SIMILAR PATTERNS OF AMINO ACIDS FOR 5OV9_B_CVIB603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 TYR A  72
TYR A 124
TRP A 286
HIS A 287
TYR A 341
 None
 0.61A 5ov9B-1b41A:
63.2		 5ov9B-1b41A:
88.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 595
GLN A 245
TRP A 248
HIS A 185
 None
 1.48A 5ov9B-1bf2A:
0.0		 5ov9B-1bf2A:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		7 TYR A  72
TYR A 124
GLN A 279
ASP A 283
TRP A 286
HIS A 287
TYR A 341
 None
 0.54A 5ov9B-1c2oA:
64.0		 5ov9B-1c2oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8n COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF00729
(Viral_coat) 		4 TYR A 159
TYR A 176
ASP A 163
HIS A 242
 None
 1.41A 5ov9B-1c8nA:
undetectable		 5ov9B-1c8nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0z FERREDOXIN

(Halobacterium
salinarum) 		PF00111
(Fer2) 		4 GLN A  14
ASP A  13
HIS A 119
TYR A  57
 None
None
ALY  A 118 ( 3.5A)
None
 1.19A 5ov9B-1e0zA:
undetectable		 5ov9B-1e0zA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 TYR A 104
TYR A 109
ASP A 100
HIS A  67
 None
 1.44A 5ov9B-1eljA:
undetectable		 5ov9B-1eljA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 511
ASP A 513
HIS A 489
TYR A 456
 None
 1.43A 5ov9B-1eovA:
0.0		 5ov9B-1eovA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		6 TYR A  70
TYR A 121
GLN A 272
ASP A 276
TRP A 279
TYR A 334
 None
 0.86A 5ov9B-1gqrA:
61.3		 5ov9B-1gqrA:
58.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		4 TYR A  95
ASP A  90
TRP A  92
HIS A  89
 None
 1.42A 5ov9B-1h0nA:
undetectable		 5ov9B-1h0nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 108
GLN A  70
ASP A  77
HIS A 111
 None
None
None
CU  A 702 (-3.2A)
 1.38A 5ov9B-1hfuA:
0.0		 5ov9B-1hfuA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 TYR A 382
GLN A 380
ASP A 384
TYR A 329
 None
 1.38A 5ov9B-1hwwA:
undetectable		 5ov9B-1hwwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		4 TYR A 372
TYR A 374
GLN A 267
HIS A 327
 None
None
None
HSO  A1001 (-3.9A)
 1.34A 5ov9B-1kaeA:
undetectable		 5ov9B-1kaeA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfr HEMOGLOBIN

(Paramphistomum
epiclitum) 		PF00042
(Globin) 		4 TYR A  66
TYR A  32
ASP A  61
HIS A  52
 HEM  A 148 (-4.0A)
None
None
None
 1.23A 5ov9B-1kfrA:
undetectable		 5ov9B-1kfrA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 TYR A 197
GLN A 238
HIS A 138
TYR A 155
 None
None
FE  A 400 (-3.3A)
None
 1.38A 5ov9B-1ltzA:
undetectable		 5ov9B-1ltzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		4 TYR A 189
TYR A 186
ASP A 151
HIS A 146
 None
None
None
ZN  A 400 (-3.3A)
 1.46A 5ov9B-1nd1A:
undetectable		 5ov9B-1nd1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p90 HYPOTHETICAL PROTEIN

(Azotobacter
vinelandii) 		PF02579
(Nitro_FeMo-Co) 		4 TYR A 170
GLN A 117
ASP A 119
HIS A 121
 None
 1.29A 5ov9B-1p90A:
undetectable		 5ov9B-1p90A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si9 STABLE PROTEIN 1

(Populus tremula) 		PF07876
(Dabb) 		4 TYR A  80
GLN A  78
ASP A  82
TYR A  33
 GOL  A 109 (-4.8A)
None
None
GOL  A 109 (-4.3A)
 1.31A 5ov9B-1si9A:
undetectable		 5ov9B-1si9A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)

(Homo sapiens) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 TYR A  59
GLN A  77
ASP A  50
TYR A 106
 TYR  A  59 ( 1.3A)
GLN  A  77 ( 0.6A)
ASP  A  50 ( 0.6A)
TYR  A 106 ( 1.3A)
 1.37A 5ov9B-1szbA:
undetectable		 5ov9B-1szbA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		4 TYR A 347
TYR A  96
GLN A 353
ASP A 349
 None
 1.44A 5ov9B-1vfwA:
undetectable		 5ov9B-1vfwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 TYR A 433
TYR A 431
ASP A 231
HIS A 323
 None
 1.18A 5ov9B-1wqlA:
undetectable		 5ov9B-1wqlA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 TYR A 633
ASP A 304
HIS A 308
TYR A 261
 None
 1.44A 5ov9B-2a3lA:
1.7		 5ov9B-2a3lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		4 TYR A 221
ASP A 208
TRP A 225
TYR A  10
 PCA  A   0 ( 4.7A)
None
None
None
 1.44A 5ov9B-2ciyA:
undetectable		 5ov9B-2ciyA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee1 CHROMODOMAIN
HELICASE-DNA-BINDING
PROTEIN 4

(Homo sapiens) 		PF00385
(Chromo) 		4 TYR A  30
TYR A  61
ASP A  55
TRP A  62
 None
 1.47A 5ov9B-2ee1A:
undetectable		 5ov9B-2ee1A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f07 YVDT

(Bacillus
subtilis) 		PF00440
(TetR_N) 		4 TYR A 125
TYR A 122
ASP A  68
HIS A  65
 None
BTB  A 289 (-3.8A)
None
None
 1.40A 5ov9B-2f07A:
undetectable		 5ov9B-2f07A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TYR A 219
ASP A 326
HIS A 252
TYR A 184
 None
None
None
BOG  A2000 (-4.5A)
 1.27A 5ov9B-2g3nA:
undetectable		 5ov9B-2g3nA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iee PROBABLE ABC
TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YCKB

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		4 TYR A 182
TYR A 181
GLN A 209
ASP A  90
 None
 1.48A 5ov9B-2ieeA:
undetectable		 5ov9B-2ieeA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 TYR A 755
GLN A 763
ASP A 760
HIS A 688
 None
 1.44A 5ov9B-2nyaA:
undetectable		 5ov9B-2nyaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		4 TYR A 163
ASP A 184
HIS A 245
TYR A 219
 None
CA  A 402 (-2.1A)
None
None
 1.19A 5ov9B-2o04A:
undetectable		 5ov9B-2o04A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 TYR A 466
GLN A 209
ASP A 442
TYR A 571
 None
 1.18A 5ov9B-2okxA:
undetectable		 5ov9B-2okxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 TYR B 266
GLN B 233
ASP B 271
HIS B  34
 None
 0.99A 5ov9B-2pbiB:
undetectable		 5ov9B-2pbiB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE

(Leptospira
interrogans) 		PF00561
(Abhydrolase_1) 		4 TYR A  78
ASP A  76
TRP A  75
TYR A 308
 None
 1.35A 5ov9B-2pl5A:
14.7		 5ov9B-2pl5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.43A 5ov9B-2uw2A:
undetectable		 5ov9B-2uw2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis) 		PF02435
(Glyco_hydro_68) 		4 TYR A 187
TYR A 237
GLN A 229
ASP A 233
 None
 1.39A 5ov9B-2vdtA:
undetectable		 5ov9B-2vdtA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 GLN A 786
ASP A 772
TRP A 524
HIS A 682
TYR A 641
 None
 1.40A 5ov9B-2x05A:
undetectable		 5ov9B-2x05A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 TYR A 241
ASP A 279
TRP A 281
TYR A 256
 None
 1.18A 5ov9B-2xheA:
undetectable		 5ov9B-2xheA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 4 TYR A 325
ASP A 423
HIS A 421
TYR A 595
 None
None
None
RAM  A 639 (-4.7A)
 1.34A 5ov9B-2zuxA:
undetectable		 5ov9B-2zuxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zw4 BLEOMYCIN
ACETYLTRANSFERASE

(Streptomyces
verticillus) 		PF13302
(Acetyltransf_3) 		4 TYR A  58
TYR A  35
TRP A  44
HIS A 161
 None
 1.48A 5ov9B-2zw4A:
undetectable		 5ov9B-2zw4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 TYR A 834
TYR A 837
ASP A 799
TRP A 838
 None
 1.46A 5ov9B-3bg9A:
undetectable		 5ov9B-3bg9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 306
GLN A   5
ASP A  65
HIS A  89
 None
 1.39A 5ov9B-3e18A:
2.5		 5ov9B-3e18A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 GLN A 229
ASP A 551
HIS A 549
TYR A 638
 None
 1.39A 5ov9B-3egwA:
undetectable		 5ov9B-3egwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 145
GLN A 108
ASP A 115
HIS A 148
 None
 1.43A 5ov9B-3g5wA:
undetectable		 5ov9B-3g5wA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 TYR A 431
TYR A 429
ASP A 230
HIS A 321
 None
 1.18A 5ov9B-3gzyA:
undetectable		 5ov9B-3gzyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 208
TYR A 215
TRP A 223
TYR A  56
 None
None
EDO  A 601 (-3.9A)
EDO  A 609 (-4.0A)
 1.27A 5ov9B-3hdxA:
undetectable		 5ov9B-3hdxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikf 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF02542
(YgbB) 		4 TYR A   9
ASP A  48
HIS A  44
TYR A 141
 None
None
ZN  A 201 ( 3.1A)
None
 1.38A 5ov9B-3ikfA:
undetectable		 5ov9B-3ikfA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 TYR A 708
GLN A 807
HIS A 735
TYR A 727
 None
None
ZN  A   1 (-3.1A)
None
 1.33A 5ov9B-3l4kA:
undetectable		 5ov9B-3l4kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 254
TYR A 226
GLN A 264
ASP A 268
 None
 1.18A 5ov9B-3lm5A:
undetectable		 5ov9B-3lm5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN

(Homo sapiens;
Mus musculus;
Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  32
GLN A  90
TRP B  96
HIS B  35
 None
 1.32A 5ov9B-3mnzA:
undetectable		 5ov9B-3mnzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 TYR A 199
GLN A 239
ASP A 235
TYR A 425
 None
 1.25A 5ov9B-3mogA:
undetectable		 5ov9B-3mogA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		4 TYR A 515
GLN A 396
TRP A 539
HIS A 530
 None
 1.38A 5ov9B-3n9oA:
undetectable		 5ov9B-3n9oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A 313
ASP A 311
HIS A 303
TYR A 267
 None
 1.28A 5ov9B-3o04A:
undetectable		 5ov9B-3o04A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 TYR A  45
GLN A  65
ASP A  48
HIS A  49
 None
 1.30A 5ov9B-3o21A:
2.8		 5ov9B-3o21A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 138
GLN A 100
ASP A 107
HIS A 141
 None
None
None
CU  A 602 ( 3.3A)
 1.43A 5ov9B-3ppsA:
undetectable		 5ov9B-3ppsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		4 TYR A 391
GLN A 487
TRP A 475
TYR A 471
 None
 1.18A 5ov9B-3q7zA:
undetectable		 5ov9B-3q7zA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvi HISTO-ASPARTIC
PROTEASE

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 TYR A 151
TYR A 313
ASP A 316
HIS A 318
 TYR  A 151 ( 1.3A)
TYR  A 313 ( 1.3A)
ASP  A 316 ( 0.6A)
HIS  A 318 ( 1.0A)
 1.48A 5ov9B-3qviA:
undetectable		 5ov9B-3qviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		4 TYR A  52
GLN A 102
ASP A 106
TYR A  12
 None
 1.19A 5ov9B-3ripA:
2.1		 5ov9B-3ripA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		4 ASP A  67
TRP A 143
HIS A 138
TYR A  22
 None
 1.42A 5ov9B-3tr7A:
0.9		 5ov9B-3tr7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  51
TYR A 306
ASP A 114
HIS A 312
 None
 1.47A 5ov9B-3ugvA:
undetectable		 5ov9B-3ugvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		4 GLN A 186
ASP A 179
HIS A 140
TYR A  10
 None
 1.00A 5ov9B-3uykA:
undetectable		 5ov9B-3uykA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.40A 5ov9B-3vpoA:
undetectable		 5ov9B-3vpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 GLN A 512
ASP A 516
HIS A 551
TYR A 588
 None
 1.29A 5ov9B-4anjA:
undetectable		 5ov9B-4anjA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 TYR A  84
TYR A  44
GLN A  53
TYR A 140
 None
 1.34A 5ov9B-4b97A:
undetectable		 5ov9B-4b97A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8g 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF02542
(YgbB) 		4 TYR A   9
ASP A  48
HIS A  44
TYR A 141
 None
None
ZN  A1162 (-3.1A)
None
 1.35A 5ov9B-4c8gA:
undetectable		 5ov9B-4c8gA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw1 MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B14

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A   7
GLN A   9
HIS A  35
TYR A 168
 None
 1.44A 5ov9B-4cw1A:
undetectable		 5ov9B-4cw1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLN A 363
ASP A 480
HIS A 432
TYR A 491
 None
 1.08A 5ov9B-4cw4A:
undetectable		 5ov9B-4cw4A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TYR A 279
ASP A  32
TRP A  35
HIS A  36
 None
 1.41A 5ov9B-4eqvA:
undetectable		 5ov9B-4eqvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 TYR A 141
GLN A 127
ASP A 147
HIS A 192
 H1L  A 501 (-3.6A)
None
None
None
 1.01A 5ov9B-4g2rA:
1.8		 5ov9B-4g2rA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 TYR A 708
GLN A 807
HIS A 735
TYR A 727
 None
 1.41A 5ov9B-4gfhA:
undetectable		 5ov9B-4gfhA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE

(Sphingobium
chlorophenolicum) 		PF00903
(Glyoxalase) 		4 GLN A  20
ASP A  24
HIS A 104
TYR A 144
 None
 1.43A 5ov9B-4huzA:
undetectable		 5ov9B-4huzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixj FIMBRIAL PROTEIN
(PILIN)

(Clostridioides
difficile) 		no annotation 4 TYR A 219
TYR A 217
ASP A 239
TYR A 108
 None
None
GOL  A 303 (-3.4A)
None
 1.48A 5ov9B-4ixjA:
undetectable		 5ov9B-4ixjA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B  52
TRP B  34
HIS B  33
TYR B  85
 None
 1.45A 5ov9B-4jznB:
undetectable		 5ov9B-4jznB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.44A 5ov9B-4m00A:
undetectable		 5ov9B-4m00A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.45A 5ov9B-4m01A:
undetectable		 5ov9B-4m01A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m02 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.40A 5ov9B-4m02A:
undetectable		 5ov9B-4m02A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLN A 341
ASP A 297
HIS A 264
TYR A 268
 None
 1.39A 5ov9B-4o9xA:
undetectable		 5ov9B-4o9xA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 TYR A 343
TYR A 339
GLN A 177
HIS A 185
 None
 1.40A 5ov9B-4ovkA:
undetectable		 5ov9B-4ovkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 4 TYR A  76
GLN A  72
ASP A  18
HIS A 462
 None
 1.17A 5ov9B-4payA:
undetectable		 5ov9B-4payA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 TYR A 394
TYR A 423
ASP A 414
TYR A 429
 None
 1.37A 5ov9B-4pl0A:
2.1		 5ov9B-4pl0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 TYR A  28
GLN A 485
ASP A 482
TYR A 140
 None
 1.46A 5ov9B-4qfuA:
undetectable		 5ov9B-4qfuA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 TYR A 121
GLN A 272
ASP A 276
TRP A 279
TYR A 334
 None
 0.72A 5ov9B-4qwwA:
62.4		 5ov9B-4qwwA:
63.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		4 TYR A  72
GLN A 158
HIS A 119
TYR A  67
 None
 1.27A 5ov9B-4wu0A:
undetectable		 5ov9B-4wu0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 TYR A  30
TYR A  29
GLN A 136
ASP A 134
 INS  A 301 (-4.6A)
None
MG  A 303 ( 2.9A)
MG  A 303 ( 4.0A)
 1.29A 5ov9B-4xf7A:
undetectable		 5ov9B-4xf7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN

(Rattus
norvegicus;
Rattus
norvegicus) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  41
TYR L  59
GLN L  99
HIS H  38
 None
 1.33A 5ov9B-4yqxL:
undetectable		 5ov9B-4yqxL:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 TYR A 313
GLN A 280
TRP A 390
TYR A 571
 None
 1.44A 5ov9B-4z2aA:
undetectable		 5ov9B-4z2aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 4 TYR A  77
GLN A  73
ASP A  19
HIS A 463
 None
 1.42A 5ov9B-4zuzA:
undetectable		 5ov9B-4zuzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq5 L-SHAPED TAIL FIBER
PROTEIN PB8

(Escherichia
virus T5) 		no annotation 4 GLN A1169
ASP A1155
TRP A1153
TYR A1175
 None
 1.45A 5ov9B-5aq5A:
undetectable		 5ov9B-5aq5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B  52
TRP B  34
HIS B  33
TYR B  85
 None
 1.42A 5ov9B-5esaB:
undetectable		 5ov9B-5esaB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 TYR A 730
ASP A 736
HIS A 739
TYR A 781
 None
 1.13A 5ov9B-5hb3A:
undetectable		 5ov9B-5hb3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 4 TYR C 899
TRP C 797
HIS C 794
TYR C 618
 None
 1.23A 5ov9B-5hr4C:
undetectable		 5ov9B-5hr4C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrz TPR DOMAIN PROTEIN
1NA0C3_3

(synthetic
construct) 		PF13174
(TPR_6)
PF13432
(TPR_16) 		4 TYR A  41
TYR A  60
ASP A  67
TYR A  14
 None
 1.40A 5ov9B-5hrzA:
undetectable		 5ov9B-5hrzA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 GLN A 201
ASP A 205
TRP A 216
TYR A 361
 None
 1.15A 5ov9B-5imuA:
undetectable		 5ov9B-5imuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 4 GLN A 548
ASP A 545
TRP A 514
TYR A 510
 None
 1.07A 5ov9B-5odsA:
undetectable		 5ov9B-5odsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 4 TYR b 351
TYR b 370
HIS b 363
TYR b 590
 CLA  b1838 (-4.4A)
None
None
CLA  b1838 (-3.8A)
 1.10A 5ov9B-5oy0b:
undetectable		 5ov9B-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2l HEAT SHOCK PROTEIN
104

(Candida
albicans) 		PF02861
(Clp_N) 		4 GLN A 122
ASP A 126
HIS A  70
TYR A  58
 None
 1.24A 5ov9B-5u2lA:
undetectable		 5ov9B-5u2lA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		4 TYR A 118
GLN A 101
ASP A  93
HIS A 186
 None
None
None
FE  A 403 ( 3.4A)
 1.48A 5ov9B-5uq6A:
undetectable		 5ov9B-5uq6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 TYR A 671
GLN A 683
ASP A 679
TYR A 644
 None
 1.25A 5ov9B-5v1wA:
undetectable		 5ov9B-5v1wA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 GLN A 324
ASP A 322
HIS A 208
TYR A 178
 None
 1.04A 5ov9B-5yy3A:
undetectable		 5ov9B-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy5 -

(-) 		no annotation 4 TYR D  35
TYR D  37
GLN D  54
ASP D  53
 None
 1.42A 5ov9B-5yy5D:
undetectable		 5ov9B-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 4 GLN I 512
ASP I 516
HIS I 551
TYR I 588
 None
 1.40A 5ov9B-6bnpI:
undetectable		 5ov9B-6bnpI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 4 TYR A 110
GLN A 218
ASP A 222
HIS A 227
 HEM  A 600 (-4.4A)
None
None
None
 1.35A 5ov9B-6c93A:
undetectable		 5ov9B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 4 TYR A 693
GLN A 735
ASP A 733
HIS A 716
 CL  A 906 ( 4.5A)
None
None
None
 1.32A 5ov9B-6fq3A:
undetectable		 5ov9B-6fq3A:
undetectable