SIMILAR PATTERNS OF AMINO ACIDS FOR 5SYJ_A_NIZA810

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		6 ARG A  92
TRP A  95
HIS A  96
LEU A 216
PRO A 221
SER A 305
 HEM  A 800 (-4.2A)
HEM  A 800 (-3.5A)
None
None
HEM  A 800 (-4.3A)
HEM  A 800 (-2.7A)
 0.19A 5syjA-1itkA:
61.8		 5syjA-1itkA:
59.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 ARG A  48
LEU A 192
PRO A 110
SER A 107
 None
 1.44A 5syjA-1ixkA:
undetectable		 5syjA-1ixkA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyn CHLOROPLASTIC
ASCORBATE PEROXIDASE

(Nicotiana
tabacum) 		PF00141
(peroxidase) 		4 ARG A  30
TRP A  33
HIS A  34
SER A 168
 HEM  A 296 (-3.9A)
HEM  A 296 (-3.7A)
None
HEM  A 296 (-2.9A)
 1.37A 5syjA-1iynA:
10.2		 5syjA-1iynA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyn CHLOROPLASTIC
ASCORBATE PEROXIDASE

(Nicotiana
tabacum) 		PF00141
(peroxidase) 		4 ARG A  30
TRP A  33
HIS A  34
SER A 173
 HEM  A 296 (-3.9A)
HEM  A 296 (-3.7A)
None
HEM  A 296 (-3.3A)
 0.39A 5syjA-1iynA:
10.2		 5syjA-1iynA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 TRP A  70
HIS A 402
LEU A 369
SER A 515
 None
 1.27A 5syjA-1j3bA:
undetectable		 5syjA-1j3bA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)

(Homo sapiens) 		PF00595
(PDZ) 		4 ARG A  16
HIS A  14
LEU A  90
SER A  46
 None
 1.50A 5syjA-1uepA:
undetectable		 5syjA-1uepA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 ARG A 335
HIS A 218
LEU A 316
PRO A 230
 None
 1.27A 5syjA-2dwcA:
undetectable		 5syjA-2dwcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		4 ARG A 240
HIS A 231
LEU A 189
PRO A 163
 None
 1.26A 5syjA-2eceA:
undetectable		 5syjA-2eceA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 HIS A 623
LEU A 139
PRO A 137
SER A 109
 MGD  A 811 ( 3.6A)
MGD  A 811 ( 4.4A)
CYN  A 813 ( 4.6A)
None
 1.46A 5syjA-2jirA:
undetectable		 5syjA-2jirA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		4 ARG A 291
HIS A 272
LEU A 251
PRO A 254
 None
 1.26A 5syjA-2phlA:
undetectable		 5syjA-2phlA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qul D-TAGATOSE
3-EPIMERASE

(Pseudomonas
cichorii) 		PF01261
(AP_endonuc_2) 		4 ARG A 217
HIS A 188
LEU A 108
PRO A 114
 MN  A 291 ( 4.8A)
None
None
None
 1.46A 5syjA-2qulA:
undetectable		 5syjA-2qulA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 HIS A 778
LEU A 785
PRO A 301
SER A 809
 None
 1.29A 5syjA-2vdaA:
2.1		 5syjA-2vdaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 ARG A 218
HIS A 220
LEU A 158
PRO A  26
 None
 1.48A 5syjA-2wknA:
undetectable		 5syjA-2wknA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj6 ASCORBATE PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 ARG A  38
TRP A  41
HIS A  42
SER A 173
 HEM  A1001 ( 4.2A)
HEM  A1001 (-3.5A)
None
HEM  A1001 (-2.7A)
 0.36A 5syjA-2xj6A:
11.4		 5syjA-2xj6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		4 HIS A  41
LEU A 198
PRO A 177
SER A 201
 None
 1.32A 5syjA-2zghA:
undetectable		 5syjA-2zghA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A 206
LEU A 179
PRO A 170
SER A 217
 None
 1.46A 5syjA-2zyjA:
undetectable		 5syjA-2zyjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ARG A 109
HIS A 195
PRO A 250
SER A 245
 OXQ  A 708 (-4.0A)
OXQ  A 708 ( 3.7A)
NAD  A 401 ( 4.5A)
OXQ  A 708 (-3.0A)
 1.48A 5syjA-3czmA:
undetectable		 5syjA-3czmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 ARG A 641
HIS A 462
LEU A 467
PRO A 654
 None
 1.46A 5syjA-3d3lA:
undetectable		 5syjA-3d3lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		4 ARG A  41
TRP A  44
HIS A  45
SER A 178
 HEM  A 296 (-4.2A)
HEM  A 296 (-3.5A)
None
HEM  A 296 (-2.6A)
 0.38A 5syjA-3e2nA:
31.7		 5syjA-3e2nA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo8 BLUB-LIKE
FLAVOPROTEIN

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		4 ARG A  10
LEU A 202
PRO A 198
SER A 159
 FMN  A 500 (-2.7A)
None
None
None
 1.44A 5syjA-3eo8A:
undetectable		 5syjA-3eo8A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 ARG A 190
LEU A 197
PRO A 184
SER A 223
 None
 1.25A 5syjA-3g77A:
undetectable		 5syjA-3g77A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TRP A 160
HIS A 311
LEU A 110
SER A  60
 None
 1.35A 5syjA-3gm8A:
undetectable		 5syjA-3gm8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gov MASP-1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 HIS A 375
LEU B 564
PRO B 562
SER B 483
 None
 1.36A 5syjA-3govA:
undetectable		 5syjA-3govA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		4 TRP A  95
LEU A 244
PRO A  51
SER A  72
 None
 1.35A 5syjA-3gseA:
undetectable		 5syjA-3gseA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 ARG A 340
LEU A 304
PRO A 264
SER A 293
 None
 1.47A 5syjA-3itaA:
undetectable		 5syjA-3itaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 ARG A 447
LEU A 450
PRO A  70
SER A 459
 None
None
None
GOL  A 490 ( 3.9A)
 1.46A 5syjA-3n6xA:
undetectable		 5syjA-3n6xA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbk PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		4 ARG A  90
LEU A 144
PRO A  12
SER A 128
 None
 1.48A 5syjA-3nbkA:
undetectable		 5syjA-3nbkA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3son HYPOTHETICAL NUDIX
HYDROLASE

(Listeria
monocytogenes) 		PF00293
(NUDIX) 		4 HIS A 109
LEU A 112
PRO A  11
SER A  53
 None
 1.12A 5syjA-3sonA:
undetectable		 5syjA-3sonA:
10.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 ARG A 137
HIS A 141
LEU A 271
PRO A 276
SER A 359
 HEM  A1500 ( 4.3A)
TOX  A 140 ( 3.9A)
None
HEM  A1500 (-4.4A)
HEM  A1500 (-2.6A)
 0.20A 5syjA-3ut2A:
66.0		 5syjA-3ut2A:
58.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		6 ARG A  91
TRP A  94
HIS A  95
LEU A 220
PRO A 225
SER A 308
 HEM  A 801 ( 4.6A)
HEM  A 801 (-3.5A)
None
None
HEM  A 801 ( 4.2A)
HEM  A 801 ( 2.6A)
 0.25A 5syjA-3wxoA:
63.3		 5syjA-3wxoA:
61.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 ARG A 537
HIS A 533
LEU A 323
PRO A 287
 None
 1.31A 5syjA-4akvA:
undetectable		 5syjA-4akvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		4 ARG A 331
LEU A  35
PRO A  22
SER A  26
 None
 1.27A 5syjA-4bn2A:
undetectable		 5syjA-4bn2A:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		6 ARG A 104
TRP A 107
HIS A 108
LEU A 227
PRO A 232
SER A 315
 HEM  A1741 (-4.0A)
HEM  A1741 (-3.6A)
None
None
HEM  A1741 ( 4.3A)
HEM  A1741 (-2.9A)
 0.32A 5syjA-4c51A:
66.5		 5syjA-4c51A:
65.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 ARG A 398
HIS A 389
LEU A 357
PRO A  52
 None
None
VNT  A 502 ( 4.9A)
None
 1.20A 5syjA-4g3jA:
undetectable		 5syjA-4g3jA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		4 ARG A  64
TRP A  67
HIS A  68
SER A 202
 HEM  A 401 ( 4.2A)
HEM  A 401 (-3.4A)
None
HEM  A 401 (-2.6A)
 0.42A 5syjA-4gedA:
31.2		 5syjA-4gedA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DM BETA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 HIS B 141
LEU D 180
PRO D 183
SER D 185
 None
 1.46A 5syjA-4i0pB:
undetectable		 5syjA-4i0pB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 HIS A 375
LEU A 564
PRO A 562
SER A 483
 None
 1.30A 5syjA-4igdA:
undetectable		 5syjA-4igdA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 ARG A 430
LEU A 381
PRO A 152
SER A 328
 None
 1.47A 5syjA-4k70A:
undetectable		 5syjA-4k70A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 ARG A 574
HIS A 619
LEU A 436
SER A 478
 GOL  A 822 ( 4.5A)
GOL  A 822 (-3.8A)
GOL  A 822 (-4.4A)
None
 1.32A 5syjA-4lgnA:
undetectable		 5syjA-4lgnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A 291
HIS A 295
LEU A 368
SER A 208
 None
None
LLP  A 205 ( 4.2A)
LLP  A 205 ( 4.6A)
 1.17A 5syjA-4oc9A:
undetectable		 5syjA-4oc9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psu ALPHA/BETA HYDROLASE

(Rhodopseudomonas
palustris) 		PF12697
(Abhydrolase_6) 		4 ARG A  34
HIS A  68
LEU A  44
PRO A  72
 None
 1.39A 5syjA-4psuA:
undetectable		 5syjA-4psuA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3

(Homo sapiens) 		PF10421
(OAS1_C) 		4 TRP A 141
LEU A  69
PRO A  21
SER A  63
 None
 1.13A 5syjA-4s3nA:
undetectable		 5syjA-4s3nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 ARG B 405
HIS B 245
LEU B 262
PRO B 260
 None
 1.27A 5syjA-4tx2B:
undetectable		 5syjA-4tx2B:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk8 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT III,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF02507
(PSI_PsaF) 		4 ARG F 154
HIS F 155
LEU F  81
PRO F  83
 None
 1.46A 5syjA-4xk8F:
2.3		 5syjA-4xk8F:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 HIS A 291
LEU A 300
PRO A 288
SER A 346
 None
 1.10A 5syjA-5dfaA:
undetectable		 5syjA-5dfaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		4 ARG A 251
HIS A 252
LEU A 213
SER A 210
 None
 1.24A 5syjA-5dgoA:
2.7		 5syjA-5dgoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 HIS A 282
LEU A 290
PRO A 279
SER A 337
 None
 1.12A 5syjA-5e9aA:
undetectable		 5syjA-5e9aA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA

(Lactococcus
lactis) 		PF00078
(RVT_1)
PF01348
(Intron_maturas2) 		4 ARG C 378
LEU C 452
PRO C 389
SER C 447
 A  B   2 ( 3.5A)
None
None
None
 1.10A 5syjA-5g2xC:
undetectable		 5syjA-5g2xC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsz KINESIN-LIKE PROTEIN
KIF19

(Mus musculus) 		PF00225
(Kinesin) 		4 HIS A  35
LEU A  44
PRO A  47
SER A 327
 None
 1.27A 5syjA-5gszA:
undetectable		 5syjA-5gszA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 TRP A  14
HIS A 232
LEU A  20
SER A 357
 None
 1.46A 5syjA-5kbpA:
undetectable		 5syjA-5kbpA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 ARG A 108
HIS A 112
LEU A 236
PRO A 241
SER A 324
 OXY  A 804 (-4.1A)
OXY  A 804 (-3.9A)
None
HEM  A 801 ( 4.3A)
HEM  A 801 (-2.6A)
 0.11A 5syjA-5kqiA:
72.2		 5syjA-5kqiA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		4 HIS A 264
LEU A  55
PRO A  79
SER A  49
 None
 1.15A 5syjA-5m8hA:
undetectable		 5syjA-5m8hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		4 ARG A 302
LEU A 295
PRO A 320
SER A 322
 None
 1.43A 5syjA-5mgvA:
undetectable		 5syjA-5mgvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Homo sapiens) 		PF04084
(ORC2) 		4 ARG E 320
HIS E 393
LEU E 313
SER E 452
 None
 1.46A 5syjA-5uj8E:
undetectable		 5syjA-5uj8E:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 ARG A  87
HIS A  91
LEU A 236
PRO A 241
SER A 324
 HEM  A 800 (-4.7A)
TOX  A  90 ( 3.8A)
None
HEM  A 800 ( 4.2A)
HEM  A 800 (-2.9A)
 0.34A 5syjA-5whsA:
67.2		 5syjA-5whsA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A 265
HIS A 269
LEU A 341
SER A 214
 None
None
LLP  A 211 ( 4.6A)
LLP  A 211 ( 4.7A)
 1.09A 5syjA-5x2vA:
undetectable		 5syjA-5x2vA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 253
HIS A 311
LEU A 367
SER A 307
 None
 1.11A 5syjA-5ykdA:
undetectable		 5syjA-5ykdA:
8.10