SIMILAR PATTERNS OF AMINO ACIDS FOR 5SYJ_A_NIZA809_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		4 GLU A  28
GLY A 210
GLN A 183
THR A 182
 FAD  A 395 ( 4.3A)
None
FAD  A 395 ( 4.4A)
None
 1.04A 5syjA-1b5tA:
0.0		 5syjA-1b5tA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 VAL P 305
GLY P   8
GLN P 108
THR P  86
 None
NAP  P 340 (-3.2A)
None
NAP  P 340 (-4.6A)
 1.03A 5syjA-1cf2P:
0.0		 5syjA-1cf2P:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 1.00A 5syjA-1dl5A:
undetectable		 5syjA-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.96A 5syjA-1f4hA:
undetectable		 5syjA-1f4hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 VAL A 104
GLY A  45
GLN A 141
LEU A  46
 None
 0.99A 5syjA-1f5nA:
3.2		 5syjA-1f5nA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		4 VAL A 144
GLY A 252
GLN A 140
LEU A 248
 None
None
BME  A1462 (-3.9A)
None
 1.10A 5syjA-1gegA:
undetectable		 5syjA-1gegA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.65A 5syjA-1ig8A:
1.3		 5syjA-1ig8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ARG A 186
VAL A 221
GLY A 188
LEU A 190
 None
 1.06A 5syjA-1pojA:
0.0		 5syjA-1pojA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 GLU L 106
VAL L  36
GLY L  19
LEU L  21
 None
U10  M 303 (-3.9A)
None
None
 1.03A 5syjA-1pssL:
0.7		 5syjA-1pssL:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py9 MYELIN-OLIGODENDROCY
TE GLYCOPROTEIN

(Mus musculus) 		PF07686
(V-set) 		4 GLU A  19
VAL A  88
LEU A  22
THR A  82
 None
 1.00A 5syjA-1py9A:
undetectable		 5syjA-1py9A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 4

(Chlamydomonas
reinhardtii) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 VAL B 126
GLY D 107
LEU D 108
THR D 110
 CLA  D 910 ( 4.3A)
None
CLA  D 910 ( 4.9A)
None
 1.10A 5syjA-1q90B:
undetectable		 5syjA-1q90B:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		4 GLU A 159
VAL A 160
GLY A 229
LEU A 287
 None
 1.07A 5syjA-1smqA:
undetectable		 5syjA-1smqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  32
GLY A  15
LEU A 108
THR A  17
 None
 1.00A 5syjA-1uqxA:
undetectable		 5syjA-1uqxA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 0.99A 5syjA-2af5A:
undetectable		 5syjA-2af5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 268
GLY B 216
LEU B 393
THR B 214
 None
 1.10A 5syjA-2amcB:
undetectable		 5syjA-2amcB:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
RIBOSOME BIOGENESIS
PROTEIN NOP10

(Methanocaldococcus
jannaschii) 		PF01472
(PUA)
PF01509
(TruB_N)
PF04135
(Nop10p)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 GLU A 209
VAL A 110
GLY B 413
LEU B 414
 None
 1.08A 5syjA-2apoA:
undetectable		 5syjA-2apoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ARG A 378
GLU A 574
GLU A 575
THR A 386
 None
 1.05A 5syjA-2dfsA:
undetectable		 5syjA-2dfsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkj OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 1.05A 5syjA-2fkjA:
undetectable		 5syjA-2fkjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 VAL A  45
GLY A  32
LEU A  62
THR A  30
 None
 1.08A 5syjA-2g39A:
undetectable		 5syjA-2g39A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		4 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.88A 5syjA-2g85A:
undetectable		 5syjA-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.97A 5syjA-2hg4A:
undetectable		 5syjA-2hg4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.85A 5syjA-2hneA:
undetectable		 5syjA-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.78A 5syjA-2hnhA:
undetectable		 5syjA-2hnhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.95A 5syjA-2id5A:
undetectable		 5syjA-2id5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixb ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Elizabethkingia
meningoseptica) 		PF01408
(GFO_IDH_MocA) 		4 GLU A 223
GLY A 229
GLN A 180
LEU A 309
 None
 1.10A 5syjA-2ixbA:
undetectable		 5syjA-2ixbA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 VAL A 204
GLY A 208
LEU A 209
THR A 211
 None
 1.01A 5syjA-2jfqA:
undetectable		 5syjA-2jfqA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		4 VAL A 126
GLY A 133
LEU A 135
THR A 131
 None
 1.06A 5syjA-2jj4A:
undetectable		 5syjA-2jj4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 GLU A 471
VAL A 436
GLY A 563
LEU A 553
 None
BII  A1687 ( 4.7A)
BII  A1687 ( 3.9A)
BII  A1687 (-4.2A)
 1.01A 5syjA-2jkmA:
undetectable		 5syjA-2jkmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol8 OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 VAL O  32
GLY O  74
LEU O  76
THR O  89
 None
 1.01A 5syjA-2ol8O:
undetectable		 5syjA-2ol8O:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 VAL A 290
GLY A 276
GLN A 282
THR A 280
 None
 1.10A 5syjA-2pqdA:
undetectable		 5syjA-2pqdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.99A 5syjA-2xwbB:
undetectable		 5syjA-2xwbB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8e RAB-PROTEIN 6

(Drosophila
melanogaster) 		PF00071
(Ras) 		4 ARG A  73
GLY A  46
GLN A  71
THR A  44
 None
None
None
MG  A1177 ( 3.1A)
 1.09A 5syjA-2y8eA:
undetectable		 5syjA-2y8eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		4 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.85A 5syjA-2yevB:
undetectable		 5syjA-2yevB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn DTDP-4-KETO-6-DEOXY-
HEXOSE 3,4-ISOMERASE

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		4 GLU B 205
VAL B 208
GLY B  30
LEU B  33
 None
 1.05A 5syjA-2yjnB:
undetectable		 5syjA-2yjnB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		4 VAL A 357
GLY A 366
GLN A 363
LEU A 400
 None
 1.10A 5syjA-2z6gA:
undetectable		 5syjA-2z6gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ARG A  55
GLY A   8
GLN A 138
LEU A 141
 None
None
None
GOL  A 654 (-4.0A)
 0.81A 5syjA-2zwsA:
undetectable		 5syjA-2zwsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		4 GLU A  61
VAL A 126
GLY A  82
LEU A  80
 None
 1.10A 5syjA-2zy2A:
1.9		 5syjA-2zy2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bru REGULATORY PROTEIN,
TETR FAMILY

(Rhodobacter
sphaeroides) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.87A 5syjA-3bruA:
undetectable		 5syjA-3bruA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 GLU A 436
GLY A 360
GLN A 466
THR A 464
 None
 0.99A 5syjA-3e1sA:
undetectable		 5syjA-3e1sA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.93A 5syjA-3fn4A:
undetectable		 5syjA-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw7 UNCHARACTERIZED
PROTEIN YEDJ

(Escherichia
coli) 		PF01966
(HD) 		4 GLU A 155
VAL A 223
LEU A 179
THR A 176
 None
 0.96A 5syjA-3gw7A:
undetectable		 5syjA-3gw7A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY A 136
GLN A 141
LEU A 137
THR A 139
 None
 1.11A 5syjA-3hsyA:
undetectable		 5syjA-3hsyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		4 GLU 4 282
VAL 4 264
GLY 4 236
LEU 4 239
 None
 1.08A 5syjA-3i9v4:
undetectable		 5syjA-3i9v4:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS

(Homo sapiens) 		PF00620
(RhoGAP) 		4 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.95A 5syjA-3iugA:
undetectable		 5syjA-3iugA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLY A 168
GLN A 174
LEU A 170
THR A 172
 None
 0.84A 5syjA-3lmdA:
undetectable		 5syjA-3lmdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		4 VAL E  61
GLY E 165
LEU E 169
THR E 167
 None
 1.02A 5syjA-3lvrE:
undetectable		 5syjA-3lvrE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		4 VAL C 246
GLY C 135
LEU C 233
THR C 231
 None
 1.00A 5syjA-3napC:
undetectable		 5syjA-3napC:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE
LY86 PROTEIN

(Bos taurus) 		PF00560
(LRR_1)
PF02221
(E1_DerP2_DerF2)
PF13855
(LRR_8) 		4 ARG C  72
GLU C  73
GLY C 114
THR A  85
 None
 1.05A 5syjA-3rg1C:
undetectable		 5syjA-3rg1C:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLU A 357
GLY A  37
LEU A  36
THR A  34
 None
 1.08A 5syjA-3vpxA:
undetectable		 5syjA-3vpxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo5 AP-4-A PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01230
(HIT) 		4 GLU A 104
GLU A 102
VAL A 100
LEU A 138
 None
 1.04A 5syjA-3wo5A:
undetectable		 5syjA-3wo5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 312
VAL A 339
GLY A 271
LEU A 267
 None
None
EDO  A1528 (-3.3A)
EDO  A1528 ( 4.8A)
 1.05A 5syjA-4akoA:
undetectable		 5syjA-4akoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bem F1FO ATPASE C1
SUBUNIT
F1FO ATPASE C2
SUBUNIT

(Acetobacterium
woodii) 		PF00137
(ATP-synt_C) 		4 VAL J  77
GLY A  26
GLN J 162
THR J 164
 HTG  J1186 (-4.7A)
None
HTG  J1186 (-4.4A)
NA  A 201 ( 4.2A)
 1.02A 5syjA-4bemJ:
undetectable		 5syjA-4bemJ:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.88A 5syjA-4bl3A:
undetectable		 5syjA-4bl3A:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ARG A 119
VAL A 196
GLY A 485
LEU A 616
THR A 618
 None
 0.25A 5syjA-4c51A:
66.5		 5syjA-4c51A:
65.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.88A 5syjA-4dxbA:
undetectable		 5syjA-4dxbA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		4 ARG A  31
GLY B 125
GLN B 127
THR B 129
 None
 1.08A 5syjA-4esaA:
undetectable		 5syjA-4esaA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens) 		PF00025
(Arf) 		4 VAL C  61
GLY C 165
LEU C 169
THR C 167
 None
 0.99A 5syjA-4fmeC:
undetectable		 5syjA-4fmeC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN

(gamma
proteobacterium
'Hot 75m4') 		PF01036
(Bac_rhodopsin) 		4 GLU A 108
VAL A 107
GLY A  66
THR A  69
 None
 0.88A 5syjA-4klyA:
undetectable		 5syjA-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		4 GLU A 122
VAL A 118
GLY A  70
LEU A  74
 None
 0.72A 5syjA-4ldsA:
0.9		 5syjA-4ldsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth) 		4 VAL A 160
GLY A 128
LEU A 102
THR A 126
 None
 0.87A 5syjA-4lhbA:
undetectable		 5syjA-4lhbA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Homo sapiens) 		no annotation 4 GLU A 956
GLY A 996
LEU A 997
THR A 990
 None
 1.10A 5syjA-4ljpA:
undetectable		 5syjA-4ljpA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		4 GLU A  97
VAL A  74
GLY A 195
THR A 158
 MN  A 402 ( 2.8A)
None
None
None
 0.90A 5syjA-4n83A:
undetectable		 5syjA-4n83A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 ARG A  53
GLU A  52
GLY A  48
THR A  25
 None
 0.87A 5syjA-4nruA:
undetectable		 5syjA-4nruA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 4 GLU A  34
GLY A  45
LEU A  47
THR A  49
 None
 1.04A 5syjA-4okmA:
undetectable		 5syjA-4okmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 VAL A -27
GLY A-179
LEU A-175
THR A-177
 None
 1.00A 5syjA-4ozqA:
undetectable		 5syjA-4ozqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 ARG A 136
GLU A 134
GLY A 138
LEU A 140
 None
FE  A 501 (-2.5A)
None
None
 1.00A 5syjA-4p1cA:
undetectable		 5syjA-4p1cA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 GLY A 144
GLN A 140
LEU A 214
THR A 141
 None
 0.88A 5syjA-4p48A:
undetectable		 5syjA-4p48A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps6 INHIBITOR OF
VERTEBRATE LYSOZYME

(Pseudomonas
aeruginosa) 		PF08816
(Ivy) 		4 VAL A  53
GLY A 106
GLN A 108
LEU A  93
 None
 0.93A 5syjA-4ps6A:
undetectable		 5syjA-4ps6A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 GLU A 113
GLY A 341
LEU A 340
THR A 338
 None
 1.08A 5syjA-4pxnA:
undetectable		 5syjA-4pxnA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 GLU A 794
GLU A 792
VAL A  80
GLY A   2
 CA  A1001 (-2.9A)
CA  A1001 (-4.5A)
None
None
 1.04A 5syjA-4q0wA:
undetectable		 5syjA-4q0wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		4 GLU A 194
GLU A 196
VAL A  72
GLY A  91
 None
GOL  A 301 (-2.6A)
None
None
 1.05A 5syjA-4r31A:
undetectable		 5syjA-4r31A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut9 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C10

(Homo sapiens) 		PF07686
(V-set) 		4 ARG L  54
VAL L  58
GLY L  64
THR L  74
 None
 1.08A 5syjA-4ut9L:
undetectable		 5syjA-4ut9L:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
ALPHA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 GLU A  52
GLN A  48
LEU A 145
THR A 112
 None
 1.05A 5syjA-4wvmA:
undetectable		 5syjA-4wvmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN

(Sesbania mosaic
virus;
Staphylococcus
aureus) 		no annotation 4 GLU A  97
VAL A  99
LEU A 108
THR A 106
 None
 1.00A 5syjA-4y5zA:
undetectable		 5syjA-4y5zA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 VAL A  72
GLY A  56
LEU A  54
THR A  16
 None
 1.09A 5syjA-4ykeA:
undetectable		 5syjA-4ykeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 GLU D 145
GLY D 139
GLN D 127
THR D 125
 None
 1.09A 5syjA-5a6bD:
1.4		 5syjA-5a6bD:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0q BETA-GLUCURONIDASE

(Acidobacterium
capsulatum) 		PF03662
(Glyco_hydro_79n) 		4 GLU A 287
GLU A 173
GLY A  78
THR A  81
 IF6  A1476 (-1.9A)
IF6  A1476 (-3.1A)
None
None
 1.04A 5syjA-5g0qA:
undetectable		 5syjA-5g0qA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 VAL A 118
GLY A  36
LEU A  40
THR A  38
 None
GDP  A 501 (-3.4A)
None
GDP  A 501 (-3.8A)
 1.02A 5syjA-5h7kA:
undetectable		 5syjA-5h7kA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 GLY A 438
GLN A 444
LEU A 440
THR A 442
 None
 1.00A 5syjA-5jz8A:
undetectable		 5syjA-5jz8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		4 GLU A  60
GLU A 144
VAL A 140
GLY A  31
 OCD  A 500 (-3.2A)
OCD  A 500 (-3.0A)
None
OCD  A 500 (-3.4A)
 0.97A 5syjA-5k52A:
undetectable		 5syjA-5k52A:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		6 ARG A 123
GLU A 128
GLU A 198
VAL A 200
GLN A 622
LEU A 623
 None
CL  A 803 ( 4.4A)
CL  A 803 (-4.8A)
None
None
None
 0.64A 5syjA-5kqiA:
72.2		 5syjA-5kqiA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		7 ARG A 123
GLU A 128
GLU A 198
VAL A 200
GLY A 493
LEU A 623
THR A 625
 None
CL  A 803 ( 4.4A)
CL  A 803 (-4.8A)
None
None
None
None
 0.17A 5syjA-5kqiA:
72.2		 5syjA-5kqiA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 GLU A 422
VAL A 519
GLY A 583
GLN A 505
 None
 0.93A 5syjA-5l9wA:
undetectable		 5syjA-5l9wA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 634
GLY A 639
LEU A 656
THR A 498
 None
 1.03A 5syjA-5lstA:
undetectable		 5syjA-5lstA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN8

(Saccharomyces
cerevisiae) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		4 VAL U 207
GLY U 227
LEU U 226
THR U 224
 None
 1.07A 5syjA-5mpdU:
undetectable		 5syjA-5mpdU:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 4 GLU A 471
VAL A 260
GLY A 474
THR A 477
 None
 0.93A 5syjA-5n2gA:
undetectable		 5syjA-5n2gA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o84 GLUTATHIONE
S-TRANSFERASE U23

(Arabidopsis
thaliana) 		no annotation 4 ARG A 213
VAL A 170
GLY A 218
LEU A 217
 None
 1.08A 5syjA-5o84A:
undetectable		 5syjA-5o84A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 VAL B  69
GLY B 297
LEU B 299
THR B 301
 None
 0.96A 5syjA-5tpwB:
undetectable		 5syjA-5tpwB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui5 RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD)
PF04963
(Sigma54_CBD) 		4 GLU I 342
VAL I 331
GLY I 287
GLN I 279
 None
 1.06A 5syjA-5ui5I:
undetectable		 5syjA-5ui5I:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 GLU A  26
GLY A 208
GLN A 181
THR A 180
 ACY  A 302 (-2.8A)
None
ACY  A 302 ( 3.9A)
None
 0.99A 5syjA-5umeA:
undetectable		 5syjA-5umeA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		4 GLU A1485
VAL A1473
GLY A1489
LEU A1491
 None
 0.99A 5syjA-5v41A:
undetectable		 5syjA-5v41A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLY A 142
GLN A 147
LEU A 143
THR A 145
 None
 1.07A 5syjA-5weoA:
2.3		 5syjA-5weoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 6 ARG A 102
GLU A 107
VAL A 180
GLY A 493
LEU A 617
THR A 619
 None
 0.51A 5syjA-5whsA:
67.2		 5syjA-5whsA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbc NSP1 PROTEIN

(Porcine
epidemic
diarrhea virus) 		no annotation 4 GLU A  14
VAL A  44
GLY A  54
LEU A  55
 None
 1.06A 5syjA-5xbcA:
undetectable		 5syjA-5xbcA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 VAL A 419
GLY A 277
LEU A 279
THR A 286
 None
 1.01A 5syjA-5xjjA:
undetectable		 5syjA-5xjjA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2v SORB

(Sorangium
cellulosum) 		no annotation 4 VAL A 188
GLY A 260
LEU A 211
THR A 262
 None
 0.84A 5syjA-6b2vA:
undetectable		 5syjA-6b2vA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 VAL A 459
GLY A 563
LEU A 567
THR A 565
 None
 1.03A 5syjA-6bbpA:
2.0		 5syjA-6bbpA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp U4 LIGHT CHAIN

(Mus musculus) 		no annotation 4 ARG B  54
VAL B  58
GLY B  64
THR B  74
 None
 1.06A 5syjA-6bspB:
undetectable		 5syjA-6bspB:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 VAL A 133
GLY A  92
LEU A  93
THR A  73
 None
None
GOL  A 503 ( 4.4A)
None
 1.07A 5syjA-6enoA:
undetectable		 5syjA-6enoA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A  18
GLY A 217
GLN A 189
THR A 188
 FAD  A 701 ( 4.2A)
None
FAD  A 701 (-4.9A)
None
 1.08A 5syjA-6fnuA:
undetectable		 5syjA-6fnuA:
9.06