SIMILAR PATTERNS OF AMINO ACIDS FOR 5QJQ_A_K1SA304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 GLU C 183
TRP C 191
VAL C 193
LEU C 246
 None
 1.47A 5qjqA-1m1jC:
0.0
5qjqB-1m1jC:
0.0		 5qjqA-1m1jC:
19.83
5qjqB-1m1jC:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5n MUHV1GPM153

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 TRP A 114
GLU A 135
VAL A 132
LEU A 144
 None
 1.21A 5qjqA-2o5nA:
0.0
5qjqB-2o5nA:
0.0		 5qjqA-2o5nA:
23.45
5qjqB-2o5nA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 GLU C 183
TRP C 191
VAL C 193
LEU C 246
 None
 1.46A 5qjqA-3bvhC:
0.0
5qjqB-3bvhC:
0.0		 5qjqA-3bvhC:
21.38
5qjqB-3bvhC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 GLU A 164
TRP A 121
VAL A 165
LEU A 767
 None
 1.50A 5qjqA-3egwA:
0.0
5qjqB-3egwA:
0.0		 5qjqA-3egwA:
10.72
5qjqB-3egwA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 GLU A 183
TRP A 191
VAL A 193
LEU A 246
 None
 1.43A 5qjqA-3fibA:
0.0
5qjqB-3fibA:
0.0		 5qjqA-3fibA:
20.08
5qjqB-3fibA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

([Eubacterium]
eligens) 		PF01497
(Peripla_BP_2) 		4 GLU A 307
TRP A 309
VAL A 313
LEU A 235
 None
 1.26A 5qjqA-4hn9A:
0.0
5qjqB-4hn9A:
0.0		 5qjqA-4hn9A:
22.02
5qjqB-4hn9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u63 DNA PHOTOLYASE

(Agrobacterium
fabrum) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 TRP A  11
TRP A  98
VAL A  97
LEU A 117
 None
 1.39A 5qjqA-4u63A:
0.0
5qjqB-4u63A:
0.0		 5qjqA-4u63A:
18.48
5qjqB-4u63A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wri OKADAIC ACID BINDING
PROTEIN 2-ALPHA

(Halichondria
okadai) 		no annotation 4 GLU A  25
TRP A  22
VAL A  36
LEU A  82
 MLY  A  47 ( 4.1A)
OKA  A 201 ( 4.7A)
None
None
 1.31A 5qjqA-4wriA:
undetectable
5qjqB-4wriA:
undetectable		 5qjqA-4wriA:
22.37
5qjqB-4wriA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TRP A 223
GLU A 224
VAL A 210
LEU A 306
 None
 1.47A 5qjqA-5h80A:
0.0
5qjqB-5h80A:
0.0		 5qjqA-5h80A:
17.60
5qjqB-5h80A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 GLU A 406
TRP A 403
VAL A 405
LEU A 378
 None
 1.32A 5qjqA-5hqnA:
0.0
5qjqB-5hqnA:
0.0		 5qjqA-5hqnA:
19.28
5qjqB-5hqnA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		4 GLU C 352
TRP C 355
VAL C 351
LEU C 179
 None
 1.34A 5qjqA-5nd7C:
undetectable
5qjqB-5nd7C:
undetectable		 5qjqA-5nd7C:
18.66
5qjqB-5nd7C:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 GLU A1776
TRP A1779
VAL A1802
LEU A1809
 None
 1.44A 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
0.4		 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
undetectable