SIMILAR PATTERNS OF AMINO ACIDS FOR 5SXQ_A_NIZA808_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 252
VAL A 160
GLY A 293
LEU A 295
 None
FAD  A 600 (-3.4A)
None
None
 0.85A 5sxqA-1bhyA:
0.0		 5sxqA-1bhyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLU A 371
GLY A 226
GLN A 230
LEU A 223
 None
None
GOL  A2010 ( 4.6A)
None
 0.88A 5sxqA-1cb8A:
0.0		 5sxqA-1cb8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 0.99A 5sxqA-1dl5A:
0.0		 5sxqA-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 314
VAL A 283
GLY A 289
LEU A 288
 None
 0.79A 5sxqA-1e3eA:
0.0		 5sxqA-1e3eA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 VAL A 216
GLY A 113
GLN A 115
THR A 269
 None
 0.93A 5sxqA-1f0xA:
0.0		 5sxqA-1f0xA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.97A 5sxqA-1f4hA:
undetectable		 5sxqA-1f4hA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 VAL A 104
GLY A  45
GLN A 141
LEU A  46
 None
 1.01A 5sxqA-1f5nA:
0.0		 5sxqA-1f5nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ARG A 295
GLY A 297
GLN A 299
THR A 300
 None
 0.62A 5sxqA-1ig8A:
1.0		 5sxqA-1ig8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 VAL A 220
GLY A 234
LEU A 233
THR A 209
 None
 0.87A 5sxqA-1krmA:
0.0		 5sxqA-1krmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.94A 5sxqA-1mg1A:
undetectable		 5sxqA-1mg1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A  45
GLY A  42
LEU A 744
THR A 746
 None
FES  A3002 (-4.0A)
FES  A3001 (-4.0A)
None
 0.96A 5sxqA-1n5xA:
undetectable		 5sxqA-1n5xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		4 GLU A 205
VAL A 203
GLY A  36
LEU A  38
 None
 1.00A 5sxqA-1opeA:
undetectable		 5sxqA-1opeA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py9 MYELIN-OLIGODENDROCY
TE GLYCOPROTEIN

(Mus musculus) 		PF07686
(V-set) 		4 GLU A  19
VAL A  88
LEU A  22
THR A  82
 None
 0.96A 5sxqA-1py9A:
undetectable		 5sxqA-1py9A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 ARG A 137
GLU A 132
GLY A  12
LEU A  19
 None
 0.93A 5sxqA-1q1lA:
undetectable		 5sxqA-1q1lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvz YDR533C PROTEIN

(Saccharomyces
cerevisiae) 		PF01965
(DJ-1_PfpI) 		4 GLU A  30
VAL A  29
GLY A  25
THR A  11
 CSO  A 138 ( 3.1A)
None
None
None
 0.96A 5sxqA-1qvzA:
undetectable		 5sxqA-1qvzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		4 ARG A 134
GLU A 129
GLY A   7
LEU A  14
 EPS  A5001 (-4.1A)
None
None
None
 0.96A 5sxqA-1qxoA:
undetectable		 5sxqA-1qxoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		4 ARG A 132
GLU A 125
GLU A 128
GLY A 122
 None
 1.00A 5sxqA-1r3dA:
undetectable		 5sxqA-1r3dA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLU A 224
VAL A 242
GLY A 228
LEU A 230
 None
 0.65A 5sxqA-1s4eA:
undetectable		 5sxqA-1s4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  32
GLY A  15
LEU A 108
THR A  17
 None
 1.01A 5sxqA-1uqxA:
undetectable		 5sxqA-1uqxA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ARG E 422
GLY E 424
GLN E 419
LEU E 423
 HDD  E 760 ( 4.5A)
None
HDD  E 760 (-3.9A)
None
 0.95A 5sxqA-1ye9E:
undetectable		 5sxqA-1ye9E:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1n SIXTEEN HEME
CYTOCHROME

(Desulfovibrio
gigas) 		PF02085
(Cytochrom_CIII)
PF14522
(Cytochrome_C7) 		4 VAL X 287
GLY X 339
GLN X 344
THR X 342
 HEC  X 608 ( 4.4A)
None
HEC  X 610 (-4.6A)
None
 0.87A 5sxqA-1z1nX:
undetectable		 5sxqA-1z1nX:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 GLU A 162
VAL A 160
GLY A 281
LEU A 303
 None
 1.01A 5sxqA-1z48A:
undetectable		 5sxqA-1z48A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 0.98A 5sxqA-2af5A:
undetectable		 5sxqA-2af5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A  39
GLY A 210
LEU A 215
THR A 217
 None
 0.96A 5sxqA-2c4nA:
undetectable		 5sxqA-2c4nA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs4 PROTEIN C12ORF2

(Homo sapiens) 		PF00788
(RA) 		4 GLU A  57
VAL A  80
LEU A  60
THR A  48
 None
 0.98A 5sxqA-2cs4A:
undetectable		 5sxqA-2cs4A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL A 310
GLY A 352
GLN A 389
LEU A 353
 MPD  A2001 (-4.0A)
None
None
None
 0.93A 5sxqA-2d4wA:
undetectable		 5sxqA-2d4wA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e84 HIGH-MOLECULAR-WEIGH
T CYTOCHROME C

(Desulfovibrio
vulgaris) 		PF02085
(Cytochrom_CIII) 		4 VAL A  73
GLY A 120
GLN A 125
THR A 123
 HEM  A1301 (-4.6A)
None
HEM  A1302 (-3.3A)
None
 0.98A 5sxqA-2e84A:
undetectable		 5sxqA-2e84A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm9 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		4 VAL A 257
GLY A 120
GLN A 126
THR A 124
 None
 0.93A 5sxqA-2fm9A:
undetectable		 5sxqA-2fm9A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		4 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.88A 5sxqA-2g85A:
undetectable		 5sxqA-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		4 ARG A 323
GLY A 291
GLN A 197
LEU A 293
 EDO  A3006 (-4.2A)
None
EDO  A3006 ( 4.6A)
None
 0.96A 5sxqA-2g8sA:
undetectable		 5sxqA-2g8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLU A 245
VAL A 278
GLY A 312
LEU A 309
 None
None
None
OHT  A 500 ( 4.0A)
 0.85A 5sxqA-2gpvA:
1.1		 5sxqA-2gpvA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.99A 5sxqA-2hg4A:
undetectable		 5sxqA-2hg4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.86A 5sxqA-2hneA:
undetectable		 5sxqA-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.81A 5sxqA-2hnhA:
undetectable		 5sxqA-2hnhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 VAL A  99
GLY A  86
LEU A 109
THR A  84
 None
 0.96A 5sxqA-2id5A:
undetectable		 5sxqA-2id5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 VAL A 496
GLY A 317
LEU A 316
THR A 315
 None
 0.93A 5sxqA-2ifyA:
undetectable		 5sxqA-2ifyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2z PAP FIMBRIAL MINOR
PILIN PROTEIN

(Escherichia
coli) 		no annotation 4 ARG B 152
GLU B 100
GLY B 113
LEU B 157
 SO4  B1176 (-3.0A)
None
None
SO4  B1176 (-3.6A)
 0.84A 5sxqA-2j2zB:
undetectable		 5sxqA-2j2zB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 GLU A 471
VAL A 436
GLY A 563
LEU A 553
 None
BII  A1687 ( 4.7A)
BII  A1687 ( 3.9A)
BII  A1687 (-4.2A)
 1.00A 5sxqA-2jkmA:
undetectable		 5sxqA-2jkmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
 None
 1.50A 5sxqA-2nq5A:
undetectable		 5sxqA-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 GLU A 261
VAL A 142
GLY A 245
LEU A 241
 GLU  A 261 ( 0.6A)
VAL  A 142 ( 0.4A)
GLY  A 245 ( 0.0A)
LEU  A 241 ( 0.6A)
 0.99A 5sxqA-2ogsA:
undetectable		 5sxqA-2ogsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol8 OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 VAL O  32
GLY O  74
LEU O  76
THR O  89
 None
 1.00A 5sxqA-2ol8O:
undetectable		 5sxqA-2ol8O:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov1 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 GLU A  63
VAL A  53
GLY A  66
LEU A 198
 None
 1.00A 5sxqA-2ov1A:
undetectable		 5sxqA-2ov1A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN

(Plasmodium
yoelii) 		PF00268
(Ribonuc_red_sm) 		5 GLU A 130
VAL A 129
GLY A 227
LEU A 228
THR A 230
 FE  A 350 (-3.1A)
None
None
None
None
 1.43A 5sxqA-2p1iA:
undetectable		 5sxqA-2p1iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		4 GLU A 100
GLY A 102
GLN A 107
LEU A 106
 None
 0.95A 5sxqA-2pkeA:
undetectable		 5sxqA-2pkeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.99A 5sxqA-2xwbB:
undetectable		 5sxqA-2xwbB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		4 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.80A 5sxqA-2yevB:
undetectable		 5sxqA-2yevB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 VAL A 623
GLY A 592
LEU A 644
THR A 594
 None
 1.00A 5sxqA-3a21A:
undetectable		 5sxqA-3a21A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		4 VAL A 343
GLY A 191
LEU A 195
THR A 193
 None
 1.01A 5sxqA-3a3cA:
undetectable		 5sxqA-3a3cA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLU A  53
VAL A 151
GLY A 127
LEU A 141
 None
 0.87A 5sxqA-3a5wA:
undetectable		 5sxqA-3a5wA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY

(Thermus
thermophilus) 		no annotation 4 GLU C 134
VAL C  72
GLY C 129
LEU C 128
 None
 1.00A 5sxqA-3anpC:
0.8		 5sxqA-3anpC:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bru REGULATORY PROTEIN,
TETR FAMILY

(Rhodobacter
sphaeroides) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.91A 5sxqA-3bruA:
2.3		 5sxqA-3bruA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		4 VAL A 101
GLY A  67
GLN A 253
LEU A 250
 None
 1.00A 5sxqA-3c3kA:
undetectable		 5sxqA-3c3kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		4 ARG A 250
VAL A 256
GLY A 301
GLN A 308
 None
 0.89A 5sxqA-3dc8A:
undetectable		 5sxqA-3dc8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 GLU A  85
VAL A 110
GLY A 116
LEU A 118
 None
None
PO4  A 328 (-4.2A)
None
 0.98A 5sxqA-3do5A:
undetectable		 5sxqA-3do5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwm 9.5 KDA CULTURE
FILTRATE ANTIGEN
CFP10A

(Mycobacterium
tuberculosis) 		PF02597
(ThiS) 		4 ARG A  45
GLU A  36
LEU A  11
THR A  15
 None
 1.01A 5sxqA-3dwmA:
undetectable		 5sxqA-3dwmA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 GLU A 436
GLY A 360
GLN A 466
THR A 464
 None
 1.01A 5sxqA-3e1sA:
undetectable		 5sxqA-3e1sA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eex OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 0.98A 5sxqA-3eexA:
undetectable		 5sxqA-3eexA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5

(Schizosaccharomyces
pombe) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 241
GLY A 273
GLN A 275
LEU A 272
 None
 0.93A 5sxqA-3fhoA:
undetectable		 5sxqA-3fhoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A  47
GLN A 341
LEU A 338
THR A 342
 None
 0.97A 5sxqA-3fn4A:
undetectable		 5sxqA-3fn4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 277
VAL A 271
GLY A 237
LEU A 186
 GOL  A 362 ( 4.2A)
None
None
None
 0.90A 5sxqA-3g5wA:
undetectable		 5sxqA-3g5wA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw7 UNCHARACTERIZED
PROTEIN YEDJ

(Escherichia
coli) 		PF01966
(HD) 		4 GLU A 155
VAL A 223
LEU A 179
THR A 176
 None
 0.98A 5sxqA-3gw7A:
undetectable		 5sxqA-3gw7A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.82A 5sxqA-3hnpA:
undetectable		 5sxqA-3hnpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.90A 5sxqA-3i23A:
undetectable		 5sxqA-3i23A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS

(Homo sapiens) 		PF00620
(RhoGAP) 		4 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.99A 5sxqA-3iugA:
undetectable		 5sxqA-3iugA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 VAL A  -1
GLY A-153
LEU A-149
THR A-151
 None
 0.96A 5sxqA-3l2jA:
undetectable		 5sxqA-3l2jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6v DNA GYRASE SUBUNIT A

(Xanthomonas
campestris) 		PF03989
(DNA_gyraseA_C) 		4 ARG A 813
GLY A 815
GLN A 854
THR A 810
 None
 0.79A 5sxqA-3l6vA:
undetectable		 5sxqA-3l6vA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLY A 168
GLN A 174
LEU A 170
THR A 172
 None
 0.87A 5sxqA-3lmdA:
undetectable		 5sxqA-3lmdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 VAL A 101
GLY A  88
LEU A 111
THR A  86
 None
 0.98A 5sxqA-3m19A:
undetectable		 5sxqA-3m19A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		4 GLU A 143
GLU A 113
GLY A 138
THR A  12
 None
SO4  A 317 ( 4.8A)
SO4  A 317 (-3.3A)
SO4  A 317 (-4.0A)
 0.96A 5sxqA-3mdqA:
1.2		 5sxqA-3mdqA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		4 VAL A 217
GLN A 299
LEU A 296
THR A 300
 None
 0.99A 5sxqA-3ncyA:
0.5		 5sxqA-3ncyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		5 GLU A  38
VAL A  77
GLY A 265
LEU A 266
THR A 268
 None
 1.35A 5sxqA-3ndnA:
undetectable		 5sxqA-3ndnA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 4 GLU A 470
GLY A 472
GLN A 411
LEU A 474
 None
 0.96A 5sxqA-3nlcA:
undetectable		 5sxqA-3nlcA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		4 GLU A 254
GLY A 249
LEU A 248
THR A 201
 None
 0.94A 5sxqA-3r7tA:
undetectable		 5sxqA-3r7tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 GLU A 151
VAL A 222
GLY A 144
THR A 232
 None
 0.94A 5sxqA-3r9sA:
undetectable		 5sxqA-3r9sA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		4 VAL A 276
GLY A 204
LEU A 205
THR A 244
 None
 0.98A 5sxqA-3u7bA:
undetectable		 5sxqA-3u7bA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 GLU A 479
GLY A 422
GLN A 424
THR A 433
 None
 0.93A 5sxqA-3up4A:
undetectable		 5sxqA-3up4A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 VAL A 795
GLY A 784
LEU A 868
THR A 819
 None
 1.01A 5sxqA-3wajA:
undetectable		 5sxqA-3wajA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo5 AP-4-A PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01230
(HIT) 		4 GLU A 104
GLU A 102
VAL A 100
LEU A 138
 None
 1.01A 5sxqA-3wo5A:
undetectable		 5sxqA-3wo5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A1042
GLY A 118
GLN A 116
THR A 115
 None
FES  A3001 (-4.4A)
MTE  A3003 (-4.0A)
None
 0.99A 5sxqA-3zyvA:
undetectable		 5sxqA-3zyvA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.91A 5sxqA-4bl3A:
undetectable		 5sxqA-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.87A 5sxqA-4blaA:
undetectable		 5sxqA-4blaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		4 GLU A 272
GLY A 466
GLN A 470
LEU A 469
 None
 0.99A 5sxqA-4c3oA:
undetectable		 5sxqA-4c3oA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ARG A 119
VAL A 196
GLY A 485
LEU A 616
THR A 618
 None
 0.24A 5sxqA-4c51A:
66.7		 5sxqA-4c51A:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 ARG A 677
GLU A 679
GLY A 728
LEU A 730
 None
 1.01A 5sxqA-4duuA:
undetectable		 5sxqA-4duuA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.87A 5sxqA-4dxbA:
undetectable		 5sxqA-4dxbA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 GLU A 239
GLY A 138
GLN A 152
LEU A 154
 None
 0.98A 5sxqA-4dyoA:
undetectable		 5sxqA-4dyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.95A 5sxqA-4gizA:
undetectable		 5sxqA-4gizA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 GLU A  68
GLY A  70
GLN A 113
LEU A 114
 None
 0.89A 5sxqA-4h8nA:
undetectable		 5sxqA-4h8nA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 1.01A 5sxqA-4ikmA:
undetectable		 5sxqA-4ikmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 108
GLN A 164
LEU A 343
THR A 166
 None
 0.94A 5sxqA-4jb6A:
undetectable		 5sxqA-4jb6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN

(gamma
proteobacterium
'Hot 75m4') 		PF01036
(Bac_rhodopsin) 		5 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.24A 5sxqA-4klyA:
undetectable		 5sxqA-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		4 GLU A 122
VAL A 118
GLY A  70
LEU A  74
 None
 0.71A 5sxqA-4ldsA:
undetectable		 5sxqA-4ldsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth) 		4 VAL A 160
GLY A 128
LEU A 102
THR A 126
 None
 0.88A 5sxqA-4lhbA:
undetectable		 5sxqA-4lhbA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 VAL A 345
GLY A 193
LEU A 197
THR A 195
 None
 0.95A 5sxqA-4logA:
undetectable		 5sxqA-4logA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		4 GLU A  28
VAL A  27
GLY A  23
THR A   9
 None
 0.96A 5sxqA-4lruA:
undetectable		 5sxqA-4lruA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		4 GLU A  97
VAL A  74
GLY A 195
THR A 158
 MN  A 402 ( 2.8A)
None
None
None
 0.93A 5sxqA-4n83A:
undetectable		 5sxqA-4n83A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 VAL A 180
GLY A  11
LEU A  13
THR A  15
 None
 0.97A 5sxqA-4nfuA:
0.7		 5sxqA-4nfuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 ARG A  53
GLU A  52
GLY A  48
THR A  25
 None
 0.86A 5sxqA-4nruA:
0.8		 5sxqA-4nruA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		4 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 1.00A 5sxqA-4o2xA:
undetectable		 5sxqA-4o2xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A4614
GLU A4597
GLY A4448
LEU A4599
 None
 0.91A 5sxqA-4opeA:
undetectable		 5sxqA-4opeA:
23.11