SIMILAR PATTERNS OF AMINO ACIDS FOR 5OWR_A_1N1A401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ALA A 220
GLU A 236
LEU A 321
ASP A 332
 None
 0.51A 5owrA-1k9aA:
22.0		 5owrA-1k9aA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ALA A 185
GLU A 202
LEU A 301
ASP A 550
 ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.53A 5owrA-1q8yA:
21.1		 5owrA-1q8yA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 642
GLU A 661
CYH A 694
LEU A 818
 None
 0.48A 5owrA-1rjbA:
19.6		 5owrA-1rjbA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 621
GLU A 640
CYH A 673
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
 0.51A 5owrA-1t46A:
20.5		 5owrA-1t46A:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 367
GLU A 386
LEU A 468
ASP A 479
 STU  A 100 (-3.2A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.37A 5owrA-1u59A:
21.9		 5owrA-1u59A:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
CYH A 108
LEU A 158
ASP A 169
VAL A 301
 None
 0.49A 5owrA-1u5qA:
29.5		 5owrA-1u5qA:
33.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  36
GLU A  55
CYH A  87
LEU A 137
ASP A 148
 HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.49A 5owrA-1zltA:
21.0		 5owrA-1zltA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  47
GLU A  65
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
None
STU  A1301 ( 4.8A)
None
 0.59A 5owrA-2bujA:
23.9		 5owrA-2bujA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		5 ALA A  39
GLU A  55
ILE A  85
LEU A 138
ASP A 154
 CKI  A 300 (-3.6A)
None
CKI  A 300 ( 4.5A)
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 0.85A 5owrA-2csnA:
20.4		 5owrA-2csnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA X  37
GLU X  54
LEU X 137
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.54A 5owrA-2dq7X:
22.6		 5owrA-2dq7X:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 184
GLU A 201
LEU A 290
ASP A 320
 None
 0.44A 5owrA-2eu9A:
22.5		 5owrA-2eu9A:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
CYH A 108
LEU A 158
ASP A 169
VAL A 301
 STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
None
 0.52A 5owrA-2gcdA:
29.3		 5owrA-2gcdA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ALA A 452
GLU A 471
CYH A 502
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.83A 5owrA-2j0jA:
21.9		 5owrA-2j0jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 GLU A 471
CYH A 502
LEU A 553
ASP A 564
VAL A 513
 4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
None
 1.13A 5owrA-2j0jA:
21.9		 5owrA-2j0jA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  31
GLU A  51
LEU A 134
ASP A 145
 None
 0.55A 5owrA-2jgzA:
22.9		 5owrA-2jgzA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 614
GLU A 633
CYH A 666
LEU A 785
 None
 0.63A 5owrA-2ogvA:
19.3		 5owrA-2ogvA:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 ALA A  46
GLU A  73
LEU A 156
ASP A 167
 ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.48A 5owrA-2phkA:
23.6		 5owrA-2phkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		5 ALA A  56
ILE A 143
LEU A 131
ASP A 138
VAL A  76
 None
 1.21A 5owrA-2q01A:
undetectable		 5owrA-2q01A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  98
GLU A 119
LEU A 202
ASP A 213
 BI8  A1417 ( 3.8A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.45A 5owrA-2vd5A:
21.4		 5owrA-2vd5A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		4 ALA A 509
GLU A 535
LEU A 656
ASP A 687
 5ID  A1800 (-3.4A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.55A 5owrA-2vuwA:
15.8		 5owrA-2vuwA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 445
GLU A 459
LEU A 542
ASP A 557
 None
 0.73A 5owrA-2wntA:
21.5		 5owrA-2wntA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  47
GLU A  66
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.51A 5owrA-2xikA:
23.0		 5owrA-2xikA:
42.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 326
GLU A 346
CYH A 379
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-3.8A)
 0.40A 5owrA-2z2wA:
23.1		 5owrA-2z2wA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 220
GLU A 236
LEU A 321
ASP A 332
 None
 0.51A 5owrA-3d7uA:
22.3		 5owrA-3d7uA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		4 ALA C 268
ILE C 265
ASP C 241
VAL C 184
 None
 0.64A 5owrA-3eiqC:
undetectable		 5owrA-3eiqC:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  65
GLU A  89
LEU A 174
ASP A 186
 985  A   1 (-3.5A)
MG  A 314 (-3.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.58A 5owrA-3f2aA:
16.2		 5owrA-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ALA A  55
CYH A 105
LEU A 155
ASP A 169
 DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
None
 0.72A 5owrA-3f3zA:
23.8		 5owrA-3f3zA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 859
GLU A 878
CYH A 912
LEU A1029
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
 0.56A 5owrA-3hngA:
20.5		 5owrA-3hngA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ALA A 665
GLU A 684
LEU A 767
ASP A 778
 None
 0.34A 5owrA-3kulA:
22.7		 5owrA-3kulA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 ALA A 700
GLU A 715
CYH A 748
LEU A 804
ASP A 828
 ADP  A2101 (-3.5A)
None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.58A 5owrA-3lj0A:
20.8		 5owrA-3lj0A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		4 ALA A 229
GLU A 244
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.67A 5owrA-3mdyA:
20.4		 5owrA-3mdyA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  46
GLU A  66
CYH A 106
LEU A 156
ASP A 167
 None
 0.35A 5owrA-3mi9A:
23.6		 5owrA-3mi9A:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  70
GLU A  91
LEU A 173
ASP A 184
 XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
None
 0.62A 5owrA-3mvjA:
23.0		 5owrA-3mvjA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 109
GLU A 130
LEU A 212
ASP A 223
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
SO4  A   5 ( 4.5A)
 0.71A 5owrA-3nuuA:
23.7		 5owrA-3nuuA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 ALA A 576
GLU A 596
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.45A 5owrA-3ppzA:
22.8		 5owrA-3ppzA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ALA A  84
GLU A 115
LEU A 197
ASP A 211
 ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.52A 5owrA-3q5iA:
22.6		 5owrA-3q5iA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 ALA B 616
GLU B 635
CYH B 889
ASP B 953
 None
 0.46A 5owrA-3qd2B:
20.4		 5owrA-3qd2B:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 103
GLU A 124
LEU A 207
ASP A 218
 NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.51A 5owrA-3qfvA:
13.4		 5owrA-3qfvA:
25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  71
GLU A  84
LEU A 173
ASP A 187
 I85  A 350 (-3.3A)
None
None
I85  A 350 (-3.3A)
 0.69A 5owrA-3sheA:
21.2		 5owrA-3sheA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ALA A 382
GLU A 403
LEU A 486
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.56A 5owrA-3txoA:
23.9		 5owrA-3txoA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 866
GLU A 885
CYH A 919
LEU A1035
 4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-4.8A)
 0.53A 5owrA-3vidA:
19.6		 5owrA-3vidA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
GLU A 885
CYH A 919
LEU A1035
ASP A1046
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.90A 5owrA-3wzdA:
20.9		 5owrA-3wzdA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  80
GLU A 101
CYH A 133
ASP A 194
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.44A 5owrA-4a4lA:
24.3		 5owrA-4a4lA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 866
GLU A 885
CYH A 919
LEU A1035
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
 0.57A 5owrA-4agdA:
19.4		 5owrA-4agdA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  31
GLU A  51
CYH A  83
LEU A 133
 D15  A 500 (-3.4A)
None
D15  A 500 (-4.3A)
D15  A 500 (-4.5A)
 0.50A 5owrA-4aguA:
23.3		 5owrA-4aguA:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A  51
CYH A  83
LEU A 133
ASP A 144
 None
D15  A 500 (-4.3A)
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
 0.74A 5owrA-4aguA:
23.3		 5owrA-4aguA:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ALA A 104
GLU A 125
LEU A 208
ASP A 219
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 ( 4.8A)
None
 0.33A 5owrA-4aw2A:
21.2		 5owrA-4aw2A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  89
GLU A 110
CYH A 142
ASP A 203
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
 0.43A 5owrA-4b6lA:
24.2		 5owrA-4b6lA:
28.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
GLU A  81
ILE A 110
CYH A 113
LEU A 164
VAL A 314
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-3.3A)
XZN  A1317 (-3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.5A)
 0.42A 5owrA-4bc6A:
41.8		 5owrA-4bc6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
LYS A  65
ILE A 110
CYH A 113
LEU A 164
 XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-3.3A)
XZN  A1317 (-3.7A)
XZN  A1317 (-4.7A)
 0.52A 5owrA-4bc6A:
41.8		 5owrA-4bc6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 ALA A  43
GLU A  64
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.45A 5owrA-4cfhA:
22.7		 5owrA-4cfhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ALA A 684
GLU A 705
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.35A 5owrA-4crsA:
22.9		 5owrA-4crsA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  36
GLU A  55
CYH A  89
ASP A 157
 BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 ( 3.7A)
 0.47A 5owrA-4eutA:
16.2		 5owrA-4eutA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  36
GLU A  55
CYH A  89
ASP A 157
 BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.6A)
 0.38A 5owrA-4euuA:
20.1		 5owrA-4euuA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  88
GLU A 104
LEU A 184
ASP A 196
 ADP  A 601 (-3.5A)
None
ADP  A 601 ( 4.9A)
MG  A 602 ( 3.1A)
 0.47A 5owrA-4f99A:
14.8		 5owrA-4f99A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  50
GLU A  71
LEU A 153
ASP A 164
 STU  A 401 (-3.2A)
None
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.34A 5owrA-4fr4A:
23.3		 5owrA-4fr4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 853
GLU A 871
LEU A 956
ASP A 967
 19S  A1201 (-3.3A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.46A 5owrA-4hviA:
14.9		 5owrA-4hviA:
28.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 109
GLU A 130
CYH A 162
ASP A 223
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
 0.52A 5owrA-4i6fA:
23.4		 5owrA-4i6fA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 ALA A  66
GLU A  87
CYH A 119
ASP A 180
 None
 0.71A 5owrA-4j7bA:
24.5		 5owrA-4j7bA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A  61
GLU A  77
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.53A 5owrA-4l52A:
21.4		 5owrA-4l52A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ALA A  99
GLU A 117
CYH A 149
LEU A 199
 STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
STU  A 601 (-4.7A)
 0.72A 5owrA-4mvfA:
23.0		 5owrA-4mvfA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ALA A 388
CYH A 435
LEU A 489
ASP A 500
 None
 0.61A 5owrA-4o1oA:
15.9		 5owrA-4o1oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  67
GLU A  85
CYH A 126
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
 0.59A 5owrA-4o38A:
21.8		 5owrA-4o38A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ALA B 390
CYH B 437
LEU B 492
ASP B 503
 ACP  B 801 (-3.2A)
ACP  B 801 (-4.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
 0.38A 5owrA-4oavB:
17.6		 5owrA-4oavB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 928
GLU A 947
LEU A1030
ASP A1041
 2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.60A 5owrA-4oliA:
21.8		 5owrA-4oliA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 ALA A  49
GLU A  70
LEU A 156
ASP A 167
 ANP  A 402 (-3.3A)
ANP  A 402 (-3.0A)
ANP  A 402 (-4.6A)
ANP  A 402 ( 2.6A)
 0.69A 5owrA-4qnyA:
21.4		 5owrA-4qnyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 642
GLU A 661
CYH A 694
LEU A 818
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
 0.42A 5owrA-4rt7A:
20.2		 5owrA-4rt7A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 ALA A 125
GLU A 146
LEU A 228
ASP A 239
 ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.55A 5owrA-4wb7A:
23.0		 5owrA-4wb7A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ALA A 214
GLU A 235
LEU A 321
ASP A 332
 ANW  A 601 (-3.4A)
None
ANW  A 601 (-4.9A)
None
 0.53A 5owrA-4wboA:
24.6		 5owrA-4wboA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  72
CYH A 129
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.42A 5owrA-4wsqA:
21.1		 5owrA-4wsqA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  72
GLU A  90
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.61A 5owrA-4wsqA:
21.1		 5owrA-4wsqA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  36
GLU A  52
ILE A  82
LEU A 135
ASP A 149
 CKI  A 401 (-3.3A)
None
CKI  A 401 ( 4.1A)
None
None
 0.78A 5owrA-4xhlA:
19.4		 5owrA-4xhlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 642
GLU A 661
CYH A 694
LEU A 818
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
 0.51A 5owrA-4xufA:
20.7		 5owrA-4xufA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 186
GLU A 203
LEU A 294
ASP A 307
 4E1  A 505 (-3.5A)
None
None
4E1  A 505 (-3.6A)
 0.51A 5owrA-4yljA:
21.3		 5owrA-4yljA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ALA A  55
GLU A  76
LEU A 158
ASP A 172
 ADP  A 506 (-3.3A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.60A 5owrA-4ysjA:
24.7		 5owrA-4ysjA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 ALA A 597
GLU A 612
ILE A 642
CYH A 645
 None
 0.55A 5owrA-4z7gA:
17.6		 5owrA-4z7gA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 ALA A 597
ILE A 642
CYH A 645
LEU A 695
 None
 0.46A 5owrA-4z7gA:
17.6		 5owrA-4z7gA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ALA A  83
GLU A 103
LEU A 185
ASP A 196
 5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.6A)
 0.72A 5owrA-5es1A:
22.7		 5owrA-5es1A:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 625
GLU A 644
CYH A 677
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 (-4.3A)
 0.42A 5owrA-5grnA:
2.1		 5owrA-5grnA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 ALA A  41
GLU A  61
LEU A 143
ASP A 157
 ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.39A 5owrA-5hu3A:
23.9		 5owrA-5hu3A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  77
GLU A  95
CYH A 133
LEU A 187
ASP A 198
 IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.78A 5owrA-5i3oA:
10.1		 5owrA-5i3oA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		4 ILE A 292
CYH A 296
LEU A  88
VAL A 451
 None
 0.70A 5owrA-5i6cA:
undetectable		 5owrA-5i6cA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		4 ALA A  45
GLU A  65
LEU A 147
ASP A 161
 None
 0.60A 5owrA-5ig1A:
23.9		 5owrA-5ig1A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  43
GLU A  61
CYH A  93
LEU A 143
ASP A 154
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.32A 5owrA-5j5tA:
32.1		 5owrA-5j5tA:
38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 176
GLU A 193
LEU A 282
ASP A 295
 7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.53A 5owrA-5lxdA:
15.7		 5owrA-5lxdA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 ALA A 645
GLU A 657
ILE A 646
ASP A 725
 None
 0.72A 5owrA-5mqsA:
undetectable		 5owrA-5mqsA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 ALA A  38
GLU A  57
CYH A  89
LEU A 139
ASP A 150
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.63A 5owrA-5tvtA:
22.3		 5owrA-5tvtA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 137
GLU A 157
CYH A 190
ASP A 251
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
 0.53A 5owrA-5vcxA:
15.2		 5owrA-5vcxA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 4 ALA A 707
GLU A 725
LEU A 810
ASP A 822
 9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.54A 5owrA-5vilA:
20.4		 5owrA-5vilA:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 150
CYH A 193
LEU A 243
ASP A 254
 9FS  A 501 (-3.4A)
9FS  A 501 (-4.3A)
9FS  A 501 (-4.7A)
None
 0.52A 5owrA-5vo1A:
20.4		 5owrA-5vo1A:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 4 ALA A  49
GLU A  69
LEU A 150
ASP A 161
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
 0.55A 5owrA-5wnmA:
22.6		 5owrA-5wnmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 4 ALA A 236
GLU A 253
LEU A 342
ASP A 355
 HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
HRM  A 601 (-4.7A)
 0.64A 5owrA-5y86A:
13.6		 5owrA-5y86A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 ALA A 754
GLU A 774
LEU A 866
ASP A 877
 CJM  A1102 (-3.1A)
None
CJM  A1102 (-4.4A)
MG  A1101 (-2.5A)
 0.41A 5owrA-6b3eA:
16.8		 5owrA-6b3eA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 ALA A 388
GLU A 409
CYH A 441
ASP A 502
 EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
DMS  A 702 ( 3.1A)
 0.63A 5owrA-6c0tA:
15.6		 5owrA-6c0tA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 ALA A  87
GLU A 107
LEU A 189
ASP A 200
 None
 0.52A 5owrA-6c9dA:
21.8		 5owrA-6c9dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 ALA A 192
GLU A 236
LEU A 319
ASP A 330
 F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
 0.44A 5owrA-6cmjA:
23.2		 5owrA-6cmjA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 4 ALA U  42
CYH U  94
LEU U 144
ASP U 157
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.30A 5owrA-6fdyU:
23.7		 5owrA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 4 GLU U  62
CYH U  94
LEU U 144
ASP U 157
 None
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.33A 5owrA-6fdyU:
23.7		 5owrA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 ALA A 191
GLU A 208
LEU A 297
ASP A 327
 3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
3NG  A 501 (-4.5A)
 0.66A 5owrA-6fylA:
14.9		 5owrA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 ALA A 189
GLU A 206
LEU A 295
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
3NG  A 501 (-4.3A)
 0.62A 5owrA-6fyvA:
22.1		 5owrA-6fyvA:
undetectable