SIMILAR PATTERNS OF AMINO ACIDS FOR 5OY0_2_PQN2843

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 TRP A 349
ILE A 213
ILE A  19
ALA A 351
ALA A 123
 None
 1.29A 5oy02-1a59A:
0.0		 5oy02-1a59A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 ILE A 131
ILE A  65
ALA A 257
LEU A 138
ALA A 139
 FAD  A 600 ( 4.7A)
None
None
None
None
 1.23A 5oy02-1d4eA:
undetectable		 5oy02-1d4eA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		6 ILE A 407
ARG A 400
ILE A 425
ALA A 417
LEU A 415
ALA A 412
 None
 1.44A 5oy02-1ecgA:
undetectable		 5oy02-1ecgA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 326
PHE A 354
ILE A 123
ALA A  36
ALA A 350
 None
 1.26A 5oy02-1k4qA:
0.0		 5oy02-1k4qA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ILE A 208
PHE A 349
ILE A 284
LEU A 299
ALA A 346
 None
 1.12A 5oy02-1lamA:
undetectable		 5oy02-1lamA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 ILE A 229
ILE A  20
ALA A  18
LEU A  97
ALA A 114
 None
 1.30A 5oy02-1n4dA:
undetectable		 5oy02-1n4dA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 ILE A 268
SER A 349
ILE A 368
ALA A 386
ALA A 311
 None
 0.94A 5oy02-1ot5A:
undetectable		 5oy02-1ot5A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 258
SER A 321
ARG A 319
ALA A 315
ALA A 199
 None
 1.06A 5oy02-1rpnA:
undetectable		 5oy02-1rpnA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 ILE A 269
ARG A 389
ILE A 396
ALA A 323
LEU A 324
 None
 1.19A 5oy02-1su7A:
0.0		 5oy02-1su7A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		5 ILE B 239
PHE B   7
SER B  13
ARG B  78
ALA B 233
 None
 1.27A 5oy02-1ta3B:
undetectable		 5oy02-1ta3B:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		5 TRP A   6
SER A 109
TRP A  96
ALA A  80
LEU A  83
 None
 1.31A 5oy02-1u0kA:
undetectable		 5oy02-1u0kA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		5 ILE A 208
ILE A 230
ALA A 234
LEU A 237
ALA A 242
 None
 1.09A 5oy02-1xfiA:
2.4		 5oy02-1xfiA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 5 PHE A 106
ILE A  44
ALA A  82
LEU A  83
ALA A 110
 None
 1.09A 5oy02-1yrgA:
undetectable		 5oy02-1yrgA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ILE A 431
PHE A 415
ALA A 425
LEU A 424
ALA A 520
 None
 1.27A 5oy02-2b3xA:
undetectable		 5oy02-2b3xA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		5 ILE A  74
ARG A 106
ALA A 102
LEU A 105
ALA A 110
 None
 1.31A 5oy02-2bkwA:
undetectable		 5oy02-2bkwA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE A 115
MET A  62
PHE A  76
ALA A 240
LEU A 242
 None
 1.29A 5oy02-2f43A:
undetectable		 5oy02-2f43A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 ILE A 685
SER A 669
ILE A 484
ALA A 479
LEU A 706
 None
 1.31A 5oy02-2f8tA:
undetectable		 5oy02-2f8tA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN
ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans)
PF03255
(ACCA) 		5 ILE A 264
SER B 209
ALA A 210
LEU A 209
ALA B 178
 None
 1.30A 5oy02-2f9yA:
undetectable		 5oy02-2f9yA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 ILE A  49
PHE A  36
ALA A 216
LEU A 215
ALA A  39
 None
 1.01A 5oy02-2felA:
undetectable		 5oy02-2felA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ILE A 304
MET A 108
ILE A 358
ALA A  75
LEU A  89
 None
 1.12A 5oy02-2i14A:
undetectable		 5oy02-2i14A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 ILE A 288
PHE A 133
SER A  77
ALA A 323
ALA A  74
 None
None
None
GUN  A 503 ( 4.1A)
None
 1.32A 5oy02-2i9uA:
undetectable		 5oy02-2i9uA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 PHE A  70
ILE A  45
ALA A 277
LEU A 278
ALA A  73
 None
 1.08A 5oy02-2o1bA:
undetectable		 5oy02-2o1bA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		5 MET A 183
PHE A 181
ALA A 168
LEU A 171
ALA A 178
 None
 1.28A 5oy02-2pkeA:
undetectable		 5oy02-2pkeA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		5 ILE A 309
MET A 210
ILE A 105
LEU A 112
ALA A 205
 None
None
None
NAD  A 400 (-4.0A)
None
 1.21A 5oy02-2pv7A:
undetectable		 5oy02-2pv7A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		6 ILE A 309
MET A 210
PHE A 203
ILE A 149
LEU A 112
ALA A 205
 None
None
None
None
NAD  A 400 (-4.0A)
None
 1.30A 5oy02-2pv7A:
undetectable		 5oy02-2pv7A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 456
SER A 436
ARG A 468
ALA A 255
LEU A 467
 None
 1.25A 5oy02-2w40A:
undetectable		 5oy02-2w40A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 ILE A 256
PHE A 236
ILE A 178
LEU A 180
ALA A 239
 None
None
GOL  A1342 (-4.4A)
None
None
 1.31A 5oy02-2wabA:
undetectable		 5oy02-2wabA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7i MEVALONATE KINASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PHE A 231
ILE A 287
ALA A 260
LEU A 277
ALA A 228
 None
 1.32A 5oy02-2x7iA:
undetectable		 5oy02-2x7iA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 TRP A 136
ILE A 315
ALA A 398
LEU A 401
ALA A 508
 None
 1.09A 5oy02-2yikA:
1.1		 5oy02-2yikA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 ILE A 279
ILE A 758
ALA A 755
LEU A 734
ALA A 737
 None
 1.18A 5oy02-2yn9A:
undetectable		 5oy02-2yn9A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 147
TRP A 135
ILE A 217
ALA A 131
LEU A 134
 None
 1.04A 5oy02-2yv3A:
undetectable		 5oy02-2yv3A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		5 ILE A 176
ILE A  28
ALA A  16
LEU A  19
ALA A  24
 None
 1.20A 5oy02-2ywbA:
undetectable		 5oy02-2ywbA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		5 ILE A 130
ILE A 333
ALA A  90
LEU A  87
ALA A  85
 None
 1.11A 5oy02-3a21A:
undetectable		 5oy02-3a21A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 ILE B 242
PHE B 199
ILE B  25
ALA B 222
LEU B 223
 None
 1.28A 5oy02-3adaB:
undetectable		 5oy02-3adaB:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		5 PHE A 185
ILE A 159
ALA A 165
LEU A 169
ALA A 188
 None
 1.30A 5oy02-3cnnA:
undetectable		 5oy02-3cnnA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya) 		PF00182
(Glyco_hydro_19) 		5 PHE A  34
ILE A 117
ALA A 154
LEU A 155
ALA A  37
 None
NAG  A 245 (-4.3A)
None
None
None
 1.01A 5oy02-3cqlA:
undetectable		 5oy02-3cqlA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6c THERMONUCLEASE

(Staphylococcus
aureus) 		PF00565
(SNase) 		5 MET A  65
PHE A  61
ALA A 109
LEU A 108
ALA A  58
 None
 1.31A 5oy02-3d6cA:
undetectable		 5oy02-3d6cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 MET A  33
PHE A  35
SER A 107
ILE A 309
LEU A 104
 None
None
MLY  A 314 ( 4.8A)
None
None
 1.16A 5oy02-3e3xA:
undetectable		 5oy02-3e3xA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		5 ILE A 267
PHE A  73
ALA A 111
LEU A 110
ALA A 106
 None
 1.25A 5oy02-3g23A:
undetectable		 5oy02-3g23A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 MET A  79
SER A  76
TRP A  18
ALA A  12
LEU A  11
 None
None
None
FAD  A 444 (-3.4A)
FAD  A 444 (-4.2A)
 1.22A 5oy02-3g5sA:
undetectable		 5oy02-3g5sA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		5 ILE A  60
PHE A 133
ILE A 212
ALA A 239
LEU A 160
 None
None
EDO  A 258 (-3.8A)
None
None
 1.26A 5oy02-3ggdA:
undetectable		 5oy02-3ggdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE

(Bordetella
bronchiseptica) 		PF07969
(Amidohydro_3) 		5 ILE A 452
ILE A  36
ALA A 426
LEU A 456
ALA A 460
 None
 1.07A 5oy02-3gipA:
undetectable		 5oy02-3gipA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		5 ILE A1613
PHE A1526
SER A1531
ALA A1537
LEU A1580
 None
 1.26A 5oy02-3hrrA:
undetectable		 5oy02-3hrrA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		5 ILE A 105
SER A 121
ILE A 100
ALA A 101
ALA A 222
 None
 1.24A 5oy02-3iibA:
undetectable		 5oy02-3iibA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 ILE A 108
SER A 424
TRP A 478
ILE A 195
LEU A 139
 None
 1.22A 5oy02-3js8A:
undetectable		 5oy02-3js8A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Legionella
pneumophila) 		PF01063
(Aminotran_4) 		5 ILE A  22
PHE A  60
ARG A  48
ILE A  32
LEU A  49
 None
None
LLP  A 140 ( 2.5A)
None
None
 1.27A 5oy02-3lulA:
undetectable		 5oy02-3lulA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgl SULFATE PERMEASE
FAMILY PROTEIN

(Vibrio cholerae) 		PF01740
(STAS) 		5 PHE A 536
SER A 508
ILE A 472
ALA A 543
LEU A 540
 None
IOD  A 602 (-3.4A)
None
None
None
 1.22A 5oy02-3mglA:
undetectable		 5oy02-3mglA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 ILE A  22
PHE A 131
ALA A 142
LEU A 141
ALA A 134
 None
AZM  A 264 (-4.4A)
None
None
None
 1.03A 5oy02-3ml5A:
undetectable		 5oy02-3ml5A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		5 MET A 204
PHE A 200
ILE A 371
ALA A 220
ALA A 197
 None
None
None
None
OAA  A 430 ( 4.4A)
 1.14A 5oy02-3msuA:
undetectable		 5oy02-3msuA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		5 ILE A 323
PHE A 254
SER A 216
ILE A 275
ALA A 274
 None
None
None
None
CA  A   4 ( 4.5A)
 1.31A 5oy02-3s6jA:
undetectable		 5oy02-3s6jA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 TRP A 453
PHE A 405
ALA A 400
LEU A 403
ALA A 404
 None
 1.28A 5oy02-3sdqA:
2.8		 5oy02-3sdqA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ILE A 302
ILE A 276
ALA A 295
LEU A 290
ALA A 289
 None
 1.17A 5oy02-3tsdA:
undetectable		 5oy02-3tsdA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A  33
PHE A  73
ARG A  71
ALA A  68
LEU A  72
 None
 1.28A 5oy02-3u5tA:
undetectable		 5oy02-3u5tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		5 ILE A 153
PHE A 268
ALA A 290
LEU A 287
ALA A 283
 None
 1.09A 5oy02-3ujhA:
3.4		 5oy02-3ujhA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 ILE A 143
PHE A 156
SER A 218
ALA A 115
LEU A 147
 None
 1.32A 5oy02-3uyqA:
undetectable		 5oy02-3uyqA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		5 PHE A  35
ILE A 116
ALA A 153
LEU A 154
ALA A  38
 None
 1.01A 5oy02-3w3eA:
undetectable		 5oy02-3w3eA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 TRP A1019
ILE A 544
SER A 977
ILE A 944
ALA A1012
 None
 1.21A 5oy02-3w9iA:
3.6		 5oy02-3w9iA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		5 ILE A 194
PHE A 184
ILE A 149
ALA A 109
ALA A 183
 None
 1.13A 5oy02-3wa8A:
undetectable		 5oy02-3wa8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 ILE A  12
SER A  49
ALA A 409
LEU A 420
ALA A 419
 None
B07  A 500 (-1.4A)
None
None
None
 1.19A 5oy02-3zvtA:
undetectable		 5oy02-3zvtA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE A 355
PHE A 377
ILE A 134
LEU A 165
ALA A 374
 None
 1.00A 5oy02-4ak9A:
undetectable		 5oy02-4ak9A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		5 MET A 209
PHE A 154
ILE A 482
LEU A 234
ALA A 228
 None
 1.27A 5oy02-4b2gA:
undetectable		 5oy02-4b2gA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg0 COMPLEMENT
REGULATOR-ACQUIRING
SURFACE PROTEIN 2
(CRASP-2 (CRASP-2)

(Borreliella
burgdorferi) 		no annotation 5 ILE A 136
ILE A 184
ALA A 204
LEU A 207
ALA A 148
 None
 1.13A 5oy02-4bg0A:
3.9		 5oy02-4bg0A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 ILE A 316
MET A 374
ALA A 383
LEU A 291
ALA A 290
 None
 1.26A 5oy02-4bhdA:
undetectable		 5oy02-4bhdA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz6 NUCLEOSIDE
DIPHOSPHATE KINASE

(Borreliella
burgdorferi) 		PF00334
(NDK) 		5 SER A  89
ARG A  94
ILE A 133
ALA A 135
ALA A 142
 None
ADP  A1001 ( 2.9A)
None
VN4  A1002 (-4.6A)
None
 1.28A 5oy02-4dz6A:
undetectable		 5oy02-4dz6A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6y CITRATE SYNTHASE

(Vibrio
vulnificus) 		PF00285
(Citrate_synt) 		5 MET A 202
PHE A 198
ILE A 369
ALA A 219
ALA A 195
 None
None
None
None
FMT  A 504 ( 4.9A)
 1.16A 5oy02-4e6yA:
undetectable		 5oy02-4e6yA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		5 PHE A  38
ILE A  62
ALA A  63
LEU A 128
ALA A  53
 None
 1.19A 5oy02-4h2kA:
undetectable		 5oy02-4h2kA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 TRP L 316
MET L  76
PHE L  75
ALA L 478
LEU L 473
 None
 1.27A 5oy02-4heaL:
3.3		 5oy02-4heaL:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		5 ILE A 254
TRP A 211
ILE A 169
ALA A 158
LEU A 156
 None
 1.32A 5oy02-4humA:
undetectable		 5oy02-4humA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 MET A 270
PHE A 125
ILE A 312
ALA A 313
ALA A 124
 None
 1.24A 5oy02-4hyyA:
undetectable		 5oy02-4hyyA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ILE A  63
PHE A  24
ALA A  34
LEU A  21
ALA A  22
 None
 1.32A 5oy02-4llsA:
2.3		 5oy02-4llsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onu ACETYLTRANSFERASE
PAT

(Mycolicibacterium
smegmatis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ILE A 106
PHE A  18
ALA A  30
LEU A  12
ALA A  13
 None
 1.15A 5oy02-4onuA:
undetectable		 5oy02-4onuA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		5 ILE A 101
PHE A  81
SER A  78
ILE A  53
LEU A  58
 None
 1.18A 5oy02-4pagA:
undetectable		 5oy02-4pagA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		5 PHE A 263
SER A 285
ILE A 295
ALA A 294
ALA A 266
 None
 1.13A 5oy02-4r89A:
undetectable		 5oy02-4r89A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		9 TRP A  55
MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.57A 5oy02-4rkuA:
34.1		 5oy02-4rkuA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		9 ILE B  21
MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
LEU B 700
ALA B 705
 CLA  A1131 ( 4.4A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 1.48A 5oy02-4rkuB:
43.3		 5oy02-4rkuB:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		12 TRP B  22
ILE B  25
MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B1201 ( 4.7A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.42A 5oy02-4rkuB:
43.3		 5oy02-4rkuB:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 ILE L 297
PHE L 421
ILE L 432
ALA L 429
LEU L 388
 None
MPD  L 604 (-4.8A)
None
None
None
 1.31A 5oy02-4u9iL:
3.6		 5oy02-4u9iL:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		5 ILE A 153
PHE A 104
ALA A 305
LEU A 306
ALA A 108
 None
 1.22A 5oy02-4ypvA:
undetectable		 5oy02-4ypvA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		5 ILE A 113
PHE A  50
SER A 195
ILE A 170
ALA A 189
 None
 1.26A 5oy02-4yt2A:
undetectable		 5oy02-4yt2A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 6 TRP A  97
ILE A 133
ILE A 311
ALA A  93
LEU A 269
ALA A 159
 None
 1.08A 5oy02-4zh7A:
5.1		 5oy02-4zh7A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A1177
PHE A1260
ILE A1225
LEU A1195
ALA A1192
 None
 1.26A 5oy02-5a42A:
2.2		 5oy02-5a42A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 317
ARG A 179
ALA A 177
LEU A 319
ALA A 318
 None
 1.10A 5oy02-5by7A:
undetectable		 5oy02-5by7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		5 ILE A  65
ILE A 165
ALA A 166
LEU A  74
ALA A 118
 None
 1.28A 5oy02-5eebA:
undetectable		 5oy02-5eebA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 6 TRP A  97
ILE A 133
ILE A 305
ALA A  93
LEU A 266
ALA A 159
 None
 1.09A 5oy02-5f9aA:
1.9		 5oy02-5f9aA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF09427
(DUF2014) 		5 ILE A 844
SER A 757
ILE A 832
LEU A 799
ALA A 800
 None
 1.24A 5oy02-5gpdA:
undetectable		 5oy02-5gpdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 PHE A 129
ILE A 137
ALA A 151
LEU A 121
ALA A 126
 None
 1.29A 5oy02-5kkgA:
undetectable		 5oy02-5kkgA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		5 ILE D 465
SER F 205
ILE D 507
LEU D 514
ALA D 515
 None
 1.28A 5oy02-5mg3D:
undetectable		 5oy02-5mg3D:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 ILE A 302
ILE A 276
ALA A 295
LEU A 290
ALA A 289
 None
 1.17A 5oy02-5uuwA:
undetectable		 5oy02-5uuwA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 ILE A 557
PHE A 610
SER A 680
ALA A 672
ALA A 603
 None
 1.14A 5oy02-5ve8A:
undetectable		 5oy02-5ve8A:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 PHE A 610
SER A 680
ILE A 621
ALA A 672
ALA A 603
 None
 1.27A 5oy02-5ve8A:
undetectable		 5oy02-5ve8A:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 5 ILE B 269
ILE B 249
ALA B 252
LEU B 256
ALA B 257
 None
 1.21A 5oy02-5vqiB:
undetectable		 5oy02-5vqiB:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7v NUCLEOSOME ASSEMBLY
PROTEIN

(Plasmodium
falciparum) 		PF00956
(NAP) 		5 ILE A 166
PHE A 123
TRP A  80
ALA A  81
LEU A 101
 None
 1.23A 5oy02-5x7vA:
undetectable		 5oy02-5x7vA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S7

(Leishmania
donovani) 		no annotation 5 SER H 173
ILE H  86
ALA H 160
LEU H 159
ALA H 144
 None
 0.92A 5oy02-6az1H:
undetectable		 5oy02-6az1H:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 5 ILE A 415
SER A 225
ALA A  21
LEU A  18
ALA A  13
 FAD  A 507 (-3.7A)
None
None
None
None
 1.17A 5oy02-6cr0A:
undetectable		 5oy02-6cr0A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 9 TRP A  46
MET A 681
PHE A 682
SER A 685
ARG A 687
TRP A 690
ILE A 694
ALA A 714
LEU A 715
 None
PQN  A2001 ( 3.3A)
PQN  A2001 (-4.3A)
PQN  A2001 (-4.4A)
None
PQN  A2001 ( 3.2A)
None
PQN  A2001 (-3.2A)
PQN  A2001 (-3.7A)
 0.83A 5oy02-6fosA:
31.9		 5oy02-6fosA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 11 TRP B  22
ILE B  25
MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1201 ( 4.6A)
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.74A 5oy02-6fosB:
32.6		 5oy02-6fosB:
85.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 10 TRP B  22
ILE B  25
PHE B 661
TRP B 665
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1201 ( 4.6A)
PQN  B2002 ( 4.3A)
None
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 1.04A 5oy02-6fosB:
32.6		 5oy02-6fosB:
85.71