRO A 231
LEU A  38
GLU A  39
 None
 1.02A 5t7bA-4ikhA:
undetectable		 5t7bA-4ikhA:
15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 LEU A 648
TYR A 652
PRO A 659
LEU A 692
TYR A 696
 None
 0.32A 5t7bA-4krfA:
60.3		 5t7bA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN

(Paraburkholderia
graminis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  23
PRO A 231
LEU A  38
GLU A  39
 None
 0.85A 5t7bA-4mf6A:
undetectable		 5t7bA-4mf6A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnh T-CELL RECEPTOR
GAMMA CHAIN V REGION
PT-GAMMA-1/2, HUMAN
NKT TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A  37
TYR A  36
LEU A  47
GLU A  60
 None
 1.01A 5t7bA-4mnhA:
undetectable		 5t7bA-4mnhA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		4 LEU A  12
TYR A  11
LYS A  22
GLU A  15
 None
 1.01A 5t7bA-4n06A:
undetectable		 5t7bA-4n06A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Pseudomonas
putida) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  23
PRO A 230
LEU A  38
GLU A  39
 None
 0.97A 5t7bA-4naxA:
undetectable		 5t7bA-4naxA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN

(Bradyrhizobium
sp. BTAi1) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  23
PRO A 231
LEU A  38
GLU A  39
 None
 0.98A 5t7bA-4nhzA:
undetectable		 5t7bA-4nhzA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 LEU A 545
TYR A 559
PRO A 583
LEU A 548
 None
 1.04A 5t7bA-4o9xA:
undetectable		 5t7bA-4o9xA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmn TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 LEU A 127
TYR A  65
LYS A  79
PRO A  80
 GOL  A 302 (-4.9A)
None
MES  A 301 (-2.7A)
None
 1.06A 5t7bA-4pmnA:
undetectable		 5t7bA-4pmnA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmr TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 LEU A 127
TYR A  65
LYS A  79
PRO A  80
 None
None
EPE  A 301 (-2.8A)
None
 1.08A 5t7bA-4pmrA:
undetectable		 5t7bA-4pmrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 LEU A 334
PRO A 264
LEU A 245
TYR A 258
 None
 1.07A 5t7bA-4rg8A:
undetectable		 5t7bA-4rg8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A  80
PRO A  68
LEU A 101
TYR A  98
 None
 0.99A 5t7bA-4u7lA:
undetectable		 5t7bA-4u7lA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 LEU A  93
LYS A  95
LEU A 137
GLU A 140
 None
 1.03A 5t7bA-4uedA:
undetectable		 5t7bA-4uedA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE

(Pyrococcus sp.
ST04) 		PF13419
(HAD_2) 		4 LEU A 195
TYR A 197
LEU A 216
GLU A 215
 None
 1.03A 5t7bA-4uw9A:
3.5		 5t7bA-4uw9A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		4 LEU A 262
LYS A 266
LEU A 247
TYR A 243
 None
 1.07A 5t7bA-4wk5A:
undetectable		 5t7bA-4wk5A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.62A 5t7bA-5a4jA:
6.4		 5t7bA-5a4jA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.88A 5t7bA-5cs0A:
undetectable		 5t7bA-5cs0A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.95A 5t7bA-5csaA:
2.7		 5t7bA-5csaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.98A 5t7bA-5cslA:
undetectable		 5t7bA-5cslA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnb SPIKE GLYCOPROTEIN

(Human
coronavirus
HKU1) 		PF09408
(Spike_rec_bind) 		4 LEU A 409
TYR A 414
PRO A 341
LEU A 401
 None
 1.01A 5t7bA-5gnbA:
undetectable		 5t7bA-5gnbA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 284
PRO A 189
LEU A 244
GLU A 245
 None
 0.78A 5t7bA-5gvsA:
undetectable		 5t7bA-5gvsA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N) 		4 LEU B1004
LYS B 999
LEU A 195
GLU A 199
 None
 0.92A 5t7bA-5h67B:
undetectable		 5t7bA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		4 LEU A 223
TYR A 221
LYS A 216
GLU A 261
 None
 0.92A 5t7bA-5j6qA:
undetectable		 5t7bA-5j6qA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		4 LEU A  35
PRO A  81
LEU A  76
TYR A 386
 None
 0.92A 5t7bA-5jxmA:
undetectable		 5t7bA-5jxmA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8

(Homo sapiens) 		no annotation 4 LEU A 412
LYS A 416
LEU A 501
GLU A 498
 None
 0.98A 5t7bA-5kdiA:
undetectable		 5t7bA-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A 170
TYR A 169
LEU A 195
GLU A 240
 None
 1.06A 5t7bA-5kgnA:
undetectable		 5t7bA-5kgnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 4 LEU A 286
PRO A 307
LEU A 339
TYR A 325
 None
 1.07A 5t7bA-5mlgA:
undetectable		 5t7bA-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvk GRB10-INTERACTING
GYF PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU B  47
TYR B  50
LEU B  79
GLU B  80
 None
 0.98A 5t7bA-5nvkB:
undetectable		 5t7bA-5nvkB:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 LEU A 126
LYS A 128
LEU A 169
GLU A 172
 None
 1.02A 5t7bA-5t47A:
undetectable		 5t7bA-5t47A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		4 LEU A  71
TYR A  72
LYS A  74
PRO A  75
 None
 1.00A 5t7bA-5twbA:
undetectable		 5t7bA-5twbA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.57A 5t7bA-5v0iA:
undetectable		 5t7bA-5v0iA:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 7 LEU A 651
TYR A 655
LYS A 661
PRO A 662
LEU A 695
GLU A 696
TYR A 699
 None
 0.78A 5t7bA-5vm9A:
undetectable		 5t7bA-5vm9A:
79.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 6 LEU A 650
LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.90A 5t7bA-5weaA:
undetectable		 5t7bA-5weaA:
98.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 6 LEU A 650
TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.65A 5t7bA-5weaA:
undetectable		 5t7bA-5weaA:
98.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A  44
LYS A  48
LEU A 132
GLU A 135
 None
 1.07A 5t7bA-5wu7A:
undetectable		 5t7bA-5wu7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A 369
TYR A 396
LEU A 252
GLU A 253
 None
 1.05A 5t7bA-5x1nA:
undetectable		 5t7bA-5x1nA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 4 LEU B 243
PRO B 129
LEU B 264
GLU B 263
 None
None
FAD  B 601 ( 4.9A)
FAD  B 601 ( 4.5A)
 1.04A 5t7bA-5x1yB:
undetectable		 5t7bA-5x1yB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		4 LEU A 368
TYR A 385
PRO A 383
GLU A 120
 None
 0.89A 5t7bA-5x62A:
undetectable		 5t7bA-5x62A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 4 LEU B 317
PRO B 316
LEU B 321
GLU B 322
 None
 1.05A 5t7bA-5xguB:
undetectable		 5t7bA-5xguB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 174
PRO A  55
LEU A 195
GLU A 194
 None
None
None
FAD  A 501 ( 4.5A)
 1.07A 5t7bA-6bz0A:
undetectable		 5t7bA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.75A 5t7bA-6dfuA:
undetectable		 5t7bA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fgk GTP
PYROPHOSPHOKINASE
YWAC

(Bacillus
subtilis) 		no annotation 4 LEU A 134
TYR A 122
LYS A 120
GLU A 154
 None
 0.77A 5t7bA-6fgkA:
undetectable		 5t7bA-6fgkA:
undetectable