SIMILAR PATTERNS OF AMINO ACIDS FOR 5QGN_A_ACTA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkb TRANSLATION
INITIATION FACTOR 5A

(Pyrobaculum
aerophilum) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		3 VAL A 137
VAL A 123
GLN A  82
 None
 0.48A 5qgnA-1bkbA:
0.0		 5qgnA-1bkbA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		3 VAL A 124
VAL A 113
GLN A 171
 None
 0.52A 5qgnA-1dcuA:
0.0		 5qgnA-1dcuA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dyo ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9) 		3 VAL A  46
VAL A  30
GLN A  57
 None
 0.62A 5qgnA-1dyoA:
undetectable		 5qgnA-1dyoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 VAL A 316
VAL A 300
GLN A 267
 None
 0.59A 5qgnA-1gq1A:
0.0		 5qgnA-1gq1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 138
VAL H 193
GLN H 203
 None
 0.58A 5qgnA-1ibgH:
0.0		 5qgnA-1ibgH:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq6 (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Aeromonas
caviae) 		PF01575
(MaoC_dehydratas) 		3 VAL A  52
VAL A  87
GLN A 118
 None
 0.64A 5qgnA-1iq6A:
0.0		 5qgnA-1iq6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mam IGG2B-KAPPA YST9.1
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 142
VAL H 189
GLN H 197
 None
 0.61A 5qgnA-1mamH:
0.0		 5qgnA-1mamH:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		3 VAL A 375
VAL A 417
GLN A 414
 None
 0.60A 5qgnA-1ph5A:
0.0		 5qgnA-1ph5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjz THIOPURINE
S-METHYLTRANSFERASE

(Pseudomonas
syringae) 		PF05724
(TPMT) 		3 VAL A 195
VAL A 171
GLN A  11
 None
 0.57A 5qgnA-1pjzA:
0.0		 5qgnA-1pjzA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3o SHANK1

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 VAL A 661
VAL A 658
GLN A 656
 None
 0.57A 5qgnA-1q3oA:
undetectable		 5qgnA-1q3oA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A 153
VAL A 167
GLN A  93
 None
 0.64A 5qgnA-1r2jA:
undetectable		 5qgnA-1r2jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 VAL A 350
VAL A 156
GLN A 152
 None
 0.48A 5qgnA-1s4eA:
undetectable		 5qgnA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 VAL B 224
VAL B 108
GLN B 113
 None
 0.64A 5qgnA-1skyB:
undetectable		 5qgnA-1skyB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 VAL A 261
VAL A 238
GLN A 204
 None
 0.56A 5qgnA-1u1hA:
undetectable		 5qgnA-1u1hA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE

(Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin) 		3 VAL A 326
VAL A 337
GLN A 378
 None
 0.64A 5qgnA-1v6uA:
undetectable		 5qgnA-1v6uA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		3 VAL A 133
VAL A  60
GLN A  58
 None
 0.65A 5qgnA-1wcxA:
undetectable		 5qgnA-1wcxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgg UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Mus musculus) 		no annotation 3 VAL A  73
VAL A  12
GLN A  36
 None
 0.47A 5qgnA-1wggA:
undetectable		 5qgnA-1wggA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whd REGULATOR OF
G-PROTEIN SIGNALING
3

(Mus musculus) 		PF00595
(PDZ) 		3 VAL A  60
VAL A  91
GLN A  18
 None
 0.63A 5qgnA-1whdA:
undetectable		 5qgnA-1whdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		3 VAL A  57
VAL A  50
GLN A 167
 None
 0.65A 5qgnA-1yhnA:
undetectable		 5qgnA-1yhnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8k COLICIN E5

(Escherichia
coli) 		PF12106
(Colicin_E5) 		3 VAL A  75
VAL A  66
GLN A 101
 None
 0.63A 5qgnA-2a8kA:
undetectable		 5qgnA-2a8kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		3 VAL 1 289
VAL 1  64
GLN 1 266
 None
 0.65A 5qgnA-2bpa1:
undetectable		 5qgnA-2bpa1:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 VAL A 348
VAL A 154
GLN A 150
 None
 0.62A 5qgnA-2dejA:
undetectable		 5qgnA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diy THIOREDOXIN-LIKE
PROTEIN 2

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 VAL A  43
VAL A  73
GLN A  28
 None
 0.61A 5qgnA-2diyA:
undetectable		 5qgnA-2diyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		3 VAL A  23
VAL A  54
GLN A  42
 None
 0.44A 5qgnA-2dvzA:
undetectable		 5qgnA-2dvzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 VAL C  42
VAL C 130
GLN C 127
 None
 0.61A 5qgnA-2erjC:
undetectable		 5qgnA-2erjC:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3x TRANSCRIPTION FACTOR
FAPR

(Bacillus
subtilis) 		PF03061
(4HBT) 		3 VAL A 164
VAL A 152
GLN A  86
 None
 0.62A 5qgnA-2f3xA:
undetectable		 5qgnA-2f3xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		3 VAL A  72
VAL A  81
GLN A 107
 None
None
NO3  A 302 ( 3.1A)
 0.53A 5qgnA-2fckA:
undetectable		 5qgnA-2fckA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 VAL A 171
VAL A 202
GLN A 200
 None
 0.64A 5qgnA-2gqwA:
undetectable		 5qgnA-2gqwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		3 VAL G 168
VAL G 146
GLN G 152
 None
 0.65A 5qgnA-2iouG:
undetectable		 5qgnA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jza NITRITE REDUCTASE
[NAD(P)H] SMALL
SUBUNIT

(Pectobacterium
atrosepticum) 		PF13806
(Rieske_2) 		3 VAL A 104
VAL A  99
GLN A  38
 None
 0.56A 5qgnA-2jzaA:
undetectable		 5qgnA-2jzaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n5u TSR0524 PROTEIN

(Thermosynechococcus
elongatus) 		PF11061
(DUF2862) 		3 VAL A  62
VAL A   7
GLN A  29
 None
 0.63A 5qgnA-2n5uA:
undetectable		 5qgnA-2n5uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		3 VAL A  60
VAL A  83
GLN A  77
 None
 0.60A 5qgnA-2nlyA:
undetectable		 5qgnA-2nlyA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou5 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED,
FMN-BINDING

(Jannaschia sp.
CCS1) 		PF12766
(Pyridox_oxase_2) 		3 VAL A 150
VAL A  91
GLN A  16
 None
 0.53A 5qgnA-2ou5A:
undetectable		 5qgnA-2ou5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owa ARFGAP-LIKE FINGER
DOMAIN CONTAINING
PROTEIN

(Cryptosporidium
parvum) 		PF01412
(ArfGap) 		3 VAL A  12
VAL A  18
GLN A  88
 None
 0.64A 5qgnA-2owaA:
undetectable		 5qgnA-2owaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q48 PROTEIN AT5G48480

(Arabidopsis
thaliana) 		no annotation 3 VAL A 148
VAL A 103
GLN A  28
 None
 0.58A 5qgnA-2q48A:
undetectable		 5qgnA-2q48A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Enterococcus
faecalis) 		PF09383
(NIL) 		3 VAL A 341
VAL A 271
GLN A 317
 None
 0.55A 5qgnA-2qswA:
undetectable		 5qgnA-2qswA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qux COAT PROTEIN

(Pseudomonas
phage PP7) 		PF09063
(Phage_coat) 		3 VAL A  78
VAL A  64
GLN A  61
 None
 0.64A 5qgnA-2quxA:
undetectable		 5qgnA-2quxA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		3 VAL A  85
VAL A 239
GLN A 255
 None
 0.64A 5qgnA-2rinA:
undetectable		 5qgnA-2rinA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		3 VAL A 133
VAL A  51
GLN A  91
 None
 0.64A 5qgnA-2vcdA:
undetectable		 5qgnA-2vcdA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 VAL D 392
VAL D 318
GLN D 275
 None
 0.46A 5qgnA-2vnuD:
undetectable		 5qgnA-2vnuD:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzz RV0802C

(Mycobacterium
tuberculosis) 		PF13302
(Acetyltransf_3) 		3 VAL A  84
VAL A  91
GLN A 118
 None
None
SCA  A 601 (-3.4A)
 0.65A 5qgnA-2vzzA:
undetectable		 5qgnA-2vzzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A 616
VAL A 548
GLN A 487
 None
 0.66A 5qgnA-2wanA:
undetectable		 5qgnA-2wanA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		3 VAL A 249
VAL A 165
GLN A 167
 None
 0.62A 5qgnA-2x60A:
undetectable		 5qgnA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 VAL A1140
VAL A1146
GLN A1111
 None
 0.54A 5qgnA-2z8cA:
undetectable		 5qgnA-2z8cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 VAL A 270
VAL A 225
GLN A 296
 None
 0.58A 5qgnA-3b2zA:
undetectable		 5qgnA-3b2zA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  39
VAL A  77
GLN A  85
 None
 0.64A 5qgnA-3b70A:
undetectable		 5qgnA-3b70A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		3 VAL A  90
VAL A  98
GLN A  21
 None
 0.65A 5qgnA-3b8yA:
undetectable		 5qgnA-3b8yA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 VAL A 319
VAL A 274
GLN A 345
 None
 0.53A 5qgnA-3b8zA:
undetectable		 5qgnA-3b8zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		3 VAL A 831
VAL A 836
GLN A 777
 None
 0.62A 5qgnA-3bdlA:
undetectable		 5qgnA-3bdlA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		3 VAL A 128
VAL A 131
GLN A 219
 None
 0.60A 5qgnA-3bl6A:
undetectable		 5qgnA-3bl6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		3 VAL A 125
VAL A  52
GLN A  50
 None
 0.60A 5qgnA-3d8nA:
undetectable		 5qgnA-3d8nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 VAL A 608
VAL A 511
GLN A 586
 None
 0.65A 5qgnA-3fjoA:
undetectable		 5qgnA-3fjoA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  32
VAL A  76
GLN A  84
 None
 0.59A 5qgnA-3gfbA:
undetectable		 5qgnA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 VAL B 435
VAL B 489
GLN B 533
 None
 0.59A 5qgnA-3hhsB:
undetectable		 5qgnA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 3 VAL B  77
VAL B  22
GLN B  35
 None
 0.62A 5qgnA-3jruB:
undetectable		 5qgnA-3jruB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Yersinia pestis) 		PF04166
(PdxA) 		3 VAL A 262
VAL A 161
GLN A 277
 None
 0.58A 5qgnA-3lxyA:
undetectable		 5qgnA-3lxyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		3 VAL C 122
VAL C 179
GLN A  23
 None
 0.66A 5qgnA-3napC:
undetectable		 5qgnA-3napC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfm GGDEF DOMAIN PROTEIN

(Pseudomonas
protegens) 		PF00563
(EAL) 		3 VAL A 442
VAL A 434
GLN A 431
 None
 0.59A 5qgnA-3pfmA:
undetectable		 5qgnA-3pfmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		3 VAL A 442
VAL A 434
GLN A 637
 EDO  A   2 (-4.4A)
None
None
 0.59A 5qgnA-3pjxA:
undetectable		 5qgnA-3pjxA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.65A 5qgnA-3thcA:
undetectable		 5qgnA-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 VAL A  88
VAL A  89
GLN A  91
 None
 0.60A 5qgnA-3v8xA:
undetectable		 5qgnA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 VAL A 191
VAL A  93
GLN A  41
 None
 0.59A 5qgnA-3vm5A:
undetectable		 5qgnA-3vm5A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A 407
VAL A 339
GLN A 276
 None
 0.64A 5qgnA-3wdjA:
undetectable		 5qgnA-3wdjA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF05207
(zf-CSL) 		3 VAL A 134
VAL A 143
GLN A 121
 None
 0.55A 5qgnA-4d4pA:
undetectable		 5qgnA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 VAL A  18
VAL A   5
GLN A  29
 None
 0.60A 5qgnA-4di1A:
undetectable		 5qgnA-4di1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		3 VAL A  70
VAL A 247
GLN A 230
 None
 0.58A 5qgnA-4fajA:
undetectable		 5qgnA-4fajA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j75 TRYPTOPHANYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		PF00579
(tRNA-synt_1b) 		3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.62A 5qgnA-4j75A:
undetectable		 5qgnA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k61 UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF11396
(PepSY_like) 		3 VAL A 103
VAL A 122
GLN A 132
 None
 0.62A 5qgnA-4k61A:
undetectable		 5qgnA-4k61A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		3 VAL A 168
VAL A  70
GLN A  83
 None
 0.66A 5qgnA-4kh8A:
undetectable		 5qgnA-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4w ESPG3

(Mycolicibacterium
smegmatis) 		PF14011
(ESX-1_EspG) 		3 VAL A  64
VAL A  58
GLN A  12
 None
 0.49A 5qgnA-4l4wA:
undetectable		 5qgnA-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdr AP-4 COMPLEX SUBUNIT
MU-1

(Homo sapiens) 		PF00928
(Adap_comp_sub) 		3 VAL A 236
VAL A 250
GLN A 285
 None
 0.56A 5qgnA-4mdrA:
undetectable		 5qgnA-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf0 PROBABLE
C4-DICARBOXYLATE-BIN
DING PROTEIN

(Pseudomonas
aeruginosa) 		PF03480
(DctP) 		3 VAL A  62
VAL A  29
GLN A  88
 None
 0.58A 5qgnA-4nf0A:
undetectable		 5qgnA-4nf0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		3 VAL A 428
VAL A 469
GLN A 466
 None
 0.59A 5qgnA-4pcsA:
undetectable		 5qgnA-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		3 VAL A 233
VAL A 113
GLN A  70
 None
 0.56A 5qgnA-4pmwA:
undetectable		 5qgnA-4pmwA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 3 VAL B 268
VAL B 217
GLN B 244
 None
 0.57A 5qgnA-4r0mB:
undetectable		 5qgnA-4r0mB:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra0 TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		3 VAL C 112
VAL C  60
GLN C  78
 None
 0.63A 5qgnA-4ra0C:
undetectable		 5qgnA-4ra0C:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 VAL A 270
VAL A 225
GLN A 296
 None
 0.55A 5qgnA-4wk7A:
undetectable		 5qgnA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxl PEPTIDE DEFORMYLASE

(Haemophilus
influenzae) 		PF01327
(Pep_deformylase) 		3 VAL A  52
VAL A   6
GLN A  41
 None
 0.60A 5qgnA-4wxlA:
undetectable		 5qgnA-4wxlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		3 VAL B 134
VAL B 143
GLN B 121
 None
 0.42A 5qgnA-4x33B:
undetectable		 5qgnA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01128
(IspD) 		3 VAL A  74
VAL A  53
GLN A  25
 None
 0.40A 5qgnA-4ys8A:
undetectable		 5qgnA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		3 VAL A 275
VAL A 359
GLN A 355
 None
 0.59A 5qgnA-5fn4A:
undetectable		 5qgnA-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 VAL A 656
VAL A 666
GLN A 715
 None
 0.61A 5qgnA-5h1kA:
undetectable		 5qgnA-5h1kA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqh LMO2119 PROTEIN

(Listeria
monocytogenes) 		PF07949
(YbbR) 		3 VAL A  53
VAL A  93
GLN A 110
 None
 0.60A 5qgnA-5hqhA:
undetectable		 5qgnA-5hqhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Yersinia pestis) 		PF04390
(LptE) 		3 VAL B  84
VAL B 100
GLN B 130
 None
 0.51A 5qgnA-5ixmB:
undetectable		 5qgnA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 VAL A 622
VAL A 530
GLN A 660
 None
 0.62A 5qgnA-5jmdA:
undetectable		 5qgnA-5jmdA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Thermococcus
kodakarensis) 		PF00697
(PRAI) 		3 VAL A 129
VAL A 100
GLN A  79
 None
 0.52A 5qgnA-5lheA:
undetectable		 5qgnA-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		3 VAL A 144
VAL A 133
GLN A 127
 None
 0.65A 5qgnA-5lq4A:
undetectable		 5qgnA-5lq4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5e CYTOKINE RECEPTOR
COMMON SUBUNIT GAMMA

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 VAL C  42
VAL C 130
GLN C 127
 None
 0.64A 5qgnA-5m5eC:
undetectable		 5qgnA-5m5eC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 3 VAL A 198
VAL A 131
GLN A  55
 None
 0.64A 5qgnA-5o6vA:
undetectable		 5qgnA-5o6vA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t3p PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7

(Homo sapiens) 		PF00293
(NUDIX) 		3 VAL A  60
VAL A  72
GLN A 188
 None
 0.34A 5qgnA-5t3pA:
28.3		 5qgnA-5t3pA:
93.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 3 VAL A1043
VAL A1053
GLN A1110
 None
 0.45A 5qgnA-5wblA:
undetectable		 5qgnA-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN

(Parastagonospora
nodorum) 		PF01266
(DAO) 		3 VAL A  37
VAL A 176
GLN A 174
 None
 0.64A 5qgnA-5xaoA:
undetectable		 5qgnA-5xaoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.58A 5qgnA-5xyaA:
undetectable		 5qgnA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysx -

(-) 		no annotation 3 VAL A  69
VAL A  82
GLN A 153
 None
 0.65A 5qgnA-5ysxA:
undetectable		 5qgnA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 3 VAL A 259
VAL A 317
GLN A 217
 None
 0.64A 5qgnA-5z24A:
undetectable		 5qgnA-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 3 VAL A 431
VAL A 435
GLN A 628
 None
 0.58A 5qgnA-6bv2A:
undetectable		 5qgnA-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 VAL B  60
VAL B  57
GLN A 127
 VAL  B  60 ( 0.6A)
VAL  B  57 ( 0.6A)
GLN  A 127 ( 0.6A)
 0.63A 5qgnA-6c0wB:
undetectable		 5qgnA-6c0wB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.50A 5qgnA-6c8zA:
undetectable		 5qgnA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 3 VAL A 621
VAL A 607
GLN A 648
 None
 0.58A 5qgnA-6f9nA:
undetectable		 5qgnA-6f9nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 3 VAL O  24
VAL O 122
GLN O 107
 None
 0.52A 5qgnA-6g2jO:
undetectable		 5qgnA-6g2jO:
undetectable