SIMILAR PATTERNS OF AMINO ACIDS FOR 5QGL_A_ACTA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ah9 INITIATION FACTOR 1

(Escherichia
coli) 		PF01176
(eIF-1a) 		3 VAL A  31
VAL A  23
GLN A   9
 None
 0.69A 5qglA-1ah9A:
0.0		 5qglA-1ah9A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Rattus rattus) 		PF01242
(PTPS) 		3 VAL A  56
VAL A 129
GLN A 118
 None
 0.65A 5qglA-1b66A:
0.0		 5qglA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9r PROTEIN
(TERPREDOXIN)

(Pseudomonas sp.) 		PF00111
(Fer2) 		3 VAL A   3
VAL A  15
GLN A  29
 None
 0.64A 5qglA-1b9rA:
0.0		 5qglA-1b9rA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkb TRANSLATION
INITIATION FACTOR 5A

(Pyrobaculum
aerophilum) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		3 VAL A 137
VAL A 123
GLN A  82
 None
 0.52A 5qglA-1bkbA:
0.0		 5qglA-1bkbA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		3 VAL A 124
VAL A 113
GLN A 171
 None
 0.54A 5qglA-1dcuA:
0.0		 5qglA-1dcuA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
alphaherpesvirus
1) 		PF02282
(Herpes_UL42) 		3 VAL A 212
VAL A 219
GLN A 184
 None
 0.71A 5qglA-1dmlA:
0.8		 5qglA-1dmlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dyo ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9) 		3 VAL A  46
VAL A  30
GLN A  57
 None
 0.61A 5qglA-1dyoA:
0.0		 5qglA-1dyoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A

(Methanocaldococcus
jannaschii) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		3 VAL A 131
VAL A 117
GLN A  80
 None
 0.69A 5qglA-1eifA:
0.0		 5qglA-1eifA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 VAL H 149
VAL H 196
GLN H 204
 None
 0.66A 5qglA-1etzH:
0.0		 5qglA-1etzH:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		3 VAL A 242
VAL A 216
GLN A 185
 None
 0.67A 5qglA-1f76A:
undetectable		 5qglA-1f76A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwu CYSTEINE-RICH DOMAIN
OF MANNOSE RECEPTOR

(Mus musculus) 		PF00652
(Ricin_B_lectin) 		3 VAL A  67
VAL A  58
GLN A  79
 None
 0.68A 5qglA-1fwuA:
undetectable		 5qglA-1fwuA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 VAL A 316
VAL A 300
GLN A 267
 None
 0.65A 5qglA-1gq1A:
undetectable		 5qglA-1gq1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 138
VAL H 193
GLN H 203
 None
 0.52A 5qglA-1ibgH:
undetectable		 5qglA-1ibgH:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq6 (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Aeromonas
caviae) 		PF01575
(MaoC_dehydratas) 		3 VAL A  52
VAL A  87
GLN A 118
 None
 0.58A 5qglA-1iq6A:
undetectable		 5qglA-1iq6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 VAL A   4
VAL A  58
GLN A  63
 None
 0.69A 5qglA-1kczA:
undetectable		 5qglA-1kczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		3 VAL H 209
VAL H 200
GLN H  30
 None
 0.60A 5qglA-1kigH:
undetectable		 5qglA-1kigH:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		3 VAL A 168
VAL A 136
GLN A 143
 None
 0.69A 5qglA-1m0sA:
undetectable		 5qglA-1m0sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mam IGG2B-KAPPA YST9.1
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 142
VAL H 189
GLN H 197
 None
 0.57A 5qglA-1mamH:
undetectable		 5qglA-1mamH:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		3 VAL A 375
VAL A 417
GLN A 414
 None
 0.68A 5qglA-1ph5A:
undetectable		 5qglA-1ph5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjz THIOPURINE
S-METHYLTRANSFERASE

(Pseudomonas
syringae) 		PF05724
(TPMT) 		3 VAL A 195
VAL A 171
GLN A  11
 None
 0.62A 5qglA-1pjzA:
undetectable		 5qglA-1pjzA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3o SHANK1

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 VAL A 661
VAL A 658
GLN A 656
 None
 0.58A 5qglA-1q3oA:
undetectable		 5qglA-1q3oA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A 153
VAL A 167
GLN A  93
 None
 0.56A 5qglA-1r2jA:
undetectable		 5qglA-1r2jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		3 VAL A 307
VAL A 306
GLN A 268
 None
 0.65A 5qglA-1rfvA:
undetectable		 5qglA-1rfvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 VAL A 350
VAL A 156
GLN A 152
 None
 0.55A 5qglA-1s4eA:
undetectable		 5qglA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 VAL B 224
VAL B 108
GLN B 113
 None
 0.60A 5qglA-1skyB:
undetectable		 5qglA-1skyB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 VAL A 261
VAL A 238
GLN A 204
 None
 0.63A 5qglA-1u1hA:
undetectable		 5qglA-1u1hA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u53 SECRETED PROTEIN
ASP-2

(Necator
americanus) 		PF00188
(CAP) 		3 VAL A 145
VAL A 154
GLN A  98
 None
 0.71A 5qglA-1u53A:
undetectable		 5qglA-1u53A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE

(Neisseria
gonorrhoeae) 		PF01128
(IspD) 		3 VAL A  74
VAL A  53
GLN A  25
 None
 0.71A 5qglA-1vgwA:
undetectable		 5qglA-1vgwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		3 VAL A   8
VAL A  38
GLN A  61
 None
 0.66A 5qglA-1vh0A:
undetectable		 5qglA-1vh0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 VAL A 133
VAL A 147
GLN A 194
 None
 0.64A 5qglA-1w6sA:
undetectable		 5qglA-1w6sA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wde PROBABLE DIPHTHINE
SYNTHASE

(Aeropyrum
pernix) 		PF00590
(TP_methylase) 		3 VAL A  38
VAL A  89
GLN A  22
 None
 0.60A 5qglA-1wdeA:
undetectable		 5qglA-1wdeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgg UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Mus musculus) 		no annotation 3 VAL A  73
VAL A  12
GLN A  36
 None
 0.50A 5qglA-1wggA:
1.4		 5qglA-1wggA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whd REGULATOR OF
G-PROTEIN SIGNALING
3

(Mus musculus) 		PF00595
(PDZ) 		3 VAL A  60
VAL A  91
GLN A  18
 None
 0.60A 5qglA-1whdA:
undetectable		 5qglA-1whdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe7 HYPOTHETICAL 22.5
KDA PROTEIN IN
TUB1-CPR3 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF06172
(Cupin_5) 		3 VAL A 136
VAL A 127
GLN A 112
 None
 0.61A 5qglA-1xe7A:
undetectable		 5qglA-1xe7A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		3 VAL A 215
VAL A 159
GLN A 190
 None
 0.70A 5qglA-1xw8A:
undetectable		 5qglA-1xw8A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		3 VAL A  57
VAL A  50
GLN A 167
 None
 0.71A 5qglA-1yhnA:
undetectable		 5qglA-1yhnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 VAL A 123
VAL A  88
GLN A  99
 None
 0.71A 5qglA-1zjjA:
undetectable		 5qglA-1zjjA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8k COLICIN E5

(Escherichia
coli) 		PF12106
(Colicin_E5) 		3 VAL A  75
VAL A  66
GLN A 101
 None
 0.64A 5qglA-2a8kA:
undetectable		 5qglA-2a8kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 VAL A 861
VAL A 915
GLN A 826
 None
 0.69A 5qglA-2b39A:
undetectable		 5qglA-2b39A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 VAL C  42
VAL C 130
GLN C 127
 None
 0.65A 5qglA-2b5iC:
undetectable		 5qglA-2b5iC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 VAL C  24
VAL C  31
GLN C 213
 None
 0.68A 5qglA-2bg9C:
undetectable		 5qglA-2bg9C:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 VAL A 214
VAL A 217
GLN A 231
 None
 0.65A 5qglA-2bmaA:
undetectable		 5qglA-2bmaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4) 		no annotation 3 VAL A 155
VAL A 117
GLN A 168
 None
 0.69A 5qglA-2ddxA:
undetectable		 5qglA-2ddxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 VAL A 348
VAL A 154
GLN A 150
 None
 0.68A 5qglA-2dejA:
undetectable		 5qglA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diy THIOREDOXIN-LIKE
PROTEIN 2

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 VAL A  43
VAL A  73
GLN A  28
 None
 0.69A 5qglA-2diyA:
undetectable		 5qglA-2diyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		3 VAL A  23
VAL A  54
GLN A  42
 None
 0.46A 5qglA-2dvzA:
undetectable		 5qglA-2dvzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e32 F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF00646
(F-box)
PF04300
(FBA) 		3 VAL A 207
VAL A 293
GLN A 184
 None
 0.68A 5qglA-2e32A:
undetectable		 5qglA-2e32A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 VAL C  42
VAL C 130
GLN C 127
 None
 0.52A 5qglA-2erjC:
undetectable		 5qglA-2erjC:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3x TRANSCRIPTION FACTOR
FAPR

(Bacillus
subtilis) 		PF03061
(4HBT) 		3 VAL A 164
VAL A 152
GLN A  86
 None
 0.70A 5qglA-2f3xA:
undetectable		 5qglA-2f3xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		3 VAL A  72
VAL A  81
GLN A 107
 None
None
NO3  A 302 ( 3.1A)
 0.52A 5qglA-2fckA:
undetectable		 5qglA-2fckA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.68A 5qglA-2fqxA:
undetectable		 5qglA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3w HYPOTHETICAL PROTEIN
XAC2396

(Xanthomonas
citri) 		PF07152
(YaeQ) 		3 VAL A 131
VAL A 104
GLN A  86
 None
 0.63A 5qglA-2g3wA:
undetectable		 5qglA-2g3wA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 VAL A 171
VAL A 202
GLN A 200
 None
 0.66A 5qglA-2gqwA:
undetectable		 5qglA-2gqwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		3 VAL G 168
VAL G 146
GLN G 152
 None
 0.71A 5qglA-2iouG:
undetectable		 5qglA-2iouG:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jza NITRITE REDUCTASE
[NAD(P)H] SMALL
SUBUNIT

(Pectobacterium
atrosepticum) 		PF13806
(Rieske_2) 		3 VAL A 104
VAL A  99
GLN A  38
 None
 0.63A 5qglA-2jzaA:
undetectable		 5qglA-2jzaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n5u TSR0524 PROTEIN

(Thermosynechococcus
elongatus) 		PF11061
(DUF2862) 		3 VAL A  62
VAL A   7
GLN A  29
 None
 0.61A 5qglA-2n5uA:
undetectable		 5qglA-2n5uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		3 VAL A  60
VAL A  83
GLN A  77
 None
 0.63A 5qglA-2nlyA:
undetectable		 5qglA-2nlyA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		3 VAL 1 396
VAL 1 266
GLN 1 371
 None
 0.68A 5qglA-2oap1:
undetectable		 5qglA-2oap1:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot2 HYDROGENASE
ISOENZYMES FORMATION
PROTEIN HYPC

(Escherichia
coli) 		PF01455
(HupF_HypC) 		3 VAL A  58
VAL A  48
GLN A   8
 None
 0.71A 5qglA-2ot2A:
undetectable		 5qglA-2ot2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou5 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED,
FMN-BINDING

(Jannaschia sp.
CCS1) 		PF12766
(Pyridox_oxase_2) 		3 VAL A 150
VAL A  91
GLN A  16
 None
 0.57A 5qglA-2ou5A:
undetectable		 5qglA-2ou5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owa ARFGAP-LIKE FINGER
DOMAIN CONTAINING
PROTEIN

(Cryptosporidium
parvum) 		PF01412
(ArfGap) 		3 VAL A  12
VAL A  18
GLN A  88
 None
 0.63A 5qglA-2owaA:
undetectable		 5qglA-2owaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Homo sapiens) 		PF10394
(Hat1_N) 		3 VAL A 219
VAL A 204
GLN A 160
 None
 0.71A 5qglA-2p0wA:
undetectable		 5qglA-2p0wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 3 VAL A 274
VAL A 292
GLN A  63
 None
 0.61A 5qglA-2p4oA:
undetectable		 5qglA-2p4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q48 PROTEIN AT5G48480

(Arabidopsis
thaliana) 		no annotation 3 VAL A 148
VAL A 103
GLN A  28
 None
 0.53A 5qglA-2q48A:
undetectable		 5qglA-2q48A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 VAL A  83
VAL A  80
GLN A 121
 None
 0.61A 5qglA-2q5oA:
undetectable		 5qglA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Enterococcus
faecalis) 		PF09383
(NIL) 		3 VAL A 341
VAL A 271
GLN A 317
 None
 0.58A 5qglA-2qswA:
undetectable		 5qglA-2qswA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qux COAT PROTEIN

(Pseudomonas
phage PP7) 		PF09063
(Phage_coat) 		3 VAL A  78
VAL A  64
GLN A  61
 None
 0.71A 5qglA-2quxA:
undetectable		 5qglA-2quxA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk5 PUTATIVE HEMOLYSIN

(Streptococcus
mutans) 		PF03471
(CorC_HlyC) 		3 VAL A  80
VAL A  75
GLN A  53
 None
 0.71A 5qglA-2rk5A:
undetectable		 5qglA-2rk5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		3 VAL A 133
VAL A  51
GLN A  91
 None
 0.71A 5qglA-2vcdA:
undetectable		 5qglA-2vcdA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd2 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
subtilis) 		PF01634
(HisG) 		3 VAL A 155
VAL A  99
GLN A 129
 None
 0.61A 5qglA-2vd2A:
undetectable		 5qglA-2vd2A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 VAL A 204
VAL A 165
GLN A 190
 None
 0.65A 5qglA-2vd9A:
undetectable		 5qglA-2vd9A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 VAL A 328
VAL A 333
GLN A 366
 None
 0.62A 5qglA-2vdaA:
undetectable		 5qglA-2vdaA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 VAL D 392
VAL D 318
GLN D 275
 None
 0.51A 5qglA-2vnuD:
undetectable		 5qglA-2vnuD:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzz RV0802C

(Mycobacterium
tuberculosis) 		PF13302
(Acetyltransf_3) 		3 VAL A  84
VAL A  91
GLN A 118
 None
None
SCA  A 601 (-3.4A)
 0.70A 5qglA-2vzzA:
undetectable		 5qglA-2vzzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		3 VAL A3893
VAL A3862
GLN A3923
 None
 0.70A 5qglA-2w5zA:
undetectable		 5qglA-2w5zA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A 616
VAL A 548
GLN A 487
 None
 0.68A 5qglA-2wanA:
undetectable		 5qglA-2wanA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		3 VAL A  34
VAL A 191
GLN A 213
 None
 0.70A 5qglA-2weuA:
undetectable		 5qglA-2weuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm8 MAGNESIUM-DEPENDENT
PHOSPHATASE 1

(Homo sapiens) 		PF12689
(Acid_PPase) 		3 VAL A  46
VAL A  38
GLN A  80
 None
 0.70A 5qglA-2wm8A:
undetectable		 5qglA-2wm8A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		3 VAL A 249
VAL A 165
GLN A 167
 None
 0.68A 5qglA-2x60A:
undetectable		 5qglA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		3 VAL B 544
VAL B 534
GLN B 520
 None
 0.69A 5qglA-2xfgB:
undetectable		 5qglA-2xfgB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvo SSO1725

(Sulfolobus
solfataricus) 		no annotation 3 VAL A  99
VAL A  78
GLN A  90
 None
 0.68A 5qglA-2xvoA:
undetectable		 5qglA-2xvoA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 VAL A 151
VAL A 133
GLN A 211
 None
 0.67A 5qglA-2yijA:
undetectable		 5qglA-2yijA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 VAL A1140
VAL A1146
GLN A1111
 None
 0.64A 5qglA-2z8cA:
undetectable		 5qglA-2z8cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 3 VAL A 371
VAL A 353
GLN A  53
 None
 0.65A 5qglA-3a71A:
undetectable		 5qglA-3a71A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 VAL A 270
VAL A 225
GLN A 296
 None
 0.66A 5qglA-3b2zA:
undetectable		 5qglA-3b2zA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  39
VAL A  77
GLN A  85
 None
 0.58A 5qglA-3b70A:
undetectable		 5qglA-3b70A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 VAL A 319
VAL A 274
GLN A 345
 None
 0.49A 5qglA-3b8zA:
undetectable		 5qglA-3b8zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		3 VAL A 831
VAL A 836
GLN A 777
 None
 0.61A 5qglA-3bdlA:
undetectable		 5qglA-3bdlA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		3 VAL A 128
VAL A 131
GLN A 219
 None
 0.66A 5qglA-3bl6A:
undetectable		 5qglA-3bl6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		3 VAL A 125
VAL A  52
GLN A  50
 None
 0.70A 5qglA-3d8nA:
undetectable		 5qglA-3d8nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		3 VAL A 201
VAL A  75
GLN A 445
 None
 0.61A 5qglA-3ehkA:
undetectable		 5qglA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A 796
VAL A 731
GLN A 659
 None
 0.66A 5qglA-3fawA:
undetectable		 5qglA-3fawA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 VAL A 608
VAL A 511
GLN A 586
 None
 0.61A 5qglA-3fjoA:
undetectable		 5qglA-3fjoA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g48 CHAPERONE CSAA

(Bacillus
anthracis) 		PF01588
(tRNA_bind) 		3 VAL A  87
VAL A  93
GLN A  48
 None
 0.68A 5qglA-3g48A:
undetectable		 5qglA-3g48A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  32
VAL A  76
GLN A  84
 None
 0.69A 5qglA-3gfbA:
undetectable		 5qglA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		3 VAL A 184
VAL A 177
GLN A 379
 None
 0.62A 5qglA-3gg0A:
undetectable		 5qglA-3gg0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxk GOOSE-TYPE LYSOZYME
1

(Gadus morhua) 		PF01464
(SLT) 		3 VAL A 158
VAL A 164
GLN A 142
 None
 0.72A 5qglA-3gxkA:
undetectable		 5qglA-3gxkA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 VAL B 435
VAL B 489
GLN B 533
 None
 0.66A 5qglA-3hhsB:
undetectable		 5qglA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i10 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacteroides
thetaiotaomicron) 		PF03009
(GDPD)
PF16387
(DUF4996) 		3 VAL A  69
VAL A  43
GLN A 283
 None
None
PEG  A  21 ( 4.5A)
 0.71A 5qglA-3i10A:
undetectable		 5qglA-3i10A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Homo sapiens) 		PF01242
(PTPS) 		3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qglA-3i2bA:
undetectable		 5qglA-3i2bA:
22.06