SIMILAR PATTERNS OF AMINO ACIDS FOR 5SYE_B_TA1B502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE


(Bos taurus)
PF07992
(Pyr_redox_2)
5 VAL A 156
ASP A 159
SER A 328
GLN A  40
GLY A 128
NAP  A 802 (-3.7A)
NAP  A 802 ( 4.3A)
NAP  A 802 (-4.1A)
None
None
1.18A 5syeB-1e1kA:
2.7
5syeB-1e1kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5)
5 VAL A 683
LEU A 622
ALA A 642
PRO A 671
GLY A 661
None
0.83A 5syeB-1n11A:
undetectable
5syeB-1n11A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 GLU A  73
VAL A  72
SER A  68
PRO A  39
GLY A  42
None
1.27A 5syeB-1wy2A:
undetectable
5syeB-1wy2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Sulfurisphaera
tokodaii)
PF00294
(PfkB)
5 GLU A 119
ASP A 120
LEU A 182
ALA A 152
GLY A   8
None
1.09A 5syeB-1wyeA:
5.4
5syeB-1wyeA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Sulfurisphaera
tokodaii)
PF00294
(PfkB)
5 VAL A 121
ASP A 120
LEU A 182
ALA A 152
GLY A   8
None
1.10A 5syeB-1wyeA:
5.4
5syeB-1wyeA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xju LYSOZYME

(Escherichia
virus P1)
PF00959
(Phage_lysozyme)
5 GLU A  36
LEU A 182
ALA A 108
SER A 111
ARG A 171
None
1.26A 5syeB-1xjuA:
undetectable
5syeB-1xjuA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3
RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens;
Mus musculus)
PF00104
(Hormone_recep)
5 ALA E 276
SER E 279
ARG E 330
PRO A 423
GLY E 324
None
1.30A 5syeB-1xlsE:
undetectable
5syeB-1xlsE:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR


(Homo sapiens)
PF00005
(ABC_tran)
PF14396
(CFTR_R)
5 ASP A 565
LEU A 526
ALA A 561
SER A 489
GLY A 509
None
1.25A 5syeB-1xmjA:
undetectable
5syeB-1xmjA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 GLU A 120
VAL A 123
ASP A 122
LEU A  14
GLY A 149
None
1.18A 5syeB-1ys4A:
3.9
5syeB-1ys4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE


(Spinacia
oleracea)
PF01450
(IlvC)
PF07991
(IlvN)
5 LEU I 224
ALA I 204
GLN I 140
ARG I 162
GLY I 134
None
NDP  I 600 (-3.4A)
None
NDP  I 600 (-3.7A)
NDP  I 600 (-4.0A)
1.18A 5syeB-1yveI:
undetectable
5syeB-1yveI:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF01380
(SIS)
5 GLU A  75
VAL A  74
LEU A 131
PRO A  56
GLY A  52
None
1.26A 5syeB-2a3nA:
5.0
5syeB-2a3nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus)
PF01425
(Amidase)
5 GLU A 404
VAL A 403
LEU A 245
ALA A 256
GLY A 177
None
1.26A 5syeB-2dc0A:
undetectable
5syeB-2dc0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlj HYPOTHETICAL PROTEIN

(Pseudomonas
putida)
PF13279
(4HBT_2)
5 GLU A 102
VAL A 103
ALA A 106
SER A  94
PRO A 145
None
1.21A 5syeB-2hljA:
undetectable
5syeB-2hljA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Mycobacterium
tuberculosis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 LEU A  28
ASP A 319
ARG A 144
PRO A 138
GLY A 136
None
1.31A 5syeB-2i3aA:
4.6
5syeB-2i3aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 VAL A 435
ASP A 303
ALA A 464
SER A 468
GLY A 477
None
MGD  A1986 (-2.9A)
None
None
None
1.30A 5syeB-2ivfA:
undetectable
5syeB-2ivfA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt7 PUTATIVE
PEPTIDOGLYCAN BOUND
PROTEIN (LPXTG
MOTIF)


(Listeria
monocytogenes)
PF06458
(MucBP)
5 GLU A  44
VAL A  43
ALA A  83
SER A  66
PRO A  68
None
1.25A 5syeB-2kt7A:
undetectable
5syeB-2kt7A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3e MAJOR AMPULLATE
SPIDROIN 1


(Latrodectus
hesperus)
PF16763
(Spidroin_N)
5 ASP A  84
LEU A  96
ASP A  94
ALA A  78
GLY A 120
None
1.10A 5syeB-2n3eA:
undetectable
5syeB-2n3eA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis)
no annotation 5 GLU A 138
VAL A 137
LEU A  98
ALA A 106
GLY A 123
None
1.24A 5syeB-2nc8A:
undetectable
5syeB-2nc8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus)
PF04960
(Glutaminase)
5 GLU A  83
VAL A  84
LEU A 191
PRO A 113
GLY A 118
None
1.24A 5syeB-2pbyA:
undetectable
5syeB-2pbyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE


(Aneurinibacillus
thermoaerophilus)
PF16363
(GDP_Man_Dehyd)
5 ASP A  60
ASP A  50
ALA A  99
SER A 103
PRO A  63
None
1.28A 5syeB-2pk3A:
5.9
5syeB-2pk3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae)
PF01368
(DHH)
PF02833
(DHHA2)
5 ASP A 147
LEU A 108
ASP A  76
ALA A  46
GLY A 144
None
1.28A 5syeB-2qb6A:
undetectable
5syeB-2qb6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE


(Francisella
tularensis)
no annotation 5 VAL B 130
ASP B 131
LEU B  62
ALA B  25
GLY B   9
None
1.26A 5syeB-2qjtB:
undetectable
5syeB-2qjtB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus)
PF00221
(Lyase_aromatic)
5 GLU A 515
ASP A 519
LEU A 372
GLN A 226
GLY A 524
None
1.24A 5syeB-2qveA:
undetectable
5syeB-2qveA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN


(Thermus
thermophilus)
PF03480
(DctP)
5 GLU A 304
VAL A 303
LEU A 177
ALA A 232
GLN A 247
None
None
None
None
ZN  A 362 ( 2.7A)
1.31A 5syeB-2zzwA:
undetectable
5syeB-2zzwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI


(Pseudomonas
putida)
PF10778
(DehI)
5 GLU A 126
VAL A 133
LEU A  30
ALA A 239
PRO A 236
None
1.12A 5syeB-3bjxA:
undetectable
5syeB-3bjxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR


(Saccharomyces
cerevisiae)
PF00996
(GDI)
5 ASP G 326
LEU G  56
ASP G  83
ALA G 362
GLY G 358
None
1.19A 5syeB-3cpiG:
undetectable
5syeB-3cpiG:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Bacteroides
thetaiotaomicron)
PF13460
(NAD_binding_10)
5 LEU A 135
ASP A 126
SER A 190
PRO A 162
GLY A 111
None
1.22A 5syeB-3dhnA:
6.1
5syeB-3dhnA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE


(Bacillus cereus)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 GLU A  34
ASP A  35
ASP A  16
ALA A  19
PRO A  62
None
1.27A 5syeB-3dhvA:
undetectable
5syeB-3dhvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus)
PF00291
(PALP)
5 GLU A  26
VAL A 279
LEU A 221
ALA A 163
GLY A 211
None
1.21A 5syeB-3fcaA:
undetectable
5syeB-3fcaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 VAL A 104
ASP A 105
LEU A 185
ALA A 145
GLY A 197
None
1.31A 5syeB-3gvcA:
7.4
5syeB-3gvcA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides)
PF00202
(Aminotran_3)
5 GLU A 225
ASP A 258
LEU A 430
ALA A 272
SER A 273
PLP  A 474 (-3.9A)
PLP  A 474 (-2.8A)
None
None
None
1.13A 5syeB-3i5tA:
4.8
5syeB-3i5tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3


(Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
5 LEU 3 477
HIS 3 468
ALA 3 452
PRO 3 696
GLY 3 768
None
1.05A 5syeB-3i9v3:
undetectable
5syeB-3i9v3:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis)
PF00149
(Metallophos)
5 VAL A 183
LEU A 233
ALA A 180
PRO A 171
GLY A 206
None
1.26A 5syeB-3ib7A:
undetectable
5syeB-3ib7A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens)
PF00400
(WD40)
5 GLU A 238
VAL A 239
LEU A 225
SER A 253
GLY A 231
None
1.04A 5syeB-3iiwA:
undetectable
5syeB-3iiwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kst ENDO-1,4-BETA-XYLANA
SE


(Bacteroides
thetaiotaomicron)
PF04616
(Glyco_hydro_43)
5 GLU A 214
ASP A 154
LEU A  46
ALA A 277
SER A 217
None
1.29A 5syeB-3kstA:
undetectable
5syeB-3kstA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE


(Pseudomonas
aeruginosa)
PF01979
(Amidohydro_1)
5 GLU A 277
ASP A 307
ALA A 282
SER A 284
GLY A 289
None
1.18A 5syeB-3mduA:
2.3
5syeB-3mduA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxl NITROSOSYNTHASE

(Micromonospora
sp. ATCC 39149)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 VAL A  17
ASP A  18
LEU A  99
ALA A  76
GLY A  52
None
1.14A 5syeB-3mxlA:
undetectable
5syeB-3mxlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
5 GLU A 298
VAL A 297
SER A 295
GLN A 217
GLY A 243
GAL  A1024 (-2.7A)
None
None
None
None
1.15A 5syeB-3ogrA:
undetectable
5syeB-3ogrA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis)
PF00378
(ECH_1)
5 GLU A 172
VAL A 173
LEU A 108
ALA A 164
GLY A  97
None
1.06A 5syeB-3pe8A:
undetectable
5syeB-3pe8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyr ECHA16_2

(Mycobacterium
avium)
PF00378
(ECH_1)
5 GLU A 171
VAL A 172
LEU A 107
ALA A 163
GLY A  96
None
1.08A 5syeB-3qyrA:
undetectable
5syeB-3qyrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0o CARNITINYL-COA
DEHYDRATASE


(Mycobacterium
avium)
PF00378
(ECH_1)
5 GLU A 187
VAL A 188
LEU A 123
ALA A 179
GLY A 112
None
1.22A 5syeB-3r0oA:
undetectable
5syeB-3r0oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI


(Mycobacterium
tuberculosis)
PF00425
(Chorismate_bind)
5 VAL A  60
ASP A  44
LEU A  71
ALA A  62
GLY A 108
None
1.27A 5syeB-3rv6A:
undetectable
5syeB-3rv6A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
5 GLU X 233
VAL X 234
ASP X 176
ALA X 300
GLY X  46
FRU  X 801 (-2.8A)
None
FRU  X 801 (-3.0A)
None
None
1.29A 5syeB-3rwkX:
undetectable
5syeB-3rwkX:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV


(Bacillus
anthracis)
PF00227
(Proteasome)
5 GLU A  99
ASP A  59
ALA A   6
SER A 131
GLY A  29
None
1.28A 5syeB-3ty6A:
undetectable
5syeB-3ty6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
5 GLU A 140
ASP A 141
LEU A 203
ALA A 172
GLY A  10
None
1.18A 5syeB-3uboA:
5.2
5syeB-3uboA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans)
PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set)
5 VAL A 310
ASP A 470
ASP A 277
PRO A 329
GLY A 327
None
1.29A 5syeB-3utoA:
undetectable
5syeB-3utoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE


(Bifidobacterium
longum)
PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C)
5 VAL A 632
LEU A 679
ASP A 627
PRO A 545
GLY A 507
None
1.24A 5syeB-3wfzA:
undetectable
5syeB-3wfzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION


(Staphylothermus
marinus)
PF00128
(Alpha-amylase)
5 GLU A 622
VAL A 621
HIS A 162
PRO A 561
GLY A 617
None
1.02A 5syeB-4aeeA:
3.2
5syeB-4aeeA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
5 VAL A  99
LEU A  64
ALA A   9
ARG A   8
GLY A  22
None
1.11A 5syeB-4aioA:
undetectable
5syeB-4aioA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0n 2-ON-2 HEMOGLOBIN

(Arabidopsis
thaliana)
PF01152
(Bac_globin)
5 GLU A 149
VAL A 145
HIS A 105
ALA A 108
GLY A  13
None
None
None
HEM  A1157 ( 3.9A)
None
1.13A 5syeB-4c0nA:
undetectable
5syeB-4c0nA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN


(Carboxydothermus
hydrogenoformans)
PF14574
(DUF4445)
5 GLU I 289
LEU I 122
ASP I 224
ALA I 292
GLY I 184
None
1.23A 5syeB-4c1nI:
undetectable
5syeB-4c1nI:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin)
5 GLU B 500
VAL B 507
SER B 322
GLN B 106
GLY B 349
None
1.15A 5syeB-4cakB:
undetectable
5syeB-4cakB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A


(Cellvibrio
japonicus)
PF02449
(Glyco_hydro_42)
5 GLU A 397
LEU A 495
ALA A 357
PRO A 373
GLY A  62
None
1.00A 5syeB-4d1iA:
undetectable
5syeB-4d1iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE


(Staphylococcus
epidermidis)
PF00288
(GHMP_kinases_N)
5 LEU A 217
HIS A 165
ALA A 164
SER A 132
GLY A 149
None
1.13A 5syeB-4dpyA:
undetectable
5syeB-4dpyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 GLU A  84
VAL A  85
LEU A  53
ALA A 304
GLY A  60
PEG  A 504 (-4.0A)
None
None
None
None
1.26A 5syeB-4dxyA:
undetectable
5syeB-4dxyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE


(Paraburkholderia
xenovorans)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 GLU A  11
LEU A 290
ALA A 344
PRO A 135
GLY A 333
None
1.14A 5syeB-4efiA:
undetectable
5syeB-4efiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL


(Rhodopseudomonas
palustris)
PF13458
(Peripla_BP_6)
5 GLU A 123
VAL A 125
LEU A 202
SER A 144
GLY A  47
None
0.95A 5syeB-4eygA:
5.4
5syeB-4eygA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2


(Mus musculus)
PF00169
(PH)
PF00621
(RhoGEF)
5 GLU A 734
LEU A 977
ASP A 924
HIS A 925
PRO A 676
None
1.29A 5syeB-4gzuA:
undetectable
5syeB-4gzuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
5 GLU M  92
VAL M  91
LEU M 106
ALA M 227
GLY M 324
None
1.17A 5syeB-4heaM:
undetectable
5syeB-4heaM:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
5 GLU A 428
VAL A 427
ASP A 426
ALA A 206
GLY A 104
GOL  A 702 (-3.1A)
None
None
None
None
1.29A 5syeB-4hozA:
2.3
5syeB-4hozA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'


(Hevea
brasiliensis)
PF00332
(Glyco_hydro_17)
5 GLU A 297
VAL A 296
LEU A 196
ALA A 251
GLY A 185
None
1.23A 5syeB-4iisA:
3.9
5syeB-4iisA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1


(Saccharomyces
cerevisiae)
PF00155
(Aminotran_1_2)
5 LEU A 423
ALA A 388
SER A 386
PRO A 384
GLY A 489
None
1.26A 5syeB-4je5A:
2.9
5syeB-4je5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjt ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
5 GLU A 171
VAL A 172
LEU A 107
ALA A 163
GLY A  96
None
1.06A 5syeB-4jjtA:
undetectable
5syeB-4jjtA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)


(Cupriavidus
metallidurans)
PF00873
(ACR_tran)
5 VAL A 993
LEU A 472
ASP A 399
ALA A 919
GLY A 390
None
1.22A 5syeB-4k0eA:
undetectable
5syeB-4k0eA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN


(Archaeoglobus
fulgidus)
PF03787
(RAMPs)
5 GLU A 124
VAL A 125
ASP A 122
LEU A 158
ALA A 129
None
1.29A 5syeB-4l6uA:
undetectable
5syeB-4l6uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN


(Helicobacter
pylori)
PF01497
(Peripla_BP_2)
5 GLU A 150
VAL A 151
ASP A 154
ASP A 209
ALA A 289
None
1.22A 5syeB-4ls3A:
undetectable
5syeB-4ls3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis)
no annotation 5 GLU A 341
ASP A 169
LEU A  47
ALA A 207
GLY A 189
None
1.19A 5syeB-4o7pA:
undetectable
5syeB-4o7pA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN


(Bordetella
bronchiseptica)
PF03480
(DctP)
5 GLU A 212
ASP A 278
HIS A 146
ALA A 145
GLY A 231
RMN  A 401 ( 4.4A)
None
RMN  A 401 (-4.2A)
None
None
1.29A 5syeB-4p56A:
undetectable
5syeB-4p56A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2g SURFACE PROTEIN
GP160


(Human
immunodeficiency
virus 1)
no annotation 5 VAL E 108
ASP E 107
LEU E 453
ASP E 474
GLN E 287
None
1.28A 5syeB-4r2gE:
undetectable
5syeB-4r2gE:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE


(Ignisphaera
aggregans)
PF01450
(IlvC)
PF07991
(IlvN)
5 GLU A 181
VAL A 151
ASP A   9
ALA A 169
PRO A 130
None
1.12A 5syeB-4xehA:
2.7
5syeB-4xehA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Homo sapiens)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
5 VAL A 117
LEU A  40
ASP A  47
GLN A 107
ARG A  91
None
1.08A 5syeB-4xwhA:
undetectable
5syeB-4xwhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
5 VAL A 246
ASP A  74
SER A 123
PRO A 207
GLY A 203
None
1.22A 5syeB-4zudA:
undetectable
5syeB-4zudA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE


(Serratia
marcescens)
PF00753
(Lactamase_B)
5 GLU A 204
VAL A 203
ALA A 173
GLN A 113
GLY A 149
None
None
None
HIW  A 321 (-3.0A)
None
1.14A 5syeB-5b1uA:
undetectable
5syeB-5b1uA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
5 VAL A1967
LEU A1978
ASP A1976
ALA A1929
GLY A1998
None
1.18A 5syeB-5cslA:
undetectable
5syeB-5cslA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
5 GLU A 727
LEU A  31
ASP A  28
ALA A 734
GLN A  72
None
1.28A 5syeB-5d3qA:
undetectable
5syeB-5d3qA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE


(Ignisphaera
aggregans)
PF01450
(IlvC)
PF07991
(IlvN)
5 GLU A 181
VAL A 151
ASP A   9
ALA A 169
PRO A 130
None
1.20A 5syeB-5e4rA:
3.0
5syeB-5e4rA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus)
no annotation 5 GLU B 194
ASP B 200
LEU B 124
ALA B 203
GLY B 177
None
1.13A 5syeB-5hdfB:
3.1
5syeB-5hdfB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus)
PF00291
(PALP)
5 GLU A  33
VAL A 301
LEU A 243
ALA A 180
GLY A 233
None
None
None
None
LLP  A  42 ( 4.0A)
1.17A 5syeB-5jjcA:
undetectable
5syeB-5jjcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Burkholderia
multivorans)
PF00171
(Aldedh)
5 GLU A 427
VAL A 428
ASP A 402
ALA A 409
GLY A 251
None
None
None
None
NDP  A 500 (-3.0A)
1.22A 5syeB-5jryA:
undetectable
5syeB-5jryA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE


(Porphyromonas
endodontalis)
PF10459
(Peptidase_S46)
5 LEU A 666
ALA A 202
SER A 108
ARG A 708
GLY A  78
None
1.04A 5syeB-5jxkA:
undetectable
5syeB-5jxkA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe)
no annotation 5 ASP A  26
LEU A 215
ASP A 224
HIS A 227
ARG A 317
None
1.31A 5syeB-5mjsA:
58.2
5syeB-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe)
no annotation 5 LEU A 215
ASP A 224
HIS A 227
ARG A 317
PRO A 357
None
0.89A 5syeB-5mjsA:
58.2
5syeB-5mjsA:
59.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
5 GLU A 874
VAL A 884
GLN A 803
ARG A 936
GLY A 813
None
1.26A 5syeB-5mqsA:
undetectable
5syeB-5mqsA:
17.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 11 GLU B  22
VAL B  23
ASP B  26
LEU B 217
ASP B 226
HIS B 229
ALA B 233
SER B 236
ARG B 320
PRO B 360
GLY B 370
None
0.71A 5syeB-5n5nB:
60.1
5syeB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 6 GLU B  22
VAL B  23
ASP B  26
LEU B 275
HIS B 229
GLY B 370
None
1.23A 5syeB-5n5nB:
60.1
5syeB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 10 GLU B  22
VAL B  23
LEU B 217
HIS B 229
ALA B 233
SER B 236
GLN B 281
ARG B 320
PRO B 360
GLY B 370
None
0.97A 5syeB-5n5nB:
60.1
5syeB-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx4 PENTALENENE SYNTHASE

(Streptomyces
clavuligerus)
no annotation 5 GLU A 281
VAL A 280
LEU A 292
ALA A 197
GLY A 270
None
1.27A 5syeB-5nx4A:
undetectable
5syeB-5nx4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE


(Apis mellifera)
no annotation 5 GLU A 262
VAL A 261
ALA A 310
SER A 289
GLY A 243
None
1.13A 5syeB-5ohxA:
undetectable
5syeB-5ohxA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 VAL A 615
ASP A 582
LEU A 769
ARG A 357
GLY A 791
None
1.24A 5syeB-5t98A:
undetectable
5syeB-5t98A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster)
PF00135
(COesterase)
5 VAL A 282
LEU A 249
ASP A 149
ALA A 227
GLY A 143
None
MLY  A 250 ( 3.7A)
None
None
None
1.19A 5syeB-5thmA:
2.8
5syeB-5thmA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
7 GLU B  22
VAL B  23
ASP B 224
GLN B 279
ARG B 318
PRO B 358
GLY B 360
TA1  B 502 ( 4.2A)
TA1  B 502 (-3.9A)
None
TA1  B 502 ( 4.3A)
None
None
TA1  B 502 (-3.6A)
1.06A 5syeB-5w3jB:
59.3
5syeB-5w3jB:
78.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
7 GLU B  22
VAL B  23
LEU B 215
ASP B 224
ARG B 318
PRO B 358
GLY B 360
TA1  B 502 ( 4.2A)
TA1  B 502 (-3.9A)
None
None
None
None
TA1  B 502 (-3.6A)
0.85A 5syeB-5w3jB:
59.3
5syeB-5w3jB:
78.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
7 GLU B  22
VAL B  23
LEU B 215
SER B 234
ARG B 318
PRO B 358
GLY B 360
TA1  B 502 ( 4.2A)
TA1  B 502 (-3.9A)
None
TA1  B 502 ( 4.9A)
None
None
TA1  B 502 (-3.6A)
0.84A 5syeB-5w3jB:
59.3
5syeB-5w3jB:
78.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 VAL B  23
ASP B  26
LEU B 215
SER B 234
ARG B 318
TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
TA1  B 502 ( 4.9A)
None
0.98A 5syeB-5w3jB:
59.3
5syeB-5w3jB:
78.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE


(Streptomyces
gandocaensis)
no annotation 5 GLU A  76
LEU A 187
ASP A 107
ALA A  81
PRO A 194
None
1.25A 5syeB-5wm4A:
undetectable
5syeB-5wm4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS


(Helicobacter
pylori)
no annotation 5 GLU A 266
ASP A 262
ASP A 273
GLN A 183
GLY A 186
None
None
None
C6P  A 502 (-3.8A)
None
1.31A 5syeB-5wt4A:
undetectable
5syeB-5wt4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE


(Hydra vulgaris)
no annotation 5 ASP A 123
ASP A  73
ALA A  98
SER A 101
ARG A 178
None
1.22A 5syeB-5xomA:
undetectable
5syeB-5xomA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))


(Sulfolobus
acidocaldarius)
no annotation 5 GLU A 181
VAL A 151
ASP A   9
ALA A 169
PRO A 130
None
1.27A 5syeB-5yeqA:
undetectable
5syeB-5yeqA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE


(Carboxydothermus
hydrogenoformans)
no annotation 5 VAL X 526
ASP X 527
ASP X  98
HIS X  95
GLY X 297
None
1.23A 5syeB-6elqX:
2.3
5syeB-6elqX:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3


(Homo sapiens)
no annotation 5 GLU A 178
VAL A 175
LEU A 158
ASP A 214
GLY A 127
None
1.25A 5syeB-6en4A:
undetectable
5syeB-6en4A:
11.85