SIMILAR PATTERNS OF AMINO ACIDS FOR 5QH8_A_ACTA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		3 CYH A 172
MET A 203
ASN A 207
 None
 1.25A 5qh8A-1ehyA:
0.0		 5qh8A-1ehyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		3 CYH A 197
MET A 220
ASN A 221
 None
 1.17A 5qh8A-1q8fA:
0.0		 5qh8A-1q8fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 CYH A 600
MET A 528
ASN A 531
 None
 1.29A 5qh8A-1sb3A:
0.2		 5qh8A-1sb3A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sum PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG 2

(Thermotoga
maritima) 		PF01895
(PhoU) 		3 CYH B  97
MET B  26
ASN B  29
 None
 1.38A 5qh8A-1sumB:
undetectable		 5qh8A-1sumB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		3 CYH A 431
MET A 404
ASN A 405
 None
 1.30A 5qh8A-1sy7A:
0.0		 5qh8A-1sy7A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		3 CYH A  78
MET A 279
ASN A  74
 None
 1.03A 5qh8A-1vfnA:
0.0		 5qh8A-1vfnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		3 CYH 1 139
MET 1 107
ASN 1 106
 None
 1.16A 5qh8A-1wao1:
0.0		 5qh8A-1wao1:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		3 CYH A 144
MET A 148
ASN A 151
 None
 1.23A 5qh8A-1wnhA:
0.0		 5qh8A-1wnhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 CYH A 311
MET A 366
ASN A 369
 None
 1.12A 5qh8A-1yfmA:
0.0		 5qh8A-1yfmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd1 SULFOTRANSFERASE 4A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 CYH A 162
MET A 261
ASN A 262
 None
 1.18A 5qh8A-1zd1A:
undetectable		 5qh8A-1zd1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57

(Trypanosoma
brucei) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		3 CYH A 361
MET A  44
ASN A  47
 None
 1.23A 5qh8A-2b4vA:
undetectable		 5qh8A-2b4vA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 CYH A 325
MET A  20
ASN A  23
 None
 0.99A 5qh8A-2bc0A:
undetectable		 5qh8A-2bc0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		3 CYH A 139
MET A 107
ASN A 106
 None
 0.96A 5qh8A-2bugA:
undetectable		 5qh8A-2bugA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 CYH A 573
MET A 351
ASN A 350
 None
 1.30A 5qh8A-2dw4A:
undetectable		 5qh8A-2dw4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 CYH A 170
MET A 140
ASN A 141
 None
 1.26A 5qh8A-2i9kA:
undetectable		 5qh8A-2i9kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		3 CYH A 211
MET A 138
ASN A 200
 None
 1.10A 5qh8A-2jgrA:
undetectable		 5qh8A-2jgrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwo ZINC FINGER PROTEIN
DPF3

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A 334
MET A 302
ASN A 301
 ZN  A 701 (-2.3A)
None
None
 0.86A 5qh8A-2kwoA:
undetectable		 5qh8A-2kwoA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 CYH A 290
MET A 261
ASN A 260
 None
 0.94A 5qh8A-2og2A:
undetectable		 5qh8A-2og2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		3 CYH A 211
MET A 138
ASN A 200
 None
None
CA  A 301 (-3.8A)
 1.10A 5qh8A-2p1rA:
undetectable		 5qh8A-2p1rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 CYH A 174
MET A 208
ASN A 211
 None
 1.27A 5qh8A-2pkgA:
undetectable		 5qh8A-2pkgA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		3 CYH A 178
MET A 173
ASN A 174
 None
 0.99A 5qh8A-2w2sA:
undetectable		 5qh8A-2w2sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		3 CYH A  24
MET A  16
ASN A  50
 None
 1.22A 5qh8A-2wtnA:
undetectable		 5qh8A-2wtnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		3 CYH A  41
MET A 131
ASN A 128
 None
 1.35A 5qh8A-2yb4A:
undetectable		 5qh8A-2yb4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 CYH A 246
MET A 215
ASN A 216
 None
 1.27A 5qh8A-2z63A:
undetectable		 5qh8A-2z63A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5a HEMOGLOBIN V

(Tokunagayusurika
akamusi) 		PF00042
(Globin) 		3 CYH A  77
MET A 132
ASN A 135
 None
 1.06A 5qh8A-3a5aA:
undetectable		 5qh8A-3a5aA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agb RED CHLOROPHYLL
CATABOLITE
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06405
(RCC_reductase) 		3 CYH A 125
MET A 299
ASN A  95
 None
 1.39A 5qh8A-3agbA:
undetectable		 5qh8A-3agbA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		3 CYH A 285
MET A 313
ASN A 316
 None
 1.23A 5qh8A-3bitA:
undetectable		 5qh8A-3bitA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		3 CYH A  65
MET A  62
ASN A  63
 None
 1.03A 5qh8A-3eoeA:
undetectable		 5qh8A-3eoeA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		3 CYH A 114
MET A 130
ASN A 129
 None
 1.36A 5qh8A-3fkdA:
undetectable		 5qh8A-3fkdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 CYH A 246
MET A 215
ASN A 216
 None
 1.30A 5qh8A-3fxiA:
undetectable		 5qh8A-3fxiA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 CYH A 222
MET A 211
ASN A 212
 None
 1.31A 5qh8A-3ghyA:
undetectable		 5qh8A-3ghyA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2d E3 SUMO-PROTEIN
LIGASE SIZ1

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		3 CYH A 205
MET A 194
ASN A 195
 None
 0.94A 5qh8A-3i2dA:
undetectable		 5qh8A-3i2dA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 CYH A  82
MET A  85
ASN A  87
 None
 0.98A 5qh8A-3jbhA:
undetectable		 5qh8A-3jbhA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		3 CYH A 390
MET A  25
ASN A  24
 None
 1.27A 5qh8A-3k1tA:
undetectable		 5qh8A-3k1tA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		3 CYH A 700
MET A 680
ASN A 679
 None
 1.35A 5qh8A-3koyA:
undetectable		 5qh8A-3koyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmf UNCHARACTERIZED
PROTEIN

(Nitrosospira
multiformis) 		no annotation 3 CYH A  84
MET A  49
ASN A  51
 None
 1.12A 5qh8A-3lmfA:
undetectable		 5qh8A-3lmfA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obv PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2)
PF06345
(Drf_DAD) 		3 CYH E 988
MET E1127
ASN E1126
 None
 1.23A 5qh8A-3obvE:
undetectable		 5qh8A-3obvE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 CYH A  82
MET A 140
ASN A 144
 None
 1.36A 5qh8A-3qakA:
undetectable		 5qh8A-3qakA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 CYH A 483
MET A 524
ASN A 570
 None
 1.04A 5qh8A-3shmA:
undetectable		 5qh8A-3shmA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT

([Eubacterium]
rectale) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 CYH A 266
MET A 302
ASN A 303
 None
 1.36A 5qh8A-3t0pA:
undetectable		 5qh8A-3t0pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Leptotrichia
buccalis) 		PF03372
(Exo_endo_phos) 		3 CYH A 108
MET A 141
ASN A 142
 None
 1.09A 5qh8A-3tebA:
undetectable		 5qh8A-3tebA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Coxiella
burnetii) 		PF02348
(CTP_transf_3) 		3 CYH A 128
MET A 225
ASN A 151
 None
 1.17A 5qh8A-3tqdA:
undetectable		 5qh8A-3tqdA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		3 CYH A  76
MET A  87
ASN A  88
 None
 0.90A 5qh8A-3tr2A:
undetectable		 5qh8A-3tr2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		3 CYH A  52
MET A  57
ASN A  59
 None
 1.38A 5qh8A-3um1A:
undetectable		 5qh8A-3um1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		3 CYH A 248
MET A 214
ASN A 215
 None
 1.08A 5qh8A-3uxjA:
undetectable		 5qh8A-3uxjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnf MEMBRANE-ASSOCIATED
PROTEIN VP24

(Sudan
ebolavirus) 		PF06389
(Filo_VP24) 		3 CYH A  27
MET A 136
ASN A 135
 None
 1.32A 5qh8A-3vnfA:
undetectable		 5qh8A-3vnfA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu9 CHROMOSOME
SEGREGATION IN
MEIOSIS PROTEIN 2

(Saccharomyces
cerevisiae) 		PF16834
(CSM2) 		3 CYH B  74
MET B 122
ASN B 125
 None
 0.98A 5qh8A-3vu9B:
undetectable		 5qh8A-3vu9B:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 CYH A 345
MET A 316
ASN A 315
 None
 0.98A 5qh8A-4ak9A:
undetectable		 5qh8A-4ak9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		3 CYH A 304
MET A 147
ASN A 148
 None
 1.08A 5qh8A-4bhdA:
undetectable		 5qh8A-4bhdA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		3 CYH A 219
MET A 332
ASN A 333
 None
 1.30A 5qh8A-4bhiA:
undetectable		 5qh8A-4bhiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 CYH A 337
MET A 423
ASN A 422
 None
 1.28A 5qh8A-4bi9A:
undetectable		 5qh8A-4bi9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		3 CYH A 704
MET A 747
ASN A 750
 None
 1.15A 5qh8A-4cekA:
undetectable		 5qh8A-4cekA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgs POLYMERASE SUBUNIT
PA

(Dhori
thogotovirus) 		no annotation 3 CYH A  43
MET A  62
ASN A  61
 CME  A  44 ( 4.8A)
None
None
 0.87A 5qh8A-4cgsA:
undetectable		 5qh8A-4cgsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg2 CYTIDINE DEAMINASE

(Vibrio cholerae) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		3 CYH A 106
MET A  90
ASN A  89
 None
None
URI  A 302 (-4.0A)
 1.16A 5qh8A-4eg2A:
undetectable		 5qh8A-4eg2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25)
PF08239
(SH3_3) 		3 CYH A 191
MET A 193
ASN A 194
 None
 1.10A 5qh8A-4krtA:
undetectable		 5qh8A-4krtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kru AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25) 		3 CYH A 191
MET A 193
ASN A 194
 None
 1.10A 5qh8A-4kruA:
undetectable		 5qh8A-4kruA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0q MEMBRANE-ASSOCIATED
PROTEIN VP24

(Zaire
ebolavirus) 		PF06389
(Filo_VP24) 		3 CYH A  27
MET A 136
ASN A 135
 None
 1.23A 5qh8A-4m0qA:
undetectable		 5qh8A-4m0qA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		3 CYH A 222
MET A 253
ASN A 255
 None
 1.04A 5qh8A-4n06A:
undetectable		 5qh8A-4n06A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		3 CYH A 245
MET A  99
ASN A  98
 None
None
BDP  A 401 (-4.4A)
 0.86A 5qh8A-4p1lA:
undetectable		 5qh8A-4p1lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		3 CYH A 466
MET A 470
ASN A 469
 None
 1.10A 5qh8A-4qlbA:
undetectable		 5qh8A-4qlbA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 CYH A 483
MET A 524
ASN A 570
 None
 1.18A 5qh8A-4rsoA:
undetectable		 5qh8A-4rsoA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur2 TETRACHLOROETHENE
REDUCTIVE
DEHALOGENASE
CATALYTIC SUBUNIT
PCEA

(Sulfurospirillum
multivorans) 		PF13484
(Fer4_16)
PF13486
(Dehalogenase) 		3 CYH A 386
MET A 292
ASN A 367
 SF4  A 502 (-2.3A)
SF4  A 501 ( 4.7A)
None
 1.01A 5qh8A-4ur2A:
undetectable		 5qh8A-4ur2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		3 CYH A 810
MET A 765
ASN A 766
 None
 1.35A 5qh8A-4uvkA:
undetectable		 5qh8A-4uvkA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9r UNCHARACTERIZED
PROTEIN

(Capnocytophaga
ochracea) 		PF00756
(Esterase) 		3 CYH A 248
MET A 159
ASN A 158
 None
 1.34A 5qh8A-4w9rA:
undetectable		 5qh8A-4w9rA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE

(Homo sapiens) 		PF01207
(Dus) 		3 CYH A 154
MET A 114
ASN A 113
 None
None
FMN  A 401 (-3.6A)
 1.34A 5qh8A-4wfsA:
undetectable		 5qh8A-4wfsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25

([Candida]
glabrata) 		PF00069
(Pkinase) 		3 CYH A 241
MET A 252
ASN A 253
 None
 1.33A 5qh8A-4xhgA:
undetectable		 5qh8A-4xhgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6) 		PF13417
(GST_N_3) 		3 CYH A  18
MET A 233
ASN A 234
 None
 1.28A 5qh8A-4yamA:
undetectable		 5qh8A-4yamA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae) 		PF13905
(Thioredoxin_8)
PF17127
(DUF5106) 		3 CYH A  89
MET A 136
ASN A 138
 None
 1.27A 5qh8A-4yodA:
undetectable		 5qh8A-4yodA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 CYH A 947
MET A 957
ASN A 958
 None
 1.21A 5qh8A-5aorA:
undetectable		 5qh8A-5aorA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0s LIN0857 PROTEIN

(Listeria
innocua) 		PF04041
(Glyco_hydro_130) 		3 CYH A 339
MET A 341
ASN A   2
 None
 1.37A 5qh8A-5b0sA:
undetectable		 5qh8A-5b0sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvr ALPHA-ACTININ-LIKE
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 CYH A 208
MET A 185
ASN A 184
 None
 1.38A 5qh8A-5bvrA:
undetectable		 5qh8A-5bvrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		3 CYH A 383
MET A  36
ASN A  37
 None
 1.17A 5qh8A-5d8gA:
undetectable		 5qh8A-5d8gA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 CYH B 506
MET B 349
ASN B 533
 None
 1.27A 5qh8A-5do8B:
undetectable		 5qh8A-5do8B:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		3 CYH A 283
MET A 300
ASN A 303
 None
 1.23A 5qh8A-5e9jA:
undetectable		 5qh8A-5e9jA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 CYH A  99
MET A 148
ASN A 151
 None
 1.37A 5qh8A-5gn5A:
undetectable		 5qh8A-5gn5A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy6 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A

(Spodoptera
frugiperda) 		PF01287
(eIF-5a) 		3 CYH A  75
MET A  81
ASN A  80
 None
 0.96A 5qh8A-5hy6A:
undetectable		 5qh8A-5hy6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF11976
(Rad60-SLD)
PF14324
(PINIT) 		3 CYH A 205
MET A 194
ASN A 195
 None
 0.78A 5qh8A-5jneA:
undetectable		 5qh8A-5jneA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbd TUMOR PROTEIN P73

(Homo sapiens) 		PF00870
(P53) 		3 CYH A 258
MET A 266
ASN A 267
 ZN  A 401 (-3.1A)
None
None
 1.30A 5qh8A-5kbdA:
undetectable		 5qh8A-5kbdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		3 CYH A 360
MET A 128
ASN A 131
 None
 1.09A 5qh8A-5l35A:
undetectable		 5qh8A-5l35A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 CYH B 328
MET B 299
ASN B 298
 None
 1.26A 5qh8A-5l3rB:
undetectable		 5qh8A-5l3rB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 3 CYH A 318
MET A 756
ASN A 755
 None
 1.33A 5qh8A-5mpmA:
undetectable		 5qh8A-5mpmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		3 CYH A 194
MET A 211
ASN A 210
 None
 1.27A 5qh8A-5mqmA:
undetectable		 5qh8A-5mqmA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n13 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		3 CYH A 392
MET A 384
ASN A 449
 None
 1.38A 5qh8A-5n13A:
undetectable		 5qh8A-5n13A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 CYH A 135
MET A 148
ASN A 151
 None
 0.92A 5qh8A-5nd1A:
undetectable		 5qh8A-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 CYH A 566
MET A 573
ASN A 572
 None
 1.03A 5qh8A-5o1pA:
undetectable		 5qh8A-5o1pA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		3 CYH A 203
MET A 122
ASN A 125
 None
 1.24A 5qh8A-5svcA:
undetectable		 5qh8A-5svcA:
14.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t3p PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7

(Homo sapiens) 		PF00293
(NUDIX) 		3 CYH A 114
MET A 192
ASN A 195
 None
 0.30A 5qh8A-5t3pA:
29.0		 5qh8A-5t3pA:
93.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 CYH A 300
MET A 279
ASN A 281
 None
 1.13A 5qh8A-5tqwA:
undetectable		 5qh8A-5tqwA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		3 CYH A  78
MET A 279
ASN A  74
 None
 1.07A 5qh8A-5ugfA:
undetectable		 5qh8A-5ugfA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 3 CYH A 403
MET A 351
ASN A 354
 None
 1.37A 5qh8A-5uxnA:
undetectable		 5qh8A-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 3 CYH B 550
MET B 629
ASN B 628
 None
 1.28A 5qh8A-5xguB:
undetectable		 5qh8A-5xguB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 3 CYH B 163
MET B  16
ASN B  19
 None
 1.17A 5qh8A-5y58B:
undetectable		 5qh8A-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 3 CYH A 286
MET A 314
ASN A 317
 None
 1.09A 5qh8A-6a8mA:
undetectable		 5qh8A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 3 CYH A 160
MET A 185
ASN A 188
 None
 1.18A 5qh8A-6bqcA:
undetectable		 5qh8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 3 CYH A 454
MET A 348
ASN A 349
 SF4  A 603 (-1.8A)
None
None
 1.00A 5qh8A-6dd6A:
undetectable		 5qh8A-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey4 GLDM

(Flavobacterium
johnsoniae) 		no annotation 3 CYH A 472
MET A 453
ASN A 452
 None
 1.12A 5qh8A-6ey4A:
undetectable		 5qh8A-6ey4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 3 CYH A 145
MET A 175
ASN A 178
 None
 1.36A 5qh8A-6f2uA:
undetectable		 5qh8A-6f2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd5 -

(-) 		no annotation 3 CYH A 153
MET A 136
ASN A 137
 None
 1.15A 5qh8A-6fd5A:
undetectable		 5qh8A-6fd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		3 CYH A  90
MET A  56
ASN A  55
 None
3TL  A 201 (-4.7A)
None
 1.29A 5qh8A-6fivA:
undetectable		 5qh8A-6fivA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 3 CYH L 402
MET L 319
ASN L 320
 None
 1.03A 5qh8A-6g2jL:
undetectable		 5qh8A-6g2jL:
undetectable