SIMILAR PATTERNS OF AMINO ACIDS FOR 5P9I_A_1E8A701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
MET A 449
ILE A 472
THR A 474
GLY A 480
ASN A 484
LEU A 528
PHE A 540
 None
 1.16A 5p9iA-1k2pA:
33.6		 5p9iA-1k2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
MET A 449
THR A 474
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
 None
 1.06A 5p9iA-1k2pA:
33.6		 5p9iA-1k2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 414
VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
PHE A 540
 None
 1.17A 5p9iA-1k2pA:
33.6		 5p9iA-1k2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
ILE A 472
THR A 474
GLY A 480
ASN A 484
LEU A 528
PHE A 540
 None
 1.25A 5p9iA-1k2pA:
33.6		 5p9iA-1k2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
THR A 474
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
 None
 1.13A 5p9iA-1k2pA:
33.6		 5p9iA-1k2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
PHE A 333
 None
 0.96A 5p9iA-1k9aA:
31.2		 5p9iA-1k9aA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
GLY A 272
LEU A 321
SER A 331
PHE A 333
 None
 0.92A 5p9iA-1k9aA:
31.2		 5p9iA-1k9aA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.58A 5p9iA-1k9aA:
31.2		 5p9iA-1k9aA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.68A 5p9iA-1k9aA:
31.2		 5p9iA-1k9aA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 273
VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
 None
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
 0.83A 5p9iA-1opkA:
30.0		 5p9iA-1opkA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  86
ALA A  99
LYS A 101
ILE A 145
GLY A 153
LEU A 201
PHE A 213
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
5EA  A1001 (-3.6A)
 0.83A 5p9iA-1s9iA:
5.7		 5p9iA-1s9iA:
24.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 377
ALA A 389
GLY A 441
LEU A 489
SER A 499
PHE A 501
 None
 0.61A 5p9iA-1snxA:
25.8		 5p9iA-1snxA:
54.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 596
VAL A 603
ALA A 621
THR A 670
GLY A 676
ASN A 680
LEU A 799
 None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.4A)
 1.18A 5p9iA-1t46A:
27.1		 5p9iA-1t46A:
34.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 345
VAL A 352
ALA A 367
GLY A 420
LEU A 468
SER A 478
PHE A 480
 STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
None
 1.48A 5p9iA-1u59A:
30.7		 5p9iA-1u59A:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
THR A 338
GLY A 344
LEU A 393
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
None
 0.66A 5p9iA-2h8hA:
35.2		 5p9iA-2h8hA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
THR A 338
GLY A 344
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
 0.90A 5p9iA-2hckA:
33.4		 5p9iA-2hckA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
MET A 314
ILE A 336
THR A 338
GLY A 344
LEU A 393
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.74A 5p9iA-2hckA:
33.4		 5p9iA-2hckA:
26.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 638
VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
SER A 771
 ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.79A 5p9iA-2henA:
27.2		 5p9iA-2henA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.52A 5p9iA-2henA:
27.2		 5p9iA-2henA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
None
 0.90A 5p9iA-2hk5A:
24.7		 5p9iA-2hk5A:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 383
VAL A 256
ALA A 269
LYS A 271
ILE A 313
THR A 315
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
 0.90A 5p9iA-2hz0A:
31.2		 5p9iA-2hz0A:
44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 256
ALA A 269
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.78A 5p9iA-2hz0A:
31.2		 5p9iA-2hz0A:
44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 589
VAL A 596
ALA A 614
THR A 663
GLY A 669
ASN A 673
LEU A 785
 None
 1.44A 5p9iA-2ogvA:
28.7		 5p9iA-2ogvA:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
LYS A 616
THR A 663
GLY A 669
LEU A 785
 None
 0.73A 5p9iA-2ogvA:
28.7		 5p9iA-2ogvA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 352
ALA A 367
LYS A 369
MET A 390
GLY A 418
LEU A 468
SER A 478
PHE A 480
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
None
 1.35A 5p9iA-2ozoA:
30.7		 5p9iA-2ozoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 352
ALA A 367
LYS A 369
MET A 390
GLY A 420
LEU A 468
SER A 478
PHE A 480
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
None
 0.64A 5p9iA-2ozoA:
30.7		 5p9iA-2ozoA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
PHE A 765
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.86A 5p9iA-2qobA:
25.2		 5p9iA-2qobA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 635
ALA A 651
LYS A 653
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
PHE A 765
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.06A 5p9iA-2qobA:
25.2		 5p9iA-2qobA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 GLY A 684
VAL A 689
ALA A 705
ILE A 751
THR A 753
SER A 817
 None
 0.87A 5p9iA-2r2pA:
31.0		 5p9iA-2r2pA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 689
ALA A 705
LYS A 707
ILE A 751
THR A 753
GLY A 759
LEU A 807
SER A 817
 None
 0.97A 5p9iA-2r2pA:
31.0		 5p9iA-2r2pA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 689
ALA A 705
LYS A 707
THR A 753
GLY A 759
LEU A 807
SER A 817
PHE A 819
 None
 1.23A 5p9iA-2r2pA:
31.0		 5p9iA-2r2pA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 732
ALA A 749
THR A 796
GLY A 802
LEU A 850
PHE A 862
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.8A)
 0.94A 5p9iA-2r4bA:
30.7		 5p9iA-2r4bA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 234
ALA A 247
LYS A 249
ILE A 299
GLY A 307
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 4.9A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.95A 5p9iA-2xk9A:
21.3		 5p9iA-2xk9A:
26.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.61A 5p9iA-2xyuA:
27.8		 5p9iA-2xyuA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 261
ALA A 273
LYS A 275
ILE A 317
THR A 319
GLY A 325
LEU A 374
PHE A 386
 None
 0.87A 5p9iA-2zv7A:
32.2		 5p9iA-2zv7A:
41.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
PHE A 333
 None
 0.96A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
GLY A 272
LEU A 321
SER A 331
PHE A 333
 None
 0.92A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.58A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.68A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
ILE A 711
THR A 713
GLY A 719
LEU A 767
PHE A 779
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 1.20A 5p9iA-3kulA:
31.7		 5p9iA-3kulA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
THR A 713
GLY A 719
LEU A 767
SER A 777
PHE A 779
 None
None
None
GOL  A 403 (-3.4A)
None
None
None
 1.13A 5p9iA-3kulA:
31.7		 5p9iA-3kulA:
39.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 689
ALA A 700
LYS A 702
ILE A 743
LEU A 804
SER A 827
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
ADP  A2101 (-4.4A)
ADP  A2101 ( 4.4A)
 0.78A 5p9iA-3lj0A:
23.1		 5p9iA-3lj0A:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1096
ALA A1112
LYS A1114
MET A1135
GLY A1167
PHE A1227
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
None
None
 0.81A 5p9iA-3plsA:
32.3		 5p9iA-3plsA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
VAL A 565
ALA A 576
THR A 625
GLY A 631
LEU A 683
PHE A 695
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
None
 1.40A 5p9iA-3ppzA:
29.8		 5p9iA-3ppzA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 VAL A 565
ALA A 576
ILE A 623
THR A 625
GLY A 631
LEU A 683
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
None
 0.96A 5p9iA-3ppzA:
29.8		 5p9iA-3ppzA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 GLY A 426
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
GLY A 495
ASN A 499
LEU A 543
SER A 553
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.88A 5p9iA-3sxsA:
34.5		 5p9iA-3sxsA:
63.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  83
ALA A  96
LYS A  98
ILE A 142
GLY A 150
LEU A 198
PHE A 210
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
CHU  A 403 (-3.8A)
 0.53A 5p9iA-3wigA:
25.7		 5p9iA-3wigA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.55A 5p9iA-3zfxA:
32.1		 5p9iA-3zfxA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
LYS A 651
THR A 697
GLY A 703
LEU A 751
SER A 761
PHE A 763
 None
 0.99A 5p9iA-3zfxA:
32.1		 5p9iA-3zfxA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 100
VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
LEU A 223
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.65A 5p9iA-4aw5A:
27.5		 5p9iA-4aw5A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.41A 5p9iA-4aw5A:
27.5		 5p9iA-4aw5A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 GLY A 570
VAL A 575
ALA A 588
LYS A 590
ILE A 634
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.3A)
 0.78A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 570
VAL A 575
ALA A 588
LYS A 590
LEU A 690
SER A 700
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
None
 1.36A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 VAL A 575
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
PHE A 702
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
None
 1.23A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 VAL A 575
ALA A 588
LYS A 590
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.74A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 385
ALA A 400
LYS A 402
GLY A 454
LEU A 501
SER A 511
PHE A 513
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
None
 1.06A 5p9iA-4f4pA:
30.2		 5p9iA-4f4pA:
37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 VAL A 335
ALA A 348
LYS A 350
GLY A 401
LEU A 447
SER A 457
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.79A 5p9iA-4fieA:
23.6		 5p9iA-4fieA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 385
ALA A 400
LYS A 402
MET A 424
GLY A 454
LEU A 501
SER A 511
PHE A 513
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
None
 0.80A 5p9iA-4fl3A:
32.9		 5p9iA-4fl3A:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A1125
VAL A1130
ALA A1148
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.64A 5p9iA-4fodA:
25.4		 5p9iA-4fodA:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1130
ALA A1148
LYS A1150
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.89A 5p9iA-4fodA:
25.4		 5p9iA-4fodA:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 GLY A 135
VAL A 140
ALA A 156
LYS A 158
MET A 181
THR A 205
PHE A 271
 None
 0.60A 5p9iA-4hzsA:
31.0		 5p9iA-4hzsA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 GLY A 138
VAL A 140
ALA A 156
LYS A 158
MET A 181
THR A 205
PHE A 271
 None
 1.45A 5p9iA-4hzsA:
31.0		 5p9iA-4hzsA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 VAL A 140
ALA A 156
MET A 181
THR A 205
GLY A 211
LEU A 259
PHE A 271
 None
 0.53A 5p9iA-4hzsA:
31.0		 5p9iA-4hzsA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
1G0  A 401 ( 4.8A)
 0.85A 5p9iA-4id7A:
26.6		 5p9iA-4id7A:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
GLY A 344
LEU A 393
PHE A 405
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
None
 0.63A 5p9iA-4k11A:
35.3		 5p9iA-4k11A:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
LYS A 295
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.51A 5p9iA-4lggA:
29.2		 5p9iA-4lggA:
37.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  36
ALA A  49
LYS A  51
MET A  65
THR A  95
LEU A 150
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
ANP  A 401 (-4.8A)
None
 0.80A 5p9iA-4m69A:
26.6		 5p9iA-4m69A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  36
ALA A  49
MET A  65
THR A  95
GLY A 101
LEU A 150
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.87A 5p9iA-4m69A:
26.6		 5p9iA-4m69A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		6 VAL A 205
ALA A 218
LYS A 220
GLY A 277
LEU A 324
SER A 334
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
 0.87A 5p9iA-4mk0A:
15.8		 5p9iA-4mk0A:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 GLY A 622
VAL A 627
ALA A 644
ILE A 690
THR A 692
LEU A 746
SER A 756
 None
 0.65A 5p9iA-4p2kA:
32.0		 5p9iA-4p2kA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
ILE A 690
THR A 692
GLY A 698
LEU A 746
SER A 756
 None
 0.32A 5p9iA-4p2kA:
32.0		 5p9iA-4p2kA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
ILE A  79
THR A  81
GLY A  87
LEU A 136
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.93A 5p9iA-4ueuA:
31.7		 5p9iA-4ueuA:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
 0.93A 5p9iA-4ueuA:
31.7		 5p9iA-4ueuA:
48.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  48
ALA A  61
LYS A  63
ILE A 106
GLY A 114
LEU A 162
 None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 0.81A 5p9iA-4usfA:
18.2		 5p9iA-4usfA:
26.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 VAL B 275
ALA B 288
LYS B 290
ILE B 332
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.60A 5p9iA-4xeyB:
25.2		 5p9iA-4xeyB:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 GLY A 411
VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
GLY A 480
LEU A 528
SER A 538
PHE A 540
 None
 0.56A 5p9iA-4xi2A:
41.2		 5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 GLY A 411
VAL A 416
LYS A 430
MET A 449
ILE A 472
GLY A 480
LEU A 528
SER A 538
PHE A 540
 None
 0.81A 5p9iA-4xi2A:
41.2		 5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
 None
 0.71A 5p9iA-4xi2A:
41.2		 5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 416
LYS A 430
MET A 449
ILE A 472
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
 None
 0.90A 5p9iA-4xi2A:
41.2		 5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		9 GLY A 411
VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
LEU A 528
SER A 538
PHE A 540
 746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
None
 0.71A 5p9iA-4y93A:
42.6		 5p9iA-4y93A:
60.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
LEU A 528
SER A 538
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
None
 0.73A 5p9iA-4y93A:
42.6		 5p9iA-4y93A:
60.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		10 VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
None
 0.48A 5p9iA-4y93A:
42.6		 5p9iA-4y93A:
60.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  13
VAL A  18
ALA A  31
LYS A  33
LEU A 135
PHE A 147
 None
 0.80A 5p9iA-4yc6A:
26.1		 5p9iA-4yc6A:
25.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 469
VAL A 471
ALA A 481
LYS A 483
ILE A 527
THR A 529
PHE A 595
 None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-3.7A)
 1.40A 5p9iA-5fd2A:
22.6		 5p9iA-5fd2A:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 600
VAL A 607
ALA A 625
THR A 674
GLY A 680
ASN A 684
LEU A 825
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
None
748  A1001 (-4.3A)
 1.24A 5p9iA-5grnA:
24.6		 5p9iA-5grnA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 607
ALA A 625
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.77A 5p9iA-5grnA:
24.6		 5p9iA-5grnA:
35.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A  94
ALA A 105
ILE A 146
THR A 148
GLY A 154
LEU A 215
 None
 0.67A 5p9iA-5gz8A:
18.9		 5p9iA-5gz8A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
PHE A 152
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.1A)
 0.85A 5p9iA-5hesA:
22.0		 5p9iA-5hesA:
28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 647
ALA A 663
ILE A 709
THR A 711
LEU A 765
SER A 775
 None
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
6P6  A1001 ( 3.7A)
 0.44A 5p9iA-5l6oA:
30.3		 5p9iA-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 6 GLY A 330
VAL A 335
ALA A 348
LYS A 350
LEU A 447
SER A 457
 M77  A 601 (-2.6A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
 0.93A 5p9iA-5vefA:
24.7		 5p9iA-5vefA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 134
VAL A 139
ALA A 150
GLY A 196
LEU A 243
SER A 253
PHE A 255
 9FS  A 501 ( 4.0A)
9FS  A 501 (-4.5A)
9FS  A 501 (-3.4A)
9FS  A 501 (-3.6A)
9FS  A 501 (-4.7A)
9FS  A 501 ( 4.3A)
None
 0.72A 5p9iA-5vo1A:
28.1		 5p9iA-5vo1A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 139
ALA A 150
ILE A 188
GLY A 196
LEU A 243
SER A 253
PHE A 255
 9FS  A 501 (-4.5A)
9FS  A 501 (-3.4A)
None
9FS  A 501 (-3.6A)
9FS  A 501 (-4.7A)
9FS  A 501 ( 4.3A)
None
 0.71A 5p9iA-5vo1A:
28.1		 5p9iA-5vo1A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.67A 5p9iA-5w5jA:
24.6		 5p9iA-5w5jA:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 ALA A 917
MET A 938
THR A 963
GLY A 969
ASN A 973
LEU A1017
PHE A1029
 ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
ANP  A1201 (-4.7A)
None
 0.70A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 GLY A 897
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
PHE A1029
 None
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
None
 1.28A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 VAL A 899
ALA A 917
ILE A 961
THR A 963
GLY A 969
ASN A 973
LEU A1017
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
ANP  A1201 (-4.7A)
None
 0.81A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
ASN A 973
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
None
None
 1.04A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 8 VAL A  41
ALA A  54
LYS A  56
MET A  74
ILE A  97
GLY A 105
LEU A 153
PHE A 165
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.91A 5p9iA-6ao5A:
24.6		 5p9iA-6ao5A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 VAL A 205
ALA A 217
ILE A 262
THR A 264
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.41A 5p9iA-6cz4A:
33.4		 5p9iA-6cz4A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 VAL A 205
ALA A 217
MET A 239
ILE A 262
THR A 264
GLY A 270
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
 0.57A 5p9iA-6cz4A:
33.4		 5p9iA-6cz4A:
17.97