SIMILAR PATTERNS OF AMINO ACIDS FOR 5T0M_A_SAMA1205_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.23A 5t0mA-1pegA:
26.0		 5t0mA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.48A 5t0mA-1pegA:
26.0		 5t0mA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.41A 5t0mA-2r3aA:
28.4		 5t0mA-2r3aA:
34.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.80A 5t0mA-2w5zA:
12.3		 5t0mA-2w5zA:
27.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.29A 5t0mA-3bo5A:
26.5		 5t0mA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.94A 5t0mA-3bo5A:
26.5		 5t0mA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		7 TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.57A 5t0mA-3bo5A:
26.5		 5t0mA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		5 TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.08A 5t0mA-3ooiA:
19.5		 5t0mA-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		6 TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.30A 5t0mA-3ooiA:
19.5		 5t0mA-3ooiA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		5 TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.05A 5t0mA-3opeA:
17.8		 5t0mA-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		6 TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.39A 5t0mA-3opeA:
17.8		 5t0mA-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		5 ASN A 182
HIS A 183
TYR A 217
PHE A 221
CYH A 229
 SAH  A1247 (-3.1A)
SAH  A1247 (-4.6A)
None
None
ZN  A1248 ( 2.3A)
 0.65A 5t0mA-4au7A:
8.4		 5t0mA-4au7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		5 TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.26A 5t0mA-4fmuA:
18.5		 5t0mA-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		6 TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.54A 5t0mA-4qeoA:
29.5		 5t0mA-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		5 TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.49A 5t0mA-4z4pA:
13.7		 5t0mA-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		5 TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.71A 5t0mA-5f59A:
13.4		 5t0mA-5f59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.80A 5t0mA-5f6lA:
13.4		 5t0mA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.55A 5t0mA-5f6lA:
13.4		 5t0mA-5f6lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		6 TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.19A 5t0mA-5lsuA:
20.3		 5t0mA-5lsuA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		12 MET A1048
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.43A 5t0mA-5tuyA:
41.1		 5t0mA-5tuyA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 5 MET A 479
SER A 406
TYR A 236
PHE A 402
GLN A 476
 None
 1.38A 5t0mA-5ukhA:
undetectable		 5t0mA-5ukhA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		11 MET A1136
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
 SAM  A3001 (-3.4A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
 0.57A 5t0mA-5vsdA:
40.0		 5t0mA-5vsdA:
77.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 6 TRP A1157
TYR A1200
ASN A1223
HIS A1224
TYR A1261
CYH A1273
 None
SAM  A1301 (-3.9A)
SAM  A1301 (-3.2A)
None
SAM  A1301 (-4.9A)
ZN  A1304 ( 2.3A)
 0.25A 5t0mA-6cenA:
19.9		 5t0mA-6cenA:
28.81