SIMILAR PATTERNS OF AMINO ACIDS FOR 5PBE_A_TYLA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		5 PRO A 351
VAL A 356
VAL A 361
TYR A 364
ASN A 407
 None
 0.47A 5pbeA-1e6iA:
17.6		 5pbeA-1e6iA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A1404
VAL A1409
VAL A1414
TYR A1417
ASN A1460
 None
 0.61A 5pbeA-1eqfA:
14.3		 5pbeA-1eqfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A1527
VAL A1532
TYR A1540
ASN A1583
 None
 0.84A 5pbeA-1eqfA:
14.3		 5pbeA-1eqfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A1532
VAL A1537
TYR A1540
ASN A1583
 None
 0.51A 5pbeA-1eqfA:
14.3		 5pbeA-1eqfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f68 HISTONE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 752
VAL A 757
TYR A 765
ASN A 808
 None
 0.80A 5pbeA-1f68A:
16.3		 5pbeA-1f68A:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcu HYALURONOGLUCOSAMINI
DASE

(Apis mellifera) 		PF01630
(Glyco_hydro_56) 		4 PRO A 264
VAL A  13
VAL A 328
ILE A 290
 None
 0.94A 5pbeA-1fcuA:
undetectable		 5pbeA-1fcuA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens) 		PF00082
(Peptidase_S8) 		4 PRO A 201
VAL A 177
VAL A 150
ILE A  11
 None
 0.91A 5pbeA-1gnsA:
undetectable		 5pbeA-1gnsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1g TRANSCRIPTIONAL
REGULATOR LRPA

(Pyrococcus
furiosus) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		4 PRO A 133
VAL A  70
VAL A 128
ILE A 118
 None
 0.81A 5pbeA-1i1gA:
undetectable		 5pbeA-1i1gA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		4 PRO A 153
VAL A 150
VAL A 209
ILE A 235
 None
 0.91A 5pbeA-1j93A:
undetectable		 5pbeA-1j93A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 PRO A 438
VAL A 511
VAL A 525
ILE A 459
 None
 0.00A 5pbeA-1q5aA:
undetectable		 5pbeA-1q5aA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 PRO A 312
VAL A 307
VAL A 338
ILE A 234
 None
 0.73A 5pbeA-1w55A:
undetectable		 5pbeA-1w55A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1l PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
BETA ISOFORM

(Rattus
norvegicus) 		PF02121
(IP_trans) 		4 PRO A  77
VAL A  72
VAL A  68
ASN A 100
 None
PCW  A 501 (-4.2A)
None
PCW  A 501 ( 3.6A)
 0.92A 5pbeA-2a1lA:
undetectable		 5pbeA-2a1lA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A  32
VAL A  37
TYR A  47
ASN A  90
ILE A  96
 None
 0.97A 5pbeA-2dvrA:
16.4		 5pbeA-2dvrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6n BROMODOMAIN PHD
FINGER TRANSCRIPTION
FACTOR

(Homo sapiens) 		PF00439
(Bromodomain)
PF00628
(PHD) 		4 PRO A  92
VAL A  97
TYR A 105
ASN A 148
 None
 0.49A 5pbeA-2f6nA:
17.9		 5pbeA-2f6nA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 PRO A 462
VAL A 471
VAL A 475
ILE A 450
 None
 0.84A 5pbeA-2h8hA:
undetectable		 5pbeA-2h8hA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
furiosus) 		PF01868
(UPF0086) 		4 PRO A  90
VAL A  79
VAL A  86
TYR A  20
 None
 0.93A 5pbeA-2ki7A:
undetectable		 5pbeA-2ki7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 PRO A 212
TYR A 225
ASN A 268
ILE A 274
 None
 0.78A 5pbeA-2r0sA:
14.0		 5pbeA-2r0sA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		5 PRO A 212
VAL A 217
TYR A 225
ASN A 268
ILE A 274
 None
 0.87A 5pbeA-2r0vA:
14.6		 5pbeA-2r0vA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 PRO A 878
VAL A 887
VAL A 891
ILE A 866
 None
 0.92A 5pbeA-2r2pA:
undetectable		 5pbeA-2r2pA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 PRO A 617
VAL A 636
VAL A 561
ILE A 514
 None
 0.62A 5pbeA-2vxoA:
undetectable		 5pbeA-2vxoA:
12.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		4 PRO A 293
VAL A 298
TYR A 308
ASN A 351
 None
 0.81A 5pbeA-2wp1A:
16.6		 5pbeA-2wp1A:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5y ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Homo sapiens) 		PF00644
(PARP) 		4 PRO A 887
VAL A 890
VAL A 839
ILE A 797
 None
 0.92A 5pbeA-2x5yA:
undetectable		 5pbeA-2x5yA:
18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A  98
VAL A 103
TYR A 113
ASN A 156
ILE A 162
 EAM  A1188 (-4.6A)
EAM  A1188 (-4.4A)
None
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
 0.88A 5pbeA-2yekA:
16.2		 5pbeA-2yekA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yyn TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A  45
VAL A  49
TYR A  52
ASN A  97
 None
 0.44A 5pbeA-2yynA:
18.1		 5pbeA-2yynA:
36.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 VAL A 240
VAL A 225
TYR A 228
ILE A 206
 None
 0.86A 5pbeA-2zb4A:
undetectable		 5pbeA-2zb4A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PRO A 449
VAL A 446
VAL A 415
ILE A 491
 None
 0.81A 5pbeA-3aiiA:
undetectable		 5pbeA-3aiiA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3t VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 VAL A 445
VAL A 450
TYR A 201
ILE A 374
 None
 0.94A 5pbeA-3g3tA:
undetectable		 5pbeA-3g3tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvd SERINE
ACETYLTRANSFERASE

(Yersinia pestis) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 PRO A 194
VAL A 170
VAL A 174
ILE A 208
 None
 0.83A 5pbeA-3gvdA:
undetectable		 5pbeA-3gvdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 PRO A 353
VAL A 369
VAL A 389
ILE A 403
 MLA  A2100 (-3.9A)
None
None
None
 0.84A 5pbeA-3h09A:
undetectable		 5pbeA-3h09A:
8.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hmh TRANSCRIPTION
INITIATION FACTOR
TFIID 210 KDA
SUBUNIT

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A1546
VAL A1551
VAL A1556
TYR A1559
ASN A1602
 None
 0.46A 5pbeA-3hmhA:
13.5		 5pbeA-3hmhA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9k ADP-RIBOSYL CYCLASE

(Aplysia
californica) 		PF02267
(Rib_hydrolayse) 		4 PRO A 167
VAL A 159
VAL A 192
TYR A 157
 None
 0.81A 5pbeA-3i9kA:
undetectable		 5pbeA-3i9kA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00682
(HMGL-like) 		4 VAL A 192
VAL A 217
TYR A 181
ILE A 210
 None
 0.88A 5pbeA-3ivuA:
undetectable		 5pbeA-3ivuA:
15.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k2j PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 375
TYR A 388
ASN A 431
ILE A 437
 CL  A   2 ( 4.2A)
None
None
None
 0.85A 5pbeA-3k2jA:
16.1		 5pbeA-3k2jA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n07 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Vibrio cholerae) 		PF08282
(Hydrolase_3) 		4 VAL A 129
VAL A 133
TYR A 119
ILE A 106
 None
 0.93A 5pbeA-3n07A:
undetectable		 5pbeA-3n07A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3num SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		4 PRO A 263
VAL A 230
TYR A 238
ASN A 234
 None
 0.90A 5pbeA-3numA:
undetectable		 5pbeA-3numA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxb CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 458
VAL A 463
TYR A 471
ASN A 514
 None
EDO  A   1 (-4.3A)
None
EDO  A   1 (-3.3A)
 0.46A 5pbeA-3nxbA:
17.3		 5pbeA-3nxbA:
32.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyz MALATE SYNTHASE

(Haloferax
volcanii) 		PF03328
(HpcH_HpaI) 		4 PRO A 341
VAL A 424
TYR A 420
ILE A 346
 None
 0.90A 5pbeA-3oyzA:
undetectable		 5pbeA-3oyzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 191
VAL A 212
VAL A 195
ILE A 181
 None
 0.80A 5pbeA-3pi7A:
undetectable		 5pbeA-3pi7A:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q2e BROMODOMAIN AND WD
REPEAT-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A1337
VAL A1342
TYR A1350
ILE A1400
 None
 0.83A 5pbeA-3q2eA:
17.6		 5pbeA-3q2eA:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 VAL A 211
VAL A 207
TYR A  56
ILE A  71
 None
 0.88A 5pbeA-3v4cA:
2.5		 5pbeA-3v4cA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 PRO A  69
VAL A  66
VAL A  54
ILE A 189
 None
 0.91A 5pbeA-3wiqA:
undetectable		 5pbeA-3wiqA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 248
VAL A 269
VAL A 252
ILE A 238
 None
None
NAP  A1447 (-3.8A)
None
 0.90A 5pbeA-4a0sA:
undetectable		 5pbeA-4a0sA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum) 		PF01115
(F_actin_cap_B) 		4 VAL B 159
VAL B 157
TYR B 169
ILE B  96
 None
 0.94A 5pbeA-4akrB:
undetectable		 5pbeA-4akrB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 PRO A1282
VAL A1279
VAL A1275
ILE A1417
 None
 0.65A 5pbeA-4bkwA:
undetectable		 5pbeA-4bkwA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gei THIOREDOXIN-INTERACT
ING PROTEIN

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 VAL A  44
VAL A  31
TYR A  99
ILE A   7
 None
 0.90A 5pbeA-4geiA:
undetectable		 5pbeA-4geiA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7o SERINE
ACETYLTRANSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 PRO A 194
VAL A 170
VAL A 174
ILE A 208
 None
 0.87A 5pbeA-4h7oA:
undetectable		 5pbeA-4h7oA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A  82
VAL A  87
TYR A  97
ILE A 146
 14X  A 201 (-4.4A)
14X  A 201 (-4.7A)
None
14X  A 201 ( 4.0A)
 0.88A 5pbeA-4hbxA:
15.4		 5pbeA-4hbxA:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A  87
TYR A  97
ASN A 140
ILE A 146
 14X  A 201 (-4.7A)
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
 0.40A 5pbeA-4hbxA:
15.4		 5pbeA-4hbxA:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzc CYSE, SERINE
ACETYLTRANSFERASE

(Brucella
abortus) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 PRO A 204
VAL A 180
VAL A 184
ILE A 218
 None
 0.83A 5pbeA-4hzcA:
undetectable		 5pbeA-4hzcA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		4 PRO A 129
VAL A 133
VAL A 165
ILE A  75
 PRO  A 129 ( 1.1A)
VAL  A 133 ( 0.6A)
VAL  A 165 ( 0.6A)
ILE  A  75 ( 0.7A)
 0.91A 5pbeA-4jbeA:
undetectable		 5pbeA-4jbeA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 PRO A 462
VAL A 471
VAL A 475
ILE A 450
 None
 0.89A 5pbeA-4k11A:
undetectable		 5pbeA-4k11A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 PRO A  46
VAL A  41
VAL A  30
ILE A  61
 None
 0.82A 5pbeA-4k3bA:
undetectable		 5pbeA-4k3bA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldf GCN5 LIKE ACETYLASE
+ BROMODOMAIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		4 PRO A  32
VAL A  37
TYR A  45
ASN A  88
 None
GOL  A 201 ( 4.9A)
None
GOL  A 201 (-2.7A)
 0.64A 5pbeA-4ldfA:
15.5		 5pbeA-4ldfA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 PRO A 462
VAL A 471
VAL A 475
ILE A 450
 None
 0.91A 5pbeA-4lggA:
undetectable		 5pbeA-4lggA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 PRO A1110
VAL A1115
TYR A1125
ASN A1168
 None
 0.49A 5pbeA-4n3wA:
13.3		 5pbeA-4n3wA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nxj BROMODOMAIN PROTEIN

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 VAL A  35
VAL A  40
TYR A  43
ASN A  86
 None
 0.53A 5pbeA-4nxjA:
15.4		 5pbeA-4nxjA:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py6 BROMODOMAIN PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 VAL A1221
TYR A1235
ASN A1278
ILE A1287
 R78  A1401 ( 4.6A)
R78  A1401 ( 4.9A)
R78  A1401 (-3.2A)
R78  A1401 (-4.1A)
 0.73A 5pbeA-4py6A:
15.2		 5pbeA-4py6A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qns HISTONE
ACETYLTRANSFERASE
GCN5, PUTATIVE

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 PRO A1380
VAL A1385
TYR A1393
ASN A1436
 None
 0.40A 5pbeA-4qnsA:
17.2		 5pbeA-4qnsA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tt6 ATPASE FAMILY AAA
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A1013
VAL A1018
TYR A1021
ILE A1074
 None
 0.84A 5pbeA-4tt6A:
15.2		 5pbeA-4tt6A:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A  82
VAL A  87
TYR A  97
ILE A 146
 V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
None
DMS  A1169 ( 4.3A)
 0.77A 5pbeA-4uydA:
15.5		 5pbeA-4uydA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A  87
TYR A  97
ASN A 140
ILE A 146
 V1T  A1171 (-4.9A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.36A 5pbeA-4uydA:
15.5		 5pbeA-4uydA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 371
VAL A 376
TYR A 386
ASN A 429
 None
73B  A1456 (-4.0A)
None
73B  A1456 (-3.3A)
 0.66A 5pbeA-4uygA:
16.7		 5pbeA-4uygA:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z93 BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 375
VAL A 380
TYR A 390
ASN A 433
 4LD  A 501 (-3.9A)
4LD  A 501 ( 3.8A)
4LD  A 501 ( 4.0A)
4LD  A 501 (-2.8A)
 0.76A 5pbeA-4z93A:
16.8		 5pbeA-4z93A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8j VWA2

(Sulfolobus
acidocaldarius) 		PF00092
(VWA) 		4 VAL A 206
VAL A 232
TYR A 209
ASN A  76
 None
None
GOL  A1368 (-3.0A)
None
 0.87A 5pbeA-5a8jA:
undetectable		 5pbeA-5a8jA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4q BROMODOMAIN

(Leishmania
donovani) 		PF00439
(Bromodomain) 		4 VAL A  36
VAL A  41
TYR A  44
ASN A  87
 BMF  A 201 (-4.6A)
BMF  A 201 (-4.2A)
BMF  A 201 ( 4.9A)
BMF  A 201 (-2.8A)
 0.92A 5pbeA-5c4qA:
15.2		 5pbeA-5c4qA:
29.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cqa BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B

(Homo sapiens) 		PF00439
(Bromodomain) 		6 PRO A1888
VAL A1893
VAL A1898
TYR A1901
ASN A1944
ILE A1950
 2LY  A2001 (-4.9A)
2LY  A2001 ( 4.8A)
2LY  A2001 ( 4.9A)
None
2LY  A2001 (-3.2A)
2LY  A2001 ( 4.5A)
 0.11A 5pbeA-5cqaA:
22.3		 5pbeA-5cqaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L19

(Deinococcus
radiodurans) 		PF01245
(Ribosomal_L19) 		4 PRO M  29
VAL M  33
VAL M  91
ILE M  57
 None
 0.95A 5pbeA-5dm6M:
undetectable		 5pbeA-5dm6M:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 PRO A 345
VAL A 348
VAL A 334
ILE A 263
 None
 0.92A 5pbeA-5f75A:
undetectable		 5pbeA-5f75A:
12.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fg6 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A 591
VAL A 596
TYR A 599
ASN A 642
 5XE  A 705 (-3.9A)
5XE  A 705 (-4.9A)
None
5XE  A 705 (-3.3A)
 0.37A 5pbeA-5fg6A:
15.3		 5pbeA-5fg6A:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA

(Homo sapiens) 		no annotation 4 VAL B 928
VAL B 932
TYR B 935
ASN B 980
 6KT  B1101 ( 4.4A)
6KT  B1101 ( 4.9A)
6KT  B1101 (-4.9A)
6KT  B1101 (-3.2A)
 0.43A 5pbeA-5h1uB:
17.8		 5pbeA-5h1uB:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h6y NUCLEOSOME-REMODELIN
G FACTOR SUBUNIT
BPTF

(Homo sapiens) 		no annotation 4 PRO A  92
VAL A  97
TYR A 105
ASN A 148
 None
 0.30A 5pbeA-5h6yA:
17.6		 5pbeA-5h6yA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjc BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 333
VAL A 338
TYR A 348
ASN A 391
 None
 0.78A 5pbeA-5hjcA:
16.8		 5pbeA-5hjcA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8g CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 PRO A1110
VAL A1115
TYR A1125
ASN A1168
 69E  A1404 (-3.7A)
69E  A1404 (-4.3A)
69E  A1404 (-4.8A)
69E  A1404 (-3.0A)
 0.46A 5pbeA-5i8gA:
15.8		 5pbeA-5i8gA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 VAL A 261
TYR A 324
ASN A 213
ILE A 512
 None
 0.93A 5pbeA-5kcaA:
undetectable		 5pbeA-5kcaA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PRO A 838
VAL A 847
VAL A 851
ILE A 826
 None
 0.92A 5pbeA-5l6oA:
undetectable		 5pbeA-5l6oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 PRO A1074
VAL A1079
TYR A1089
ASN A1132
 None
 0.51A 5pbeA-5lkzA:
16.8		 5pbeA-5lkzA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpk HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A1074
VAL A1079
TYR A1089
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.7A)
XDM  A1201 (-3.1A)
 0.53A 5pbeA-5lpkA:
17.5		 5pbeA-5lpkA:
27.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A1527
VAL A1532
VAL A1537
TYR A1540
ASN A1583
 7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
None
None
7M8  A1704 (-3.1A)
 0.67A 5pbeA-5mg2A:
13.7		 5pbeA-5mg2A:
32.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B

(Mus musculus) 		no annotation 4 PRO A 746
VAL A 751
TYR A 759
ASN A 802
 P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 ( 4.6A)
P2L  A 901 (-3.2A)
 0.40A 5pbeA-5ml0A:
18.3		 5pbeA-5ml0A:
26.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n13 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		4 PRO A 410
VAL A 415
TYR A 425
ASN A 468
 GOL  A 502 (-4.4A)
GOL  A 502 ( 4.0A)
GOL  A 501 ( 4.9A)
GOL  A 501 (-3.1A)
 0.57A 5pbeA-5n13A:
16.5		 5pbeA-5n13A:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		6 PRO A 233
VAL A 238
VAL A 245
TYR A 248
ASN A 291
ILE A 297
 IOD  A 405 ( 4.4A)
None
IOD  A 401 ( 4.1A)
None
IOD  A 404 (-3.9A)
IOD  A 404 ( 4.8A)
 0.89A 5pbeA-5n15A:
14.6		 5pbeA-5n15A:
27.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o5a PEREGRIN

(Homo sapiens) 		no annotation 4 VAL A 657
VAL A 662
TYR A 665
ASN A 708
 9LN  A 802 ( 4.1A)
None
None
9LN  A 802 (-3.2A)
 0.37A 5pbeA-5o5aA:
16.0		 5pbeA-5o5aA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 4 PRO A 345
VAL A 348
VAL A 334
ILE A 263
 None
 0.89A 5pbeA-5oexA:
undetectable		 5pbeA-5oexA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B

(Homo sapiens) 		PF00439
(Bromodomain) 		6 PRO A1888
VAL A1893
VAL A1898
TYR A1901
ASN A1944
ILE A1950
 None
None
None
None
EDO  A2001 (-3.2A)
EDO  A2001 ( 4.6A)
 0.16A 5pbeA-5pfrA:
22.1		 5pbeA-5pfrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pq9 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A  59
VAL A  64
TYR A  67
ASN A 110
 EDO  A 202 (-4.5A)
None
None
EDO  A 201 (-3.2A)
 0.41A 5pbeA-5pq9A:
15.3		 5pbeA-5pq9A:
42.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7k AOAA13

(Aspergillus
oryzae) 		PF03067
(LPMO_10) 		4 PRO A 202
VAL A 199
VAL A  81
ILE A  99
 None
 0.65A 5pbeA-5t7kA:
undetectable		 5pbeA-5t7kA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tpx HISTONE
ACETYLTRANSFERASE
GCN5

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 PRO A1380
VAL A1385
TYR A1393
ASN A1436
 None
7H7  A1505 (-4.0A)
None
7H7  A1505 (-3.1A)
 0.68A 5pbeA-5tpxA:
16.6		 5pbeA-5tpxA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		no annotation 4 PRO A 371
VAL A 376
TYR A 386
ASN A 429
 7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
None
7WY  A 501 (-3.4A)
 0.65A 5pbeA-5u6vA:
17.0		 5pbeA-5u6vA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 PRO A1111
VAL A1116
TYR A1126
ASN A1169
 None
 0.69A 5pbeA-5u7gA:
16.1		 5pbeA-5u7gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		4 VAL A 332
TYR A 346
ASN A 413
ILE A 422
 BMF  A 501 (-4.2A)
None
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
 0.65A 5pbeA-5u9nA:
15.3		 5pbeA-5u9nA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiy BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 1A

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A1453
VAL A1458
VAL A1463
TYR A1466
ASN A1509
 None
 0.69A 5pbeA-5uiyA:
17.4		 5pbeA-5uiyA:
27.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v84 CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 458
VAL A 463
TYR A 471
ASN A 514
 96V  A 602 (-4.5A)
96V  A 602 (-3.9A)
None
96V  A 602 (-2.6A)
 0.54A 5pbeA-5v84A:
16.7		 5pbeA-5v84A:
34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Homo sapiens) 		no annotation 4 PRO A  51
VAL A  56
TYR A  66
ILE A 115
 IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 ( 4.3A)
IBI  A 201 ( 3.8A)
 0.83A 5pbeA-5vbrA:
17.2		 5pbeA-5vbrA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Homo sapiens) 		no annotation 4 VAL A  56
TYR A  66
ASN A 109
ILE A 115
 IBI  A 201 ( 4.6A)
IBI  A 201 ( 4.3A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.52A 5pbeA-5vbrA:
17.2		 5pbeA-5vbrA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		4 PRO A 180
VAL A 168
VAL A 166
ILE A 152
 None
 0.92A 5pbeA-5vprA:
undetectable		 5pbeA-5vprA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0e CREB-BINDING PROTEIN

(Homo sapiens) 		no annotation 4 PRO A1110
VAL A1115
TYR A1125
ASN A1168
 9U4  A1201 (-3.9A)
9U4  A1201 (-4.6A)
None
9U4  A1201 (-3.2A)
 0.45A 5pbeA-5w0eA:
17.3		 5pbeA-5w0eA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		no annotation 4 PRO A  82
VAL A  87
TYR A  97
ILE A 146
 H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
None
H1V  A 501 (-3.8A)
 0.86A 5pbeA-6dneA:
15.5		 5pbeA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		no annotation 4 VAL A  87
TYR A  97
ASN A 140
ILE A 146
 H1V  A 501 ( 4.4A)
None
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.50A 5pbeA-6dneA:
15.5		 5pbeA-6dneA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A

(Homo sapiens) 		no annotation 5 PRO A1817
VAL A1822
VAL A1827
TYR A1830
ASN A1873
 6RZ  A1901 (-4.8A)
6RZ  A1901 (-3.8A)
6RZ  A1901 ( 4.8A)
6RZ  A1901 ( 4.8A)
6RZ  A1901 (-3.2A)
 0.46A 5pbeA-6fghA:
19.5		 5pbeA-6fghA:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 4 PRO A 134
VAL A 137
VAL A  96
TYR A 139
 None
 0.94A 5pbeA-6h20A:
undetectable		 5pbeA-6h20A:
undetectable