SIMILAR PATTERNS OF AMINO ACIDS FOR 5QJQ_B_K1SB304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 TRP C 191
VAL C 193
LEU C 246
GLU C 183
 None
 1.47A 5qjqA-1m1jC:
0.0
5qjqB-1m1jC:
0.0		 5qjqA-1m1jC:
19.83
5qjqB-1m1jC:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ka7 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Thermotoga
maritima) 		PF01597
(GCV_H) 		4 VAL A  65
LEU A  80
TRP A  12
GLU A  11
 None
 1.50A 5qjqA-2ka7A:
0.0
5qjqB-2ka7A:
0.0		 5qjqA-2ka7A:
22.82
5qjqB-2ka7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 TRP A  94
VAL A  93
LEU A  65
GLU A  97
 None
 1.48A 5qjqA-2nt8A:
0.0
5qjqB-2nt8A:
0.0		 5qjqA-2nt8A:
19.23
5qjqB-2nt8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5n MUHV1GPM153

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 VAL A 132
LEU A 144
TRP A 114
GLU A 135
 None
 1.22A 5qjqA-2o5nA:
0.0
5qjqB-2o5nA:
0.0		 5qjqA-2o5nA:
23.45
5qjqB-2o5nA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 TRP C 191
VAL C 193
LEU C 246
GLU C 183
 None
 1.46A 5qjqA-3bvhC:
0.0
5qjqB-3bvhC:
0.0		 5qjqA-3bvhC:
21.38
5qjqB-3bvhC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 TRP A 121
VAL A 165
LEU A 767
GLU A 164
 None
 1.50A 5qjqA-3egwA:
0.0
5qjqB-3egwA:
0.0		 5qjqA-3egwA:
10.72
5qjqB-3egwA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 TRP A 191
VAL A 193
LEU A 246
GLU A 183
 None
 1.42A 5qjqA-3fibA:
0.0
5qjqB-3fibA:
0.0		 5qjqA-3fibA:
20.08
5qjqB-3fibA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

([Eubacterium]
eligens) 		PF01497
(Peripla_BP_2) 		4 TRP A 309
VAL A 313
LEU A 235
GLU A 307
 None
 1.26A 5qjqA-4hn9A:
0.0
5qjqB-4hn9A:
0.0		 5qjqA-4hn9A:
22.02
5qjqB-4hn9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u63 DNA PHOTOLYASE

(Agrobacterium
fabrum) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 TRP A  98
VAL A  97
LEU A 117
TRP A  11
 None
 1.36A 5qjqA-4u63A:
0.0
5qjqB-4u63A:
0.0		 5qjqA-4u63A:
18.48
5qjqB-4u63A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wri OKADAIC ACID BINDING
PROTEIN 2-ALPHA

(Halichondria
okadai) 		no annotation 4 TRP A  22
VAL A  36
LEU A  82
GLU A  25
 OKA  A 201 ( 4.7A)
None
None
MLY  A  47 ( 4.1A)
 1.31A 5qjqA-4wriA:
undetectable
5qjqB-4wriA:
undetectable		 5qjqA-4wriA:
22.37
5qjqB-4wriA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 VAL A 210
LEU A 306
TRP A 223
GLU A 224
 None
 1.50A 5qjqA-5h80A:
undetectable
5qjqB-5h80A:
undetectable		 5qjqA-5h80A:
17.60
5qjqB-5h80A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 TRP A 403
VAL A 405
LEU A 378
GLU A 406
 None
 1.31A 5qjqA-5hqnA:
undetectable
5qjqB-5hqnA:
undetectable		 5qjqA-5hqnA:
19.28
5qjqB-5hqnA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		4 TRP C 355
VAL C 351
LEU C 179
GLU C 352
 None
 1.34A 5qjqA-5nd7C:
undetectable
5qjqB-5nd7C:
undetectable		 5qjqA-5nd7C:
18.66
5qjqB-5nd7C:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 TRP A 187
VAL A 185
LEU A 170
TRP A 183
 None
 1.50A 5qjqA-5y30A:
undetectable
5qjqB-5y30A:
undetectable		 5qjqA-5y30A:
undetectable
5qjqB-5y30A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 TRP B 187
VAL B 185
LEU B 170
TRP B 183
 None
 1.49A 5qjqA-5y31B:
undetectable
5qjqB-5y31B:
2.4		 5qjqA-5y31B:
undetectable
5qjqB-5y31B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 TRP A1779
VAL A1775
LEU A1809
GLU A1776
 None
 1.49A 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
0.4		 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 TRP A1779
VAL A1802
LEU A1809
GLU A1776
 None
 1.43A 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
0.4		 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
undetectable