SIMILAR PATTERNS OF AMINO ACIDS FOR 5SYE_B_TA1B502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e1k | ADRENODOXINREDUCTASE (Bos taurus) |
PF07992(Pyr_redox_2) | 5 | VAL A 156ASP A 159SER A 328GLN A 40GLY A 128 | NAP A 802 (-3.7A)NAP A 802 ( 4.3A)NAP A 802 (-4.1A)NoneNone | 1.18A | 5syeB-1e1kA:2.7 | 5syeB-1e1kA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n11 | ANKYRIN (Homo sapiens) |
PF00023(Ank)PF12796(Ank_2)PF13637(Ank_4)PF13857(Ank_5) | 5 | VAL A 683LEU A 622ALA A 642PRO A 671GLY A 661 | None | 0.83A | 5syeB-1n11A:undetectable | 5syeB-1n11A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy2 | XAA-PRO DIPEPTIDASE (Pyrococcushorikoshii) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | GLU A 73VAL A 72SER A 68PRO A 39GLY A 42 | None | 1.27A | 5syeB-1wy2A:undetectable | 5syeB-1wy2A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wye | 2-KETO-3-DEOXYGLUCONATE KINASE (Sulfurisphaeratokodaii) |
PF00294(PfkB) | 5 | GLU A 119ASP A 120LEU A 182ALA A 152GLY A 8 | None | 1.09A | 5syeB-1wyeA:5.4 | 5syeB-1wyeA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wye | 2-KETO-3-DEOXYGLUCONATE KINASE (Sulfurisphaeratokodaii) |
PF00294(PfkB) | 5 | VAL A 121ASP A 120LEU A 182ALA A 152GLY A 8 | None | 1.10A | 5syeB-1wyeA:5.4 | 5syeB-1wyeA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xju | LYSOZYME (Escherichiavirus P1) |
PF00959(Phage_lysozyme) | 5 | GLU A 36LEU A 182ALA A 108SER A 111ARG A 171 | None | 1.26A | 5syeB-1xjuA:undetectable | 5syeB-1xjuA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xls | ORPHAN NUCLEARRECEPTOR NR1I3RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens;Mus musculus) |
PF00104(Hormone_recep) | 5 | ALA E 276SER E 279ARG E 330PRO A 423GLY E 324 | None | 1.30A | 5syeB-1xlsE:undetectable | 5syeB-1xlsE:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xmj | CYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (Homo sapiens) |
PF00005(ABC_tran)PF14396(CFTR_R) | 5 | ASP A 565LEU A 526ALA A 561SER A 489GLY A 509 | None | 1.25A | 5syeB-1xmjA:undetectable | 5syeB-1xmjA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys4 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Methanocaldococcusjannaschii) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | GLU A 120VAL A 123ASP A 122LEU A 14GLY A 149 | None | 1.18A | 5syeB-1ys4A:3.9 | 5syeB-1ys4A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yve | ACETOHYDROXY ACIDISOMEROREDUCTASE (Spinaciaoleracea) |
PF01450(IlvC)PF07991(IlvN) | 5 | LEU I 224ALA I 204GLN I 140ARG I 162GLY I 134 | NoneNDP I 600 (-3.4A)NoneNDP I 600 (-3.7A)NDP I 600 (-4.0A) | 1.18A | 5syeB-1yveI:undetectable | 5syeB-1yveI:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3n | PUTATIVEGLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Salmonellaenterica) |
PF01380(SIS) | 5 | GLU A 75VAL A 74LEU A 131PRO A 56GLY A 52 | None | 1.26A | 5syeB-2a3nA:5.0 | 5syeB-2a3nA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dc0 | PROBABLE AMIDASE (Thermusthermophilus) |
PF01425(Amidase) | 5 | GLU A 404VAL A 403LEU A 245ALA A 256GLY A 177 | None | 1.26A | 5syeB-2dc0A:undetectable | 5syeB-2dc0A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hlj | HYPOTHETICAL PROTEIN (Pseudomonasputida) |
PF13279(4HBT_2) | 5 | GLU A 102VAL A 103ALA A 106SER A 94PRO A 145 | None | 1.21A | 5syeB-2hljA:undetectable | 5syeB-2hljA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3a | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Mycobacteriumtuberculosis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 28ASP A 319ARG A 144PRO A 138GLY A 136 | None | 1.31A | 5syeB-2i3aA:4.6 | 5syeB-2i3aA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEALPHA-SUBUNIT (Aromatoleumaromaticum) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | VAL A 435ASP A 303ALA A 464SER A 468GLY A 477 | NoneMGD A1986 (-2.9A)NoneNoneNone | 1.30A | 5syeB-2ivfA:undetectable | 5syeB-2ivfA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kt7 | PUTATIVEPEPTIDOGLYCAN BOUNDPROTEIN (LPXTGMOTIF) (Listeriamonocytogenes) |
PF06458(MucBP) | 5 | GLU A 44VAL A 43ALA A 83SER A 66PRO A 68 | None | 1.25A | 5syeB-2kt7A:undetectable | 5syeB-2kt7A:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n3e | MAJOR AMPULLATESPIDROIN 1 (Latrodectushesperus) |
PF16763(Spidroin_N) | 5 | ASP A 84LEU A 96ASP A 94ALA A 78GLY A 120 | None | 1.10A | 5syeB-2n3eA:undetectable | 5syeB-2n3eA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nc8 | LIPOPROTEIN LPPM (Mycobacteriumtuberculosis) |
no annotation | 5 | GLU A 138VAL A 137LEU A 98ALA A 106GLY A 123 | None | 1.24A | 5syeB-2nc8A:undetectable | 5syeB-2nc8A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pby | GLUTAMINASE (Geobacilluskaustophilus) |
PF04960(Glutaminase) | 5 | GLU A 83VAL A 84LEU A 191PRO A 113GLY A 118 | None | 1.24A | 5syeB-2pbyA:undetectable | 5syeB-2pbyA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pk3 | GDP-6-DEOXY-D-LYXO-4-HEXULOSE REDUCTASE (Aneurinibacillusthermoaerophilus) |
PF16363(GDP_Man_Dehyd) | 5 | ASP A 60ASP A 50ALA A 99SER A 103PRO A 63 | None | 1.28A | 5syeB-2pk3A:5.9 | 5syeB-2pk3A:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qb6 | EXOPOLYPHOSPHATASE (Saccharomycescerevisiae) |
PF01368(DHH)PF02833(DHHA2) | 5 | ASP A 147LEU A 108ASP A 76ALA A 46GLY A 144 | None | 1.28A | 5syeB-2qb6A:undetectable | 5syeB-2qb6A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjt | NICOTINAMIDE-NUCLEOTIDEADENYLYLTRANSFERASE (Francisellatularensis) |
no annotation | 5 | VAL B 130ASP B 131LEU B 62ALA B 25GLY B 9 | None | 1.26A | 5syeB-2qjtB:undetectable | 5syeB-2qjtB:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qve | TYROSINE AMINOMUTASE (Streptomycesglobisporus) |
PF00221(Lyase_aromatic) | 5 | GLU A 515ASP A 519LEU A 372GLN A 226GLY A 524 | None | 1.24A | 5syeB-2qveA:undetectable | 5syeB-2qveA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzw | ABC TRANSPORTER,SOLUTE-BINDINGPROTEIN (Thermusthermophilus) |
PF03480(DctP) | 5 | GLU A 304VAL A 303LEU A 177ALA A 232GLN A 247 | NoneNoneNoneNone ZN A 362 ( 2.7A) | 1.31A | 5syeB-2zzwA:undetectable | 5syeB-2zzwA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjx | HALOCARBOXYLIC ACIDDEHALOGENASE DEHI (Pseudomonasputida) |
PF10778(DehI) | 5 | GLU A 126VAL A 133LEU A 30ALA A 239PRO A 236 | None | 1.12A | 5syeB-3bjxA:undetectable | 5syeB-3bjxA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpi | RAB GDP-DISSOCIATIONINHIBITOR (Saccharomycescerevisiae) |
PF00996(GDI) | 5 | ASP G 326LEU G 56ASP G 83ALA G 362GLY G 358 | None | 1.19A | 5syeB-3cpiG:undetectable | 5syeB-3cpiG:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dhn | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Bacteroidesthetaiotaomicron) |
PF13460(NAD_binding_10) | 5 | LEU A 135ASP A 126SER A 190PRO A 162GLY A 111 | None | 1.22A | 5syeB-3dhnA:6.1 | 5syeB-3dhnA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dhv | D-ALANINE-POLY(PHOSPHORIBITOL) LIGASE (Bacillus cereus) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | GLU A 34ASP A 35ASP A 16ALA A 19PRO A 62 | None | 1.27A | 5syeB-3dhvA:undetectable | 5syeB-3dhvA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fca | CYSTEINE SYNTHASE (Thermusthermophilus) |
PF00291(PALP) | 5 | GLU A 26VAL A 279LEU A 221ALA A 163GLY A 211 | None | 1.21A | 5syeB-3fcaA:undetectable | 5syeB-3fcaA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvc | PROBABLE SHORT-CHAINTYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | VAL A 104ASP A 105LEU A 185ALA A 145GLY A 197 | None | 1.31A | 5syeB-3gvcA:7.4 | 5syeB-3gvcA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5t | AMINOTRANSFERASE (Rhodobactersphaeroides) |
PF00202(Aminotran_3) | 5 | GLU A 225ASP A 258LEU A 430ALA A 272SER A 273 | PLP A 474 (-3.9A)PLP A 474 (-2.8A)NoneNoneNone | 1.13A | 5syeB-3i5tA:4.8 | 5syeB-3i5tA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 3 (Thermusthermophilus) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 5 | LEU 3 477HIS 3 468ALA 3 452PRO 3 696GLY 3 768 | None | 1.05A | 5syeB-3i9v3:undetectable | 5syeB-3i9v3:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib7 | ICC PROTEIN (Mycobacteriumtuberculosis) |
PF00149(Metallophos) | 5 | VAL A 183LEU A 233ALA A 180PRO A 171GLY A 206 | None | 1.26A | 5syeB-3ib7A:undetectable | 5syeB-3ib7A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iiw | POLYCOMB PROTEIN EED (Homo sapiens) |
PF00400(WD40) | 5 | GLU A 238VAL A 239LEU A 225SER A 253GLY A 231 | None | 1.04A | 5syeB-3iiwA:undetectable | 5syeB-3iiwA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kst | ENDO-1,4-BETA-XYLANASE (Bacteroidesthetaiotaomicron) |
PF04616(Glyco_hydro_43) | 5 | GLU A 214ASP A 154LEU A 46ALA A 277SER A 217 | None | 1.29A | 5syeB-3kstA:undetectable | 5syeB-3kstA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | GLU A 277ASP A 307ALA A 282SER A 284GLY A 289 | None | 1.18A | 5syeB-3mduA:2.3 | 5syeB-3mduA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mxl | NITROSOSYNTHASE (Micromonosporasp. ATCC 39149) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | VAL A 17ASP A 18LEU A 99ALA A 76GLY A 52 | None | 1.14A | 5syeB-3mxlA:undetectable | 5syeB-3mxlA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogr | BETA-GALACTOSIDASE (Trichodermareesei) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | GLU A 298VAL A 297SER A 295GLN A 217GLY A 243 | GAL A1024 (-2.7A)NoneNoneNoneNone | 1.15A | 5syeB-3ogrA:undetectable | 5syeB-3ogrA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pe8 | ENOYL-COA HYDRATASE (Mycolicibacteriumsmegmatis) |
PF00378(ECH_1) | 5 | GLU A 172VAL A 173LEU A 108ALA A 164GLY A 97 | None | 1.06A | 5syeB-3pe8A:undetectable | 5syeB-3pe8A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qyr | ECHA16_2 (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | GLU A 171VAL A 172LEU A 107ALA A 163GLY A 96 | None | 1.08A | 5syeB-3qyrA:undetectable | 5syeB-3qyrA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0o | CARNITINYL-COADEHYDRATASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | GLU A 187VAL A 188LEU A 123ALA A 179GLY A 112 | None | 1.22A | 5syeB-3r0oA:undetectable | 5syeB-3r0oA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 5 | VAL A 60ASP A 44LEU A 71ALA A 62GLY A 108 | None | 1.27A | 5syeB-3rv6A:undetectable | 5syeB-3rv6A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwk | INULINASE (Aspergillusficuum) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | GLU X 233VAL X 234ASP X 176ALA X 300GLY X 46 | FRU X 801 (-2.8A)NoneFRU X 801 (-3.0A)NoneNone | 1.29A | 5syeB-3rwkX:undetectable | 5syeB-3rwkX:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty6 | ATP-DEPENDENTPROTEASE SUBUNITHSLV (Bacillusanthracis) |
PF00227(Proteasome) | 5 | GLU A 99ASP A 59ALA A 6SER A 131GLY A 29 | None | 1.28A | 5syeB-3ty6A:undetectable | 5syeB-3ty6A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | GLU A 140ASP A 141LEU A 203ALA A 172GLY A 10 | None | 1.18A | 5syeB-3uboA:5.2 | 5syeB-3uboA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uto | TWITCHIN (Caenorhabditiselegans) |
PF00041(fn3)PF00069(Pkinase)PF07679(I-set) | 5 | VAL A 310ASP A 470ASP A 277PRO A 329GLY A 327 | None | 1.29A | 5syeB-3utoA:undetectable | 5syeB-3utoA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfz | LACTO-N-BIOSEPHOSPHORYLASE (Bifidobacteriumlongum) |
PF09508(Lact_bio_phlase)PF17385(LBP_M)PF17386(LBP_C) | 5 | VAL A 632LEU A 679ASP A 627PRO A 545GLY A 507 | None | 1.24A | 5syeB-3wfzA:undetectable | 5syeB-3wfzA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aee | ALPHA AMYLASE,CATALYTIC REGION (Staphylothermusmarinus) |
PF00128(Alpha-amylase) | 5 | GLU A 622VAL A 621HIS A 162PRO A 561GLY A 617 | None | 1.02A | 5syeB-4aeeA:3.2 | 5syeB-4aeeA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aio | LIMIT DEXTRINASE (Hordeum vulgare) |
PF02922(CBM_48)PF11852(DUF3372) | 5 | VAL A 99LEU A 64ALA A 9ARG A 8GLY A 22 | None | 1.11A | 5syeB-4aioA:undetectable | 5syeB-4aioA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0n | 2-ON-2 HEMOGLOBIN (Arabidopsisthaliana) |
PF01152(Bac_globin) | 5 | GLU A 149VAL A 145HIS A 105ALA A 108GLY A 13 | NoneNoneNoneHEM A1157 ( 3.9A)None | 1.13A | 5syeB-4c0nA:undetectable | 5syeB-4c0nA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1n | IRON-SULFUR CLUSTERBINDING PROTEIN (Carboxydothermushydrogenoformans) |
PF14574(DUF4445) | 5 | GLU I 289LEU I 122ASP I 224ALA I 292GLY I 184 | None | 1.23A | 5syeB-4c1nI:undetectable | 5syeB-4c1nI:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 5 | GLU B 500VAL B 507SER B 322GLN B 106GLY B 349 | None | 1.15A | 5syeB-4cakB:undetectable | 5syeB-4cakB:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d1i | BETA-GALACTOSIDASE,PUTATIVE, BGL35A (Cellvibriojaponicus) |
PF02449(Glyco_hydro_42) | 5 | GLU A 397LEU A 495ALA A 357PRO A 373GLY A 62 | None | 1.00A | 5syeB-4d1iA:undetectable | 5syeB-4d1iA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpy | MEVALONATEDIPHOSPHATEDECARBOXYLASE (Staphylococcusepidermidis) |
PF00288(GHMP_kinases_N) | 5 | LEU A 217HIS A 165ALA A 164SER A 132GLY A 149 | None | 1.13A | 5syeB-4dpyA:undetectable | 5syeB-4dpyA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | GLU A 84VAL A 85LEU A 53ALA A 304GLY A 60 | PEG A 504 (-4.0A)NoneNoneNoneNone | 1.26A | 5syeB-4dxyA:undetectable | 5syeB-4dxyA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4efi | 3-OXOACYL-(ACYL-CARRIER PROTEIN)SYNTHASE (Paraburkholderiaxenovorans) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | GLU A 11LEU A 290ALA A 344PRO A 135GLY A 333 | None | 1.14A | 5syeB-4efiA:undetectable | 5syeB-4efiA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyg | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNAL (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 5 | GLU A 123VAL A 125LEU A 202SER A 144GLY A 47 | None | 0.95A | 5syeB-4eygA:5.4 | 5syeB-4eygA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gzu | FERM, RHOGEF ANDPLECKSTRINDOMAIN-CONTAININGPROTEIN 2 (Mus musculus) |
PF00169(PH)PF00621(RhoGEF) | 5 | GLU A 734LEU A 977ASP A 924HIS A 925PRO A 676 | None | 1.29A | 5syeB-4gzuA:undetectable | 5syeB-4gzuA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 13 (Thermusthermophilus) |
PF00361(Proton_antipo_M) | 5 | GLU M 92VAL M 91LEU M 106ALA M 227GLY M 324 | None | 1.17A | 5syeB-4heaM:undetectable | 5syeB-4heaM:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hoz | SUCROSE ISOMERASE (Erwiniarhapontici) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | GLU A 428VAL A 427ASP A 426ALA A 206GLY A 104 | GOL A 702 (-3.1A)NoneNoneNoneNone | 1.29A | 5syeB-4hozA:2.3 | 5syeB-4hozA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iis | BETA-1,3-GLUCANASEFORM 'RRII GLN 2' (Heveabrasiliensis) |
PF00332(Glyco_hydro_17) | 5 | GLU A 297VAL A 296LEU A 196ALA A 251GLY A 185 | None | 1.23A | 5syeB-4iisA:3.9 | 5syeB-4iisA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4je5 | AROMATIC/AMINOADIPATE AMINOTRANSFERASE 1 (Saccharomycescerevisiae) |
PF00155(Aminotran_1_2) | 5 | LEU A 423ALA A 388SER A 386PRO A 384GLY A 489 | None | 1.26A | 5syeB-4je5A:2.9 | 5syeB-4je5A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjt | ENOYL-COA HYDRATASE (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 5 | GLU A 171VAL A 172LEU A 107ALA A 163GLY A 96 | None | 1.06A | 5syeB-4jjtA:undetectable | 5syeB-4jjtA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0e | HEAVY METAL CATIONTRICOMPONENT EFFLUXPUMP ZNEA(CZCA-LIKE) (Cupriavidusmetallidurans) |
PF00873(ACR_tran) | 5 | VAL A 993LEU A 472ASP A 399ALA A 919GLY A 390 | None | 1.22A | 5syeB-4k0eA:undetectable | 5syeB-4k0eA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l6u | PUTATIVEUNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF03787(RAMPs) | 5 | GLU A 124VAL A 125ASP A 122LEU A 158ALA A 129 | None | 1.29A | 5syeB-4l6uA:undetectable | 5syeB-4l6uA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls3 | NICKEL (III) ABCTRANSPORTER,PERIPLASMICIRON-BINDIN GPROTEIN (Helicobacterpylori) |
PF01497(Peripla_BP_2) | 5 | GLU A 150VAL A 151ASP A 154ASP A 209ALA A 289 | None | 1.22A | 5syeB-4ls3A:undetectable | 5syeB-4ls3A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7p | MALTOKINASE (Mycobacteriumtuberculosis) |
no annotation | 5 | GLU A 341ASP A 169LEU A 47ALA A 207GLY A 189 | None | 1.19A | 5syeB-4o7pA:undetectable | 5syeB-4o7pA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p56 | PUTATIVEEXTRACELLULARSOLUTE-BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 5 | GLU A 212ASP A 278HIS A 146ALA A 145GLY A 231 | RMN A 401 ( 4.4A)NoneRMN A 401 (-4.2A)NoneNone | 1.29A | 5syeB-4p56A:undetectable | 5syeB-4p56A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2g | SURFACE PROTEINGP160 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | VAL E 108ASP E 107LEU E 453ASP E 474GLN E 287 | None | 1.28A | 5syeB-4r2gE:undetectable | 5syeB-4r2gE:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeh | KETOL-ACIDREDUCTOISOMERASE (Ignisphaeraaggregans) |
PF01450(IlvC)PF07991(IlvN) | 5 | GLU A 181VAL A 151ASP A 9ALA A 169PRO A 130 | None | 1.12A | 5syeB-4xehA:2.7 | 5syeB-4xehA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwh | ALPHA-N-ACETYLGLUCOSAMINIDASE (Homo sapiens) |
PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | VAL A 117LEU A 40ASP A 47GLN A 107ARG A 91 | None | 1.08A | 5syeB-4xwhA:undetectable | 5syeB-4xwhA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zud | CHIMERA PROTEIN OFSOLUBLE CYTOCHROMEB562 AND TYPE-1ANGIOTENSIN IIRECEPTOR (Escherichiacoli;Homo sapiens) |
PF00001(7tm_1)PF07361(Cytochrom_B562) | 5 | VAL A 246ASP A 74SER A 123PRO A 207GLY A 203 | None | 1.22A | 5syeB-4zudA:undetectable | 5syeB-4zudA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1u | METALLO-BETA-LACTAMASE (Serratiamarcescens) |
PF00753(Lactamase_B) | 5 | GLU A 204VAL A 203ALA A 173GLN A 113GLY A 149 | NoneNoneNoneHIW A 321 (-3.0A)None | 1.14A | 5syeB-5b1uA:undetectable | 5syeB-5b1uA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 5 | VAL A1967LEU A1978ASP A1976ALA A1929GLY A1998 | None | 1.18A | 5syeB-5cslA:undetectable | 5syeB-5cslA:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3q | DYNAMIN-1,DYNAMIN-1 (Homo sapiens) |
PF00350(Dynamin_N)PF01031(Dynamin_M) | 5 | GLU A 727LEU A 31ASP A 28ALA A 734GLN A 72 | None | 1.28A | 5syeB-5d3qA:undetectable | 5syeB-5d3qA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4r | KETOL-ACIDREDUCTOISOMERASE (Ignisphaeraaggregans) |
PF01450(IlvC)PF07991(IlvN) | 5 | GLU A 181VAL A 151ASP A 9ALA A 169PRO A 130 | None | 1.20A | 5syeB-5e4rA:3.0 | 5syeB-5e4rA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdf | HYDROLASE (Streptomycesflocculus) |
no annotation | 5 | GLU B 194ASP B 200LEU B 124ALA B 203GLY B 177 | None | 1.13A | 5syeB-5hdfB:3.1 | 5syeB-5hdfB:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjc | CYSTEINE SYNTHASE (Brucellaabortus) |
PF00291(PALP) | 5 | GLU A 33VAL A 301LEU A 243ALA A 180GLY A 233 | NoneNoneNoneNoneLLP A 42 ( 4.0A) | 1.17A | 5syeB-5jjcA:undetectable | 5syeB-5jjcA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jry | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Burkholderiamultivorans) |
PF00171(Aldedh) | 5 | GLU A 427VAL A 428ASP A 402ALA A 409GLY A 251 | NoneNoneNoneNoneNDP A 500 (-3.0A) | 1.22A | 5syeB-5jryA:undetectable | 5syeB-5jryA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxk | ASP/GLU-SPECIFICDIPEPTIDYL-PEPTIDASE (Porphyromonasendodontalis) |
PF10459(Peptidase_S46) | 5 | LEU A 666ALA A 202SER A 108ARG A 708GLY A 78 | None | 1.04A | 5syeB-5jxkA:undetectable | 5syeB-5jxkA:19.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 5 | ASP A 26LEU A 215ASP A 224HIS A 227ARG A 317 | None | 1.31A | 5syeB-5mjsA:58.2 | 5syeB-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 5 | LEU A 215ASP A 224HIS A 227ARG A 317PRO A 357 | None | 0.89A | 5syeB-5mjsA:58.2 | 5syeB-5mjsA:59.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqs | BETA-L-ARABINOBIOSIDASE (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2) | 5 | GLU A 874VAL A 884GLN A 803ARG A 936GLY A 813 | None | 1.26A | 5syeB-5mqsA:undetectable | 5syeB-5mqsA:17.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 11 | GLU B 22VAL B 23ASP B 26LEU B 217ASP B 226HIS B 229ALA B 233SER B 236ARG B 320PRO B 360GLY B 370 | None | 0.71A | 5syeB-5n5nB:60.1 | 5syeB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 6 | GLU B 22VAL B 23ASP B 26LEU B 275HIS B 229GLY B 370 | None | 1.23A | 5syeB-5n5nB:60.1 | 5syeB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 10 | GLU B 22VAL B 23LEU B 217HIS B 229ALA B 233SER B 236GLN B 281ARG B 320PRO B 360GLY B 370 | None | 0.97A | 5syeB-5n5nB:60.1 | 5syeB-5n5nB:97.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nx4 | PENTALENENE SYNTHASE (Streptomycesclavuligerus) |
no annotation | 5 | GLU A 281VAL A 280LEU A 292ALA A 197GLY A 270 | None | 1.27A | 5syeB-5nx4A:undetectable | 5syeB-5nx4A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohx | CYSTATHIONINEBETA-SYNTHASE (Apis mellifera) |
no annotation | 5 | GLU A 262VAL A 261ALA A 310SER A 289GLY A 243 | None | 1.13A | 5syeB-5ohxA:undetectable | 5syeB-5ohxA:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t98 | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | VAL A 615ASP A 582LEU A 769ARG A 357GLY A 791 | None | 1.24A | 5syeB-5t98A:undetectable | 5syeB-5t98A:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5thm | ESTERASE-6 (Drosophilamelanogaster) |
PF00135(COesterase) | 5 | VAL A 282LEU A 249ASP A 149ALA A 227GLY A 143 | NoneMLY A 250 ( 3.7A)NoneNoneNone | 1.19A | 5syeB-5thmA:2.8 | 5syeB-5thmA:21.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | GLU B 22VAL B 23ASP B 224GLN B 279ARG B 318PRO B 358GLY B 360 | TA1 B 502 ( 4.2A)TA1 B 502 (-3.9A)NoneTA1 B 502 ( 4.3A)NoneNoneTA1 B 502 (-3.6A) | 1.06A | 5syeB-5w3jB:59.3 | 5syeB-5w3jB:78.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | GLU B 22VAL B 23LEU B 215ASP B 224ARG B 318PRO B 358GLY B 360 | TA1 B 502 ( 4.2A)TA1 B 502 (-3.9A)NoneNoneNoneNoneTA1 B 502 (-3.6A) | 0.85A | 5syeB-5w3jB:59.3 | 5syeB-5w3jB:78.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | GLU B 22VAL B 23LEU B 215SER B 234ARG B 318PRO B 358GLY B 360 | TA1 B 502 ( 4.2A)TA1 B 502 (-3.9A)NoneTA1 B 502 ( 4.9A)NoneNoneTA1 B 502 (-3.6A) | 0.84A | 5syeB-5w3jB:59.3 | 5syeB-5w3jB:78.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | VAL B 23ASP B 26LEU B 215SER B 234ARG B 318 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)NoneTA1 B 502 ( 4.9A)None | 0.98A | 5syeB-5w3jB:59.3 | 5syeB-5w3jB:78.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wm4 | SALICYLATE-AMPLIGASE (Streptomycesgandocaensis) |
no annotation | 5 | GLU A 76LEU A 187ASP A 107ALA A 81PRO A 194 | None | 1.25A | 5syeB-5wm4A:undetectable | 5syeB-5wm4A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wt4 | CYSTEINE DESULFURASEISCS (Helicobacterpylori) |
no annotation | 5 | GLU A 266ASP A 262ASP A 273GLN A 183GLY A 186 | NoneNoneNoneC6P A 502 (-3.8A)None | 1.31A | 5syeB-5wt4A:undetectable | 5syeB-5wt4A:10.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xom | GLYCOSAMINOGLYCANXYLOSYLKINASE (Hydra vulgaris) |
no annotation | 5 | ASP A 123ASP A 73ALA A 98SER A 101ARG A 178 | None | 1.22A | 5syeB-5xomA:undetectable | 5syeB-5xomA:11.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yeq | KETOL-ACIDREDUCTOISOMERASE(NADP(+)) (Sulfolobusacidocaldarius) |
no annotation | 5 | GLU A 181VAL A 151ASP A 9ALA A 169PRO A 130 | None | 1.27A | 5syeB-5yeqA:undetectable | 5syeB-5yeqA:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6elq | CARBON MONOXIDEDEHYDROGENASE (Carboxydothermushydrogenoformans) |
no annotation | 5 | VAL X 526ASP X 527ASP X 98HIS X 95GLY X 297 | None | 1.23A | 5syeB-6elqX:2.3 | 5syeB-6elqX:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3 (Homo sapiens) |
no annotation | 5 | GLU A 178VAL A 175LEU A 158ASP A 214GLY A 127 | None | 1.25A | 5syeB-6en4A:undetectable | 5syeB-6en4A:11.85 |