SIMILAR PATTERNS OF AMINO ACIDS FOR 5SYJ_B_NIZB809_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 252
VAL A 160
GLY A 293
LEU A 295
 None
FAD  A 600 (-3.4A)
None
None
 0.85A 5syjB-1bhyA:
0.3		 5syjB-1bhyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A  91
GLN A  93
LEU A  96
THR A  94
 None
None
None
NET  A4011 (-4.1A)
 0.99A 5syjB-1c30A:
0.0		 5syjB-1c30A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A 643
GLN A 645
LEU A 648
THR A 646
 None
 0.96A 5syjB-1c30A:
0.0		 5syjB-1c30A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 0.98A 5syjB-1dl5A:
undetectable		 5syjB-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 314
VAL A 283
GLY A 289
LEU A 288
 None
 0.78A 5syjB-1e3eA:
0.0		 5syjB-1e3eA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.98A 5syjB-1f4hA:
0.0		 5syjB-1f4hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.76A 5syjB-1ig8A:
1.6		 5syjB-1ig8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 VAL A 220
GLY A 234
LEU A 233
THR A 209
 None
 0.89A 5syjB-1krmA:
0.0		 5syjB-1krmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		4 GLU A 218
VAL A  56
GLY A 105
GLN A 110
 None
SAH  A 401 (-4.3A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.3A)
 0.97A 5syjB-1m6yA:
0.0		 5syjB-1m6yA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.97A 5syjB-1mg1A:
0.0		 5syjB-1mg1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mmf GLYCEROL DEHYDRASE
BETA SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		4 GLU B 174
GLY B 103
GLN B 100
THR B 105
 None
 0.99A 5syjB-1mmfB:
undetectable		 5syjB-1mmfB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A  45
GLY A  42
LEU A 744
THR A 746
 None
FES  A3002 (-4.0A)
FES  A3001 (-4.0A)
None
 0.96A 5syjB-1n5xA:
undetectable		 5syjB-1n5xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozb PROTEIN-EXPORT
PROTEIN SECB

(Haemophilus
influenzae) 		PF02556
(SecB) 		4 VAL A 123
GLY A  48
LEU A  47
THR A  74
 None
 1.00A 5syjB-1ozbA:
0.9		 5syjB-1ozbA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 ARG A 137
GLU A 132
GLY A  12
LEU A  19
 None
 0.93A 5syjB-1q1lA:
undetectable		 5syjB-1q1lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu0 LAMININ ALPHA2 CHAIN

(Mus musculus) 		PF02210
(Laminin_G_2) 		4 VAL A3060
GLY A3073
GLN A3071
LEU A3074
 None
 0.97A 5syjB-1qu0A:
undetectable		 5syjB-1qu0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvz YDR533C PROTEIN

(Saccharomyces
cerevisiae) 		PF01965
(DJ-1_PfpI) 		4 GLU A  30
VAL A  29
GLY A  25
THR A  11
 CSO  A 138 ( 3.1A)
None
None
None
 0.99A 5syjB-1qvzA:
undetectable		 5syjB-1qvzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		4 ARG A 134
GLU A 129
GLY A   7
LEU A  14
 EPS  A5001 (-4.1A)
None
None
None
 0.96A 5syjB-1qxoA:
undetectable		 5syjB-1qxoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLU A 224
VAL A 242
GLY A 228
LEU A 230
 None
 0.65A 5syjB-1s4eA:
undetectable		 5syjB-1s4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmf THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP3)

(Cardiovirus B) 		PF00073
(Rhv) 		4 GLY 3 123
GLN 3 192
LEU 3 196
THR 3 194
 None
 0.90A 5syjB-1tmf3:
undetectable		 5syjB-1tmf3:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  32
GLY A  15
LEU A 108
THR A  17
 None
 0.97A 5syjB-1uqxA:
undetectable		 5syjB-1uqxA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Thermus
thermophilus) 		PF02219
(MTHFR) 		5 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.37A 5syjB-1v93A:
undetectable		 5syjB-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01135
(PCMT) 		4 VAL A  23
GLY A  59
LEU A  56
THR A  54
 None
 0.97A 5syjB-1vbfA:
undetectable		 5syjB-1vbfA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ARG E 422
GLY E 424
GLN E 419
LEU E 423
 HDD  E 760 ( 4.5A)
None
HDD  E 760 (-3.9A)
None
 0.85A 5syjB-1ye9E:
undetectable		 5syjB-1ye9E:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A  39
GLY A 210
LEU A 215
THR A 217
 None
 0.91A 5syjB-2c4nA:
undetectable		 5syjB-2c4nA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		4 GLU A 273
VAL A 275
GLY A 328
LEU A 329
 None
 1.00A 5syjB-2c5aA:
0.5		 5syjB-2c5aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs4 PROTEIN C12ORF2

(Homo sapiens) 		PF00788
(RA) 		4 GLU A  57
VAL A  80
LEU A  60
THR A  48
 None
 0.96A 5syjB-2cs4A:
undetectable		 5syjB-2cs4A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL A 310
GLY A 352
GLN A 389
LEU A 353
 MPD  A2001 (-4.0A)
None
None
None
 0.98A 5syjB-2d4wA:
undetectable		 5syjB-2d4wA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epu ZINC FINGER PROTEIN
32

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 GLY A 118
GLN A 124
LEU A 120
THR A 122
 None
 0.96A 5syjB-2epuA:
undetectable		 5syjB-2epuA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		4 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.88A 5syjB-2g85A:
undetectable		 5syjB-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 ARG A 598
GLU A 591
GLY A 812
LEU A 627
THR A 815
 None
 1.38A 5syjB-2gahA:
undetectable		 5syjB-2gahA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLU A 245
VAL A 278
GLY A 312
LEU A 309
 None
None
None
OHT  A 500 ( 4.0A)
 0.87A 5syjB-2gpvA:
0.9		 5syjB-2gpvA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 GLU A 304
GLY A 246
GLN A 286
THR A 248
 None
 0.91A 5syjB-2h21A:
undetectable		 5syjB-2h21A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		4 ARG X  27
GLU X  29
GLY X   8
THR X 132
 EDO  X 501 (-4.0A)
None
EDO  X 501 (-3.6A)
None
 0.99A 5syjB-2h3gX:
undetectable		 5syjB-2h3gX:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.98A 5syjB-2hg4A:
undetectable		 5syjB-2hg4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.80A 5syjB-2hneA:
undetectable		 5syjB-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.78A 5syjB-2hnhA:
2.1		 5syjB-2hnhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.90A 5syjB-2id5A:
undetectable		 5syjB-2id5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 VAL A 496
GLY A 317
LEU A 316
THR A 315
 None
 0.92A 5syjB-2ifyA:
undetectable		 5syjB-2ifyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2z PAP FIMBRIAL MINOR
PILIN PROTEIN

(Escherichia
coli) 		no annotation 4 ARG B 152
GLU B 100
GLY B 113
LEU B 157
 SO4  B1176 (-3.0A)
None
None
SO4  B1176 (-3.6A)
 0.86A 5syjB-2j2zB:
undetectable		 5syjB-2j2zB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 VAL A 204
GLY A 208
LEU A 209
THR A 211
 None
 1.00A 5syjB-2jfqA:
undetectable		 5syjB-2jfqA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krr NUCLEOLIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLU A 109
GLU A 112
VAL A 113
GLY A 157
 None
 0.91A 5syjB-2krrA:
undetectable		 5syjB-2krrA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP3)

(Cardiovirus A) 		PF00073
(Rhv) 		4 GLY 3 122
GLN 3 191
LEU 3 195
THR 3 193
 None
 0.90A 5syjB-2mev3:
undetectable		 5syjB-2mev3:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
 None
 1.46A 5syjB-2nq5A:
undetectable		 5syjB-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 GLU A 261
VAL A 142
GLY A 245
LEU A 241
 GLU  A 261 ( 0.6A)
VAL  A 142 ( 0.4A)
GLY  A 245 ( 0.0A)
LEU  A 241 ( 0.6A)
 1.00A 5syjB-2ogsA:
undetectable		 5syjB-2ogsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN

(Plasmodium
yoelii) 		PF00268
(Ribonuc_red_sm) 		5 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.41A 5syjB-2p1iA:
undetectable		 5syjB-2p1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A1312
GLY A1595
GLN A1385
LEU A1597
 None
 0.96A 5syjB-2pffA:
undetectable		 5syjB-2pffA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 GLU A 267
VAL A  69
GLY A 153
LEU A 154
 ZN  A 412 (-2.0A)
None
ZN  A 411 ( 4.3A)
None
 0.96A 5syjB-2wknA:
undetectable		 5syjB-2wknA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		5 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.36A 5syjB-2xfsA:
undetectable		 5syjB-2xfsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLU A 509
GLN A 497
LEU A 496
THR A 498
 None
 1.00A 5syjB-2xt6A:
2.1		 5syjB-2xt6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.99A 5syjB-2xwbB:
undetectable		 5syjB-2xwbB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		4 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.85A 5syjB-2yevB:
undetectable		 5syjB-2yevB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 VAL A 623
GLY A 592
LEU A 644
THR A 594
 None
 0.99A 5syjB-3a21A:
undetectable		 5syjB-3a21A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLU A  53
VAL A 151
GLY A 127
LEU A 141
 None
 0.91A 5syjB-3a5wA:
undetectable		 5syjB-3a5wA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS

(Leptospira
interrogans) 		PF00682
(HMGL-like) 		4 GLY A  57
GLN A  63
LEU A  59
THR A  61
 None
 0.87A 5syjB-3bleA:
undetectable		 5syjB-3bleA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bru REGULATORY PROTEIN,
TETR FAMILY

(Rhodobacter
sphaeroides) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.82A 5syjB-3bruA:
1.5		 5syjB-3bruA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		4 VAL A 101
GLY A  67
GLN A 253
LEU A 250
 None
 0.93A 5syjB-3c3kA:
undetectable		 5syjB-3c3kA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		4 ARG A 250
VAL A 256
GLY A 301
GLN A 308
 None
 0.80A 5syjB-3dc8A:
undetectable		 5syjB-3dc8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 GLU A  85
VAL A 110
GLY A 116
LEU A 118
 None
None
PO4  A 328 (-4.2A)
None
 0.96A 5syjB-3do5A:
undetectable		 5syjB-3do5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwm 9.5 KDA CULTURE
FILTRATE ANTIGEN
CFP10A

(Mycobacterium
tuberculosis) 		PF02597
(ThiS) 		4 ARG A  45
GLU A  36
LEU A  11
THR A  15
 None
 1.00A 5syjB-3dwmA:
undetectable		 5syjB-3dwmA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwm 9.5 KDA CULTURE
FILTRATE ANTIGEN
CFP10A

(Mycobacterium
tuberculosis) 		PF02597
(ThiS) 		4 VAL A   5
GLY A  29
LEU A  28
THR A  27
 None
 0.99A 5syjB-3dwmA:
undetectable		 5syjB-3dwmA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 GLU A 436
GLY A 360
GLN A 466
THR A 464
 None
 0.96A 5syjB-3e1sA:
2.5		 5syjB-3e1sA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.83A 5syjB-3fn4A:
undetectable		 5syjB-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 415
VAL A 339
GLY A 410
LEU A 409
 None
 1.00A 5syjB-3g2fA:
undetectable		 5syjB-3g2fA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 277
VAL A 271
GLY A 237
LEU A 186
 GOL  A 362 ( 4.2A)
None
None
None
 0.92A 5syjB-3g5wA:
undetectable		 5syjB-3g5wA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw7 UNCHARACTERIZED
PROTEIN YEDJ

(Escherichia
coli) 		PF01966
(HD) 		4 GLU A 155
VAL A 223
LEU A 179
THR A 176
 None
 0.95A 5syjB-3gw7A:
undetectable		 5syjB-3gw7A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.78A 5syjB-3hnpA:
undetectable		 5syjB-3hnpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.87A 5syjB-3i23A:
undetectable		 5syjB-3i23A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS

(Homo sapiens) 		PF00620
(RhoGAP) 		4 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.96A 5syjB-3iugA:
undetectable		 5syjB-3iugA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 GLU A  39
VAL A 685
GLY A 689
LEU A 690
 None
 0.81A 5syjB-3jbhA:
undetectable		 5syjB-3jbhA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kho B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Mus musculus) 		no annotation 4 VAL B  88
GLN B  96
LEU B 105
THR B  97
 None
 0.98A 5syjB-3khoB:
undetectable		 5syjB-3khoB:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLU A 238
VAL A 340
GLN A 345
LEU A 222
 None
 0.97A 5syjB-3kmuA:
undetectable		 5syjB-3kmuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 VAL A  -1
GLY A-153
LEU A-149
THR A-151
 None
 1.00A 5syjB-3l2jA:
undetectable		 5syjB-3l2jA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6v DNA GYRASE SUBUNIT A

(Xanthomonas
campestris) 		PF03989
(DNA_gyraseA_C) 		4 ARG A 813
GLY A 815
GLN A 854
THR A 810
 None
 0.90A 5syjB-3l6vA:
undetectable		 5syjB-3l6vA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLY A 168
GLN A 174
LEU A 170
THR A 172
 None
 0.83A 5syjB-3lmdA:
undetectable		 5syjB-3lmdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		4 VAL E  61
GLY E 165
LEU E 169
THR E 167
 None
 1.00A 5syjB-3lvrE:
undetectable		 5syjB-3lvrE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 VAL A 101
GLY A  88
LEU A 111
THR A  86
 None
 0.95A 5syjB-3m19A:
undetectable		 5syjB-3m19A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		4 VAL C 246
GLY C 135
LEU C 233
THR C 231
 None
 1.00A 5syjB-3napC:
undetectable		 5syjB-3napC:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		5 GLU A  38
VAL A  77
GLY A 265
LEU A 266
THR A 268
 None
 1.28A 5syjB-3ndnA:
undetectable		 5syjB-3ndnA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		5 ARG A  68
VAL A  64
GLY A  60
GLN A 186
LEU A 142
 None
 1.40A 5syjB-3oqqA:
undetectable		 5syjB-3oqqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		4 GLU A 254
GLY A 249
LEU A 248
THR A 201
 None
 0.95A 5syjB-3r7tA:
undetectable		 5syjB-3r7tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 GLU A 151
VAL A 222
GLY A 144
THR A 232
 None
 0.93A 5syjB-3r9sA:
undetectable		 5syjB-3r9sA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ARG X 351
GLU X 354
GLY X 315
THR X 318
 None
 1.00A 5syjB-3ss7X:
0.0		 5syjB-3ss7X:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		4 VAL A 276
GLY A 204
LEU A 205
THR A 244
 None
 0.95A 5syjB-3u7bA:
undetectable		 5syjB-3u7bA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 VAL A 127
GLY A  17
LEU A  21
THR A  19
 None
 0.98A 5syjB-3wbkA:
undetectable		 5syjB-3wbkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.92A 5syjB-4bl3A:
undetectable		 5syjB-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.92A 5syjB-4blaA:
undetectable		 5syjB-4blaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0n 2-ON-2 HEMOGLOBIN

(Arabidopsis
thaliana) 		PF01152
(Bac_globin) 		4 GLY A  32
GLN A  34
LEU A  33
THR A  35
 None
 0.95A 5syjB-4c0nA:
undetectable		 5syjB-4c0nA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		5 GLU A 272
GLY A 466
GLN A 470
LEU A 469
THR A 468
 None
 1.28A 5syjB-4c3oA:
undetectable		 5syjB-4c3oA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ARG A 119
VAL A 196
GLY A 485
LEU A 616
THR A 618
 None
 0.27A 5syjB-4c51A:
66.2		 5syjB-4c51A:
65.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 ARG A 677
GLU A 679
GLY A 728
LEU A 730
 None
 1.00A 5syjB-4duuA:
undetectable		 5syjB-4duuA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.91A 5syjB-4dxbA:
undetectable		 5syjB-4dxbA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxo LEA X(6) GFP-LIKE
PROTEINS

(synthetic
construct) 		PF01353
(GFP) 		4 VAL A  67
GLY A  29
GLN A  38
THR A  39
 None
None
CR8  A  63 ( 3.7A)
None
 0.98A 5syjB-4dxoA:
undetectable		 5syjB-4dxoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 GLU A 239
GLY A 138
GLN A 152
LEU A 154
 None
 0.98A 5syjB-4dyoA:
undetectable		 5syjB-4dyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev1 ANABENA TIC22

(Anabaena sp.) 		PF04278
(Tic22) 		4 GLY A 221
GLN A 227
LEU A 223
THR A 225
 NHE  A 302 (-3.2A)
None
None
NHE  A 302 (-3.1A)
 0.96A 5syjB-4ev1A:
undetectable		 5syjB-4ev1A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 GLU A 241
GLY A 219
LEU A 329
THR A 322
 None
 1.00A 5syjB-4ex4A:
1.7		 5syjB-4ex4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens) 		PF00025
(Arf) 		4 VAL C  61
GLY C 165
LEU C 169
THR C 167
 None
 0.98A 5syjB-4fmeC:
undetectable		 5syjB-4fmeC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU B 211
VAL B 150
GLY B 206
LEU B 205
 None
 0.99A 5syjB-4fzdB:
undetectable		 5syjB-4fzdB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2

(Homo sapiens) 		PF13181
(TPR_8) 		4 GLU A 173
GLY A 143
LEU A 147
THR A 145
 None
 0.94A 5syjB-4g1tA:
undetectable		 5syjB-4g1tA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.98A 5syjB-4gizA:
undetectable		 5syjB-4gizA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		4 GLU A  24
VAL A 101
LEU A  27
THR A 106
 None
 1.00A 5syjB-4hu8A:
undetectable		 5syjB-4hu8A:
22.28