SIMILAR PATTERNS OF AMINO ACIDS FOR 5Q1S_A_AWYA1103

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apa POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		4 VAL A 106
ILE A  97
LYS A  72
TYR A  54
 None
 1.43A 5q1sA-1apaA:
0.0		 5q1sA-1apaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et9 SUPERANTIGEN SPE-H

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 VAL A  50
LYS A  40
ILE A  68
LYS A  46
 None
 1.45A 5q1sA-1et9A:
undetectable		 5q1sA-1et9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 VAL A 317
LYS A 319
ILE A 279
TYR A 348
 None
 1.28A 5q1sA-1f3lA:
0.0		 5q1sA-1f3lA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 VAL A 553
LYS A 549
ILE A 524
LYS A 529
 None
 1.36A 5q1sA-1gz4A:
2.0		 5q1sA-1gz4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc0 BILIVERDIN REDUCTASE
A

(Rattus
norvegicus) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		4 LYS A 116
VAL A  93
LYS A  91
ILE A  83
 None
 1.44A 5q1sA-1lc0A:
undetectable		 5q1sA-1lc0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		4 VAL A 298
ILE A 185
LYS A 191
TYR A 300
 None
 1.39A 5q1sA-1or8A:
undetectable		 5q1sA-1or8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LYS A 472
VAL A 468
ILE A 535
LYS A 149
 None
 1.22A 5q1sA-1r5mA:
undetectable		 5q1sA-1r5mA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 LYS A  74
VAL A 195
LYS A 220
ILE A  70
 None
None
None
ACY  A1001 (-4.8A)
 1.41A 5q1sA-1uisA:
0.1		 5q1sA-1uisA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 LYS A 301
VAL A 276
LYS A 272
ILE A 266
 None
 1.25A 5q1sA-1vluA:
undetectable		 5q1sA-1vluA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		4 VAL A 258
ILE A 275
LYS A 289
TYR A 260
 None
 1.50A 5q1sA-1vmeA:
8.8		 5q1sA-1vmeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsq MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT

(Escherichia
coli) 		PF03830
(PTSIIB_sorb) 		4 LYS C 205
VAL C 194
ILE C 192
LYS C 225
 None
 0.98A 5q1sA-1vsqC:
2.9		 5q1sA-1vsqC:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		4 VAL B  33
LYS B 165
ILE B  39
LYS B 160
 None
 1.45A 5q1sA-1y56B:
undetectable		 5q1sA-1y56B:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 VAL A  60
LYS A   1
ILE A  62
TYR A  25
 None
 1.37A 5q1sA-2ag8A:
undetectable		 5q1sA-2ag8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 LYS A 272
VAL A  14
LYS A   9
ILE A  68
 None
 1.33A 5q1sA-2b4mA:
undetectable		 5q1sA-2b4mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		4 VAL A 225
ILE A 243
LYS A   2
TYR A 211
 None
 1.43A 5q1sA-2b4wA:
undetectable		 5q1sA-2b4wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 400
LYS A 402
ILE A 386
LYS A 396
 None
 1.46A 5q1sA-2jifA:
undetectable		 5q1sA-2jifA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		4 VAL A  82
LYS A 104
ILE A  84
LYS A  99
 None
 1.33A 5q1sA-2nypA:
2.8		 5q1sA-2nypA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		4 LYS A  50
VAL A 180
ILE A 174
TYR A 197
 AGS  A 300 (-2.6A)
None
None
None
 1.45A 5q1sA-2ozeA:
1.8		 5q1sA-2ozeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 LYS A 100
VAL A  93
LYS A  95
ILE A  72
 None
 1.00A 5q1sA-2r8uA:
undetectable		 5q1sA-2r8uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425

(Thermoplasma
volcanium) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LYS A  57
VAL A  38
ILE A  11
TYR A  27
 None
 1.14A 5q1sA-2rfmA:
undetectable		 5q1sA-2rfmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 VAL A 281
ILE A 363
LYS A  98
TYR A 127
 None
 1.42A 5q1sA-2vk9A:
undetectable		 5q1sA-2vk9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		4 VAL A 116
LYS A 136
ILE A 110
LYS A 154
 None
 1.16A 5q1sA-2z61A:
2.9		 5q1sA-2z61A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		4 VAL A  66
LYS A  70
ILE A 175
TYR A 168
 None
 1.31A 5q1sA-3c7kA:
2.8		 5q1sA-3c7kA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE

(Thermotoga
maritima) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LYS A  18
VAL A 135
ILE A 150
LYS A 145
 None
 1.09A 5q1sA-3dfyA:
undetectable		 5q1sA-3dfyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		4 LYS A 354
VAL A  40
ILE A  52
LYS A  49
 None
 1.49A 5q1sA-3gmiA:
undetectable		 5q1sA-3gmiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		4 VAL A  49
LYS A   1
ILE A  51
TYR A  25
 None
 1.32A 5q1sA-3h1gA:
2.1		 5q1sA-3h1gA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 LYS A   1
VAL A   9
ILE A  33
LYS A  25
 None
 1.43A 5q1sA-3n71A:
undetectable		 5q1sA-3n71A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 VAL A  60
LYS A   2
ILE A  62
TYR A  25
 None
 1.42A 5q1sA-3q3cA:
undetectable		 5q1sA-3q3cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF13944
(Calycin_like) 		4 VAL A 155
ILE A 233
LYS A 182
TYR A 159
 None
MLY  A 232 ( 3.9A)
MLY  A 181 ( 3.3A)
MLY  A 283 ( 3.9A)
 1.40A 5q1sA-3rwxA:
undetectable		 5q1sA-3rwxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL C 687
LYS C 618
ILE C 667
LYS C 616
 None
 1.42A 5q1sA-3sr6C:
undetectable		 5q1sA-3sr6C:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF08501
(Shikimate_dh_N) 		4 LYS A  82
VAL A  58
LYS A  56
ILE A  19
 None
 1.00A 5q1sA-3tnlA:
undetectable		 5q1sA-3tnlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 VAL A  24
ILE A 126
LYS A 165
TYR A 164
 None
 1.49A 5q1sA-3to3A:
undetectable		 5q1sA-3to3A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvw CALCIUM-BINDING AND
COILED-COIL
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07888
(CALCOCO1) 		4 VAL A  75
ILE A  79
LYS A  88
TYR A  42
 None
 1.40A 5q1sA-3vvwA:
undetectable		 5q1sA-3vvwA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 VAL A 204
ILE A 192
LYS A 198
TYR A 217
 None
 1.48A 5q1sA-3wquA:
undetectable		 5q1sA-3wquA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 LYS A 349
VAL A 354
LYS A 301
ILE A 297
 None
 1.38A 5q1sA-3zppA:
undetectable		 5q1sA-3zppA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxo FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		4 LYS A1877
VAL A1898
ILE A1932
TYR A1918
 None
 1.42A 5q1sA-4bxoA:
undetectable		 5q1sA-4bxoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		4 VAL A 221
LYS A 202
ILE A 181
LYS A 200
 None
 1.30A 5q1sA-4gz2A:
undetectable		 5q1sA-4gz2A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		4 VAL Q 566
LYS Q 563
ILE Q 619
LYS Q 559
 None
 1.50A 5q1sA-4h62Q:
undetectable		 5q1sA-4h62Q:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LYS C 567
VAL C 603
LYS C 605
ILE C 651
 CL  C1105 ( 3.9A)
None
None
None
 1.42A 5q1sA-4hb4C:
undetectable		 5q1sA-4hb4C:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 VAL A  62
LYS A  68
ILE A  90
TYR A  19
 None
 1.21A 5q1sA-4r9mA:
undetectable		 5q1sA-4r9mA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tql THREE HELIX BUNDLE

(synthetic
construct) 		no annotation 4 LYS A 162
LYS A 167
LYS A   9
TYR A   9
 None
 1.32A 5q1sA-4tqlA:
undetectable		 5q1sA-4tqlA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v23 MATRIX PROTEIN

(Respiratory
syncytial virus) 		PF03393
(Pneumo_matrix) 		4 LYS A   1
VAL A  22
LYS A 113
ILE A  57
 None
 1.12A 5q1sA-4v23A:
undetectable		 5q1sA-4v23A:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN

(Homo sapiens) 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		6 LYS A 831
VAL A1004
LYS A1008
ILE A1012
LYS A1035
TYR A1040
 None
 0.48A 5q1sA-5ahrA:
45.6		 5q1sA-5ahrA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		4 LYS A   6
VAL A 185
ILE A  37
LYS A  90
 None
 1.36A 5q1sA-5eebA:
undetectable		 5q1sA-5eebA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elj SUMO-AFFIRMER-S2D5

(synthetic
construct) 		PF16845
(SQAPI) 		4 LYS A 113
VAL A  75
LYS A 101
ILE A  68
 None
 1.40A 5q1sA-5eljA:
undetectable		 5q1sA-5eljA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 LYS A 468
VAL A 501
ILE A 498
LYS A 166
 None
 1.22A 5q1sA-5ikrA:
undetectable		 5q1sA-5ikrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9s PROTEIN ENL

(Homo sapiens) 		PF03366
(YEATS) 		4 VAL A  87
LYS A  50
ILE A  44
LYS A  90
 None
SO4  A 201 (-3.2A)
None
None
 0.90A 5q1sA-5j9sA:
undetectable		 5q1sA-5j9sA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvv BETA-1,3-GLUCOSYLTRA
NSFERASE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 VAL B 186
ILE B 210
LYS B 296
TYR B 294
 None
 1.30A 5q1sA-5jvvB:
undetectable		 5q1sA-5jvvB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		4 LYS A 150
VAL A 155
LYS A 166
ILE A 285
 None
 1.24A 5q1sA-5lt1A:
undetectable		 5q1sA-5lt1A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LYS A   1
VAL A  70
LYS A  64
ILE A  79
 None
 1.47A 5q1sA-5n9uA:
undetectable		 5q1sA-5n9uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile) 		no annotation 4 LYS B  52
VAL B 158
LYS B 152
ILE B 179
 None
 1.32A 5q1sA-5ol2B:
undetectable		 5q1sA-5ol2B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 4 LYS A  61
VAL A  46
ILE A  16
LYS A  38
 None
 1.49A 5q1sA-5zbyA:
3.9		 5q1sA-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 4 VAL A  74
LYS A  94
ILE A  68
LYS A 119
 None
 1.05A 5q1sA-6blgA:
2.0		 5q1sA-6blgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A   3
LYS A   1
ILE A1346
LYS A1265
 None
 1.42A 5q1sA-6eojA:
undetectable		 5q1sA-6eojA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwv -

(-) 		no annotation 4 VAL A 281
LYS A 311
ILE A 264
LYS A 326
 None
 1.13A 5q1sA-6fwvA:
undetectable		 5q1sA-6fwvA:
undetectable