SIMILAR PATTERNS OF AMINO ACIDS FOR 5OY0_B_PQNB1844

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)

(Pyrococcus
woesei) 		PF00382
(TFIIB) 		5 SER B1222
ILE B1232
ALA B1229
LEU B1255
ALA B1216
 None
 1.47A 5oy0b-1aisB:
0.0		 5oy0b-1aisB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 PHE A 387
ARG A 410
ILE A 400
ALA A 406
LEU A 409
 None
 1.44A 5oy0b-1b0kA:
0.0		 5oy0b-1b0kA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds9 OUTER ARM DYNEIN

(Chlamydomonas
reinhardtii) 		PF12799
(LRR_4) 		5 MET A  69
SER A  65
ILE A  34
ALA A   4
ALA A  42
 None
 1.39A 5oy0b-1ds9A:
undetectable		 5oy0b-1ds9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq7 OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 MET A 468
ARG A 460
TRP A 464
ALA A 457
ALA A 462
 None
 1.24A 5oy0b-1iq7A:
undetectable		 5oy0b-1iq7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 MET A 285
PHE A 289
ILE A 237
ALA A 264
ALA A 292
 None
 1.46A 5oy0b-1r6vA:
undetectable		 5oy0b-1r6vA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		5 MET A  49
SER A  71
ARG A 202
ILE A 375
LEU A 203
 None
 1.31A 5oy0b-1tg5A:
undetectable		 5oy0b-1tg5A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 MET A 335
PHE A 331
ILE A 367
LEU A 323
ALA A 328
 None
 1.46A 5oy0b-2gb3A:
undetectable		 5oy0b-2gb3A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 MET A 353
PHE A 351
ALA A 449
LEU A 417
ALA A 350
 None
 1.45A 5oy0b-2ocaA:
undetectable		 5oy0b-2ocaA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		5 MET A 183
PHE A 181
ALA A 168
LEU A 171
ALA A 178
 None
 1.34A 5oy0b-2pkeA:
1.0		 5oy0b-2pkeA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		5 MET A 210
PHE A 203
ILE A 105
LEU A 112
ALA A 205
 None
None
None
NAD  A 400 (-4.0A)
None
 1.23A 5oy0b-2pv7A:
undetectable		 5oy0b-2pv7A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		5 MET A 210
PHE A 203
ILE A 149
LEU A 112
ALA A 205
 None
None
None
NAD  A 400 (-4.0A)
None
 1.35A 5oy0b-2pv7A:
undetectable		 5oy0b-2pv7A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		5 SER A  87
ARG A  37
ALA A  60
LEU A  38
ALA A  36
 None
 1.48A 5oy0b-2wsbA:
undetectable		 5oy0b-2wsbA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7i MEVALONATE KINASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PHE A 231
ILE A 287
ALA A 260
LEU A 277
ALA A 228
 None
 1.30A 5oy0b-2x7iA:
undetectable		 5oy0b-2x7iA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		5 PHE A 179
ILE A 134
ALA A 132
LEU A 267
ALA A 275
 None
 1.45A 5oy0b-2zymA:
undetectable		 5oy0b-2zymA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 PHE A  88
SER A  92
ALA A 237
LEU A 240
ALA A 244
 None
 1.43A 5oy0b-3aatA:
undetectable		 5oy0b-3aatA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya) 		PF00182
(Glyco_hydro_19) 		5 PHE A  34
ILE A 117
ALA A 154
LEU A 155
ALA A  37
 None
NAG  A 245 (-4.3A)
None
None
None
 1.06A 5oy0b-3cqlA:
undetectable		 5oy0b-3cqlA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6c THERMONUCLEASE

(Staphylococcus
aureus) 		PF00565
(SNase) 		5 MET A  65
PHE A  61
ALA A 109
LEU A 108
ALA A  58
 None
 1.42A 5oy0b-3d6cA:
undetectable		 5oy0b-3d6cA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 PHE A 249
TRP A  82
ALA A  83
LEU A  88
ALA A 267
 None
 1.27A 5oy0b-3d6kA:
undetectable		 5oy0b-3d6kA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 MET A  33
PHE A  35
SER A 107
ILE A 309
LEU A 104
 None
None
MLY  A 314 ( 4.8A)
None
None
 1.21A 5oy0b-3e3xA:
undetectable		 5oy0b-3e3xA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacillus
halodurans) 		PF13460
(NAD_binding_10) 		5 SER A 109
ILE A  94
ALA A  90
LEU A  87
ALA A 129
 None
 1.42A 5oy0b-3e8xA:
undetectable		 5oy0b-3e8xA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep1 PGRP-HD -
PEPTIDOGLYCAN
RECOGNITION PROTEIN
HOMOLOGUE

(Alvinella
pompejana) 		PF01510
(Amidase_2) 		5 PHE A 235
SER A 198
ILE A 163
ALA A 204
LEU A 205
 None
 1.44A 5oy0b-3ep1A:
undetectable		 5oy0b-3ep1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwr CHITINASE

(Oryza sativa) 		PF00182
(Glyco_hydro_19) 		5 PHE A 121
ILE A 204
ALA A 241
LEU A 242
ALA A 124
 None
MES  A   1 (-4.6A)
None
None
None
 1.08A 5oy0b-3iwrA:
undetectable		 5oy0b-3iwrA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		5 MET A 420
PHE A 418
ILE A  61
LEU A  82
ALA A 401
 None
 1.49A 5oy0b-3mtwA:
undetectable		 5oy0b-3mtwA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 120
ILE A 344
ALA A 309
LEU A 313
ALA A 127
 None
 1.42A 5oy0b-3r11A:
undetectable		 5oy0b-3r11A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 SER A 590
ILE A 499
ALA A 490
LEU A 488
ALA A 456
 None
 1.45A 5oy0b-3vi3A:
undetectable		 5oy0b-3vi3A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		5 PHE A  35
ILE A 116
ALA A 153
LEU A 154
ALA A  38
 None
 1.03A 5oy0b-3w3eA:
undetectable		 5oy0b-3w3eA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		5 PHE A 171
ILE A 200
ALA A 180
LEU A 173
ALA A 172
 None
 1.39A 5oy0b-3wj9A:
undetectable		 5oy0b-3wj9A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 MET A 481
SER A 478
ILE A 555
ALA A 564
LEU A 568
 None
 1.45A 5oy0b-4a2qA:
1.9		 5oy0b-4a2qA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 MET A 481
SER A 478
ILE A 555
ALA A 564
LEU A 568
 None
 1.45A 5oy0b-4a2wA:
1.9		 5oy0b-4a2wA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg0 COMPLEMENT
REGULATOR-ACQUIRING
SURFACE PROTEIN 2
(CRASP-2 (CRASP-2)

(Borreliella
burgdorferi) 		no annotation 5 PHE A 145
ILE A 184
ALA A 204
LEU A 207
ALA A 148
 None
 1.46A 5oy0b-4bg0A:
undetectable		 5oy0b-4bg0A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz6 NUCLEOSIDE
DIPHOSPHATE KINASE

(Borreliella
burgdorferi) 		PF00334
(NDK) 		5 SER A  89
ARG A  94
ILE A 133
ALA A 135
ALA A 142
 None
ADP  A1001 ( 2.9A)
None
VN4  A1002 (-4.6A)
None
 1.25A 5oy0b-4dz6A:
undetectable		 5oy0b-4dz6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 PHE A 334
ILE A 322
ALA A 323
LEU A 305
ALA A 330
 None
 1.43A 5oy0b-4ehiA:
undetectable		 5oy0b-4ehiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 MET A 229
ILE A  60
ALA A  76
LEU A 222
ALA A 223
 None
 1.49A 5oy0b-4fx5A:
undetectable		 5oy0b-4fx5A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 SER A 493
ARG A 744
ALA A 716
LEU A 711
ALA A 710
 None
 1.42A 5oy0b-4g9iA:
undetectable		 5oy0b-4g9iA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		5 PHE A  38
ILE A  62
ALA A  63
LEU A 128
ALA A  53
 None
 1.27A 5oy0b-4h2kA:
undetectable		 5oy0b-4h2kA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 MET A 270
PHE A 125
ILE A 312
ALA A 313
ALA A 124
 None
 1.28A 5oy0b-4hyyA:
undetectable		 5oy0b-4hyyA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 MET A 627
ILE A 615
ALA A 592
LEU A 595
ALA A 598
 None
 1.36A 5oy0b-4k17A:
undetectable		 5oy0b-4k17A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of0 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set)
PF08205
(C2-set_2) 		5 SER A 229
TRP A 165
ILE A 245
ALA A 166
LEU A 180
 None
 1.48A 5oy0b-4of0A:
undetectable		 5oy0b-4of0A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 5 SER H 428
TRP H 377
TRP H 295
ILE H 503
ALA H 378
 None
 1.31A 5oy0b-4qfkH:
undetectable		 5oy0b-4qfkH:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		8 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.65A 5oy0b-4rkuA:
34.2		 5oy0b-4rkuA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		10 MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.45A 5oy0b-4rkuB:
43.5		 5oy0b-4rkuB:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ail POLY [ADP-RIBOSE]
POLYMERASE 9

(Homo sapiens) 		PF01661
(Macro) 		5 MET A 448
PHE A 412
SER A 445
ALA A 394
ALA A 408
 None
 1.43A 5oy0b-5ailA:
undetectable		 5oy0b-5ailA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		5 MET A 267
SER A 277
ARG A 311
ILE A 314
ALA A 313
 None
 1.44A 5oy0b-5gwnA:
undetectable		 5oy0b-5gwnA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		5 MET A 283
PHE A 284
ILE A 309
ALA A 299
LEU A 298
 None
 1.37A 5oy0b-5h7dA:
undetectable		 5oy0b-5h7dA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		5 PHE A  58
SER A 130
ALA A  46
LEU A  61
ALA A  57
 None
SO4  A 304 (-4.1A)
None
None
None
 1.48A 5oy0b-5hk2A:
undetectable		 5oy0b-5hk2A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 SER A 404
ILE A  95
ALA A  57
LEU A  80
ALA A  79
 None
 1.46A 5oy0b-5ixdA:
undetectable		 5oy0b-5ixdA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		5 PHE A 242
ARG A 240
ILE A 299
LEU A 243
ALA A 239
 None
 1.49A 5oy0b-5jk6A:
undetectable		 5oy0b-5jk6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S7

(Leishmania
donovani) 		no annotation 5 SER H 173
ILE H  86
ALA H 160
LEU H 159
ALA H 144
 None
 0.97A 5oy0b-6az1H:
2.4		 5oy0b-6az1H:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 7 MET A 681
PHE A 682
SER A 685
ARG A 687
TRP A 690
ILE A 694
ALA A 714
 PQN  A2001 ( 3.3A)
PQN  A2001 (-4.3A)
PQN  A2001 (-4.4A)
None
PQN  A2001 ( 3.2A)
None
PQN  A2001 (-3.2A)
 0.81A 5oy0b-6fosA:
32.1		 5oy0b-6fosA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 7 MET A 681
PHE A 682
SER A 685
TRP A 690
ILE A 694
ALA A 714
LEU A 715
 PQN  A2001 ( 3.3A)
PQN  A2001 (-4.3A)
PQN  A2001 (-4.4A)
PQN  A2001 ( 3.2A)
None
PQN  A2001 (-3.2A)
PQN  A2001 (-3.7A)
 0.71A 5oy0b-6fosA:
32.1		 5oy0b-6fosA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 9 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.66A 5oy0b-6fosB:
32.7		 5oy0b-6fosB:
85.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 9 PHE B 661
SER B 664
TRP B 665
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.96A 5oy0b-6fosB:
32.7		 5oy0b-6fosB:
85.00