SIMILAR PATTERNS OF AMINO ACIDS FOR 5SYF_B_TA1B502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 VAL A 348
LEU A 106
ALA A 288
SER A 332
ARG A 311
 None
 1.35A 5syfB-1crkA:
undetectable		 5syfB-1crkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 VAL A 346
ASP A 349
ALA A 266
ARG A 202
LEU A 215
 None
 1.17A 5syfB-1db3A:
7.3		 5syfB-1db3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ASP A 639
LEU A 157
HIS A 202
SER A 241
GLN A 172
 None
 1.42A 5syfB-1dedA:
undetectable		 5syfB-1dedA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ASP A 459
LEU A 657
ASP A  47
SER A 118
ARG A 658
 PGD  A 782 (-3.0A)
None
None
PGD  A 782 (-2.6A)
None
 1.28A 5syfB-1dmsA:
2.2		 5syfB-1dmsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ASP A 459
LEU A 657
ASP A  47
SER A 118
ARG A 658
 MGD  A1001 (-3.0A)
None
None
MGD  A1001 (-2.7A)
None
 1.30A 5syfB-1eu1A:
2.2		 5syfB-1eu1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 VAL A 158
ASP A 341
ALA A 148
PRO A 295
LEU A 296
 None
 1.39A 5syfB-1f0kA:
8.8		 5syfB-1f0kA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		5 ASP A 342
LEU A 326
ALA A 333
SER A 334
ARG A 338
 None
 1.19A 5syfB-1ka0A:
undetectable		 5syfB-1ka0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Thermotoga
maritima) 		PF01259
(SAICAR_synt) 		5 ASP A 185
LEU A  88
ASP A 168
ALA A 148
LEU A  54
 None
 1.43A 5syfB-1kutA:
undetectable		 5syfB-1kutA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL B 138
ASP B 139
ASP B 108
SER B  58
PRO B 142
 None
 1.34A 5syfB-1n60B:
undetectable		 5syfB-1n60B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 VAL A 389
LEU A 204
ASP A 396
ALA A 403
PRO A 376
 None
 1.32A 5syfB-1ocmA:
undetectable		 5syfB-1ocmA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 ASP A 140
LEU A 160
ALA A 156
PRO A 153
LEU A 113
 None
 1.41A 5syfB-1pc3A:
undetectable		 5syfB-1pc3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 383
ASP A 382
ALA A 425
PRO A 464
LEU A 466
 None
 1.35A 5syfB-1pvdA:
undetectable		 5syfB-1pvdA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 VAL A 353
LEU A 110
ALA A 293
SER A 337
ARG A 316
 None
 1.41A 5syfB-1qh4A:
undetectable		 5syfB-1qh4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		5 VAL A  25
ASP A  26
ALA A 139
GLN A 365
PRO A  29
 None
 1.18A 5syfB-1r53A:
undetectable		 5syfB-1r53A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		5 VAL A 156
ASP A 148
HIS A 151
ALA A 143
ARG A 138
 None
 1.33A 5syfB-1t98A:
undetectable		 5syfB-1t98A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE A
CHAIN

(Bacillus
smithii) 		PF02979
(NHase_alpha) 		5 VAL A 177
LEU A  85
SER A 173
PRO A 127
LEU A 130
 None
 1.20A 5syfB-1v29A:
undetectable		 5syfB-1v29A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		5 ASP A   9
ALA A 352
SER A 356
PRO A 401
LEU A 384
 None
BTB  A1301 (-3.5A)
BTB  A1301 (-3.3A)
None
None
 1.32A 5syfB-1vclA:
undetectable		 5syfB-1vclA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 VAL A  15
LEU A 378
ALA A  94
ARG A 129
LEU A 125
 None
 1.35A 5syfB-1wdtA:
undetectable		 5syfB-1wdtA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2) 		5 ASP A 165
ALA A 189
PRO A  88
ARG A  87
LEU A  91
 None
 1.42A 5syfB-1zcmA:
undetectable		 5syfB-1zcmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa1 HEMOGLOBIN BETA-C
CHAIN

(Trematomus
newnesi) 		PF00042
(Globin) 		5 VAL B  75
ASP B  72
ASP B  13
ARG B 117
LEU B 110
 None
 1.29A 5syfB-2aa1B:
undetectable		 5syfB-2aa1B:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvg ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 ASP A  62
HIS A  60
ALA A  59
GLN A 209
LEU A  56
 None
 1.38A 5syfB-2fvgA:
2.7		 5syfB-2fvgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goy ADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01507
(PAPS_reduct) 		5 ASP A  44
ALA A  49
ARG A  78
PRO A 195
LEU A  69
 None
 1.26A 5syfB-2goyA:
2.2		 5syfB-2goyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goy ADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01507
(PAPS_reduct) 		5 ASP A  44
LEU A 213
ALA A  73
PRO A 195
LEU A 196
 None
 1.21A 5syfB-2goyA:
2.2		 5syfB-2goyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		5 LEU A 123
ALA A 170
SER A 166
PRO A  87
LEU A  65
 None
None
None
NAP  A1340 ( 4.3A)
NAP  A1340 (-3.7A)
 1.34A 5syfB-2iodA:
5.7		 5syfB-2iodA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		5 VAL A 159
ASP A 239
LEU A 209
ALA A 179
PRO A 155
 None
 1.19A 5syfB-2jg7A:
2.5		 5syfB-2jg7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l73 NADPH OXIDASE
ORGANIZER 1

(Homo sapiens) 		PF00787
(PX) 		5 VAL A  10
ASP A 125
SER A  99
GLN A  22
LEU A  92
 None
 1.19A 5syfB-2l73A:
undetectable		 5syfB-2l73A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		5 ASP A 155
ALA A 179
PRO A  78
ARG A  77
LEU A  81
 None
None
None
None
CSO  A  82 ( 4.4A)
 1.27A 5syfB-2nqaA:
undetectable		 5syfB-2nqaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqi CALPAIN-1 CATALYTIC
SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		5 ASP A 165
ALA A 189
PRO A  88
ARG A  87
LEU A  91
 None
 1.37A 5syfB-2nqiA:
undetectable		 5syfB-2nqiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		5 LEU A 521
ALA A 628
GLN A 552
ARG A 511
LEU A 621
 None
 1.33A 5syfB-2o8rA:
2.7		 5syfB-2o8rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		5 VAL A  77
LEU A  57
HIS A  95
ALA A  80
PRO A  67
 None
 1.39A 5syfB-2ozkA:
undetectable		 5syfB-2ozkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13343
(SBP_bac_6) 		5 VAL A 325
LEU A 169
ARG A 314
GLN A 313
ARG A 323
 None
 1.42A 5syfB-2qryA:
undetectable		 5syfB-2qryA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 VAL A 310
ASP A 312
ALA A 264
ARG A 308
LEU A 280
 None
 1.40A 5syfB-2wpgA:
undetectable		 5syfB-2wpgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Pseudomonas
aeruginosa) 		PF01063
(Aminotran_4) 		5 ASP A  17
LEU A 139
PRO A 100
ARG A 101
LEU A  58
 None
 1.33A 5syfB-2y4rA:
undetectable		 5syfB-2y4rA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 LEU A  29
ALA A 290
ARG A 277
PRO A  61
LEU A 321
 None
None
FNR  A 669 (-2.8A)
None
None
 1.38A 5syfB-3b05A:
2.7		 5syfB-3b05A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF13714
(PEP_mutase) 		5 VAL A 167
LEU A 217
HIS A 195
ALA A 198
ARG A 173
 None
None
None
None
GOL  A 291 (-4.2A)
 1.33A 5syfB-3b8iA:
3.4		 5syfB-3b8iA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 ASP A 194
LEU A 145
ASP A 157
ARG A 190
LEU A 101
 None
 1.32A 5syfB-3bjbA:
undetectable		 5syfB-3bjbA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		5 LEU B 133
ALA B 156
PRO B  98
ARG B 191
LEU B  97
 None
 1.40A 5syfB-3bn3B:
undetectable		 5syfB-3bn3B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		5 ASP A  85
LEU A 254
ALA A 219
GLN A 187
LEU A 212
 None
 1.35A 5syfB-3clqA:
undetectable		 5syfB-3clqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		5 VAL A 232
ASP A 237
ARG A 275
GLN A 273
ARG A 259
 None
 1.32A 5syfB-3cs3A:
undetectable		 5syfB-3cs3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 VAL A  50
LEU A 201
ASP A  25
ARG A 447
PRO A 105
 None
 1.27A 5syfB-3fahA:
undetectable		 5syfB-3fahA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 100
ASP A 107
ALA A 111
ARG A  72
LEU A  75
 None
 1.41A 5syfB-3h8fA:
undetectable		 5syfB-3h8fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 ASP A 331
LEU A 310
SER A 370
ARG A 333
LEU A 212
 None
None
None
SO4  A 436 (-3.4A)
None
 1.36A 5syfB-3ie1A:
2.8		 5syfB-3ie1A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		5 VAL B 243
LEU A  10
ASP B 269
ARG A  12
GLN A  14
 None
 1.32A 5syfB-3it4B:
undetectable		 5syfB-3it4B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 VAL A 155
ASP A 232
LEU A 206
ALA A 175
PRO A 151
 None
 1.27A 5syfB-3iwjA:
undetectable		 5syfB-3iwjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		5 ASP A 270
ALA A 276
SER A 279
ARG A 303
LEU A 393
 None
 1.43A 5syfB-3jz4A:
undetectable		 5syfB-3jz4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kio RIBONUCLEASE H2
SUBUNIT B
RIBONUCLEASE H2
SUBUNIT C

(Mus musculus) 		PF08615
(RNase_H2_suC)
PF09468
(RNase_H2-Ydr279) 		5 VAL C  44
ASP C  45
ASP C 102
HIS C  30
SER B  78
 None
 1.36A 5syfB-3kioC:
undetectable		 5syfB-3kioC:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkd TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		5 VAL A  61
LEU A 165
ASP A  80
ALA A  44
GLN A 157
 None
 1.39A 5syfB-3kkdA:
undetectable		 5syfB-3kkdA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		5 VAL A 189
LEU A  62
ALA A 132
ARG A  72
LEU A 146
 None
None
PO4  A 290 ( 3.8A)
None
None
 1.23A 5syfB-3ksrA:
5.4		 5syfB-3ksrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis) 		PF09754
(PAC2) 		5 VAL A  33
ASP A  37
LEU A 122
ALA A  17
ARG A  90
 None
 1.41A 5syfB-3mnfA:
3.7		 5syfB-3mnfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 ASP A 119
ALA A 195
PRO A  12
ARG A  11
LEU A  18
 None
None
None
GOL  A 264 (-4.7A)
None
 1.30A 5syfB-3moyA:
undetectable		 5syfB-3moyA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o44 HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		5 VAL A 580
ASP A 579
ASP A 449
HIS A 452
PRO A 140
 None
 1.31A 5syfB-3o44A:
undetectable		 5syfB-3o44A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 VAL A  59
ALA A 125
ARG A 200
PRO A 105
LEU A 205
 None
 1.36A 5syfB-3qk8A:
undetectable		 5syfB-3qk8A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmw THIOESTERASE

(Streptomyces
coelicolor) 		PF00975
(Thioesterase) 		5 ASP A 100
ALA A 125
PRO A 128
ARG A 129
LEU A 103
 None
 1.42A 5syfB-3qmwA:
3.9		 5syfB-3qmwA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		5 VAL A  96
LEU A 160
HIS A 127
PRO A  27
LEU A 196
 None
 1.41A 5syfB-3sg1A:
undetectable		 5syfB-3sg1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ASP A 401
LEU A  61
ALA A 118
PRO A 142
LEU A 410
 None
 1.43A 5syfB-3sm9A:
5.3		 5syfB-3sm9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 VAL A 621
ASP A 620
GLN A 597
ARG A 617
LEU A 599
 None
 1.32A 5syfB-3t6qA:
undetectable		 5syfB-3t6qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ASP A2005
ALA A2038
SER A4164
ARG A2011
LEU A2059
 None
 1.36A 5syfB-3vkgA:
undetectable		 5syfB-3vkgA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		5 ASP A 322
ALA A 316
SER A 314
PRO A  38
LEU A  37
 None
 1.38A 5syfB-3wecA:
undetectable		 5syfB-3wecA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		5 VAL A 327
LEU A 252
ASP A 302
ALA A 385
LEU A 416
 None
 1.28A 5syfB-4agsA:
undetectable		 5syfB-4agsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhk FLORICAULA/LEAFY
HOMOLOG 1

(Physcomitrella
patens) 		PF17538
(C_LFY_FLO) 		5 LEU A 283
ALA A 271
GLN A 299
PRO A 332
ARG A 264
 None
 1.33A 5syfB-4bhkA:
undetectable		 5syfB-4bhkA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 VAL A 580
HIS A 577
ALA A 538
SER A 542
GLN A 437
 None
 1.41A 5syfB-4bsnA:
undetectable		 5syfB-4bsnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 ASP A 511
LEU B  44
ARG B  37
ARG A 519
LEU B  17
 None
 1.37A 5syfB-4cakA:
undetectable		 5syfB-4cakA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE

(Pseudomonas
aeruginosa) 		PF04199
(Cyclase) 		5 VAL A 164
ALA A 170
PRO A  58
ARG A  62
LEU A  66
 None
 1.24A 5syfB-4cobA:
undetectable		 5syfB-4cobA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)

(Pseudomonas
stutzeri) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ASP A 267
LEU A 222
PRO A 209
ARG A 237
LEU A 208
 None
None
NAD  A 401 (-3.7A)
SO3  A 402 ( 2.6A)
NAD  A 401 (-4.5A)
 1.33A 5syfB-4e5kA:
undetectable		 5syfB-4e5kA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		5 VAL A 183
ASP A 184
HIS A 146
ALA A 174
LEU A 170
 GOL  A 402 (-3.8A)
None
None
None
None
 1.32A 5syfB-4eb5A:
undetectable		 5syfB-4eb5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		5 HIS A 206
ALA A 208
SER A 210
PRO A 141
LEU A  91
 ZN  A 401 (-3.4A)
ZN  A 401 ( 4.0A)
None
None
None
 1.18A 5syfB-4h0fA:
undetectable		 5syfB-4h0fA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA

(Homo sapiens;
Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		5 VAL A  50
ASP A  49
LEU A 116
GLN A 103
ARG A 122
 None
 1.37A 5syfB-4hqpA:
undetectable		 5syfB-4hqpA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 ASP A 229
ALA A 364
ARG A 383
PRO A 337
LEU A 265
 CO  A 402 (-2.1A)
None
None
None
None
 1.27A 5syfB-4hxxA:
undetectable		 5syfB-4hxxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 ASP A 176
LEU A 283
ALA A 239
PRO A 173
ARG A 175
 None
ACT  A 501 (-4.5A)
None
None
None
 1.34A 5syfB-4i5uA:
undetectable		 5syfB-4i5uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 VAL A 157
ASP A 234
LEU A 208
ALA A 177
PRO A 153
 None
 1.16A 5syfB-4i8pA:
undetectable		 5syfB-4i8pA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 VAL A 155
ASP A 232
LEU A 206
ALA A 175
PRO A 151
 None
 1.18A 5syfB-4i8qA:
undetectable		 5syfB-4i8qA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 ASP A 229
ALA A 364
ARG A 383
PRO A 337
LEU A 265
 CO  A 402 (-1.9A)
None
None
None
None
 1.28A 5syfB-4iu6A:
undetectable		 5syfB-4iu6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuk NREA PROTEIN

(Staphylococcus
carnosus) 		PF13185
(GAF_2) 		5 LEU A  87
ASP A  82
SER A 135
ARG A  21
LEU A 122
 None
 1.39A 5syfB-4iukA:
undetectable		 5syfB-4iukA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU A 633
ASP A 630
ALA A 666
PRO A 746
LEU A 749
 None
 1.27A 5syfB-4knhA:
undetectable		 5syfB-4knhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		5 LEU A 111
ASP A 106
ALA A 135
PRO A 167
LEU A 166
 None
 1.27A 5syfB-4oe1A:
undetectable		 5syfB-4oe1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		5 ASP A 171
LEU A 219
ASP A 153
ALA A 161
ARG A 167
 None
 1.19A 5syfB-4wgxA:
undetectable		 5syfB-4wgxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 VAL A  68
ASP A  59
ALA A 101
ARG A  69
LEU A  38
 None
 1.41A 5syfB-4yztA:
undetectable		 5syfB-4yztA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 5 VAL A 369
ASP A 258
ARG A 549
PRO A 397
LEU A 582
 None
 1.43A 5syfB-5awpA:
undetectable		 5syfB-5awpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c12 GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF17288
(Terminase_3C) 		5 VAL A 379
LEU A 403
ALA A 227
ARG A 218
ARG A 377
 None
 1.43A 5syfB-5c12A:
undetectable		 5syfB-5c12A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		5 VAL A 618
LEU B  24
ALA B  18
PRO A 613
ARG A 616
 None
 1.20A 5syfB-5c6gA:
undetectable		 5syfB-5c6gA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 VAL A  79
ASP A  33
LEU A 109
PRO A  49
LEU A  51
 None
 1.13A 5syfB-5d8wA:
2.1		 5syfB-5d8wA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		5 VAL A   8
ASP A   7
ALA A  43
ARG A   5
LEU A   3
 None
 1.43A 5syfB-5h67A:
undetectable		 5syfB-5h67A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B

(Homo sapiens) 		PF00646
(F-box) 		5 VAL A1180
ASP A1179
ASP A1224
ARG A1219
LEU A1243
 None
 1.26A 5syfB-5jh5A:
undetectable		 5syfB-5jh5A:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 7 ASP A  26
LEU A 215
ASP A 224
HIS A 227
ALA A 231
PRO A 357
LEU A 360
 None
 0.91A 5syfB-5mjsA:
58.9		 5syfB-5mjsA:
59.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ASP A 411
ALA A 407
SER A 404
ARG A 428
PRO A 122
 None
 1.32A 5syfB-5mkkA:
undetectable		 5syfB-5mkkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1
PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 2

(Mus musculus) 		PF02251
(PA28_alpha)
PF02252
(PA28_beta) 		5 VAL B  16
ASP B  15
LEU B 130
SER A  38
GLN B 136
 None
 1.21A 5syfB-5mx5B:
undetectable		 5syfB-5mx5B:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
LEU B 217
ASP B 226
HIS B 229
ALA B 233
SER B 236
GLN B 281
PRO B 360
LEU B 371
 None
 1.34A 5syfB-5n5nB:
61.1		 5syfB-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 383
HIS A 184
ALA A 453
SER A 451
ARG A 458
 None
 1.35A 5syfB-5nd5A:
2.4		 5syfB-5nd5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB

(Shigella
flexneri) 		PF00006
(ATP-synt_ab) 		5 ASP A 357
HIS A 360
ALA A 364
GLN A 153
LEU A 147
 None
 1.43A 5syfB-5swjA:
undetectable		 5syfB-5swjA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
LEU B 215
ASP B 224
SER B 234
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
None
TA1  B 502 ( 4.9A)
TA1  B 502 (-3.7A)
 0.75A 5syfB-5w3jB:
60.1		 5syfB-5w3jB:
78.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
LEU B 215
SER B 234
PRO B 358
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
TA1  B 502 ( 4.9A)
None
TA1  B 502 (-3.7A)
 0.74A 5syfB-5w3jB:
60.1		 5syfB-5w3jB:
78.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 5 VAL A 417
ASP A 418
LEU A 394
PRO A 346
LEU A 381
 None
MN  A 701 ( 2.5A)
None
None
None
 1.10A 5syfB-5xt3A:
undetectable		 5syfB-5xt3A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL

(Homo sapiens) 		PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 LEU M 452
ASP M 447
ALA M 480
GLN M 677
PRO M 373
 None
 1.41A 5syfB-5xtbM:
undetectable		 5syfB-5xtbM:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae) 		no annotation 5 ASP A 131
LEU A 244
ALA A 197
PRO A 128
ARG A 130
 None
 1.12A 5syfB-5xyhA:
3.2		 5syfB-5xyhA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis) 		no annotation 5 VAL A  28
ASP A  30
ALA A  68
GLN A  93
PRO A  48
 None
 1.30A 5syfB-5y3xA:
undetectable		 5syfB-5y3xA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 5 VAL A  46
LEU A 314
ASP A 313
PRO A  71
LEU A  74
 None
HEM  A 501 (-4.9A)
None
None
None
 1.40A 5syfB-5yhjA:
undetectable		 5syfB-5yhjA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		5 VAL A 602
ALA A 662
SER A 665
ARG A 653
GLN A 708
 None
 1.16A 5syfB-6axeA:
undetectable		 5syfB-6axeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A 174
LEU A  60
ASP A  26
SER A 149
GLN A  63
 None
 1.30A 5syfB-6c4nA:
3.5		 5syfB-6c4nA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 5 VAL A 219
ASP A 337
ARG A 373
PRO A 352
LEU A 355
 None
 1.28A 5syfB-6c66A:
undetectable		 5syfB-6c66A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B  55
ASP B  43
ALA B  69
SER B  70
ARG B  61
 None
 1.25A 5syfB-6emkB:
undetectable		 5syfB-6emkB:
12.04