SIMILAR PATTERNS OF AMINO ACIDS FOR 5OV9_A_CVIA609_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 TYR A  72
TYR A 124
TRP A 286
HIS A 287
TYR A 341
 None
 0.57A 5ov9A-1b41A:
62.8		 5ov9A-1b41A:
88.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		6 TYR A  72
TYR A 124
ASP A 283
TRP A 286
HIS A 287
TYR A 341
 None
 0.53A 5ov9A-1c2oA:
63.5		 5ov9A-1c2oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8n COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF00729
(Viral_coat) 		4 TYR A 159
TYR A 176
ASP A 163
HIS A 242
 None
 1.39A 5ov9A-1c8nA:
undetectable		 5ov9A-1c8nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 TYR A 104
TYR A 109
ASP A 100
HIS A  67
 None
 1.41A 5ov9A-1eljA:
undetectable		 5ov9A-1eljA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 511
ASP A 513
HIS A 489
TYR A 456
 None
 1.45A 5ov9A-1eovA:
undetectable		 5ov9A-1eovA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 TYR A  70
TYR A 121
ASP A 276
TRP A 279
TYR A 334
 None
 0.81A 5ov9A-1gqrA:
59.3		 5ov9A-1gqrA:
58.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 TYR A  76
TYR A  75
ASP A 302
TYR A 131
 G6P  A 901 (-4.5A)
None
None
G6P  A 901 ( 4.8A)
 1.47A 5ov9A-1gz5A:
0.0		 5ov9A-1gz5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		4 TYR A  95
ASP A  90
TRP A  92
HIS A  89
 None
 1.42A 5ov9A-1h0nA:
undetectable		 5ov9A-1h0nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 TYR A  78
ASP A 147
HIS A 150
TYR A 246
 2PE  A 503 (-3.4A)
None
None
2PE  A 503 ( 4.1A)
 1.27A 5ov9A-1icpA:
3.0		 5ov9A-1icpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfr HEMOGLOBIN

(Paramphistomum
epiclitum) 		PF00042
(Globin) 		4 TYR A  66
TYR A  32
ASP A  61
HIS A  52
 HEM  A 148 (-4.0A)
None
None
None
 1.29A 5ov9A-1kfrA:
undetectable		 5ov9A-1kfrA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		4 TYR A 189
TYR A 186
ASP A 151
HIS A 146
 None
None
None
ZN  A 400 (-3.3A)
 1.47A 5ov9A-1nd1A:
0.2		 5ov9A-1nd1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 TYR A 298
TYR A 295
ASP A 350
TYR A 270
 None
 1.47A 5ov9A-1pw4A:
undetectable		 5ov9A-1pw4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 TYR A 633
ASP A 304
HIS A 308
TYR A 261
 None
 1.44A 5ov9A-2a3lA:
undetectable		 5ov9A-2a3lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		4 TYR A 221
ASP A 208
TRP A 225
TYR A  10
 PCA  A   0 ( 4.7A)
None
None
None
 1.40A 5ov9A-2ciyA:
undetectable		 5ov9A-2ciyA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		4 TYR A 163
ASP A 184
HIS A 245
TYR A 219
 None
CA  A 402 (-2.1A)
None
None
 1.19A 5ov9A-2o04A:
undetectable		 5ov9A-2o04A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE

(Leptospira
interrogans) 		PF00561
(Abhydrolase_1) 		4 TYR A  78
ASP A  76
TRP A  75
TYR A 308
 None
 1.32A 5ov9A-2pl5A:
12.6		 5ov9A-2pl5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B

(Mus musculus) 		PF03643
(Vps26) 		4 TYR A 128
ASP A 146
HIS A  27
TYR A 116
 None
 1.50A 5ov9A-2r51A:
undetectable		 5ov9A-2r51A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.44A 5ov9A-2uw2A:
undetectable		 5ov9A-2uw2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASP A 772
TRP A 524
HIS A 682
TYR A 641
 None
 1.28A 5ov9A-2x05A:
undetectable		 5ov9A-2x05A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 TYR A 241
ASP A 279
TRP A 281
TYR A 256
 None
 1.12A 5ov9A-2xheA:
1.6		 5ov9A-2xheA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 4 TYR A 325
ASP A 423
HIS A 421
TYR A 595
 None
None
None
RAM  A 639 (-4.7A)
 1.34A 5ov9A-2zuxA:
undetectable		 5ov9A-2zuxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 TYR A 292
ASP A 390
HIS A 388
TYR A 579
 None
 1.31A 5ov9A-2zuyA:
undetectable		 5ov9A-2zuyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 TYR A 834
TYR A 837
ASP A 799
TRP A 838
 None
 1.49A 5ov9A-3bg9A:
undetectable		 5ov9A-3bg9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bql ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 TYR A1530
TYR A1526
ASP A1259
HIS A1257
 None
 1.39A 5ov9A-3bqlA:
undetectable		 5ov9A-3bqlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0q A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD)
PF14815
(NUDIX_4) 		4 TYR A  89
ASP A  77
HIS A  96
TYR A  57
 None
 1.21A 5ov9A-3g0qA:
undetectable		 5ov9A-3g0qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 208
TYR A 215
TRP A 223
TYR A  56
 None
None
EDO  A 601 (-3.9A)
EDO  A 609 (-4.0A)
 1.29A 5ov9A-3hdxA:
undetectable		 5ov9A-3hdxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikf 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF02542
(YgbB) 		4 TYR A   9
ASP A  48
HIS A  44
TYR A 141
 None
None
ZN  A 201 ( 3.1A)
None
 1.31A 5ov9A-3ikfA:
undetectable		 5ov9A-3ikfA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A 313
ASP A 311
HIS A 303
TYR A 267
 None
 1.25A 5ov9A-3o04A:
undetectable		 5ov9A-3o04A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		4 ASP A  67
TRP A 143
HIS A 138
TYR A  22
 None
 1.36A 5ov9A-3tr7A:
undetectable		 5ov9A-3tr7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  51
TYR A 306
ASP A 114
HIS A 312
 None
 1.47A 5ov9A-3ugvA:
undetectable		 5ov9A-3ugvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.40A 5ov9A-3vpoA:
undetectable		 5ov9A-3vpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn6 VP16

(Thermus virus
P23-77) 		no annotation 4 TYR B  95
TYR B  99
ASP B  74
TYR B  62
 None
 1.47A 5ov9A-3zn6B:
undetectable		 5ov9A-3zn6B:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8g 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF02542
(YgbB) 		4 TYR A   9
ASP A  48
HIS A  44
TYR A 141
 None
None
ZN  A1162 (-3.1A)
None
 1.30A 5ov9A-4c8gA:
undetectable		 5ov9A-4c8gA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		4 TYR A 182
TYR A 265
ASP A 224
HIS A 170
 None
 1.36A 5ov9A-4l7aA:
undetectable		 5ov9A-4l7aA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.48A 5ov9A-4m00A:
undetectable		 5ov9A-4m00A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.50A 5ov9A-4m01A:
undetectable		 5ov9A-4m01A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m02 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.46A 5ov9A-4m02A:
undetectable		 5ov9A-4m02A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 TYR A 394
TYR A 423
ASP A 414
TYR A 429
 None
 1.38A 5ov9A-4pl0A:
2.1		 5ov9A-4pl0A:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 TYR A 121
ASP A 276
TRP A 279
TYR A 334
 None
 0.73A 5ov9A-4qwwA:
58.9		 5ov9A-4qwwA:
63.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		4 TYR A  59
ASP A  57
HIS A 305
TYR A  90
 None
None
ZN  A 402 ( 3.3A)
None
 1.30A 5ov9A-4zo3A:
undetectable		 5ov9A-4zo3A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 4 ASP A  45
TRP A  47
HIS A 171
TYR A 161
 None
 1.45A 5ov9A-5e4mA:
undetectable		 5ov9A-5e4mA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 TYR A 730
ASP A 736
HIS A 739
TYR A 781
 None
 1.19A 5ov9A-5hb3A:
undetectable		 5ov9A-5hb3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 4 TYR C 899
TRP C 797
HIS C 794
TYR C 618
 None
 1.24A 5ov9A-5hr4C:
2.1		 5ov9A-5hr4C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrz TPR DOMAIN PROTEIN
1NA0C3_3

(synthetic
construct) 		PF13174
(TPR_6)
PF13432
(TPR_16) 		4 TYR A  41
TYR A  60
ASP A  67
TYR A  14
 None
 1.31A 5ov9A-5hrzA:
undetectable		 5ov9A-5hrzA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TYR A  89
ASP A  77
HIS A  96
TYR A  57
 None
 1.43A 5ov9A-5kn8A:
undetectable		 5ov9A-5kn8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 TYR A 592
TYR A 590
ASP A 595
HIS A 576
 None
 1.49A 5ov9A-5ohsA:
undetectable		 5ov9A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 4 TYR b 351
TYR b 370
HIS b 363
TYR b 590
 CLA  b1838 (-4.4A)
None
None
CLA  b1838 (-3.8A)
 1.04A 5ov9A-5oy0b:
undetectable		 5ov9A-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x55 PROBABLE URACIL-DNA
GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF03167
(UDG) 		4 ASP A 191
TRP A 272
HIS A 268
TYR A 146
 None
 1.46A 5ov9A-5x55A:
1.4		 5ov9A-5x55A:
18.05