SIMILAR PATTERNS OF AMINO ACIDS FOR 5T7B_A_IPHA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 PRO A 219
VAL A 119
ALA A 247
PHE A 274
 None
 1.14A 5t7bA-1brtA:
4.5		 5t7bA-1brtA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 112
VAL A  83
ALA A  85
THR A 153
 None
None
SBT  A 353 ( 4.4A)
None
 1.11A 5t7bA-1bxzA:
0.0		 5t7bA-1bxzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 PHE A  26
PRO A  17
ALA A  23
THR A 914
 None
 1.13A 5t7bA-1c30A:
0.0		 5t7bA-1c30A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		4 PHE A 216
PRO A 223
VAL A 226
ALA A 213
 None
 1.05A 5t7bA-1eywA:
undetectable		 5t7bA-1eywA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		4 PHE B 155
PRO B 160
VAL B 161
ALA B 197
 None
 1.01A 5t7bA-1fftB:
0.0		 5t7bA-1fftB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		4 PRO A 287
VAL A 285
ALA A 130
PHE A 237
 None
 1.01A 5t7bA-1h79A:
2.1		 5t7bA-1h79A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		4 PRO A 287
VAL A 285
PHE A 237
THR A 198
 None
 1.09A 5t7bA-1h79A:
2.1		 5t7bA-1h79A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 PHE A 212
PRO A 193
VAL A 194
ALA A 211
 None
 1.17A 5t7bA-1mppA:
undetectable		 5t7bA-1mppA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9l PUTATIVE BLUE LIGHT
RECEPTOR

(Chlamydomonas
reinhardtii) 		PF13426
(PAS_9) 		4 PHE A  41
PRO A  49
VAL A  52
ALA A  37
 None
 1.10A 5t7bA-1n9lA:
undetectable		 5t7bA-1n9lA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8p PUTATUVE
ENDO-XYLANASE

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		4 PHE A 135
PRO A 138
VAL A 139
PHE A 112
 None
 1.11A 5t7bA-1o8pA:
undetectable		 5t7bA-1o8pA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A 256
PRO A 237
VAL A 238
ALA A 257
 PO4  A1404 (-4.7A)
None
None
None
 1.00A 5t7bA-1ozhA:
4.4		 5t7bA-1ozhA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suj CONE ARRESTIN

(Ambystoma
tigrinum) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 PHE A 114
PRO A  35
VAL A  36
THR A  95
 None
 0.79A 5t7bA-1sujA:
undetectable		 5t7bA-1sujA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 112
VAL A  83
ALA A  85
THR A 153
 None
None
CAC  A1001 ( 4.0A)
None
 1.16A 5t7bA-1y9aA:
undetectable		 5t7bA-1y9aA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 PRO A 218
VAL A 219
ALA A 247
PHE A 273
 None
 0.98A 5t7bA-1zoiA:
3.2		 5t7bA-1zoiA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A 271
ALA A 269
PHE A 102
THR A 187
 None
 1.14A 5t7bA-2bi0A:
undetectable		 5t7bA-2bi0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF16914
(TetR_C_12) 		4 PHE A 112
VAL A  73
ALA A  69
THR A  28
 None
 0.94A 5t7bA-2hkuA:
undetectable		 5t7bA-2hkuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 PHE A 446
VAL A 424
ALA A 445
THR A 131
 None
 1.15A 5t7bA-2htvA:
undetectable		 5t7bA-2htvA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 PHE A  73
PRO A 216
VAL A 217
PHE A  65
 None
 1.02A 5t7bA-2hufA:
undetectable		 5t7bA-2hufA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 125
ALA A 103
PHE A  68
THR A  99
 None
 1.05A 5t7bA-2hzhA:
undetectable		 5t7bA-2hzhA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5p GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Kluyveromyces
marxianus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE O 230
VAL O 175
ALA O 229
THR O 150
 None
None
BME  O1023 ( 4.8A)
None
 1.10A 5t7bA-2i5pO:
3.5		 5t7bA-2i5pO:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		4 PHE A  25
PRO A 141
VAL A 144
ALA A  26
 None
 1.01A 5t7bA-2i6dA:
2.3		 5t7bA-2i6dA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 342
PRO A 322
VAL A 320
PHE A 391
 None
 1.16A 5t7bA-2p0uA:
undetectable		 5t7bA-2p0uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 PHE A 158
PRO A 147
VAL A 148
THR A 109
 None
 1.18A 5t7bA-2q9uA:
3.9		 5t7bA-2q9uA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		4 PHE A 234
PRO A 214
VAL A 215
ALA A 233
 None
 1.15A 5t7bA-2rmpA:
undetectable		 5t7bA-2rmpA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		4 PHE A 201
PRO A 187
VAL A 188
ALA A 200
 None
 0.90A 5t7bA-2wl3A:
undetectable		 5t7bA-2wl3A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE

(Paraburkholderia
xenovorans) 		PF12146
(Hydrolase_4) 		4 PRO A 208
VAL A 120
ALA A 235
PHE A 261
 None
 1.07A 5t7bA-2xuaA:
4.0		 5t7bA-2xuaA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3m PROTEIN TRANSPORT
PROTEIN HOFQ

(Aggregatibacter
actinomycetemcomitans) 		PF03958
(Secretin_N) 		4 PHE A  98
PRO A  29
VAL A  30
THR A 148
 None
 1.15A 5t7bA-2y3mA:
undetectable		 5t7bA-2y3mA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.14A 5t7bA-2y4fA:
undetectable		 5t7bA-2y4fA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 PHE A 181
ALA A 177
PHE A  37
THR A  61
 None
None
None
SO4  A1287 (-4.2A)
 1.17A 5t7bA-2ykfA:
undetectable		 5t7bA-2ykfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		4 PHE A  80
PRO A 120
VAL A 121
ALA A 117
 None
 1.05A 5t7bA-2ypqA:
undetectable		 5t7bA-2ypqA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		4 PHE A 152
ALA A 149
PHE A 145
THR A 126
 22B  A 270 ( 4.1A)
None
22B  A 270 (-3.5A)
None
 1.17A 5t7bA-2z55A:
undetectable		 5t7bA-2z55A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE A  98
PRO A  96
VAL A  94
ALA A 105
 None
 0.91A 5t7bA-2zecA:
undetectable		 5t7bA-2zecA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		4 PHE A 153
PRO A 155
VAL A 158
PHE A 203
 None
 1.05A 5t7bA-3at7A:
undetectable		 5t7bA-3at7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 529
PRO A 112
VAL A 111
PHE A 109
 None
 1.16A 5t7bA-3cttA:
undetectable		 5t7bA-3cttA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		4 PRO A  38
VAL A  39
ALA A  20
THR A  44
 None
None
None
K  A 289 (-3.9A)
 0.68A 5t7bA-3dclA:
undetectable		 5t7bA-3dclA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 PHE A 257
VAL A 248
PHE A 273
THR A 277
 None
 0.96A 5t7bA-3ed3A:
undetectable		 5t7bA-3ed3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 PHE A 418
VAL A 417
ALA A 422
THR A   4
 None
 1.05A 5t7bA-3eqnA:
undetectable		 5t7bA-3eqnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc3 BETA-ARRESTIN-1

(Bos taurus) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 PHE A 117
PRO A  36
VAL A  37
THR A  98
 None
 0.74A 5t7bA-3gc3A:
undetectable		 5t7bA-3gc3A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 PHE A  80
PRO A  46
VAL A  47
ALA A  81
 None
 1.12A 5t7bA-3gx8A:
undetectable		 5t7bA-3gx8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv9 PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 PHE A 531
PRO A 462
VAL A 463
PHE A 686
 None
 0.83A 5t7bA-3hv9A:
undetectable		 5t7bA-3hv9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A  82
PRO A 311
VAL A  80
PHE A 450
 None
 1.18A 5t7bA-3jq1A:
undetectable		 5t7bA-3jq1A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		4 PHE A 178
PRO A 181
VAL A 182
ALA A 126
 None
 0.85A 5t7bA-3lahA:
undetectable		 5t7bA-3lahA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN

(Streptococcus
agalactiae) 		PF04816
(TrmK) 		4 PHE A  35
PRO A  33
ALA A  13
THR A  92
 None
 1.16A 5t7bA-3lecA:
undetectable		 5t7bA-3lecA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 243
PRO A 241
ALA A 244
THR A 275
 None
 1.11A 5t7bA-3lgxA:
2.5		 5t7bA-3lgxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT

(Parabacteroides
distasonis) 		PF04205
(FMN_bind) 		4 PHE A 116
PRO A 144
VAL A 145
ALA A 115
 None
 1.06A 5t7bA-3lwxA:
undetectable		 5t7bA-3lwxA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 PHE A 193
VAL A 217
ALA A 194
PHE A 212
 None
 1.14A 5t7bA-3n0lA:
undetectable		 5t7bA-3n0lA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		4 PHE A 220
PRO A 192
ALA A 223
PHE A  84
 None
 1.02A 5t7bA-3o7wA:
2.2		 5t7bA-3o7wA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		4 PHE A 486
ALA A 498
PHE A 502
THR A 464
 None
 1.16A 5t7bA-3ol2A:
undetectable		 5t7bA-3ol2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A 231
VAL A 176
ALA A 230
THR A 151
 None
 1.04A 5t7bA-3pymA:
3.7		 5t7bA-3pymA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Bacillus
licheniformis) 		PF00171
(Aldedh) 		4 PHE A 404
VAL A 422
PHE A 314
THR A 345
 None
 0.98A 5t7bA-3rjlA:
3.6		 5t7bA-3rjlA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A 235
VAL A 178
ALA A 234
THR A 153
 None
 1.06A 5t7bA-3sthA:
3.1		 5t7bA-3sthA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 PHE A 534
PRO A 512
VAL A 513
ALA A 533
 None
 0.94A 5t7bA-3wy2A:
undetectable		 5t7bA-3wy2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgo EFEM M75 PEPTIDASE

(Pseudomonas
syringae) 		PF09375
(Peptidase_M75) 		4 PHE A 164
PRO A 166
VAL A 169
PHE A 214
 None
 1.02A 5t7bA-4bgoA:
undetectable		 5t7bA-4bgoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chc POLYMERASE ACIDIC
PROTEIN

(Thogoto
thogotovirus) 		no annotation 4 PHE A 119
VAL A  98
ALA A 118
THR A 110
 None
 1.10A 5t7bA-4chcA:
undetectable		 5t7bA-4chcA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 PHE B1514
PRO B1516
VAL B1518
ALA B1350
 None
 1.11A 5t7bA-4f92B:
undetectable		 5t7bA-4f92B:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 VAL A 524
ALA A 507
PHE A 693
THR A 611
 None
 1.18A 5t7bA-4g9iA:
undetectable		 5t7bA-4g9iA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvb KP6 KILLER TOXIN
SUBUNIT BETA

(Ustilago maydis
virus P6) 		no annotation 4 PHE B  55
PRO B   6
VAL B   7
ALA B  48
 None
 1.04A 5t7bA-4gvbB:
undetectable		 5t7bA-4gvbB:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3e SUPEROXIDE DISMUTASE

(Trypanosoma
cruzi) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 PHE A 128
VAL A 224
PHE A 112
THR A  22
 None
 1.16A 5t7bA-4h3eA:
undetectable		 5t7bA-4h3eA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		4 PRO A 219
VAL A 119
ALA A 247
PHE A 274
 None
 1.10A 5t7bA-4iq4A:
4.4		 5t7bA-4iq4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 4 PHE B 345
PRO B 284
VAL B 286
ALA B 279
 None
 1.16A 5t7bA-4iu9B:
undetectable		 5t7bA-4iu9B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		4 PHE A 151
PRO A 155
VAL A 157
ALA A 150
 None
 0.98A 5t7bA-4iyjA:
4.6		 5t7bA-4iyjA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j40 FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 PHE A 531
PRO A 462
VAL A 463
PHE A 686
 None
 0.74A 5t7bA-4j40A:
undetectable		 5t7bA-4j40A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A 238
VAL A 183
ALA A 237
THR A 158
 None
 1.07A 5t7bA-4k9dA:
2.2		 5t7bA-4k9dA:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		6 PHE A 585
PRO A 588
VAL A 589
ALA A 618
PHE A 651
THR A 655
 None
 0.18A 5t7bA-4krfA:
60.3		 5t7bA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgq PUTATIVE POLYKETIDE
CYCLASE

(Chromobacterium
violaceum) 		PF07366
(SnoaL) 		4 PHE A  36
PRO A  34
VAL A  32
ALA A 121
 None
 1.17A 5t7bA-4lgqA:
undetectable		 5t7bA-4lgqA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A 237
VAL A 182
ALA A 236
THR A 157
 None
 1.03A 5t7bA-4lsmA:
3.7		 5t7bA-4lsmA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE O 230
VAL O 175
ALA O 229
THR O 150
 None
 1.01A 5t7bA-4o59O:
undetectable		 5t7bA-4o59O:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A 231
VAL A 176
ALA A 230
THR A 151
 None
 1.06A 5t7bA-4p8rA:
3.6		 5t7bA-4p8rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 PRO A 383
VAL A 384
ALA A 345
PHE A 130
 None
None
PEG  A 403 ( 3.8A)
None
 0.98A 5t7bA-4q1zA:
undetectable		 5t7bA-4q1zA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Clostridium
perfringens) 		PF00936
(BMC) 		4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.88A 5t7bA-4tlhA:
undetectable		 5t7bA-4tlhA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 PHE A2652
VAL A2695
ALA A2651
THR A2640
 None
 1.16A 5t7bA-4tvcA:
undetectable		 5t7bA-4tvcA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		4 PHE A 152
PRO A 155
VAL A 156
THR A 467
 None
 1.13A 5t7bA-4wedA:
undetectable		 5t7bA-4wedA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 PHE A  64
PRO A 293
VAL A 314
THR A 288
 None
 1.15A 5t7bA-4wpzA:
undetectable		 5t7bA-4wpzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		4 PHE A  67
VAL A 263
PHE A  42
THR A 275
 None
 0.80A 5t7bA-4yfmA:
undetectable		 5t7bA-4yfmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 PHE A 488
PRO A 502
VAL A 501
THR A 851
 None
 1.13A 5t7bA-4zg7A:
undetectable		 5t7bA-4zg7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw0 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ

(Candidatus
Liberibacter
asiaticus) 		PF07977
(FabA) 		4 PHE A  86
PRO A  92
VAL A 148
ALA A  81
 None
 1.07A 5t7bA-4zw0A:
undetectable		 5t7bA-4zw0A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 PRO A  11
VAL A   9
ALA A 248
THR A 252
 None
 1.17A 5t7bA-4zwvA:
undetectable		 5t7bA-4zwvA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.) 		PF06778
(Chlor_dismutase) 		4 PHE A 196
PRO A 148
VAL A 149
ALA A 194
 HEM  A 250 (-3.8A)
None
HEM  A 250 ( 4.4A)
None
 1.13A 5t7bA-5a12A:
undetectable		 5t7bA-5a12A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		4 PHE A 195
PRO A 248
VAL A 249
THR A 350
 None
 1.02A 5t7bA-5bugA:
3.1		 5t7bA-5bugA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 PRO A 114
VAL A 115
PHE A 132
THR A  92
 None
 0.97A 5t7bA-5bzaA:
undetectable		 5t7bA-5bzaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Mus musculus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE O 337
VAL O 282
ALA O 336
THR O 257
 None
 1.06A 5t7bA-5c7iO:
4.1		 5t7bA-5c7iO:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Homo sapiens) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE O 305
VAL O 250
ALA O 304
THR O 225
 None
None
None
OCS  O 224 ( 4.2A)
 1.01A 5t7bA-5c7oO:
2.8		 5t7bA-5c7oO:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PRO A 681
VAL A 682
ALA A 580
PHE A 540
 None
 0.81A 5t7bA-5f7sA:
undetectable		 5t7bA-5f7sA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm9 MAMO PROTEASE DOMAIN

(Magnetospirillum
magneticum) 		PF13365
(Trypsin_2) 		4 PHE A 137
VAL A 186
ALA A 136
THR A 210
 None
 1.09A 5t7bA-5hm9A:
undetectable		 5t7bA-5hm9A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 PHE A  90
PRO A 130
VAL A 131
ALA A 127
 None
 1.06A 5t7bA-5hucA:
undetectable		 5t7bA-5hucA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 583
VAL A 585
ALA A 561
THR A 745
 None
 1.09A 5t7bA-5iudA:
3.7		 5t7bA-5iudA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		4 PRO A 110
VAL A 111
ALA A  72
PHE A  92
 None
 0.86A 5t7bA-5jipA:
2.3		 5t7bA-5jipA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 VAL A  42
ALA A 197
PHE A  56
THR A 220
 None
 1.11A 5t7bA-5kjmA:
undetectable		 5t7bA-5kjmA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 PHE A 263
VAL A 310
ALA A 265
THR A 119
 None
 0.86A 5t7bA-5ko3A:
2.5		 5t7bA-5ko3A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 PHE A  81
VAL A  49
ALA A  61
PHE A  39
 None
 1.17A 5t7bA-5ti1A:
undetectable		 5t7bA-5ti1A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv1 BETA-ARRESTIN-2

(Bos taurus) 		no annotation 4 PHE A 118
PRO A  37
VAL A  38
THR A  99
 None
 0.84A 5t7bA-5tv1A:
undetectable		 5t7bA-5tv1A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Naegleria
gruberi) 		no annotation 4 PHE A 230
VAL A 175
ALA A 229
THR A 150
 None
None
None
OCS  A 149 ( 3.8A)
 1.02A 5t7bA-5ur0A:
3.5		 5t7bA-5ur0A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 6 PHE A 588
PRO A 591
VAL A 592
ALA A 621
PHE A 654
THR A 658
 None
 0.39A 5t7bA-5vm9A:
56.3		 5t7bA-5vm9A:
79.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 PHE A 263
VAL A 310
ALA A 265
THR A 119
 None
 0.85A 5t7bA-5w8uA:
undetectable		 5t7bA-5w8uA:
16.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 6 PHE A 587
PRO A 590
VAL A 591
ALA A 620
PHE A 653
THR A 657
 None
 0.39A 5t7bA-5weaA:
60.0		 5t7bA-5weaA:
98.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 PRO A 665
VAL A 666
ALA A 564
PHE A 524
 None
 0.82A 5t7bA-5x3jA:
undetectable		 5t7bA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 4 PHE A 294
PRO A 297
VAL A 298
ALA A 291
 None
 1.08A 5t7bA-6bxnA:
4.0		 5t7bA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 PRO A 150
VAL A 151
ALA A 268
PHE A 158
 None
FAD  A 503 (-4.8A)
None
None
 0.70A 5t7bA-6cmzA:
undetectable		 5t7bA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 4 PRO A 323
VAL A 324
ALA A 320
THR A 356
 None
 1.09A 5t7bA-6ehnA:
2.4		 5t7bA-6ehnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 PRO A  58
VAL A  57
ALA A  60
PHE A  77
 None
 1.13A 5t7bA-6fhwA:
undetectable		 5t7bA-6fhwA:
undetectable